# overview
One of our two current research areas involves iron metabolism in mitochondria. The iron imported into these organelles is assembled into iron-sulfur clusters and heme prosthetic groups. Some of these centers are exported into the cytosol, while others are installed into mitochondrial apo-proteins. All of these processes are regulated in healthy cells, but various genetic mutations giving rise to diseases can cause iron to accumulate (e.g. Friedreich's ataxia) or become depleted (e.g. Sideroblastic anemia). We have developed a biophysical approach involving Mossbauer, electron paramagnetic resonance, and electronic absorption spectroscopy, to study the entire iron content of intact mitochondria in healthy and genetically altered cells. This Systems Biology approach allows us to characterize the "iron-ome" of mitochondria at an unprecedented level of detail. We are also using analytical tools (e.g. liquid chromatography) to identify complexes that are involved in "trafficking" iron into and out of the organelle.

Our other research area involves mathematical modeling of cellular self-replication on the mechanistic biochemical level. We collaborate on this multidisciplinary NSF-sponsored project with a mathematician at the University of Houston (Professor Jeffrey Morgan). We have developed a modeling framework that facilitates such modeling efforts, and have designed a number of very simple and symbolic in silico cells that exhibit self-replicative behavior. Our minimal in silico cell model includes just 5 components and 5 reactions. A second generation model includes a more realistic mechanism of mitotic regulation. One novel aspect of our approach is that cellular concentration dynamics impact (and are impacted by) cellular geometry. By minimizing membrane bending energies, we are now calculating cell geometry during growth and division. Our results suggest that the "pinching" observed in real cells is enforced by cytoskeletal structures.

# keywords[]
Transferrin, Non-transferrin-bound Iron, Or Ntbi

# keywords[]
Circadian Rhythm Signaling Peptides And Proteins

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
0306 Physical Chemistry (incl. Structural)

# educationAndTraining[].organization.label
North Park University - (Chicago, Illinois, United States)

# educationAndTraining[].organization.label
Massachusetts Institute of Technology - (Cambridge, Massachusetts, United States)

# publications[].label
Low-temperature Mssbauer spectroscopy of organs from 57Fe-enriched HFE(-/-) hemochromatosis mice: aniron-dependent threshold for generating hemosiderin.

# publications[].label
SPECIATION OF NON-TRANSFERRIN BOUND IRON IN BLOOD PLASMA OF IRON DEFICIENT SWINE

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Autocatalytic activation of acetyl-CoA synthase.

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IRON EXAFS OF THE IRON MOLYBDENUM COFACTOR OF NITROGENASE

# publications[].label
Function and CO binding properties of the NiFe complex in carbon monoxide dehydrogenase from Clostridium thermoaceticum.

# publications[].label
Recovery of mrs3mrs4 Saccharomyces cerevisiae Cells under Iron-Sufficient Conditions and the Role of Fe580.

# publications[].label
The lack of synchronization between iron uptake and cell growth leads to iron overload in Saccharomyces cerevisiae during post-exponential growth modes.

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Biophysical investigation of the ironome of human jurkat cells and mitochondria.

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Evaluation of multivalent dendrimers based on melamine: kinetics of thiol-disulfide exchange depends on the structure of the dendrimer.

# publications[].label
Mssbauer-based molecular-level decomposition of the Saccharomyces cerevisiae ironome, and preliminary characterization of isolated nuclei.

# publications[].label
Kinetics of CO insertion and acetyl group transfer steps, and a model of the acetyl-CoA synthase catalytic mechanism.

# publications[].label
Cis-Divacant Octahedral Fe(II) in a Dimensionally Reduced Family of 2-(Pyridin-2-yl)pyrrolide Complexes.

# publications[].label
Role of Superoxide Anion in Exercise Training-Enhanced, Endothelium-Mediated Vasodilatation in Collateral-Dependent Coronary Arterioles

# publications[].label
STABILITY OF THE NI-C STATE AND OXIDATIVE TITRATIONS OF DESULFOVIBRIO-GIGAS HYDROGENASE MONITORED BY EPR AND ELECTRONIC ABSORPTION SPECTROSCOPIES

# publications[].label
DISCOVERY OF A LABILE NICKEL ION REQUIRED FOR CO ACETYL-COA EXCHANGE ACTIVITY IN THE NIFE COMPLEX OF CARBON-MONOXIDE DEHYDROGENASE FROM CLOSTRIDIUM-THERMOACETICUM

# publications[].label
The Human Iron-Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 That Can Be Transferred to Acceptor Molecules.

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Evidence for a proposed intermediate redox state in the CO/CO(2) active site of acetyl-CoA synthase (Carbon monoxide dehydrogenase) from Clostridium thermoaceticum.

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Nature of the C-cluster in Ni-containing carbon monoxide dehydrogenases

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Acetyl-coenzyme A synthase: the case for a Ni(p)(0)-based mechanism of catalysis.

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The Ni-containing carbon monoxide dehydrogenase family: light at the end of the tunnel?

# publications[].label
Mathematical modeling of a minimal protocell with coordinated growth and division.

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Dynamic responses of protein homeostatic regulatory mechanisms to perturbations from steady state.

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ENZYMOLOGY AND METAL ENVIRONMENT OF CORRINOID PROTEINS INVOLVED IN ACETYL-COA SYNTHESIS IN CLOSTRIDIUM THERMOACETICUM

# publications[].label
Mixed-valence nickel-iron dithiolate models of the [NiFe]-hydrogenase active site.

# publications[].label
Might nontransferrin-bound iron in blood plasma and sera be a nonproteinaceous high-molecular-mass FeIII aggregate?

# publications[].label
Mssbauer, EPR, and modeling study of iron trafficking and regulation in ccc1 and CCC1-up Saccharomyces cerevisiae.

# publications[].label
Decomposition of carbon monoxide dehydrogenase into alpha metallosubunits and a catalytically-active form consisting primarily of beta metallosubunits.

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Mossbauer and EPR study of the Ni-activated alpha-subunit of carbon monoxide dehydrogenase from Clostridium thermoaceticum

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The Chemical Biology of Cellular Iron Pools in Prokaryotes

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Kinetics of iron import into developing mouse organs determined by a pup-swapping method.

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Tunnel mutagenesis and Ni-dependent reduction and methylation of the alpha subunit of acetyl coenzyme A synthase/carbon monoxide dehydrogenase.

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THE AMINO-ACID-SEQUENCE AND REDOX PROPERTIES OF THE 8-IRON FERREDOXIN-II FROM CLOSTRIDIUM-THERMOACETICUM

# publications[].label
Unraveling the structures and functions of the unusual Ni-Fe-S clusters in carbon monoxide dehydrogenase

# publications[].label
Active acetyl-CoA synthase from Clostridium thermoaceticum obtained by cloning and heterologous expression of acsAB in Escherichia coli.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Ferric ions accumulate in the walls of metabolically inactivating Saccharomyces cerevisiae cells and are reductively mobilized during reactivation.

# publications[].label
Mitochondrial Iron-Sulfur Cluster Activity and Cytosolic Iron Regulate Iron Traffic in Saccharomyces cerevisiae.

# publications[].label
Biophysical characterization of iron in mitochondria isolated from respiring and fermenting yeast.

# publications[].label
LdpA: a component of the circadian clock senses redox state of the cell.

# publications[].label
Kinetic modeling of the assembly, dynamic steady state, and contraction of the FtsZ ring in prokaryotic cytokinesis.

# publications[].label
Structures, Interconversions, and Spectroscopy of Iron Carbonyl Clusters with an Interstitial Carbide: Localized Metal Center Reduction by Overall Cluster Oxidation.

# publications[].label
Inactivation of acetyl-CoA synthase/carbon monoxide dehydrogenase by copper.

# publications[].label
NICKEL AND IRON EXAFS OF F-420-REDUCING HYDROGENASE FROM METHANOBACTERIUM-THERMOAUTOTROPHICUM

# publications[].label
Redox titrations of carbon monoxide dehydrogenase from Clostridium thermoaceticum.

# publications[].label
Spectroscopic states of the CO oxidation/CO2 reduction active site of carbon monoxide dehydrogenase and mechanistic implications.

# publications[].label
Spectroelectrochemical characterization of the metal centers in carbon monoxide dehydrogenase (CODH) and nickel-deficient CODH from Rhodospirillum rubrum.

# publications[].label
Mssbauer and LC-ICP-MS investigation of iron trafficking between vacuoles and mitochondria in vma2Saccharomyces cerevisiae.

# publications[].label
EXAFS, EPR, AND ELECTRONIC ABSORPTION SPECTROSCOPIC STUDY OF THE ALPHA-METALLOSUBUNIT OF CO DEHYDROGENASE FROM CLOSTRIDIUM-THERMOACETICUM

# publications[].label
Whole-cell modeling framework in which biochemical dynamics impact aspects of cellular geometry.

# publications[].label
A comprehensive mechanistic model of iron metabolism in Saccharomyces cerevisiae.

# publications[].label
Thermal decarboxylation for the generation of hierarchical porosity in isostructural metal-organic frameworks containing open metal sites.

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Equilibrium dialysis study and mechanistic implications of coenzyme A binding to acetyl-CoA synthase/carbon monoxide dehydrogenase from Clostridium thermoaceticum.

# publications[].label
Insights into the iron-ome and manganese-ome of mtm1 Saccharomyces cerevisiae mitochondria.

# publications[].label
IRON EXAFS STUDIES OF THE IRON MOLYBDENUM COFACTOR OF NITROGENASE AND THE 3FE FERREDOXIN-II OF DESULFOVIBRIO-GIGAS

# publications[].label
Effect of sodium sulfide on Ni-containing carbon monoxide dehydrogenases.

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4. The utility of Mssbauer spectroscopy in eukaryotic cell biology and animal physiology

# publications[].label
Biophysical probes of iron metabolism in cells and organelles.

# publications[].label
High-spin ferric ions in Saccharomyces cerevisiae vacuoles are reduced to the ferrous state during adenine-precursor detoxification.

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Utilization of copper as a paramagnetic probe for the binuclear metal center of phosphotriesterase.

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Assembly of an exchange-coupled [Ni:Fe4S4] cluster in the alpha metallosubunit of carbon monoxide dehydrogenase from Clostridium thermoaceticum with spectroscopic properties and CO-binding ability mimicking those of the acetyl-CoA synthase active site

# publications[].label
Nickel-dependent oligomerization of the alpha subunit of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase.

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Reduction and methyl transfer kinetics of the alpha subunit from acetyl coenzyme a synthase.

# publications[].label
Biophysical investigation of the iron in Aft1-1(up) and Gal-YAH1 Saccharomyces cerevisiae.

# publications[].label
Kinetic mechanism of acetyl-CoA synthase: steady-state synthesis at variable Co/Co2 pressures.

# publications[].label
Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe-S Assembly Complex.

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Mossbauer and EPR studies of iron in vacuoles Iiolated from S. cerevisiae

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Detection of Labile Low-Molecular-Mass Transition Metal Complexes in Mitochondria.

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Mssbauer Spectra of Mouse Hearts Reveal Age-dependent Changes in Mitochondrial and Ferritin Iron Levels.

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A multinuclear ENDOR study of the C-cluster in CO dehydrogenase from Clostridium thermoaceticum: Evidence for HxO and histidine coordination to the [Fe4S4] center

# publications[].label
Mssbauer, EPR, and optical studies of the corrinoid/iron-sulfur protein involved in the synthesis of acetyl coenzyme A by Clostridium thermoaceticum.

# publications[].label
Low-molecular-mass iron in healthy blood plasma is not predominately ferric citrate.

# publications[].label
Novel Domain Arrangement in the Crystal Structure of a Truncated Acetyl-CoA Synthase from Moorella thermoacetica (vol 48, pg 7916, 2009)

# publications[].label
A nonheme high-spin ferrous pool in mitochondria isolated from fermenting Saccharomyces cerevisiae.

# publications[].label
Mssbauer study of CO dehydrogenase from Clostridium thermoaceticum.

# publications[].label
Evidence for a proton transfer network and a required persulfide-bond-forming cysteine residue in Ni-containing carbon monoxide dehydrogenases.

# publications[].label
Mssbauer and EPR study of iron in vacuoles from fermenting Saccharomyces cerevisiae.

# publications[].label
MOSSBAUER AND ELECTRON-PARAMAGNETIC-RES SPECTROSCOPY OF CO DEHYDROGENASE AND THE CO/FE-S PROTEIN FROM CLOSTRIDIUM-THERMOACETICUM

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Mssbauer and EPR study of recombinant acetyl-CoA synthase from Moorella thermoacetica.

# publications[].label
Carbon monoxide dehydrogenase from Rhodospirillum rubrum: effect of redox potential on catalysis.

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Chromatographic detection of low-molecular-mass metal complexes in the cytosol of Saccharomyces cerevisiae.

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Evidence of a molecular tunnel connecting the active sites for CO2 reduction and acetyl-CoA synthesis in acetyl-CoA synthase from Clostridium thermoaceticum

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The Pyrococcus furiosus ironome is dominated by [Fe4S4]2+ clusters or thioferrate-like iron depending on the availability of elemental sulfur.

# publications[].label
Carbon monoxide dehydrogenase from Clostridium thermoaceticum: quaternary structure, stoichiometry of its SDS-induced dissociation, and characterization of the faster-migrating form.

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Speciation of iron in mouse liver during development, iron deficiency, IRP2 deletion and inflammatory hepatitis.

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NEW DESIGNS IN CURRENTLY MARKETED COOLING-TOWERS

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Mossbauer evidence for an exchange-coupled {[Fe4S4]1+ Nip1+} A-cluster in isolated alpha subunits of acetyl-coenzyme A synthase/carbon monoxide dehydrogenase.

# publications[].label
COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase.

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ANTIFERROMAGNETIC COUPLING IN THE BINUCLEAR METAL CLUSTER OF MANGANESE-SUBSTITUTED PHOSPHOTRIESTERASE

# publications[].label
Mathematical model of a cell size checkpoint.

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Acetylcoenzyme A Synthases and NickelContaining Carbon Monoxide Dehydrogenases

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Direct Detection of the Labile Nickel Pool in Escherichia coli: New Perspectives on Labile Metal Pools.

# publications[].label
EPR and Mssbauer studies of nucleotide-bound nitrogenase iron protein from Azotobacter vinelandii.

# publications[].label
The tunnel of acetyl-coenzyme a synthase/carbon monoxide dehydrogenase regulates delivery of CO to the active site.

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CUP1 Metallothionein from Healthy Saccharomyces cerevisiae Colocalizes to the Cytosol and Mitochondrial Intermembrane Space.

# publications[].label
Effect of Zn on acetyl coenzyme a synthase: evidence for a conformational change in the alpha subunit during catalysis.

# publications[].label
Structure, function, and biosynthesis of the novel Ni-X-Fe4S4 clusters of acetyl-coenzyme A synthase (carbon monoxide dehydrogenase)

# publications[].label
Organization of clusters and internal electron pathways in CO dehydrogenase from Clostridium thermoaceticum: relevance to the mechanism of catalysis and cyanide inhibition.

# publications[].label
Mossbauer, EPR, and magnetization studies of the Azotobacter vinelandii Fe protein

# publications[].label
Mssbauer studies of solid thionin-oxidized MoFe protein of nitrogenase.

# publications[].label
Identification and preliminary characterization of AcsF, a putative Ni-insertase used in the biosynthesis of acetyl-CoA synthase from Clostridium thermoaceticum.

# publications[].label
Mathematical model for positioning the FtsZ contractile ring in Escherichia coli.

# publications[].label
Carbon monoxide dehydrogenase: purification and characterization of active recombinant protein

# publications[].label
Electron paramagnetic resonance and Mssbauer spectroscopy of intact mitochondria from respiring Saccharomyces cerevisiae.

# publications[].label
Catalytic mechanism and three-dimensional structure of adenine deaminase.

# publications[].label
6. The utility of Mssbauer spectroscopy in eukaryotic cell biology and animal physiology

# publications[].label
Stopped-Flow Kinetics of Methyl Group Transfer between the Corrinoid-Iron-Sulfur Protein and Acetyl-Coenzyme A Synthase from Clostridium thermoaceticum.

# publications[].label
Whole-cell modeling framework in which biochemical dynamics impact aspects of cellular geometry (vol 244, pg 154, 2007)

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Stepwise evolution of nonliving to living chemical systems.

# publications[].label
Evidence that a respiratory shield in Escherichia coli protects a low-molecular-mass FeII pool from O2-dependent oxidation.

# publications[].label
Kinetic mechanism of acetyl-CoA synthesis catalyzed by CO dehydrogenase acetyl-CoA synthase: preliminary evidence for a molecular tunnel

# publications[].label
EFFECTS OF SULFUR SITE MODIFICATION ON THE REDOX POTENTIALS OF DERIVATIVES OF [N,N'-BIS(2-MERCAPTOETHYL)-1,5-DIAZACYCLOOCTANATO]NICKEL(II)

# publications[].label
Novel domain arrangement in the crystal structure of a truncated acetyl-CoA synthase from Moorella thermoacetica.

# publications[].label
Analysis of oxidative titrations of Desulfovibrio gigas hydrogenase; implications for the catalytic mechanism.

# publications[].label
Methylation of carbon monoxide dehydrogenase from Clostridium thermoaceticum and mechanism of acetyl coenzyme A synthesis

# publications[].label
Mssbauer, EPR, and magnetization studies of the Azotobacter vinelandii Fe protein. Evidence for a [4Fe-4S]1+ cluster with spin S = 3/2.

# publications[].label
A mathematical model of iron import and trafficking in wild-type and Mrs3/4 yeast cells.

# publications[].label
Spectroscopic, redox, and structural characterization of the Ni-labile and nonlabile forms of the acetyl-CoA synthase active. Site of carbon monoxide dehydrogenase

# publications[].label
Stoichiometric redox titrations of complex metalloenzymes.

# publications[].label
Iron content of Saccharomyces cerevisiae cells grown under iron-deficient and iron-overload conditions.

# publications[].label
Redox states of heme centers in anaerobically-isolated mitochondria from Saccharomyces cerevisiae

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Low-molecular-mass metal complexes in the mouse brain.

# publications[].label
Implications of a carboxylate-bound C-cluster structure of carbon monoxide dehydrogenase.

# publications[].label
Low-molecular-mass labile metal pools in Escherichia coli: advances using chromatography and mass spectrometry.

# publications[].label
The catalase activity of diiron adenine deaminase.

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Mitochondria Export Sulfur Species Required for Cytosolic tRNA Thiolation.

# publications[].label
Catalytic coupling of the active sites in acetyl-CoA synthase, a bifunctional CO-channeling enzyme.

# publications[].label
Genetic construction of truncated and chimeric metalloproteins derived from the alpha subunit of acetyl-CoA synthase from Clostridium thermoaceticum.

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Reactivities and biological functions of iron-sulfur clusters

# publications[].label
The thermally induced decarboxylation mechanism of a mixed-oxidation state carboxylate-based iron metal-organic framework.

# publications[].label
Labile Iron Pool of Isolated Escherichia coli Cytosol Likely Includes Fe-ATP and Fe-Citrate but not Fe-Glutathione or Aqueous Fe.

# publications[].label
Structures, Interconversions, and Spectroscopy of Iron Carbonyl Clusters with an Interstitial Carbide: Localized Metal Center Reduction by Overall Cluster Oxidation.

# publications[].label
EXAFS STUDIES OF THE NITROGENASE IRON PROTEIN FROM AZOTOBACTER-VINELANDII

# publications[].label
Analysis of protein homeostatic regulatory mechanisms in perturbed environments at steady state.

# publications[].label
CO dehydrogenase from Clostridium thermoaceticum. EPR and electrochemical studies in CO2 and argon atmospheres.

# publications[].label
REDOX, SPECTRAL AND MECHANISTIC STUDIES OF CARBON-MONOXIDE DEHYDROGENASE

# publications[].label
Biophysical characterization of the iron in mitochondria from Atm1p-depleted Saccharomyces cerevisiae.

# publications[].label
Acetyl-coenzyme A synthase/carbon monoxide dehydrogenase: An enzyme with novel transition-metal-sulfide clusters and an organometallic mechanism.

# publications[].label
Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] clusters in closed and open subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase.

# publications[].label
Labile Low-Molecular-Mass Metal Complexes in Mitochondria: Trials and Tribulations of a Burgeoning Field.

# publications[].label
Low spin quantitation of NiFeC EPR signal from carbon monoxide dehydrogenase is not due to damage incurred during protein purification.

# publications[].label
Mssbauer study and modeling of iron import and trafficking in human jurkat cells.

# publications[].label
CO/CO2 potentiometric titrations of carbon monoxide dehydrogenase from Clostridium thermoaceticum and the effect of CO2.

# publications[].label
Changing iron content of the mouse brain during development.

# publications[].label
Function of the tunnel in acetylcoenzyme A synthase/carbon monoxide dehydrogenase.

# publications[].label
Low-molecular-mass iron complexes in blood plasma of iron-deficient pigs do not originate directly from nutrient iron.

# publications[].label
Biophysical probes of iron metabolism in eukaryotic cells

# publications[].label
EPR and Mssbauer spectroscopy of intact mitochondria isolated from Yah1p-depleted Saccharomyces cerevisiae.

# publications[].label
Structures and energetics of models for the active site of acetyl-coenzyme a synthase: role of distal and proximal metals in catalysis.

# publications[].label
SQUID measurement of metalloprotein magnetization. New methods applied to the nitrogenase proteins.

# publications[].label
Stoichiometric CO reductive titrations of acetyl-CoA synthase (Carbon monoxide dehydrogenase) from Clostridium thermoaceticum.

# publications[].label
Yeast cells depleted of the frataxin homolog Yfh1 redistribute cellular iron: Studies using Mssbauer spectroscopy and mathematical modeling.

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A framework for whole-cell mathematical modeling.

# publications[].label
Chapter 15 Isolation of Saccharomyces cerevisiae mitochondria for Mssbauer, EPR, and electronic absorption spectroscopic analyses.

# researcherOn[].label
Iron in Mitochondrial Physiology and Disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Iron Trafficking and Regulation in Biological Systems

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Design and Testing of Math Models of Iron Trafficking and Regulation in Eukaryotes

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# streetAddress
Texas A&M University; Chemistry Department; 3255 TAMU

# etdChairOf[].label
Kim, Eun Jin (2004-09). Crystallization and mutational studies of carbon monoxide dehydrogenase from moorella thermoacetica. Master's Thesis.

# etdChairOf[].label
Garber Morales, Jessica H. (2011-08). Biophysical and Bioanalytical Analysis of the Iron-ome in Mitochondria Isolated from Saccharomyces cerevisiae. Doctoral Dissertation.

# etdChairOf[].label
Park, Jinkyu (2013-12). Exploring Iron Metabolism and Regulation in Saccharomyces cerevisiae Using an Integrative Biophysical and Bioanalytical Approach. Doctoral Dissertation.

# etdChairOf[].label
Cockrell, Allison Leigh (2013-11). Investigating the Roles of Vacuoles in Iron Trafficking in Saccharomyces cerevisiae. Doctoral Dissertation.

# etdChairOf[].label
Holmes-Hampton, Gregory (2012-10). Biophysical Probes of Iron Metabolism in Yeast Cells, Mitochondria, and Mouse Brains. Doctoral Dissertation.

# etdChairOf[].label
Miao, Ren (2012-02). Probing Iron Accumulation in Sacchromyces cerevisiae Using Integrative Biophysical and Biochemical Techniques. Doctoral Dissertation.

# etdChairOf[].label
Hudder, Brandon Neal (2006-10). Spectroscopic and analytical characterization of the distribution of iron in intact mitochondria from Saccharomyces cerevisiae. Doctoral Dissertation.

# etdChairOf[].label
Moore, Michael John (2017-06). An Integrative Biophysical and Bioanalytical Approach for Investigating the Mitochondrial Labile Iron Pool. Doctoral Dissertation.

# etdChairOf[].label
Jhurry, Nema (2013-08). Biophysical Investigation of the 'Ironome' of Jurkat Cells and Saccharomyces cerevisiae. Doctoral Dissertation.

# etdChairOf[].label
Feng, Jian (2005-08). Effect of redox potential, sulfide ions and a persulfide forming cysteine residue on carbon monoxide dehydrogenase. Doctoral Dissertation.

# etdChairOf[].label
Wofford, Joshua D (2018-08). Use of Mathematical Modeling and Other Biophysical Methods for  Insights into Iron-Related Phenomena of Biological Systems. Doctoral Dissertation.

# etdChairOf[].label
Bramlett, Matthew Richard (2006-04). Mechanistic investigations of the A-cluster of acetyl-CoA synthase. Doctoral Dissertation.

# etdChairOf[].label
McCormick, Sean P. (2014-12). The Application of LC-ICP-MS to Study Metal Ion Homeostasis in Biological Systems. Doctoral Dissertation.