# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Basic Helix-loop-helix Leucine Zipper Transcription Factors

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
Oxidoreductases Acting On Ch-ch Group Donors

# keywords[]
Enoyl-acyl Carrier Protein Reductase (inha)

# keywords[]
Circadian Rhythm Signaling Peptides And Proteins

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
Basic Helix-loop-helix Leucine Zipper Transcription Factors

# keywords[]
Oxidoreductases Acting On Ch-ch Group Donors

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
High-temperature Requirement A Serine Peptidase 2

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Oxidoreductases Acting On Ch-ch Group Donors

# educationAndTraining[].organization.label
Saint Louis University - (St Louis, Missouri, United States)

# educationAndTraining[].organization.label
Saint Louis University - (St Louis, Missouri, United States)

# publications[].label
TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

# publications[].label
PROTEIN LONG CHAIN FATTY-ACID INTERACTIONS - A X-RAY CRYSTALLOGRAPHIC STUDY USING E-COLI-DERIVED RAT INTESTINAL FATTY-ACID BINDING-PROTEIN

# publications[].label
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.

# publications[].label
Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.

# publications[].label
The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP.

# publications[].label
Regulation of product chain length by isoprenyl diphosphate synthases.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A DNA-binding protein tunes septum placement during Bacillus subtilis sporulation

# publications[].label
Gene-target recognition among members of the myc superfamily and implications for oncogenesis.

# publications[].label
THE USE OF CRYSTAL-STRUCTURE ANALYSIS OF RECOMBINANT CLASS-I MHC-PEPTIDE COMPLEXES TO ANALYZE THE MOLECULAR-BASIS OF PEPTIDE MHC TCR INTERACTIONS

# publications[].label
The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.

# publications[].label
Development of single-cell-level microfluidic technology for long-term growth visualization of living cultures of Mycobacterium smegmatis.

# publications[].label
Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA binding activity.

# publications[].label
A comparative study of the backbone dynamics of two closely related lipid binding proteins: bovine heart fatty acid binding protein and porcine ileal lipid binding protein.

# publications[].label
Human intestinal fatty acid binding protein: report of an assay with studies in normal volunteers and intestinal ischemia.

# publications[].label
Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.

# publications[].label
TB drug discovery: addressing issues of persistence and resistance.

# publications[].label
Automated structure determination with phenix

# publications[].label
High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors.

# publications[].label
Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening.

# publications[].label
Solution structure of ileal lipid binding protein in complex with glycocholate (vol 267, pg 2929, 2000)

# publications[].label
Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily.

# publications[].label
The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence.

# publications[].label
Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum.

# publications[].label
X-ray crystal structure of the soybean agglutinin cross-linked with a biantennary analog of the blood group I carbohydrate antigen.

# publications[].label
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.

# publications[].label
Compositions and methods for drug-sensitization or inhibition of a cancer cell

# publications[].label
Evidence for the non-essentiality of the Plasmodium candidate drug target enoyl acp reductase

# publications[].label
Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.

# publications[].label
Erratum for Perkowski et al., "The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection".

# publications[].label
Molecular mapping of the 8.12 SLE-associated idiotype specificity at the single amino acid level.

# publications[].label
Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase.

# publications[].label
Structure of the Mtb CarD/RNAP -lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD.

# publications[].label
Mechanism of thioamide drug action against tuberculosis and leprosy.

# publications[].label
Development of a Novel Lead that Targets M.tuberculosis Polyketide Synthase 13.

# publications[].label
Three-dimensional structure of recombinant human muscle fatty acid-binding protein.

# publications[].label
Efficient retrieval of electron density patterns for modeling proteins by X-ray crystallography

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.

# publications[].label
3-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN MUSCLE FATTY ACID-BINDING PROTEIN

# publications[].label
Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution.

# publications[].label
TEXTALTM: Artificial Intelligence Techniques for Automated Protein Structure Determination.

# publications[].label
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
The tuberculosis structural genomics consortium: a structural genomics approach to drug discovery.

# publications[].label
Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.

# publications[].label
Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.

# publications[].label
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.

# publications[].label
THE TUBERCULOSIS STRUCTURAL GENOMICS CONSORTIUM: A STRUCTURAL GENOMICS APPROACH TO DRUG DISCOVERY

# publications[].label
THE USE OF CRYSTAL-STRUCTURE ANALYSIS OF RECOMBINANT CLASS-I MHC-PEPTIDE COMPLEXES TO ANALYZE THE MOLECULAR-BASIS OF PEPTIDE/MHC/TCR INTERACTIONS

# publications[].label
Effective electron-density map improvement and structure validation on a Linux multi-CPU web cluster: The TB Structural Genomics Consortium Bias Removal Web Service.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
The structure of crystalline Escherichia coli-derived rat intestinal fatty acid-binding protein at 2.5-A resolution.

# publications[].label
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing.

# publications[].label
Rational design of potent human transthyretin amyloid disease inhibitors (vol 7, pg 312, 2000)

# publications[].label
Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L.

# publications[].tags
12 Responsible Consumption and Production

# publications[].label
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis.

# publications[].label
Mutations in pepQ Confer Low-Level Resistance to Bedaquiline and Clofazimine in Mycobacterium tuberculosis.

# publications[].label
Guide RNA biogenesis involves a novel RNase III family endoribonuclease in Trypanosoma brucei.

# publications[].label
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

# publications[].label
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.

# publications[].label
Crystal structure of precorrin-8x methyl mutase.

# publications[].label
Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis.

# publications[].label
GWAS for quantitative resistance phenotypes in Mycobacterium tuberculosis reveals resistance genes and regulatory regions.

# publications[].label
Compositions and methods for inhibition of mycobacteria

# publications[].label
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe.

# publications[].label
Compositions and methods for drug sensitization of parasites

# publications[].label
Triclosan derivatives: towards potent inhibitors of drug-sensitive and drug-resistant Mycobacterium tuberculosis.

# publications[].label
Differential solvation of "core" trimannoside complexes of the Dioclea grandiflora lectin and concanavalin A detected by primary solvent isotope effects in isothermal titration microcalorimetry.

# publications[].label
Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids.

# publications[].label
Natural product inhibitors of fatty acid biosynthesis: synthesis of the marine microbial metabolites pseudopyronines A and B and evaluation of their anti-infective activities

# publications[].label
Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Extracting fractal features for analyzing protein structure

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Crystal structure of the human 20S proteasome in complex with carfilzomib.

# publications[].label
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.

# publications[].label
TEXTAL - Crystallographic protein model building using AI and pattern recognition

# publications[].label
Structural basis of fumarate hydratase deficiency.

# publications[].label
Deletion of SenX3-RegX3, a key two-component regulatory system of Mycobacterium smegmatis, results in growth defects under phosphate-limiting conditions.

# publications[].label
Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1.

# publications[].label
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4 '-substituted triclosan derivatives (vol 15, pg 5247, 2005)

# publications[].label
Imaging tuberculosis with endogenous beta-lactamase reporter enzyme fluorescence in live mice.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis.

# publications[].label
The HPr proteins from the thermophile Bacillus stearothermophilus can form domain-swapped dimers.

# publications[].label
Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Recent developments in the PHENIX software for automated crystallographic structure determination.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Amino acid sequence of porcine heart fumarase.

# publications[].label
Crystallization of a deglycosylated T cell receptor (TCR) complexed with an anti-TCR Fab fragment.

# publications[].label
Determining protein structure from electron-density maps using pattern matching.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Front Cover: Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes (ChemBioChem 15/2018)

# publications[].label
The effect of hinge mutations on effector binding and domain rotation in Escherichia coli D-3-phosphoglycerate dehydrogenase.

# publications[].label
C-13 NMR-STUDIES OF FATTY-ACID PROTEIN INTERACTIONS - COMPARISON OF HOMOLOGOUS FATTY ACID-BINDING PROTEINS PRODUCED IN THE INTESTINAL EPITHELIUM

# publications[].label
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis.

# publications[].label
Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Folate pathway disruption leads to critical disruption of methionine derivatives in Mycobacterium tuberculosis.

# publications[].label
Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof

# publications[].label
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.

# publications[].label
The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

# publications[].label
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.

# publications[].label
The mouse intestinal fatty acid binding protein gene: nucleotide sequence, pattern of developmental and regional expression, and proposed structure of its protein product.

# publications[].label
Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.

# publications[].label
Rapid in vitro assembly of class I major histocompatibility complex

# publications[].label
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase: 2 '- and 4 '-substituted triclosan derivatives

# publications[].label
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

# publications[].label
The non-clonality of drug resistance in Beijing-genotype isolates of Mycobacterium tuberculosis from the Western Cape of South Africa.

# publications[].label
CRYSTALLOGRAPHIC ELUCIDATION OF THE ACTIVE-SITE STRUCTURE OF BETA-AMYLASE

# publications[].label
Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.

# publications[].label
A novel antimycobacterial compound acts as an intracellular iron chelator.

# publications[].label
Crystal structure of kappa-bungarotoxin at 2.3-A resolution.

# publications[].label
Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.

# publications[].label
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.

# publications[].label
A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide.

# publications[].label
Multivalent protein-carbohydrate interactions. A new paradigm for supermolecular assembly and signal transduction.

# publications[].label
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.

# publications[].label
Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis.

# publications[].label
Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.

# publications[].label
13C NMR studies of fatty acid-protein interactions: comparison of homologous fatty acid-binding proteins produced in the intestinal epithelium

# publications[].label
Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis-2,3-Epoxy-Succinic Acid.

# publications[].label
Crystallization of rat cellular retinol binding protein II. Preliminary X-ray data obtained from the apoprotein expressed in Escherichia coli.

# publications[].label
Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.

# publications[].label
A low-cost, novel endoscopic repeated-access port for small animal research.

# publications[].label
The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.

# publications[].label
Structure, activity, and inhibition of the Carboxyltransferase -subunit of acetyl coenzyme A carboxylase (AccD6) from Mycobacterium tuberculosis.

# publications[].label
Rat intestinal fatty acid binding protein. A model system for analyzing the forces that can bind fatty acids to proteins.

# publications[].label
Crystal Structure and Thermodynamic Analysis of Human Brain Fatty Acid-binding Protein*

# publications[].label
2-ANGSTROM RESOLUTION STRUCTURE OF BETA-AMYLASE COMPLEXED WITH ALPHA-CYCLODEXTRIN

# publications[].label
Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme (vol 288, pg 18473, 2013)

# publications[].label
Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein.

# publications[].label
Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.

# publications[].label
Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.

# publications[].label
Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.

# publications[].label
Inhibiting transthyretin amyloid formation with small molecules.

# publications[].label
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.

# publications[].label
Crystal structure of Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase: extreme asymmetry in a tetramer of identical subunits.

# publications[].label
A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells.

# publications[].label
Mycobacterium tuberculosis: a model system for structural genomics.

# publications[].label
Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis.

# publications[].label
Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data.

# publications[].label
Automatic modeling of protein backbones in electron-density maps via prediction of Calpha coordinates.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
High throughput crystallography of TB drug targets.

# publications[].label
High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions

# publications[].label
Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution.

# publications[].label
A vitamin B transporter in Mycobacterium tuberculosis.

# publications[].label
An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured.

# publications[].label
X-ray crystallographic studies of unique cross-linked lattices between four isomeric biantennary oligosaccharides and soybean agglutinin.

# publications[].label
Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.

# publications[].label
Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing.

# publications[].label
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.

# publications[].label
A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Asp79 makes a large, unfavorable contribution to the stability of RNase Sa.

# publications[].label
PHENIX: building new software for automated crystallographic structure determination.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Mycobacteriophage Lysin B is a novel mycolylarabinogalactan esterase.

# publications[].label
Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis.

# publications[].label
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .

# publications[].label
Crystal structure of Mycobacterium tuberculosis LrpA, a leucine-responsive global regulator associated with starvation response.

# publications[].label
Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing.

# publications[].label
Subfamily-specific adaptations in the structures of two penicillin-binding proteins from Mycobacterium tuberculosis.

# publications[].label
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.

# publications[].label
Solution structure of ileal lipid binding protein in complex with glycocholate.

# publications[].label
The effect of modifying a fully conserved residue on the allosteric response of bacillus stearothermophilds phosphofructokinase

# publications[].label
Benzoxazoles as Transthyretin Amyloid Fibril Inhibitors: Synthesis, Evaluation, and Mechanism of Action

# publications[].label
Structural evidence for a pH-sensitive dilysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release.

# publications[].label
Expression of rat intestinal fatty acid-binding protein in Escherichia coli. Purification and comparison of ligand binding characteristics with that of Escherichia coli-derived rat liver fatty acid-binding protein.

# publications[].label
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.

# publications[].label
The Tuberculosis Drug Accelerator at year 10: what have we learned?

# publications[].label
Novel diaryl ureas with efficacy in a mouse model of malaria.

# publications[].label
Catechol oxidase - structure and activity.

# publications[].label
Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.

# publications[].label
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.

# publications[].label
Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway.

# publications[].label
NDM-1, the ultimate promiscuous enzyme: substrate recognition and catalytic mechanism.

# publications[].label
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate

# publications[].label
TEXTAL system: artificial intelligence techniques for automated protein model building.

# publications[].label
Compositions and methods for inhibition of mycobacteria

# publications[].label
Reannotation of translational start sites in the genome of Mycobacterium tuberculosis.

# publications[].label
Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor.

# publications[].label
The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection.

# publications[].label
The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD.

# publications[].label
Compositions and methods for drug-sensitization or inhibition of a cancer cell

# publications[].label
Correction: TnSeq of Mycobacterium tuberculosis clinical isolates reveals strain-specific antibiotic liabilities.

# publications[].label
Developmental and structural studies of an intracellular lipid binding protein expressed in the ileal epithelium.

# publications[].label
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.

# publications[].label
Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15.

# publications[].label
Mechanisms for isoniazid action and resistance.

# publications[].label
A structural difference limited to one residue of the antigenic peptide can profoundly alter the biological outcome of the TCR-peptide/MHC class I interaction.

# publications[].publisher
The American Association of Immunologists

# publications[].label
MHC class I-peptide interactions and TCR recognition.

# publications[].label
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

# publications[].label
Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein.

# publications[].label
Crystal structure, sequence, and mechanism of catechol oxidase

# publications[].label
A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation.

# publications[].label
Evaluation of geometric & probabilistic distance measures to retrieve electron density patterns for protein structure determination

# publications[].label
Compositions and methods for drug sensitization of parasites

# publications[].label
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).

# publications[].label
Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein.

# publications[].label
Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories.

# publications[].label
The TB Structural Genomics Consortium: a decade of progress.

# publications[].label
Biochemical and genetic analyses of murine hepatitis virus Nsp15 endoribonuclease.

# publications[].label
Escherichia coli-derived rat intestinal fatty acid binding protein with bound myristate at 1.5 A resolution and I-FABPArg106-->Gln with bound oleate at 1.74 A resolution.

# publications[].label
Binding of catalase-peroxidase-activated isoniazid to wild-type and mutant Mycobacterium tuberculosis enoyl-ACP reductases

# publications[].label
Crystallization of rat intestinal fatty acid binding protein. Preliminary X-ray data obtained from protein expressed in Escherichia coli.

# publications[].label
Specificity normalization for identifying selective inhibitors in virtual screening

# publications[].label
AN AMINO-ACID SUBSTITUTION IN THE HUMAN INTESTINAL FATTY-ACID-BINDING PROTEIN ALTERS THE RATE OF TRANSPORT OF FATTY-ACIDS ACROSS INTESTINE-LIKE CELLS

# publications[].label
Mechanistic and structural studies of H373Q flavocytochrome b2: effects of mutating the active site base.

# publications[].label
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection.

# publications[].label
Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.

# publications[].label
Redefining the Role of the Quaternary Shift in the Allosteric Inhibition of Bacillus Stearothermophilus Phosphofructokinase

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Redefining the role of the quaternary shift in Bacillus stearothermophilus phosphofructokinase.

# publications[].label
Comparison of T54 allele with normal A54 allele of human intestinal fatty acid binding protein.

# publications[].label
The structure and function of the isoniazid target in M. tuberculosis.

# publications[].label
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.

# publications[].label
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.

# publications[].label
Structure of the apo form of Bacillus stearothermophilus phosphofructokinase.

# publications[].label
Erratum: Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding (Protein Science (1999) 8:5 (1023-1031))

# publications[].label
Anion- Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids.

# publications[].label
The mycobacterial antigens 85 complex--from structure to function: response.

# publications[].label
Global assessment of genomic regions required for growth in Mycobacterium tuberculosis.

# publications[].label
Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway.

# publications[].label
Whole genome sequencing identifies bacterial factors affecting transmission of multidrug-resistant tuberculosis in a high-prevalence setting.

# publications[].label
Expression of rat intestinal fatty acid binding protein in E. coli and its subsequent structural analysis: a model system for studying the molecular details of fatty acid-protein interaction

# publications[].label
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

# publications[].label
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor.

# publications[].label
Expression of rat intestinal fatty acid binding protein in E. coli and its subsequent structural analysis: a model system for studying the molecular details of fatty acid-protein interaction.

# publications[].label
Structure-Based Design of N-Phenyl Phenoxazine Transthyretin Amyloid Fibril Inhibitors

# publications[].label
Synthesis, biological activity, and x-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase

# publications[].label
Erratum: Rational design of potent human transthyretin amyloid disease inhibitors (Nature Structural Biology (2000) 7 (312-321))

# publications[].label
A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins

# publications[].label
Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase.

# publications[].label
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.

# publications[].label
Disulfide isomerization after membrane release of its SAR domain activates P1 lysozyme.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi.

# publications[].label
Intracellular fatty-acid-binding proteins and their genes: useful models for diverse biological questions

# publications[].label
Charged residue changes in the carboxy-terminus of alpha-tropomyosin alter mouse cardiac muscle contractility.

# publications[].label
Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis

# publications[].label
Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

# publications[].label
An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
TEM studies of IniA from Mycobacterium tuberculosis

# publications[].label
Automated structure solution with the PHENIX suite.

# publications[].label
Crystal structure of a plant catechol oxidase containing a dicopper center.

# publications[].label
Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes.

# publications[].label
Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB.

# publications[].label
Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.

# publications[].label
The three-dimensional structure of H-2Db at 2.4 A resolution: implications for antigen-determinant selection.

# publications[].label
Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis.

# publications[].label
TEXTAL: a pattern recognition system for interpreting electron density maps.

# publications[].label
Rat heart fatty acid-binding protein is highly homologous to the murine adipocyte 422 protein and the P2 protein of peripheral nerve myelin.

# publications[].label
High-Throughput Differentiation and Screening of a Library of Mutant Stem Cell Clones Defines New Host-Based Genes Involved in Rabies Virus Infection.

# publications[].label
FINDMOL: automated identification of macromolecules in electron-density maps.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
A comparative study of the backbone dynamics of two closely related lipid binding proteins: Bovine heart fatty acid binding protein and porcine ileal lipid binding protein

# publications[].label
The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis.

# publications[].label
A Solution NMR and Crystallographic Study of the Role of the Quaternary Shift in the Allosteric Regulation of Phosphofructokinase from B. stearothermophilus

# publications[].label
1,3-diaryl ureas and surrogates as inhibitors of Plasmodium falciparum enoyl ACP reductase and potential antimalarial therapeutics

# publications[].label
Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.

# publications[].label
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.

# publications[].label
Discovery of InhA inhibitors with anti-mycobacterial activity through a matched molecular pair approach.

# publications[].label
Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver.

# publications[].label
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

# publications[].label
Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.

# publications[].label
Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases.

# publications[].label
Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa.

# publications[].label
ChemInform Abstract: Natural Product Inhibitors of Fatty Acid Biosynthesis: Synthesis of the Marine Microbial Metabolites Pseudopyronines A (Ia) and B (Ib) and Evaluation of Their Antiinfective Activities.

# publications[].label
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.

# publications[].label
13C NMR studies of fatty acid-protein interactions: comparison of homologous fatty acid-binding proteins produced in the intestinal epithelium.

# publications[].label
Organ failure, infection, and the systemic inflammatory response syndrome are associated with elevated levels of urinary intestinal fatty acid binding protein: study of 100 consecutive patients in a surgical intensive care unit.

# publications[].label
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs.

# publications[].label
Improving amino-acid identification, fit and C(alpha) prediction using the Simplex method in automated model building.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
The three-dimensional structures of a polysaccharide binding antibody to Cryptococcus neoformans and its complex with a peptide from a phage display library: implications for the identification of peptide mimotopes.

# publications[].label
Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.

# publications[].label
Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.

# publications[].label
Crystal structure of circadian clock protein KaiA from Synechococcus elongatus.

# publications[].label
THERMODYNAMIC CHARACTERIZATION OF THE STRUCTURAL STABILITY OF A PREDOMINANTLY BETA-STRUCTURE PROTEIN - RAT INTESTINAL FATTY-ACID-BINDING PROTEIN (I-FABP)

# publications[].label
Crystal structure of Rsr, a Ro ortholog from D. radiodurans provides insights into Ro-Y RNA interactions

# publications[].label
Identification of a novel class of small compounds with anti-tuberculosis activity by in silico structure-based drug screening.

# publications[].label
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme.

# publications[].label
Structural studies of class I major histocompatibility complex proteins: insights into antigen presentation.

# publications[].label
Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus.

# publications[].label
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding (vol 8, pg 1023, 1999)

# publications[].label
Identification of compounds with potential antibacterial activity against Mycobacterium through structure-based drug screening.

# publications[].label
Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness.

# publications[].label
KasA, another brick in the mycobacterial cell wall.

# publications[].label
The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition.

# publications[].label
Multidimensional NMR studies of the structure of human intestinal fatty acid binding protein (I-FABP)

# publications[].label
Purification, crystallization, and preliminary X-ray data for porcine fumarase.

# publications[].label
Kinetic and structural characterization of phosphofructokinase from Lactobacillus bulgaricus.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy.

# publications[].label
Crystal structure of monoclonal 6B5 Fab complexed with phencyclidine.

# publications[].label
Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine.

# publications[].label
Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.

# publications[].label
Therapeutic strategies for human amyloid diseases.

# publications[].label
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.

# publications[].label
Probing the pathway of allosteric regulation of DNA binding in zinc sensor proteins from the SmtB/ArsR family

# publications[].label
Rational design of potent human transthyretin amyloid disease inhibitors.

# publications[].label
Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.

# publications[].label
Impact of immunopathology on the antituberculous activity of pyrazinamide.

# publications[].label
Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility

# publications[].label
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

# publications[].label
D-3-Phosphoglycerate dehydrogenase from Mycobacterium tuberculosis is a link between the Escherichia coli and mammalian enzymes.

# publications[].label
Gastrotropin: not an enterooxyntin but a member of a family of cytoplasmic hydrophobic ligand binding proteins.

# publications[].label
A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.

# publications[].label
Inosine-uridine nucleoside hydrolase from Crithidia fasciculata. Genetic characterization, crystallization, and identification of histidine 241 as a catalytic site residue.

# publications[].label
The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis.

# publications[].label
Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama.

# publications[].label
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis.

# publications[].label
Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2.

# publications[].label
Second-Shell Amino Acid R266 Helps Determine N-Succinylamino Acid Racemase Reaction Specificity in Promiscuous N-Succinylamino Acid Racemase/o-Succinylbenzoate Synthase Enzymes.

# publications[].label
Crystal structure of Lyme disease variable surface antigen VlsE of Borrelia burgdorferi.

# publications[].label
Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening.

# publications[].label
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
THE USE OF RECOMBINANT CLASS-I MHO - PEPTIDE COMPLEXES TO DEFINE THE MOLECULAR-BASIS OF PEPTIDE MHC TCR INTERACTIONS

# publications[].label
High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria.

# publications[].label
Database approaches and data representation in structural bioinformatics

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
The 2.0-A resolution structure of soybean beta-amylase complexed with alpha-cyclodextrin.

# publications[].label
Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics

# publications[].label
THE GELATINOLYTIC ACTIVITY OF RAT UTERUS COLLAGENASE

# publications[].label
Structural anatomy of C1 domain interactions with DAG and other agonists

# publications[].label
Primary structure and binding characteristics of locust and human muscle fatty-acid-binding proteins.

# publications[].label
Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme.

# publications[].label
The gelatinolytic activity of rat uterus collagenase.

# publications[].label
TEXTAL: Al-based structural determination for X-ray protein crystallography

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism.

# publications[].label
Correction: Global Assessment of Genomic Regions Required for Growth in Mycobacterium tuberculosis

# publications[].label
A Lysine Acetyltransferase Contributes to the Metabolic Adaptation to Hypoxia in Mycobacterium tuberculosis.

# publications[].label
Crystal structure of hen apo-ovotransferrin. Both lobes adopt an open conformation upon loss of iron.

# publications[].label
Cocrystal structures of NC6.8 Fab identify key interactions for high potency sweetener recognition: implications for the design of synthetic sweeteners.

# publications[].label
R pyocin tail fiber structure reveals a receptor-binding domain with a lectin fold.

# publications[].label
Perturbation of cytochrome c maturation reveals adaptability of the respiratory chain in Mycobacterium tuberculosis.

# publications[].label
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase.

# publications[].label
Trypanosomal nucleoside hydrolase. A novel mechanism from the structure with a transition-state inhibitor.

# publications[].label
The contribution of polar group burial to protein stability is strongly context-dependent.

# publications[].label
Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography

# publications[].label
Identifying non-crystallographic symmetry in protein electron-density maps: a feature-based approach.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Structure-guided design of a potent peptide inhibitor targeting the interaction between CRK and ABL kinase.

# publications[].label
PURIFICATION, CRYSTALLIZATION, AND PRELIMINARY-X-RAY DATA FOR PORCINE FUMARASE

# publications[].label
A collagenolytic serine protease with trypsin-like specificity from the fiddler crab Uca pugilator.

# publications[].label
Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.

# publications[].label
Ein antibakterielles Lacton bekmpft Mycobacterium tuberculosis durch Infiltration der Mykolsurebiosynthese

# publications[].label
A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase.

# publications[].label
Multidrug-resistant tuberculosis in panama is driven by clonal expansion of a multidrug-resistant Mycobacterium tuberculosis strain related to the KZN extensively drug-resistant M. tuberculosis strain from South Africa.

# publications[].label
Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo--lactamase.

# publications[].label
Nuclear magnetic resonance studies of 6-fluorotryptophan-substituted rat cellular retinol-binding protein II produced in Escherichia coli. Analysis of the apoprotein and the holoprotein containing bound all-trans-retinol and all-trans-retinal.

# publications[].label
Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.

# publications[].label
M. tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs).

# publications[].label
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.

# publications[].label
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.

# publications[].label
Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.

# publications[].label
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.

# publications[].label
Weighting features to recognize 3D patterns of electron density in X-ray protein crystallography.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Compositions and methods for drug sensitization of parasites

# publications[].label
High resolution X-ray studies of mammalian intestinal and muscle fatty acid-binding proteins provide an opportunity for defining the chemical nature of fatty acid: protein interactions.

# publications[].label
Binding Mechanism of the N-Terminal SH3 Domain of CrkII and Proline-Rich Motifs in cAbl.

# publications[].label
The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.

# publications[].label
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.

# publications[].label
Elevated intestinal fatty acid binding protein and gastrointestinal complications following cardiopulmonary bypass: a preliminary analysis.

# publications[].label
Regulation of a muralytic enzyme by dynamic membrane topology.

# publications[].label
The 1.25 A resolution structure of phosphoribosyl-ATP pyrophosphohydrolase from Mycobacterium tuberculosis.

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis.

# publications[].label
Crystal structures of soybean beta-amylase reacted with beta-maltose and maltal: active site components and their apparent roles in catalysis.

# publications[].label
Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.

# publications[].label
Identification of differentially regulated gene targets in the Myc and Mad family proteins

# publications[].label
Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit.

# publications[].label
A metal-ligand-mediated intersubunit allosteric switch in related SmtB/ArsR zinc sensor proteins.

# publications[].label
Mtb Bla-specific fluorescent probes for tuberculosis detection and imaging

# publications[].label
Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis.

# publications[].label
Analysis of protein-ligand interactions using localized stereochemical features

# publications[].label
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.

# publications[].label
Crystallographic protein model-building on the web.

# publications[].label
Structural studies on human muscle fatty acid binding protein at 1.4 A resolution: binding interactions with three C18 fatty acids.

# publications[].label
MEDI 204-Structure-based design, synthesis, and biological evaluation of novel inhibitors of Mycobacterium tuberculosis malate synthase

# publications[].label
Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa).

# publications[].label
Binding of fatty acids and peroxisome proliferators to orthologous fatty acid binding proteins from human, murine, and bovine liver.

# publications[].label
THERMODYNAMIC CHARACTERIZATION OF THE STRUCTURAL STABILITY OF A PREDOMINANTLY BETA-STRUCTURE PROTEIN - RAT INTESTINAL FATTY-ACID-BINDING PROTEIN (I-FABP)

# publications[].label
Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.

# publications[].label
The TB structural genomics consortium: providing a structural foundation for drug discovery.

# publications[].label
?-lactamase substrates and methods of their use for the diagnosis of tuberculosis

# publications[].label
Locations and functional roles of conserved lysine residues in Salmonella typhimurium orotate phosphoribosyltransferase.

# publications[].label
Structure of Ribosomal Silencing Factor Bound to Mycobacterium tuberculosis Ribosome.

# publications[].label
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.

# publications[].label
Fatty acid interactions with rat intestinal and liver fatty acid-binding proteins expressed in Escherichia coli. A comparative 13C NMR study.

# publications[].label
-lactamase substrates and methods of their use for the diagnosis of tuberculosis

# publications[].label
Active site modifications of organophosphorus hydrolase for improved detoxification of organophosphorus neurotoxins

# publications[].label
Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.

# publications[].label
Primary structure and crystallization of orotate phosphoribosyltransferase from Salmonella typhimurium.

# publications[].label
Crystal structure of a plant catechol oxidase containing a dicopper center

# publications[].label
1H, 13C and 15N chemical shift assignments of the C-terminal, 133-residue pseudo-receiver domain of circadian input kinase (CikA) in Synechococcus elongatus.

# publications[].label
Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.

# publications[].label
THE TERTIARY STRUCTURES OF FATTY-ACID BINDING-PROTEINS

# publications[].label
Determining relevant features to recognize electron density patterns in x-ray protein crystallography.

# publications[].label
N-Benzyl-4-((heteroaryl)methyl)benzamides: A New Class of Direct NADH-Dependent 2-trans Enoyl-Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity.

# publications[].label
Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: protein complementation reveals shared active sites.

# publications[].label
Electron microscopy and single particle analysis of a mycobacterial preprotein translocation, ATPase

# publications[].label
Compositions and methods for drug-sensitization or inhibition of a cancer cell

# publications[].label
Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity.

# publications[].label
Compositions and methods for drug sensitization of parasites

# publications[].label
Crystal structure of Mycobacterium tuberculosis diaminopimelate decarboxylase, an essential enzyme in bacterial lysine biosynthesis.

# publications[].label
Protein determinants of phage T4 lysis inhibition.

# publications[].label
An Antibacterial -Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis.

# publications[].label
Crystal structure of the lectin from Dioclea grandiflora complexed with core trimannoside of asparagine-linked carbohydrates.

# publications[].label
Structural genomics approach to drug discovery for Mycobacterium tuberculosis.

# publications[].label
Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis.

# publications[].label
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.

# publications[].label
Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries.

# publications[].label
Refinement of the structure of Escherichia coli-derived rat intestinal fatty acid binding protein with bound oleate to 1.75-A resolution. Correlation with the structures of the apoprotein and the protein with bound palmitate.

# publications[].label
Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.

# researcherOn[].label
Applying Structural Genomics and Drug Discovery to Understanding Drug Resistance

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Structure-Based Discovery of Critical Vulnerabilities of Mycobacteria

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
Biophysical Constraints on Evolution of Enzyme Specificity

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Structures of Mtb proteins conferring susceptibility to known Mtb inhibitors

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Structure-Based Discovery of Critical Vulnerabilities of Mycobacteria

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU

# schools[]
College of Agriculture and Life Sciences

# inTheNews[].label
Promising study offers hope for Menkes disease treatment

# etdChairOf[].label
Yu, Hong (2007-05). Structural studies of Mycobacterium tuberculosis KatG, an INH drug activator, and Brucella abortus VirB11, an ATPase of type IV translocation system. Doctoral Dissertation.

# etdChairOf[].label
Lucumi Moreno, Edinson (2005-12). Structural determination of triclosan derivatives as inhibitors of Plasmodium falciparum enoyl reductase (PfENR). Master's Thesis.

# etdChairOf[].label
Yang, Dong (2009-06). Structural studies of terpenoid biosynthesis and bacterial cell division. Doctoral Dissertation.

# etdChairOf[].label
Harshbarger, Wayne (2015-02). X-Ray Crystal Structure of Human 20s Proteasome in Complex with Carfilzomib. Doctoral Dissertation.

# etdChairOf[].label
Lalgondar, Mallikarjun (2014-03). Structural Studies and Evaluation of Inhibitors of Mycobacterium tuberculosis H37Rv Shikimate Dehydrogenase (MtSDH). Master's Thesis.

# etdChairOf[].label
Kuznetsov, Vladimir 1973- (2011-08). Structural Studies of Phage Lysis Proteins and Their Targets. Doctoral Dissertation.

# etdChairOf[].label
Kuo, Mack Ryan (2009-05). Structure, function, and inhibition of enoyl reductases. Doctoral Dissertation.

# etdChairOf[].label
LaiHing, Steven 1983- (2011-07). Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium tuberculosis. Master's Thesis.

# etdChairOf[].label
Sun, Qingan (2011-08). Structural Studies of Bacteriophage Lysins and their Implication in Human Diseases. Doctoral Dissertation.

# etdChairOf[].label
Reyes Caballero, Hermes (2012-10). Biochemical Characterization of the Mycobacterium tuberculosis Ni(II) Sensor NmtR and Streptococcus pneumoniae Zn(II) Sensor AdcR. Doctoral Dissertation.

# etdChairOf[].label
Zhu, Wan Wen (2012-10). Structural and Functional Studies of Mycothiol Biosynthesis Precursor Enzyme in Mycobacterium tuberculosis. Master's Thesis.

# etdChairOf[].label
Tsai, Han-Chun (2013-08). Structural Study of Lipid-binding Proteins. Doctoral Dissertation.

# etdChairOf[].label
Hughes, Ryan C (2016-12). Identification of Whole Cell Active Molecules of Mycobacterium Tuberculosis, Elucidation of Molecular Mechanisms Responsible for Resistance, and Characterization of Rv0272: A potential Therapeutic Target. Doctoral Dissertation.

# etdChairOf[].label
Mire, Joseph Andrew (2013-07). Application of Structure Activity Relationships of the Mycobacterium Tuberculosis Beta-Lactamase (BlaC) and the New Delhi Metallo-Beta-Lactamase (NDM-1) to Combating Beta-Lactamase Mediated Drug Resistance. Doctoral Dissertation.

# etdChairOf[].label
Dey, Sanghamitra (2009-05). Structural insights into the enzymes of the serine and biotin biosynthetic pathways in mycobacterium tuberculosis. Doctoral Dissertation.

# etdChairOf[].label
Wang, Feng (2009-05). Structure-based drug mechanism study and inhibitor design targeting tuberculosis. Doctoral Dissertation.

# etdChairOf[].label
Joseph, Sonia (2014-06). The Biochemical Investigation and Isolation of Small Molecule Inhibitors for Two Essential Proteins of Mycobacterium tuberculosis H37Rv: IspD and Wag31. Master's Thesis.

# etdChairOf[].label
Liu, Zhen (2013-12). Understanding and Targeting Lipid Metabolism of Mycobacterium tuberculosis. Doctoral Dissertation.

# etdChairOf[].label
Jung, Hunmin (2014-12). Development of Potent and Selective Inhibitors of Mycobacterium Tuberculosis, Plasmodium Falciparum and Staphylococcus Aureus Dihydrofolate Reductase. Doctoral Dissertation.

# etdChairOf[].label
Harshbarger, Wayne (2012-10). Crystal Structures of Binary and Ternary Complexes of Thymidylate Synthase (ThyA) from Mycobacterium tuberculosis: Insights into Selectivity and Inhibition. Master's Thesis.

# etdChairOf[].label
Ramesh, Arati (2009-05). Structural studies of the Ro ribonucleoprotein and the metalloregulator CsoR. Doctoral Dissertation.