# overview
We are interested in the interface between intracellular bacterial pathogens and the hosts they infect. In particular, we study the notorious human pathogen, Mycbacterium tuberculosis, which remains a major global health threat. M. tuberculosis has evolved a variety of specific adaptations to not only survive but also replicate within the harsh environment inside a macrophage. We want to understand the mechanisms by which M. tuberculosis is able to modulate the innate immune response to establish an infection as well as how the host detects and responds to M. tuberculosis.

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
2.2 Factors Relating To The Physical Environment

# educationAndTraining[].organization.label
University of California, Irvine - (Irvine, California, United States)

# educationAndTraining[].organization.label
University of California, San Francisco - (San Francisco, California, United States)

# educationAndTraining[].organization.label
Yale University - (New Haven, Connecticut, United States)

# educationAndTraining[].organization.label
University of California, Berkeley - (Berkeley, California, United States)

# awardsAndHonors[].label
IAI Future Leader in the Field of Host-Microbe Interactions

# publications[].label
TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.

# publications[].publisher
The American Association of Immunologists

# publications[].label
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.

# publications[].label
Signal transduction in Campylobacter jejuni-induced cytokine production.

# publications[].label
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.

# publications[].label
Role of tyrosine kinases and the tyrosine phosphatase SptP in the interaction of Salmonella with host cells.

# publications[].label
The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages.

# publications[].label
Unique features of a highly pathogenic Campylobacter jejuni strain.

# publications[].label
A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection.

# publications[].label
Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection.

# publications[].label
Identification of Rgg-regulated exoproteins of Streptococcus pyogenes.

# publications[].label
Campylobacter jejuni survives within epithelial cells by avoiding delivery to lysosomes.

# publications[].label
A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.

# publications[].label
Mitochondria: Powering the Innate Immune Response to Mycobacterium tuberculosis Infection.

# publications[].label
Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes.

# publications[].label
The ubiquitin ligase parkin mediates resistance to intracellular pathogens.

# publications[].label
Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway.

# publications[].label
Mitochondrial reactive oxygen species: double agents in Mycobacterium tuberculosis infection.

# publications[].label
Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat.

# publications[].label
For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses.

# publications[].label
Studies on thermal denaturation of DNA from various chlamydiae.

# publications[].label
The radioisotope precipitation test for psittacosis group antibody.

# publications[].label
Unique features of a highly pathogenic Campylobacter jejuni strain (vol 74, pg 4694, 2006)

# researcherOn[].label
The splicing factor SF3b1 is a master regulator of the innate immune response to Mycobacterium tuberculosis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
The Secreted Effector SseC is a Key Regulator of Retrograde Transport During Salmonella Enterica Serovar Typhimurium Infection

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
TRIM Proteins Polarize DNA Sensing Outcomes During the Innate Immune Response to Mycobacterium Tuberculosis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
The Molecular Basis of Viral DNA Sensing through the cGAS-STING Pathway

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# streetAddress
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1114 TAMUS