# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
Mammalian comparative genomics, phylogeny, biogeography, and molecular evolution, with a specific emphasis on feline evolutionary genomics, including: gene mapping, sex chromosome genetics, speciation and mechanisms of male hybrid sterility.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Human Epidermal Growth Factor Receptor 2

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Dickkopf wnt signaling pathway Inhibitor 4

# educationAndTraining[].organization.label
Frederick National Laboratory for Cancer Research - (Frederick, Maryland, United States)

# educationAndTraining[].organization.label
University of Tulsa - (Tulsa, Oklahoma, United States)

# educationAndTraining[].organization.label
Illinois State University - (Normal, Illinois, United States)

# awardsAndHonors[].label
Association of Former Students University-Level Distinguished Achievement Award, The

# awardsAndHonors[].label
AVMF/Winn Feline Foundation Research Award

# awardsAndHonors[].label
Enhancing Development and Generating Excellence in Scholarship (EDGES) Fellow

# publications[].label
Novel gene acquisition on carnivore Y chromosomes.

# publications[].label
Applications and efficiencies of the first cat 63K DNA array.

# publications[].label
The Birth and Death of Olfactory Receptor Gene Families in Mammalian Niche Adaptation.

# publications[].label
Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
37Genomic improvement of the horse X chromosome and characterization of the pseudoautosomal boundary

# publications[].publisher
Karger Medical and Scientific Publishers

# publications[].label
Technical comment on "The placental mammal ancestor and the post-K-Pg radiation of placentals".

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Ultracontinuous Single Haplotype Genome Assemblies for the Domestic Cat (Felis catus) and Asian Leopard Cat (Prionailurus bengalensis).

# publications[].label
Supermatrix and species tree methods resolve phylogenetic relationships within the big cats, Panthera (Carnivora: Felidae).

# publications[].label
Gene discovery and comparative analysis of X-degenerate genes from the domestic cat Y chromosome.

# publications[].label
Nuclear gene sequences confirm an ancient link between New Zealand's short-tailed bat and South American noctilionoid bats.

# publications[].label
A Molecular Classification for the Living Orders of Placental Mammals and the Phylogenetic Placement of Primates

# publications[].label
Efficient cross-species capture hybridization and next-generation sequencing of mitochondrial genomes from noninvasively sampled museum specimens.

# publications[].label
Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells.

# publications[].label
Second-generation integrated genetic linkage/radiation hybrid maps of the domestic cat (Felis catus).

# publications[].label
Werewolf, There Wolf: Variants in Hairless Associated with Hypotrichia and Roaning in the Lykoi Cat Breed.

# publications[].label
Sequence analysis in Bos taurus reveals pervasiveness of X-Y arms races in mammalian lineages.

# publications[].label
A comparative genomics multitool for scientific discovery and conservation.

# publications[].label
Genetic and anatomical determinants of olfaction in dogs and wild canids.

# publications[].label
Phylogenetic relationships within the aplocheiloid fish genus Rivulus (Cyprinodontiformes, Rivulidae): implications for Caribbean and Central American biogeography.

# publications[].label
Patterns of diversity among SINE elements isolated from three Y-chromosome genes in carnivores.

# publications[].label
Evolutionary conservation of Y Chromosome ampliconic gene families despite extensive structural variation.

# publications[].label
Molecular and genomic data identify the closest living relative of primates.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
A radiation hybrid map of the cat genome: implications for comparative mapping.

# publications[].label
Insertional polymorphisms of endogenous feline leukemia viruses.

# publications[].label
The use of rare genomic changes in mammalian phylogeny estimation and the phylogenetic position of Primates.

# publications[].label
A rhesus macaque radiation hybrid map and comparative analysis with the human genome.

# publications[].label
Interordinal gene capture, the phylogenetic position of Steller's sea cow based on molecular and morphological data, and the macroevolutionary history of Sirenia.

# publications[].label
Fertile male tortoiseshell cat with true chimerism 38,XY/38,XY.

# publications[].label
Insights into mammalian TE diversity through the curation of 248 genome assemblies.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Appropriate fossil calibrations and tree constraints uphold the Mesozoic divergence of solenodons from other extant mammals.

# publications[].label
Horse Y chromosome assembly displays unique evolutionary features and putative stallion fertility genes.

# publications[].label
Three-dimensional genome rewiring in loci with human accelerated regions.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Radiation hybrid mapping of 304 novel microsatellites in the domestic cat genome.

# publications[].label
Using genomic data to unravel the root of the placental mammal phylogeny.

# publications[].label
A gene catalogue of the euchromatic male-specific region of the horse Y chromosome: comparison with human and other mammals.

# publications[].label
Integration of the feline radiation hybrid and linkage maps.

# publications[].label
Exploring the correlations between sequence evolution rate and phenotypic divergence across the Mammalian tree provides insights into adaptive evolution.

# publications[].label
Genome-wide signatures of complex introgression and adaptive evolution in the big cats.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Rapid Macrosatellite Evolution Promotes X-Linked Hybrid Male Sterility in a Feline Interspecies Cross.

# publications[].label
The origin of human chromosome 1 and its homologs in placental mammals.

# publications[].label
A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats.

# publications[].label
Emerging Frontiers in the Study of Molecular Evolution.

# publications[].label
Designing and optimizing comparative anchor primers for comparative gene mapping and phylogenetic inference.

# publications[].label
Population monitoring of snow leopards using noninvasive collection of scat samples: a pilot study

# publications[].label
Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on mammal diversification.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Tree House Explorer: A Novel Genome Browser for Phylogenomics.

# publications[].label
Comparison of noninvasive genetic and camera-trapping techniques for surveying snow leopards

# publications[].label
Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Sequencing the mouse Y chromosome reveals convergent gene acquisition and amplification on both sex chromosomes.

# publications[].label
A genomic timescale for placental mammal evolution

# publications[].label
Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps.

# publications[].label
Mammalian evolution and biomedicine: new views from phylogeny.

# publications[].label
Development of a feline whole genome radiation hybrid panel and comparative mapping of human chromosome 12 and 22 loci.

# publications[].label
Response to Comment on "Impacts of the Cretaceous Terrestrial Revolution and KPg Extinction on Mammal Diversification"

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
The late Miocene radiation of modern Felidae: a genetic assessment.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
A radiation hybrid mapping panel for the rhesus macaque.

# publications[].label
The genome of the black-footed cat: Revealing a rich natural history and urgent conservation priorities for small felids.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Development of an ASO therapy for Angelman syndrome by targeting an evolutionarily conserved region at the start of the UBE3A-AS transcript

# publications[].label
Evidence for multiple species of Sunda colugo.

# publications[].label
Persistence and expansion of cryptic endangered red wolf genomic ancestry along the American Gulf coast.

# publications[].label
Precision medicine validation: identifying the MYBPC3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathy.

# publications[].label
Genetic swamping of the critically endangered Scottish wildcat was recent and accelerated by disease.

# publications[].label
A 1.5-Mb-resolution radiation hybrid map of the cat genome and comparative analysis with the canine and human genomes.

# publications[].label
Mammalian evolution of human cis-regulatory elements and transcription factor binding sites.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Range-Wide Snow Leopard Phylogeography Supports Three Subspecies.

# publications[].label
The Lone Star Pioneer of Genomics: James E. Womack (March 30, 1941-August 13, 2023)

# publications[].label
De novo mutations in domestic cat are consistent with an effect of reproductive longevity on both the rate and spectrum of mutations

# publications[].label
Mitochondrial DNA phylogeny of West African aplocheiloid killifishes (Cyprinodontiformes, Aplocheilidae).

# publications[].label
The adequacy of morphology for reconstructing the early history of placental mammals.

# publications[].label
Molecular Evidence for major placental clades

# publications[].label
A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition

# publications[].label
A cluster of olfactory receptor genes linked to frugivory in bats.

# publications[].label
Evolution of mammalian genome organization inferred from comparative gene mapping.

# publications[].label
Mapping of 53 loci in American mink (Mustela vison).

# publications[].label
The value of hybrid genomes: Building two highly contiguous reference genome assemblies to advance Canis genomic studies.

# publications[].label
Resolution of the early placental mammal radiation using Bayesian phylogenetics.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Relating enhancer genetic variation across mammals to complex phenotypes using machine learning.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Initial sequence and comparative analysis of the cat genome.

# publications[].label
Molecular phylogenetics and the origins of placental mammals.

# publications[].label
Limited historical admixture between European wildcats and domestic cats.

# publications[].label
A Deletion in GDF7 is Associated with a Heritable Forebrain Commissural Malformation Concurrent with Ventriculomegaly and Interhemispheric Cysts in Cats.

# publications[].label
Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping.

# publications[].label
Phylogeny of the Neotropical killifish family Rivulidae (Cyprinodontiformes, Aplocheiloidei) inferred from mitochondrial DNA sequences.

# publications[].label
A genomic timescale for placental mammal evolution.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Toward telomere-to-telomere cat genomes for precision medicine and conservation biology.

# publications[].label
Reduced genetic diversity and isolation of remnant ocelot populations occupying a severely fragmented landscape in southern Texas

# publications[].label
Comparative analysis of mammalian Y chromosomes illuminates ancestral structure and lineage-specific evolution.

# publications[].label
Waking the undead: Implications of a soft explosive model for the timing of placental mammal diversification.

# publications[].label
Integrating gene annotation with orthology inference at scale.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Phylogenetic assessment of introns and SINEs within the Y chromosome using the cat family felidae as a species tree.

# publications[].label
A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism.

# publications[].label
DNA methylation networks underlying mammalian traits.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Molecular dating and biogeography of the early placental mammal radiation.

# publications[].label
Evolutionary Models for the Diversification of Placental Mammals Across the KPg Boundary.

# publications[].label
Whole-genome sequences shed light onto demographic history and contemporaneous genetic erosion of free-ranging jaguar (Panthera onca) populations

# publications[].label
Whole-genome sequences shed light on the demographic history and contemporary genetic erosion of free-ranging jaguar (Panthera onca) populations.

# publications[].label
Precision Medicine in Cats: Novel Niemann-Pick Type C1 Diagnosed by Whole-Genome Sequencing.

# publications[].label
Near-Gapless Genome Assemblies of the Domestic Cat (Felis silvestris catus) and the African Serval (Leptailurus serval) Derived from Trio-Binning.

# publications[].label
Genetic and anatomical determinants of olfaction in dogs and wild canids

# publications[].label
Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor.

# publications[].label
Phylogenomics and the Genetic Architecture of the Placental Mammal Radiation.

# publications[].label
Northern Bobwhite (Colinus virginianus) Mitochondrial Population Genomics Reveals Structure, Divergence, and Evidence for Heteroplasmy.

# publications[].label
Genomic analysis reveals hidden biodiversity within colugos, the sister group to primates.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Evolutionary constraint and innovation across hundreds of placental mammals.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Characterization of 9 microsatellites and primers in snow leopards and a species-specific PCR assay for identifying noninvasive samples

# publications[].label
An approximately 140-kb deletion associated with feline spinal muscular atrophy implies an essential LIX1 function for motor neuron survival.

# publications[].label
Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species.

# publications[].label
The mitochondrial genome sequence of the Tasmanian tiger (Thylacinus cynocephalus).

# publications[].label
Construction of radiation hybrid panels.

# publications[].label
A new approach method for characterizing inter-species toxicodynamic variability.

# publications[].label
An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Spatiotemporal Genetic Diversity of Lions Reveals the Influence of Habitat Fragmentation across Africa.

# publications[].label
A molecular phylogeny for aplocheiloid fishes (Atherinomorpha, Cyprinodontiformes): the role of vicariance and the origins of annualism.

# publications[].label
Persistence and expansion of cryptic endangered red wolf genomic ancestry along the American Gulf coast

# publications[].label
The historical biogeography of Mammalia.

# publications[].label
Using Illumina next generation sequencing technologies to sequence multigene families in de novo species.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Phylogenomic evidence for ancient hybridization in the genomes of living cats (Felidae).

# publications[].label
Pattern and timing of diversification of the mammalian order Carnivora inferred from multiple nuclear gene sequences.

# publications[].label
Who's behind that mask and cape? The Asian leopard cat's Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed.

# publications[].label
A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae.

# publications[].label
Molecular Phylogeny and Dating of Early Primate Divergences

# publications[].label
Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
A High-Resolution SNP Array-Based Linkage Map Anchors a New Domestic Cat Draft Genome Assembly and Provides Detailed Patterns of Recombination.

# publications[].label
Evolution, phylogeny, ecology, and conservation of the clade Glires: Lagomorpha and Rodentia

# publications[].label
A family matter: conclusive resolution of the taxonomic position of the long-fingered bats, miniopterus.

# publications[].label
Karyotypic stasis and swarming influenced the evolution of viral tolerance in a species-rich bat radiation.

# publications[].label
Extreme genomic erosion after recurrent demographic bottlenecks in the highly endangered Iberian lynx.

# publications[].label
HER2 Overexpression and Amplification in Feline Pulmonary Carcinoma.

# publications[].label
Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits.

# publications[].label
The promise of comparative genomics in mammals.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Phylogenetic relationships of African killifishes in the genera Aphyosemion and Fundulopanchax inferred from mitochondrial DNA sequences.

# publications[].label
Single-haplotype comparative genomics provides insights into lineage-specific structural variation during cat evolution.

# publications[].label
The contribution of historical processes to contemporary extinction risk in placental mammals.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Mining the 99 Lives Cat Genome Sequencing Consortium database implicates genes and variants for the Ticked locus in domestic cats (Feliscatus).

# publications[].label
Genome maps 10. Comparative genomics. Mammalian radiations. Wall chart.

# publications[].label
Massive inter-species introgression overwhelms phylogenomic relationships among jaguar, lion, and leopard.

# publications[].label
Genome-Wide SNPs Clarify a Complex Radiation and Support Recognition of an Additional Cat Species.

# publications[].label
How genomic insights into the evolutionary history of clouded leopards inform their conservation.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Tracking genome organization in rodents by Zoo-FISH.

# publications[].label
Genomics. On choosing mammalian genomes for sequencing.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Mesozoic origin for West Indian insectivores.

# publications[].label
Resolution of a concatenation/coalescence kerfuffle: partitioned coalescence support and a robust family-level tree for Mammalia.

# publications[].label
Inherited motor neuron disease in domestic cats: a model of spinal muscular atrophy.

# publications[].label
De novo Mutations in Domestic Cat are Consistent with an Effect of Reproductive Longevity on Both the Rate and Spectrum of Mutations.

# publications[].label
Novel Gene Acquisition on Carnivore Y Chromosomes

# publications[].label
A conserved segmental duplication within ELA.

# publications[].label
Leveraging base-pair mammalian constraint to understand genetic variation and human disease.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Morphology and placental mammal phylogeny.

# publications[].label
Molecular decay of the tooth gene Enamelin (ENAM) mirrors the loss of enamel in the fossil record of placental mammals.

# publications[].label
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.

# publications[].label
Genomic architecture constrained placental mammal X Chromosome evolution.

# publications[].label
A novel fishing cat reference genome for the evaluation of potential germline risk variants

# publications[].label
Comparative Phylogeography of Forest-Dependent Mammals Reveals Paleo-Forest Corridors throughout Sundaland.

# publications[].label
Extensive Phylogenomic Discordance and the Complex Evolutionary History of the Neotropical Cat Genus Leopardus.

# publications[].label
Macroevolutionary dynamics and historical biogeography of primate diversification inferred from a species supermatrix.

# publications[].label
Aquatic Adaptation and Depleted Diversity: A Deep Dive into the Genomes of the Sea Otter and Giant Otter.

# publications[].label
Accelerated evolution of CES7, a gene encoding a novel major urinary protein in the cat family.

# publications[].label
The functional and evolutionary impacts of human-specific deletions in conserved elements.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
The feline major histocompatibility complex is rearranged by an inversion with a breakpoint in the distal class I region.

# publications[].label
Mitogenomic sequences support a north-south subspecies subdivision within Solenodon paradoxus.

# publications[].label
Recombination-Aware Phylogenomics Reveals the Structured Genomic Landscape of Hybridizing Cat Species.

# publications[].label
Mechanisms Underlying Mammalian Hybrid Sterility in Two Feline Interspecies Models.

# publications[].label
A mitochondrial genetic divergence proxy predicts the reproductive compatibility of mammalian hybrids.

# publications[].label
28-way vertebrate alignment and conservation track in the UCSC Genome Browser.

# publications[].label
Placental mammal diversification and the Cretaceous-Tertiary boundary.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A molecular phylogeny for bats illuminates biogeography and the fossil record.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
An ancient haplotype containing antimicrobial peptide gene variants is associated with severe fungal skin disease in Persian cats.

# researcherOn[].label
Collaborative Research: The Genetic and Anatomical Determinants of Olfaction

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
Phylogenomics and the roles of chromosome architecture, recombination and hybridization on phylogenetic accuracy in the cat family (Felidae).

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
Understanding the co-evolution of phylogenomic signal, gene linkage, and recombination rate through comparative genomics

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# streetAddress
Texas A&M University; Veterinary Integrative Biosciences; 4458 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
School of Veterinary Medicine and Biomedical Sciences

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
School of Veterinary Medicine and Biomedical Sciences

# inTheNews[].label
The Unappreciated Importance of Cats (to Medical Science)

# inTheNews[].label
One More Thing We Have in Common With Cats

# inTheNews[].label
Texas A&M 2020 University Professorship Announced

# inTheNews[].label
Texas A&M University Announces 2020 EDGES Fellows

# etdChairOf[].label
Davis, Brian W (2013-05). Genomics and Transcriptomics of Hybrid Male Sterility Assessed in Multiple Interspecies Feline Breeds. Doctoral Dissertation.

# websites[].label
Laboratory of Mammalian Comparative Genomics