# overview
Throughout my research career, I have been committed to applying engineering mechanics to address prevalent challenges in cardiovascular biology, physiology, and medicine. The broad scope of my research program is to understand the interactions between mechanics and cardiovascular disease, focusing on translating efforts and establishing disruptive technologies that advance patient management. I leverage my unique expertise in solid and fluid mechanics, across both the experimental and computational domains, to comprehensively characterize the mechanical stimuli vascular tissues are subjected to in the setting of health and disease. The two broad objectives of my research are 1) to advance the diagnosis, prognosis, and treatment of cardiovascular disease in the clinical setting and 2) to understand how mechanics drive the structure, function, and remodeling of vascular tissues.

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
3201 Cardiovascular Medicine And Haematology

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Phase Contrast Magnetic Resonance (pcmr)

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Cardiac Computational Fluid Dynamics Modeling

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
Phase Contrast Magnetic Resonance Imaging

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Receptor, Transforming Growth Factor-beta Type I

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Receptors, Transforming Growth Factor Beta

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Intracoronary Doppler Velocity And Pressure

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4012 Fluid Mechanics And Thermal Engineering

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3201 Cardiovascular Medicine And Haematology

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Georgia Institute of Technology - (Atlanta, Georgia, United States)

# publications[].label
Effect of regional analysis methods on assessing the association between wall shear stress and coronary artery disease progression in the clinical setting

# publications[].label
Evaluation of a framework for the co-registration of intravascular ultrasound and optical coherence tomography coronary artery pullbacks.

# publications[].label
Comparison of Prospective and Retrospective Gated 4D Flow Cardiac MR Image Acquisitions in the Carotid Bifurcation

# publications[].label
Correlation of Longitudinal Intravascular Ultrasound Data for the Clinical Assessment of Coronary Artery Disease Progression

# publications[].label
CTGF is a Modifiable Mediator of Flow-dependent Atherosclerosis under Peripheral Artery Disease Conditions

# publications[].label
Stented artery biomechanics and device design optimization

# publications[].label
Intimal Thickening Sourced From Low Wall Shear Stress in Human Left Coronary Artery Was Observed by Optical Coherence Tomography

# publications[].label
TCT-22 Combination of High Wall Shear Stress, Plaque Burden, and Plaque Phenotype has Incremental Value for Prediction of Increased Plaque Vulnerability in Patients with Coronary Artery Disease

# publications[].label
Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications.

# publications[].label
Co-localization of Disturbed Flow Patterns and Occlusive Cardiac Allograft Vasculopathy Lesion Formation in Heart Transplant Patients.

# publications[].label
Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1

# publications[].label
Catheter-based optical approaches for cardiovascular medicine: progress, challenges and new directions

# publications[].label
Increased artery wall stress post-stenting leads to greater intimal thickening.

# publications[].label
Establishment of an Automated Algorithm Utilizing Optical Coherence Tomography and Micro-Computed Tomography Imaging to Reconstruct the 3-D Deformed Stent Geometry.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
TCT-265 Combination of Large Plaque Burden and Low Wall Shear Stress Results in Greater Progression of Coronary Atherosclerosis than Low Wall Shear Stress Alone in Patients with Coronary Artery Disease

# publications[].label
ELEVATED HYPEREMIC MICROVASCULAR RESISTANCE IS ASSOCIATED WITH LOWER CORONARY WALL SHEAR STRESS IN PATIENTS WITH NON-OBSTRUCTIVE CORONARY ARTERY DISEASE

# publications[].label
Mechanical modeling of stents deployed in tapered arteries.

# publications[].label
Influence of Material Parameter Variability on the Predicted Coronary Artery Biomechanical Environment via Uncertainty Quantification

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Colocalization of low and oscillatory coronary wall shear stress with subsequent culprit lesion resulting in myocardial infarction in an orthotopic heart transplant patient.

# publications[].label
EXPERIMENTAL INVESTIGATION OF MECHANICAL AND STRUCTURAL INHOMOGENEITY IN BOVINE CAROTID ARTERIES

# publications[].label
A New Method for Quantifying Abdominal Aortic Wall Shear Stress Using Phase Contrast Magnetic Resonance Imaging and the Womersley Solution.

# publications[].label
Effects of stent design and atherosclerotic plaque composition on arterial wall biomechanics.

# publications[].label
Comparison of angiographic and IVUS derived coronary geometric reconstructions for evaluation of the association of hemodynamics with coronary artery disease progression.

# publications[].label
Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: implications for cardiovascular events in women.

# publications[].label
Abstract 102: Number of Reentry Tears Influences Flap Motion and Flow Reversal in an in vitro Model of Type B Aortic Dissection

# publications[].label
Computational Fluid Dynamics Simulations of Hemodynamics in Plaque Erosion.

# publications[].label
Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion.

# publications[].label
Investigation of the Influence of Side-Branches on Wall Shear Stress in Coronary Arteries Reconstructed from Intravascular Ultrasound

# publications[].label
Structural inhomogeneity and fiber orientation in the inner arterial media.

# publications[].label
CFD and VH-IVUS Biomechanical Analysis of Coronary Artery Disease With One Year Follow-Up

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Sleeve gastrectomy may improve arterial health in obese adolescents.

# publications[].label
"Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions".

# publications[].label
3.4 Characterisation of the Two-Layered Media in the Mammalian Carotid Artery

# publications[].label
Collagen Molecular Damage is a Hallmark of Early Atherosclerosis Development.

# publications[].label
Flow-based method demonstrates improved accuracy for calculating wall shear stress in arterial flows from 4D flow MRI data.

# publications[].label
IMPAIRED CORONARY MICROVASCULAR FUNCTION IS ASSOCIATED WITH FEATURES OF PLAQUE VULNERABILITY

# publications[].label
Influence of material parameter variability on the predicted coronary artery biomechanical environment via uncertainty quantification.

# publications[].label
Quantification of the focal progression of coronary atherosclerosis through automated co-registration of virtual histology-intravascular ultrasound imaging data.

# publications[].label
Stented artery biomechanics in the presence of stenoses and tapering

# publications[].label
Effects of stent design parameters on normal artery wall mechanics.

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A computational framework to optimize the mechanical behavior of synthetic vascular grafts.

# publications[].label
Chapter 9 Effect of regional analysis methods on assessing the association between wall shear stress and coronary artery disease progression in the clinical setting

# publications[].label
Fibrin Network Changes in Neonates after Cardiopulmonary Bypass.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
Focal association between wall shear stress and clinical coronary artery disease progression.

# publications[].label
Framework to co-register longitudinal virtual histology-intravascular ultrasound data in the circumferential direction.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Influence of Material Parameter Variability on the Predicted Coronary Artery Biomechanical Environment via Uncertainty Quantification.

# publications[].label
Association of coronary wall shear stress with atherosclerotic plaque burden, composition, and distribution in patients with coronary artery disease.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
Geometric and Hemodynamic Evaluation of 3-Dimensional Reconstruction Techniques for the Assessment of Coronary Artery Wall Shear Stress in the Setting of Clinical Disease Progression

# publications[].label
COMPUTATIONAL AND IN VIVO ANALYSIS OF THE ROLE OF SOLID BIOMECHANICS IN THE DEVELOPMENT OF INTIMAL THICKENING POST-STENTING

# publications[].label
Impact of combined plaque structural stress and wall shear stress on coronary plaque progression, regression, and changes in composition.

# publications[].label
Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease.

# publications[].label
Integration of Febio as an Instructional Tool in the Undergraduate Biomechanics Curriculum.

# publications[].label
Comparison of Prospective and Retrospective Gated 4D Flow Cardiac MR Image Acquisitions in the Carotid Bifurcation.

# publications[].label
PC42. Phase-Contrast Magnetic Resonance Imaging Reveals Novel Fluid Dynamics in a Patient-Derived Silicone Model of Descending Thoracic Aortic Dissection

# publications[].label
Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
The influence of multidirectional shear stress on plaque progression and composition changes in human coronary arteries.

# publications[].label
Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis.

# publications[].label
An endovascular model of ischemic myopathy from peripheral arterial disease.

# publications[].label
Vascular Geometry and Flow Profile Mediate Pathological Cell-Cell Interactions in Sickle Cell Disease As Measured with Do-It-Yourself Endothelial-Ized Microfluidics

# publications[].label
Biomechanical assessment of fully bioresorbable devices.

# publications[].label
Myocardial bridging: contemporary understanding of pathophysiology with implications for diagnostic and therapeutic strategies.

# publications[].label
Effect of Patient-Specific Coronary Flow Reserve Values on the Accuracy of MRI-Based Virtual Fractional Flow Reserve.

# publications[].label
Development of Framework to Examine the Focal Association Between Wall Shear Stress and Coronary Artery Disease Progression in the Clinical Setting

# publications[].label
Coronary artery wall shear stress is associated with progression and transformation of atherosclerotic plaque and arterial remodeling in patients with coronary artery disease.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
HIGHER CORONARY WALL SHEAR STRESS IS ASSOCIATED WITH GREATER IMPAIRMENT IN MICROVASCULAR FUNCTION IN PATIENTS WITH NONOBSTRUCTIVE CORONARY ARTERY DISEASE

# publications[].label
Endothelial cell (EC)-specific CTGF/CCN2 Expression Increases EC Reprogramming and Atherosclerosis.

# publications[].label
On the use of constrained reactive mixtures of solids to model finite deformation isothermal elastoplasticity and elastoplastic damage mechanics.

# publications[].label
Comprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double-Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease.

# publications[].publisher
Ovid Technologies (Wolters Kluwer Health)

# publications[].label
A Nonparametric Approach for Estimating Three-Dimensional Fiber Orientation Distribution Functions (ODFs) in Fibrous Materials.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
An assessment of intra-patient variability on observed relationships between wall shear stress and plaque progression in coronary arteries.

# publications[].label
A Computational Framework to Optimize the Mechanical Behavior of Synthetic Vascular Grafts.

# publications[].label
Effect of Subject-Specific, Spatially Reduced, and Idealized Boundary Conditions on the Predicted Hemodynamic Environment in the Murine Aorta.

# publications[].label
PC008. Number of Reentry Tears Influences Flap Motion and Flow Reversal in an In Vitro Model of Type B Aortic Dissection

# publications[].label
Combination of plaque burden, wall shear stress, and plaque phenotype has incremental value for prediction of coronary atherosclerotic plaque progression and vulnerability.

# publications[].label
Corrigendum to ```On the use of constrained reactive mixtures of solids to model finite deformation isothermal elastoplasticity and elastoplastic damage mechanics' [Journal of the Mechanics and Physics of Solids 155 (2021) 104534]''

# publications[].label
Model-Directed Design of Tissue Engineering Scaffolds.

# publications[].label
Coronary artery bifurcation biomechanics and implications for interventional strategies.

# publications[].label
Stented artery biomechanics and device design optimization.

# publications[].label
Pulsatile Flow Leads to Intimal Flap Motion and Flow Reversal in an In Vitro Model of Type B Aortic Dissection.

# researcherOn[].label
3D Stent Reconstruction in Bifurcating Lesions By Fusion of OCT and Micro-CT Data

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Biomechanical Indices for Coronary Lesion Rupture Risk and Lesion Prognostication

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)