# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Our goal is to develop novel, non-toxic antimicrobial formualtions with efficacy against gram-positive and gram-negative multi-drug resistant pathogens.

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# educationAndTraining[].organization.label
Worcester Polytechnic Institute - (Worcester, Massachusetts, United States)

# educationAndTraining[].organization.label
Boston Children's Hospital - (Boston, Massachusetts, United States)

# educationAndTraining[].organization.label
The University of Texas Health Science Center at Houston - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
The University of Texas Health Science Center at Houston - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Brigham and Women's Hospital - (Boston, Massachusetts, United States)

# publications[].label
CFTR is a pattern recognition molecule that extracts Pseudomonas aeruginosa LPS from the outer membrane into epithelial cells and activates NF-kappa B translocation.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Superiority of Nebulized Methylated Caffeine Silver Acetate, SCC1, over Tobramycin for Treatment of Multi-Drug Resistant Pseudomonas aeruginosa in a Mouse Model of Pneumonia.

# publications[].label
Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel.

# publications[].label
Synthesis, stability, and antimicrobial studies of electronically tuned silver acetate N-heterocyclic carbenes.

# publications[].label
A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens.

# publications[].label
Reconstitution of recombinant pICln in planar lipid bilayers

# publications[].label
Pharmacokinetics and pharmacodynamics of linezolid in children with cystic fibrosis.

# publications[].label
Electrospun Antimicrobial, Anti-Inflammatory and Analgesic Bandages for Comprehensive Wound Treatment

# publications[].label
The application of PTR-MS and non-targeted analysis to characterize VOCs emitted from a plastic recycling facility fire.

# publications[].label
The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials.

# publications[].label
Antimicrobial Activity of Ibuprofen against Cystic Fibrosis-Associated Gram-Negative Pathogens.

# publications[].label
Silver incorporated shell-crosslinked nanoparticles as antimicrobial therapeutics for lung infections

# publications[].label
CHAPTER 15 Biologically Active N-Heterocyclic CarbeneMetal Complexes

# publications[].label
IL-12 p80-dependent macrophage recruitment primes the host for increased survival following a lethal respiratory viral infection.

# publications[].label
Nebulized Nanoparticles Loaded with Broad-Spectrum Silver-Based Antimicrobials for Depot Treatment of Pulmonary Infections.

# publications[].label
Promoting the STEM Pipeline and Enhancing STEM Career Awareness Through Participation in Authentic Research Activities (RTP, Diversity)

# publications[].publisher
American Society for Engineering Education

# publications[].label
Effects of Diagnosis by Newborn Screening for Cystic Fibrosis on Weight and Length in the First Year of Life.

# publications[].label
Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel

# publications[].label
Lung infections associated with cystic fibrosis.

# publications[].label
Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients.

# publications[].label
Lack of correlation between pulmonary disease and cystic fibrosis transmembrane conductance regulator dysfunction in cystic fibrosis: a case report.

# publications[].label
Antimicrobial Effects of Ibuprofen Combined with Standard of Care Antimicrobials against Cystic Fibrosis Pathogens

# publications[].label
A new way to target bacteria: Hetero-multivalent binding of glycolipids to Pseudomonas aeruginosa

# publications[].label
Ibuprofen Displays Synergistic Antibacterial Activity with Standard-of-Care Antibiotics Against Pseudomonas Aeruginosa

# publications[].label
BACTERIA-SPECIFIC DRUG DELIVERY: HETERO-MULTIVALENT TARGETED LIPOSOMES FOR TREATMENT OF PSEUDOMONAS AERUGINOSA

# publications[].label
Synthesis, characterization, and in vivo efficacy of shell cross-linked nanoparticle formulations carrying silver antimicrobials as aerosolized therapeutics.

# publications[].label
Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist.

# publications[].label
Association of Viral Respiratory Illness With Asthma Hospitalizations and ED Visits

# publications[].label
Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease.

# publications[].label
Mycobacterium abscessus infection in cystic fibrosis. Colonization or infection?

# publications[].label
Ionic strength regulates volume sensitivity of the swelling-activated anion conductance ICl swell.

# publications[].label
Host Protease Activity on Bacterial Pathogens Promotes Complement and Antibiotic-Directed Killing.

# publications[].label
Panton-Valentine Leukocidin-positive methicillin-resistant Staphylococcus aureus lung infection in patients with cystic fibrosis.

# publications[].label
Chapter 4: Biologically active N-heterocyclic carbene-metal complexes

# publications[].label
Synergistic Antimicrobial Effects of Ibuprofen Combined with Standard-of-Care Antibiotics against Cystic Fibrosis Pathogens.

# publications[].label
SOCIALIZATION AMONG INPATIENTS WITH CYSTIC FIBROSIS VIA TECHNOLOGY AND AN INFECTION CONTROL-APPROVED NOVEL PLAYROOM

# publications[].label
Clinical Practice Guidelines From the Cystic Fibrosis Foundation for Preschoolers With Cystic Fibrosis.

# publications[].label
Comparison of Two Nebulized Silver Carbene Complexes, SCC1 and SCC5, as Treatment of Respiratory Infections in a Mouse Model of Pseudomonas aeruginosa Pneumonia.

# publications[].label
Transmission of Panton-Valentine leukocidin-positive Staphylococcus aureus between patients with cystic fibrosis.

# publications[].label
Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Improving therapeutic delivery for lung diseases: In vitro and in vivo characterization of PEGylated polyphosphoester-based nanocarrier

# publications[].label
The antimicrobial efficacy of sustained release silver-carbene complex-loaded L-tyrosine polyphosphate nanoparticles: characterization, in vitro and in vivo studies.

# publications[].label
Investigating the pharmacokinetics and biological distribution of silver-loaded polyphosphoester-based nanoparticles using 111Ag as a radiotracer

# publications[].label
N-Acetyl Cysteine Abrogates Silver-Induced Reactive Oxygen Species in Human Cells Without Altering Silver-based Antimicrobial Activity

# publications[].label
Synthesis, characterization, and antimicrobial activity of silver carbene complexes derived from 4,5,6,7-tetrachlorobenzimidazole against antibiotic resistant bacteria.

# publications[].label
The medicinal applications of imidazolium carbene-metal complexes.

# publications[].label
Mycobacterium abscessus infection in cystic fibrosis: Colonization or infection?

# publications[].label
Azithromycin attenuates airway inflammation in a mouse model of viral bronchiolitis.

# publications[].label
NEBULIZED SHELL CROSSLINKED NANOPARTICLES CARRYING BROAD-SPECTRUM SILVER-BASED ANTIMICROBIALS FOR DEPOT TREATMENT OF CYSTIC FIBROSIS PULMONARY INFECTIONS

# publications[].label
Development of degradable diblock copolymer, polyphosphoester-block-poly(L-lactide), and its conversion into well-defined shell crosslinked nanoparticles as delivery carriers for antimicrobial agents

# publications[].label
Predictors of mucoid Pseudomonas colonization in cystic fibrosis patients.

# publications[].label
Ciprofloxacin overdose: acute renal failure with prominent apoptotic changes.

# publications[].label
Shell crosslinked nanoparticles carrying silver antimicrobials as therapeutics.

# publications[].label
Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa.

# publications[].label
Immunolocalization of chloride-transporting membrane vesicles in tracheal epithelial cells.

# publications[].label
Cystic fibrosis mutations for p.F508del compound heterozygotes predict sweat chloride levels and pancreatic sufficiency.

# publications[].label
N-Acetyl cysteine abrogates silver-induced reactive oxygen species in human cells without altering silver-based antimicrobial activity.

# publications[].label
In vitro and murine efficacy and toxicity studies of nebulized SCC1, a methylated caffeine-silver(I) complex, for treatment of pulmonary infections.

# publications[].label
Isolation of a chloride channel-enriched membrane fraction from tracheal and renal epithelia.

# publications[].label
Electrospun Antimicrobial, AntiInflammatory, and Analgesic Bandages for Comprehensive Wound Treatment

# publications[].label
Entry of Burkholderia organisms into respiratory epithelium: CFTR, microfilament and microtubule dependence.

# publications[].label
Recombinant pICln forms highly cation-selective channels when reconstituted into artificial and biological membranes.

# publications[].label
ESTROGEN CAUSES DYSREGULATED INFLAMMATION AND HINDERS THE INNATE IMMUNE RESPONSE TO PSEUDOMONAS AERUGINOSA INFECTION IN MICE

# publications[].label
Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria.

# publications[].label
Degradable polyphosphoester-based silver-loaded nanoparticles as therapeutics for bacterial lung infections.

# publications[].label
In Vitro Therapeutic Index Is A Strong Predictor Of The Efficacy Of Silver-Based Drug And Nanoparticle Formulations In A Mouse Model Of Bacterial Pneumonia

# publications[].label
ATP7B detoxifies silver in ciliated airway epithelial cells.

# publications[].label
Ag-111: A radiotracer for the chemistry and biochemistry of silver antimicrobials

# publications[].label
Betaine Adducts of NHeterocyclic Carbenes: Synthesis, Properties, and Reactivity / Synthesis and Study of 5,5Bibenzimidazolylidenes and Their Bimetallic Complexes / Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria / Structure and Reactivity of Dinitrogen Rhodium Complexes Containing NHeterocyclic Carbene Ligands / SambVca: A Web Application for the Calculation of the Buried Volume of NHeterocyclic Carbene Ligands  (Eur. J. Inorg. Chem. 13/2009)

# publications[].label
Synthesis from caffeine of a mixed N-heterocyclic carbene-silver acetate complex active against resistant respiratory pathogens.

# publications[].label
Azithromycin Attenuated Airway Inflammation in a Non-Infectious Mouse Model of Allergic Asthma

# publications[].label
Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics.

# publications[].label
A novel in vitro metric predicts in vivo efficacy of inhaled silver-based antimicrobials in a murine Pseudomonas aeruginosa pneumonia model.

# publications[].label
Antimicrobial Efficacy and Targeted Nanoparticle Delivery of Silver Ibuprofen to Treat Multi-Drug Resistant Gram-Positive and Gram-Negative Pathogens

# publications[].label
Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.

# publications[].label
Host protease activity on bacterial pathogens promotes complement- and antibiotic-directed killing

# publications[].label
ORGN 250-Complex nanoscale objects as diverse carrier systems for broad applications in nanomedicine

# publications[].label
Aerosolized antimicrobial agents based on degradable dextran nanoparticles loaded with silver carbene complexes.

# publications[].label
Azithromycin attenuates airway inflammation in a noninfectious mouse model of allergic asthma.

# publications[].label
Design and synthesis of degradable polyphosphoester-based nanoparticles carrying silver-based antimicrobials as therapeutics for lung infections

# publications[].label
In vitro antimicrobial studies of silver carbene complexes: activity of free and nanoparticle carbene formulations against clinical isolates of pathogenic bacteria.

# publications[].label
Eradication of First Isolation Burkholderia Cenocepacia in a Young Patient with Cystic Fibrosis

# publications[].label
Central Sleep Apnea in Down Syndrome and Its Association with Abnormal Head and Neck Imaging

# publications[].label
Pseudomonas aeruginosa-induced apoptosis is defective in respiratory epithelial cells expressing mutant cystic fibrosis transmembrane conductance regulator.

# publications[].label
Unexpected Histopathology After Resection of Suspected Congenital Lobar Emphysema

# publications[].label
Pulmonary pathology in thyroid transcription factor-1 deficiency syndrome.

# publications[].label
Modeling the response of a biofilm to silver-based antimicrobial.

# publications[].label
N-Heterocyclic carbene-silver complexes

# publications[].label
Hetero-Multivalent Targeted Liposomal Drug Delivery to Treat Pseudomonas aeruginosa Infections.

# publications[].label
Antimicrobial activity of a natural compound and analogs against multi-drug-resistant Gram-positive pathogens.

# publications[].label
Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel.

# researcherOn[].label
Antimicrobial, Anti-Inflammatory, Analgesic, Silver-Based, Electrospun Bandages for Superior Wound Healing

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
The MENTORS (Model Education Networks to Optimize Rural Science) Project

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
The MENTORS (Model Education Networks to Optimize Rural Science) Project

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-Office of Director-Office of Research Infrastructure Programs

# streetAddress
Texas A&M Medicine; Microbial Pathogenesis And Immunology; 1359 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# etdChairOf[].label
Chen, Qingquan (2019-08). Identification of Synergistic Drug Combinations  Against Cystic Fibrosis Pathogens. Doctoral Dissertation.

# etdChairOf[].label
Kasaraneni, Nagarjun (2017-08). Vector Engineering for Cell and Gene Therapy. Doctoral Dissertation.