# overview
The goals of my lab are to understand the role of mechanical forces in vascular growth and remodeling processes. Cells within the blood vessel wall are exposed to numerous mechanical forces including fluid shear stress, circumferential wall stress, and axial stress as part of their normal environment and alterations in these parameters plays important roles in the development and progression of vascular pathologies such as atherosclerosis, hypertension and aneurysms. Our experiments are focused on how understanding how vascular smooth muscle cells sense changes in the mechanical environment and how this leads to changes in gene expression and cellular phenotype.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Platelet Endothelial Cell Adhesion Molecule-1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptor, Platelet-Derived Growth Factor Beta

# educationAndTraining[].organization.label
Emory University - (Atlanta, Georgia, United States)

# educationAndTraining[].organization.label
Utah State University - (Logan, Utah, United States)

# educationAndTraining[].organization.label
Utah State University - (Logan, Utah, United States)

# publications[].label
Quantification of the mechanical behavior of carotid arteries from wild-type, dystrophin-deficient, and sarcoglycan-delta knockout mice.

# publications[].label
Determinants of mitochondrial O2 dependence in kidney.

# publications[].label
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst

# publications[].label
Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms.

# publications[].label
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis.

# publications[].label
Growth, matrix and differential MAP kinase activation in allylamine injured vascular smooth muscle cells

# publications[].label
Regional changes in elastic fiber organization and transforming growth factor  signaling in aortas from a mouse model of marfan syndrome.

# publications[].label
Isoform-specific knockout of endothelial myosin light chain kinase: closing the gap on inflammatory lung disease.

# publications[].label
Matrix-dependent gene expression of egr-1 and PDGF A regulate angiotensin II-induced proliferation in human vascular smooth muscle cells.

# publications[].label
Complementary roles of theoretical modeling and computer-controlled experimentation in vascular growth and remodeling

# publications[].label
Short-duration increases in intraluminal pressure improve vasoconstrictor responses in aged skeletal muscle feed arteries.

# publications[].label
Altered phenotypic gene expression of 10T1/2 mesenchymal cells in nonuniformly stretched PEGDA hydrogels.

# publications[].label
Analysis of the molecular basis of calmodulin defects that affect ion channel-mediated cellular responses: site-specific mutagenesis and microinjection.

# publications[].label
Mechanics of carotid arteries in a mouse model of Marfan Syndrome.

# publications[].label
Differential orientation of 10T1/2 mesenchymal cells on non-uniform stretch environments.

# publications[].label
Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism.

# publications[].label
Computational and site-specific mutagenesis analyses of the asymmetric charge distribution on calmodulin.

# publications[].label
Alpha 7 beta 1 integrin: putting the brakes on smooth muscle cell proliferation.

# publications[].label
Photoaffinity labeling of an antimycin-binding site in Rhodopseudomonas sphaeroides.

# publications[].label
Vascular smooth muscle cells: isolation, culture, and characterization.

# publications[].label
Regulation of endothelial cell integrin expression by angiogenic growth factors

# publications[].label
Time courses of growth and remodeling of porcine aortic media during hypertension: a quantitative immunohistochemical examination.

# publications[].label
Modulation of expressed L-type calcium channels by alpha 5 beta 1 integrin requires tyrosine phosphorylation of alpha(1c) channel subunit

# publications[].label
Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF.

# publications[].label
Strain-responsive regions in the platelet-derived growth factor-A gene promoter

# publications[].label
Acute mechanical effects of elastase on the infrarenal mouse aorta: implications for models of aneurysms.

# publications[].label
Modulation of cyclin dependent kinase inhibitor proteins and ERK1/2 activity in allylamine-injured vascular smooth muscle cells.

# publications[].label
Modulation of alpha4 integrin mRNA levels is coupled to deficits in vasomotor function in rat arterioles by allylamine.

# publications[].label
Development and characterization of endothelial cells from rat microlymphatics.

# publications[].label
Rapid induction and translocation of Egr-1 in response to mechanical strain in vascular smooth muscle cells.

# publications[].label
Importance of pulsatility in hypertensive carotid artery growth and remodeling.

# publications[].label
NADH dehydrogenase from bovine neutrophil membranes. Purification and properties.

# publications[].label
Myosin light chain kinase redistribution end activation of myosin light chain regulate endothelial barrier function

# publications[].label
Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability.

# publications[].label
Modulation of L-type calcium channels by alpha 5 beta 1 integrin: Test for maintaining regulation in a heterologous expression system

# publications[].label
Novel genomic targets in oxidant-induced vascular injury.

# publications[].label
Immunocytochemical localization of protein kinase C in resting and activated human neutrophils.

# publications[].label
Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways.

# publications[].label
Role of the cytoskeleton and focal adhesion proteins in regulation of vascular smooth muscle L-type calcium channels by alpha 5 beta 1 integrin

# publications[].label
Effects of thoracic spinal cord stimulation on cardiac autonomic regulation of the sinus and atrioventricular nodes.

# publications[].label
Adaptation of mesenteric lymphatic vessels to prolonged changes in transmural pressure.

# publications[].label
Differential progressive remodeling of coronary and cerebral arteries and arterioles in an aortic coarctation model of hypertension.

# publications[].label
A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways.

# publications[].label
Phospholipase C gamma activation, phosphotidylinositol hydrolysis, and calcium mobilization are not required for FGF receptor-mediated chemotaxis.

# publications[].label
Mechanical properties of suprarenal and infrarenal abdominal aorta: implications for mouse models of aneurysms.

# publications[].label
Activation of Na+/H+ exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma.

# publications[].label
Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils.

# publications[].label
Determinants of mitochondrial O2 dependence in kidney.

# publications[].label
Mutant analysis approaches to understanding calcium signal transduction through calmodulin and calmodulin regulated enzymes.

# publications[].label
Transforming growth factor-beta signaling in hypertensive remodeling of porcine aorta.

# publications[].label
Regulation of ion channels by protein tyrosine phosphorylation.

# publications[].label
Effect of age and exercise training on protein:protein interactions among eNOS and its regulatory proteins in rat aortas.

# publications[].label
Biaxial biomechanical adaptations of mouse carotid arteries cultured at altered axial extension.

# publications[].label
Non-capacitative calcium entry in Chinese hamster ovary cells expressing the platelet-derived growth factor receptor.

# publications[].label
Mechanical strain increases smooth muscle and decreases nonmuscle myosin expression in rat vascular smooth muscle cells.

# publications[].label
NF-B and matrix-dependent regulation of osteopontin promoter activity in allylamine-activated vascular smooth muscle cells.

# publications[].label
A multiaxial computer-controlled organ culture and biomechanical device for mouse carotid arteries.

# publications[].label
Mesenteric lymphatic vessels adapt to mesenteric venous hypertension by becoming weaker pumps.

# publications[].label
Regulation of ion channels by integrins.

# publications[].label
Time course of carotid artery growth and remodeling in response to altered pulsatility.

# publications[].label
Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension.

# publications[].label
Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis.

# publications[].label
Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
A device to study the effects of stretch gradients on cell behavior.

# publications[].label
Altered biomechanical properties of carotid arteries in two mouse models of muscular dystrophy.

# publications[].label
Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity.

# publications[].label
Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins.

# publications[].label
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst.

# publications[].label
Chronic oxidative injury of vascular smooth muscle cells alters expression of cell cycle regulatory proteins and activation of MAP kinase

# publications[].label
Modulation of alpha7-integrin-mediated adhesion and expression by platelet-derived growth factor in vascular smooth muscle cells.

# publications[].label
Extracellular matrix changes and vascular smooth muscle signaling

# publications[].label
Regulation of integrin alpha(v)beta(3) expression on endothelial cells by angiogenic stimulators.

# publications[].label
Bi-axial biomechanical behavior of mouse carotid arteries in culture in response to altered axial stretch

# publications[].label
Integrins as unique receptors for vascular control.

# publications[].label
Role of MCP-1 in tumor necrosis factor-alpha-induced endothelial dysfunction in type 2 diabetic mice.

# publications[].label
Collagen suppresses the proliferative phenotype of allylamine-injured vascular smooth muscle cells.

# publications[].label
Strain-responsive regions in the platelet-derived growth factor-A gene promoter.

# publications[].label
Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
A potential role of smooth muscle tone in early hypertension: a theoretical study.

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 1364 TAMUS

# etdChairOf[].label
Taucer, Anne Irene (2009-05). Biomechanics of common carotid arteries from mice heterozygous for mgR, the most common mouse model of Marfan syndrome. Master's Thesis.

# etdChairOf[].label
Jones, Sarah Anne Louise (2004-09). Differential expressions of cell cycle regulatory proteins and ERK1/2 characterize the proliferative smooth muscle cell phenotype induced by allylamine. Doctoral Dissertation.