# overview
My laboratory conducts research in two areas of molecular and cellular medicine:  the mechanism through which primary human endothelial cells invade into 3D matrices, and communication between invading endothelial cells and their surrounding 3D collagen matrix.

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5 Development Of Treatments And Therapeutic Interventions

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Intercellular Signaling Peptides And Proteins

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Intracellular Signaling Peptides And Proteins

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Intercellular Signaling Peptides And Proteins

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Receptor, Transforming Growth Factor-beta Type I

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Receptors, Transforming Growth Factor Beta

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Intracellular Signaling Peptides And Proteins

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Hypoxia-Inducible Factor 1, Alpha Subunit

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Vascular Endothelial Growth Factor Receptor-3

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Receptor, Transforming Growth Factor-beta Type I

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Receptor, Transforming Growth Factor-beta Type I

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Receptors, Transforming Growth Factor Beta

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Intracellular Signaling Peptides And Proteins

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1.1 Normal Biological Development And Functioning

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Human Uterine Microvascular Endothelial Cells

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1.1 Normal Biological Development And Functioning

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Vascular Endothelial Growth Factor Receptor-2

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Reverse Transcriptase Polymerase Chain Reaction

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Vascular Endothelial Growth Factor Receptor-3

# educationAndTraining[].organization.label
Texas A&M Health Science Center - (College Station, Texas, United States)

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Texas Lutheran University - (Seguin, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M Health Science Center - (College Station, Texas, United States)

# awardsAndHonors[].label
Junior Faculty Research Excellence Award

# publications[].label
Integrin  is necessary for the attachment of trophectoderm cells to osteopontin to mediate adhesion of the conceptus to the uterus during implantation in pigs

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Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.

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2D Nanosilicates Loaded with Proangiogenic Factors Stimulate Endothelial Sprouting

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Perfusability and immunogenicity of implantable pre-vascularized tissues recapitulating native capillary network

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Molecular basis of endothelial cell morphogenesis in three-dimensional extracellular matrices.

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Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK).

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Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture.

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The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices.

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The sphingosine 1-phosphate (S1P) signaling pathway is regulated during pregnancy in sheep.

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Investigating endothelial invasion and sprouting behavior in three-dimensional collagen matrices.

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Endothelial tubes assemble from intracellular vacuoles in vivo.

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AFFINITY OF OSTEOPONTIN FOR LEUKOCYTE INTEGRINS, EXTRACELLULAR MATRICES AND APOPTOTIC CELLS

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Osteopontin is a ligand for the alpha4beta1 integrin.

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TGFBR1 is required for mouse myometrial development.

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Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells.

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Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing.

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Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.

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Abstract W MP51: Insulin-like Growth Factor (igf-1) Enhances The Angiogenic Response Of Aging Endothelial Cells

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RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha(v)beta(3) and alpha(5)beta(1) integrins.

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ULTRASHORT PULSE MULTISPECTRAL NONLINEAR OPTICAL MICROSCOPY.

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Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices.

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An integrin and Rho GTPase-dependent pinocytic vacuole mechanism controls capillary lumen formation in collagen and fibrin matrices.

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Hypoxic tumor microenvironment: Implications for cancer therapy.

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ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion.

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Fluid shear stress promotes proprotein convertase-dependent activation of MT1-MMP.

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Selective regulation of Notch ligands during angiogenesis is mediated by vimentin.

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Proceedings of the National Academy of Sciences

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Materials composed of the Drosophila melanogaster protein ultrabithorax are cytocompatible.

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Nanoengineered injectable hydrogels for wound healing application.

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Role of the cytoskeleton in formation and maintenance of angiogenic sprouts.

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Sphingosine-1-phosphate markedly induces matrix metalloproteinase and integrin-dependent human endothelial cell invasion and lumen formation in three-dimensional collagen and fibrin matrices.

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Matrix density alters zyxin phosphorylation, which limits peripheral process formation and extension in endothelial cells invading 3D collagen matrices.

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Tumor Lymphatic Interactions Induce CXCR2-CXCL5 Axis and Alter Cellular Metabolism and Lymphangiogenic Pathways to Promote Cholangiocarcinoma.

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Assembly of a mechanosensitive complex is required to initiate sprouting angiogenesis

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Targeting Lymphangiogenesis and Lymph Node Metastasis in Liver Cancer.

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Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function.

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Fiber Optically Delivered Laser Pulses for Multispectral Nonlinear Optical Microscopy

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Osteopontin is a ligand for the alpha4beta1 integrin.

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Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation.

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Engineering ubx-based materials to promote and guide neovascularization

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MMP-1 activation by serine proteases and MMP-10 induces human capillary tubular network collapse and regression in 3D collagen matrices.

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Enhanced focal adhesion assembly reflects increased mechanosensation and mechanotransduction at maternal-conceptus interface and uterine wall during ovine pregnancy.

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Functionalization of Ultrabithorax Materials with Vascular Endothelial Growth Factor Enhances Angiogenic Activity.

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Establishment of a three-dimensional model to study human uterine angiogenesis.

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Microtubule depolymerization rapidly collapses capillary tube networks in vitro and angiogenic vessels in vivo through the small GTPase Rho.

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Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells.

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Angiogenesis: 2D Nanosilicates Loaded with Proangiogenic Factors Stimulate Endothelial Sprouting (Adv. Biosys. 7/2018)

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Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress.

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Capillary morphogenesis during human endothelial cell invasion of three-dimensional collagen matrices.

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Recruitment and Modulation of Porcine Endothelial Progenitor Cells by Secreted Phosphoprotein 1 (SPP1, Osteopontin).

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Isolation and biological properties of osteopontin from bovine milk.

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CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function.

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American Association for the Advancement of Science (AAAS)

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OPN binds alpha V integrin to promote endothelial progenitor cell incorporation into vasculature.

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Guanosine triphosphatase activation occurs downstream of calcineurin in cardiac hypertrophy*.

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Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses.

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The Cdc42 and Rac1 GTPases are required for capillary lumen formation in three-dimensional extracellular matrices

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Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation.

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S1P Synergizes with Wall Shear Stress and Other Angiogenic Factors to Induce Endothelial Cell Sprouting Responses.

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Endorepellin and endostatin affect the neurovascular unit in vitro

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Novel pathways for implantation and establishment and maintenance of pregnancy in mammals.

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NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-B pathway.

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Angiogenic responses are enhanced in mechanically and microscopically characterized, microbial transglutaminase crosslinked collagen matrices with increased stiffness.

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Functionalized protein-based materials and their uses

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Effects of Fluid Shear Stress on Endothelial Cell Invasion Into Three-Dimensional Matrices

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EZH2 and Endometrial Cancer Development: Insights from a Mouse Model.

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Fluid shear stress enhances the effects of sphingosine-1-phosphate on endothelial cell invasion into collagen matrices

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Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome.

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SPP1 (Osteopontin) and SPARC (Osteonectin) May Interact Developmentally During Mouse Pregnancy.

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Ischemia-induced cleavage of cadherins in NRK cells: evidence for a role of metalloproteinases.

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Akt, 14-3-3, and vimentin mediate a drug-resistant invasive phenotype in diffuse large B-cell lymphoma.

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Progesterone and placentation increase secreted phosphoprotein one (SPP1 or osteopontin) in uterine glands and stroma for histotrophic and hematotrophic support of ovine pregnancy.

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Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling.

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Direct Involvement of CD8+ T Cells in Retinal Angiogenesis.

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Nonlinear optical microscopy reveals invading endothelial cells anisotropically alter three-dimensional collagen matrices.

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FTY720, a sphingosine analog, altered placentome histoarchitecture in ewes.

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ADAM17 co-purifies with TIMP-3 and modulates endothelial invasion responses in three-dimensional collagen matrices.

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Effects of fluid shear stress on endothelial cell invasion into three-dimensional matrices

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Hypertensive Stimuli Indirectly Stimulate Lymphangiogenesis through Immune Cell Secreted Factors.

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The NF-B RelB protein is an oncogenic driver of mesenchymal glioma.

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MATRICRYPTIC INTEGRIN BINDING SITES IN OSTEOPONTIN REGULATE INFLAMMATION

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Fluid shear stress and sphingosine 1-phosphate activate calpain to promote membrane type 1 matrix metalloproteinase (MT1-MMP) membrane translocation and endothelial invasion into three-dimensional collagen matrices.

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Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules.

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Secreted phosphoprotein 1 (SPP1, osteopontin) binds to integrin alpha v beta 6 on porcine trophectoderm cells and integrin alpha v beta 3 on uterine luminal epithelial cells, and promotes trophectoderm cell adhesion and migration.

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Synergistic Regulation of Angiogenic Sprouting by Biochemical Factors and Wall Shear Stress.

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Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis.

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Conjugated Bile Acids Promote Lymphangiogenesis by Modulation of the Reactive Oxygen Species-p90RSK-Vascular Endothelial Growth Factor Receptor 3 Pathway.

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MicroRNA-150 (miR-150) and Diabetic Retinopathy: Is miR-150 Only a Biomarker or Does It Contribute to Disease Progression?

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Antagonism of the S1P Signaling Pathway Affects Placental and Fetal Development.

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Capillary morphogenesis during human endothelial cell invasion of three-dimensional collagen matrices

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Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses

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Transforming growth factor beta signaling and decidual integrity in mice.

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Identification of dual alpha 4beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin.

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Identification of multiple dityrosine bonds in materials composed of the Drosophila protein Ultrabithorax.

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Mechanotransduction drives morphogenesis to develop folding during placental development in pigs.

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Expression of SPP1 (Osteopontin) and the Aggregation of Integrins into Focal Adhesions Is an Adaptation to Mechanical Forces at the Uterine-Placental Interface in Pigs.

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Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity.

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Vimentin as an integral regulator of cell adhesion and endothelial sprouting.

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Fluid shear stress and sphingosine 1-phosphate promote Filamin A membrane translocation and complex formation with VE-cadherin during endothelial cell invasion.

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Antagonism of the Sphingosine 1-Phosphate (S1P) Signaling Pathway in Pregnant Ewes Alters Placentome Architecture, Amino Acid Transport, and Fetal Growth.

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Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.

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Conjugated Bile Acids activate Reactive Oxygen Speciesp90RSKVascular Endothelial Growth Factor Receptor 3 signaling axis to promote lymphangiogenesis

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Separating full-length protein from aggregating proteolytic products using filter flow-through purification.

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Piezo1 mediates angiogenesis through activation of MT1-MMP signaling.

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Dynamic multicomponent engineered tissue reorganization and matrix deposition measured with an integrated nonlinear optical microscopy-optical coherence microscopy system.

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SPIE, the international society for optics and photonics

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Molecular Regulation of Sprouting Angiogenesis.

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Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation

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Fluid Shear Stress Modulates S1P-Induced Endothelial Cell Invasion Into Three-Dimensional Matrices

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Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis.

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The 1-integrin plays a key role in LEC invasion in an optimized 3-D collagen matrix model.

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Mechanisms of Angiogenic Switch Activation During Wound Repair

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Heart, Lung, and Blood Institute

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NIK Promotes a Leader Cell Phenotype in Glioma

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of Neurological Disorders and Stroke

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Filamins stabilize a transmembrane complex to initiate angiogenesis

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American Heart Association - (New York, New York, United States)

# streetAddress
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS

# etdChairOf[].label
Duran, Camille L (2017-04). Noncanonical NF-KB Signaling Drives Glioma Invasion by Promoting MT1-MMP Activation, Pseudopodia Formation, and ITGA11 Expression. Doctoral Dissertation.

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Tsai, Shang-Pu (2016-05). Ubx as a Novel Protein-Based Material: Structural Insights, Functionalization via Gene Fusion and Biomedical Applications. Doctoral Dissertation.

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Su, Shih-Chi (2011-08). Study of Endothelial Morphogenesis in Three-Dimensional Collagen Matrices. Doctoral Dissertation.

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Kang, Ho Jin (2012-07). The Synergic Effects of Flow and Sphingosine 1-Phosphate on Sprouting Angiogenesis Into Three-Dimensional Collagen Matrices. Doctoral Dissertation.

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Dave, Jui Mayank (2014-12). Identification of Scaffold Proteins RACK1 and Hic-5 as Regulators of Endothelial Sprouting Resoponses. Doctoral Dissertation.

# etdChairOf[].label
Smith, Rebecca (2014-01). Annexin A2 is Required for Endothelial Cell Junctional Response to S1P. Master's Thesis.