# overview
My current research primarily focuses on understanding the organization, distribution, and comparison of information in Biological Systems. Our work encompasses two key levels of investigation:

Molecular Genetics: We employ the filamentous fungus Neurospora crassa as a model organism to uncover and comprehend the intricate molecular components responsible for sequence-based comparisons between homologous chromosomes, leading to the initiation of Meiotic Silencing, a phenomenon driven by RNA-mediated processes. Currently, our primary focus centers on the exploration of whether genes recognized for their significance in Meiotic Transvection/Silencing also contribute to the occurrence of Repeat Induced Point Mutation (RIP) phenomena.

Computational Analysis: We are developing novel computational pipelines dedicated to detecting sequence variations within related genomes. We are particularly intrigued by the prospect of simplifying (i.e., digitizing) the information present in DNA, RNA, and Proteins so as to simplify its manipulation and analysis. We think that digitizing emerging genomic data will not only enable us to use this data effectively but also to integrate it into Artificial Intelligence, Data Clustering, and Image Recognition Algorithms, in ways not done before. We posit that this process of converting biological features into digital equivalents has the potential to simplify genomic information, making it easier to uncover previously unnoticed patterns through complex computational comparisons. This approach has already yielded promising results by revealing unexpected informational patterns across various organisms' chromosomes. We believe that it will streamline and enhance our ability to comprehend different cellular and organismal states. Moreover, it holds significant promise in revolutionizing our understanding of diseases, particularly Cancer and Metagenomics. This informational perspective also contributes to our comprehension of genome evolution, especially in the field of comparative genomics and microbial metagenomics.

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1.1 Normal Biological Development And Functioning

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3102 Bioinformatics And Computational Biology

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Reverse Transcriptase Polymerase Chain Reaction

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4101 Climate Change Impacts And Adaptation

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1.1 Normal Biological Development And Functioning

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3102 Bioinformatics And Computational Biology

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1.1 Normal Biological Development And Functioning

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University of Wisconsin - Madison - (Madison, Wisconsin, United States)

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University of Brasilia - (Brasília, Brazil)

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Stanford University - (Stanford, California, United States)

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University of Georgia - (Athens, Georgia, United States)

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University of Brasilia - (Brasília, Brazil)

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Draft de novo transcriptome assembly and proteome characterization of the electric lobe of Tetronarce californica: a molecular tool for the study of cholinergic neurotransmission in the electric organ.

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Rapid molecular evolution of Spiroplasma symbionts of Drosophila

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Translational control of methionine and serine metabolic pathways underpin the paralog-specific phenotypes of Rpl22 ribosomal protein mutants in cell division and replicative longevity

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A re-analysis of an existing Drosophila melanogaster dataset reveals a new set of genes involved in post-mating response

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Unpaired genes do not silence their paired neighbors.

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Assessing the Influence of Sequence Duplications and Genome Annotations on Transcriptional Profiling Measurements

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Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development.

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Hym1p affects cell cycle progression in Saccharomyces cerevisiae.

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Control of seizures by ketogenic diet-induced modulation of metabolic pathways.

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Diverse toxin repertoire but limited metabolic capacities inferred from the draft genome assemblies of three Spiroplasma (Citri clade) strains associated with Drosophila

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A GATEWAY Destination Vector For High-Throughput Construction of Neurospora crassa histidine-3 Gene Replacement Plasmids

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A cytosine methyltransferase homologue is essential for sexual development in Aspergillus nidulans.

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PREreview of "Epigenetic deprogramming driven by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers"

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DNA methylation is independent of RNA interference in Neurospora.

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American Association for the Advancement of Science (AAAS)

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A large cluster of highly expressed genes is dispensable for growth and development in Aspergillus nidulans.

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NUC-2, a component of the phosphate-regulated signal transduction pathway in Neurospora crassa, is an ankyrin repeat protein.

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Properties of unpaired DNA required for efficient silencing in Neurospora crassa.

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Improving the efficiency of gene replacements in Neurospora crassa: a first step towards a large-scale functional genomics project.

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Catabolic plasmid specifying polychlorinated biphenyl degradation in Cupriavidus sp. strain SK-4: mobilization and expression in a pseudomonad.

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Meiotic trans-Sensing and Silencing in Neurospora

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Evidence for a precursor molecule of Brazil nut 2 S seed proteins from biosynthesis and cDNA analysis

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Synaptic vesicles contain small ribonucleic acids (sRNAs) including transfer RNA fragments (trfRNA) and microRNAs (miRNA).

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PREreview of "Cytoplasmic ribosomes hitchhike on mitochondria to dendrites"

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Effect of heritable symbionts on maternally-derived embryo transcripts.

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American Association for the Advancement of Science (AAAS)

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Sequence and molecular structure of the Aspergillus nidulans yA (laccase I) gene.

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Meiotic silencing and the epigenetics of sex.

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The Aspergillus nidulans yA gene is regulated by abaA.

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De Novo Assembly and Annotation of the Complete Genome Sequence of Myxococcus xanthus DZ2.

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Loss of growth polarity and mislocalization of septa in a Neurospora mutant altered in the regulatory subunit of cAMP-dependent protein kinase.

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Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.

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Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity.

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Neurospora crassa, a model system for epigenetics research.

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Do Public Databases Need Higher Standards for Next-Generation Data Submissions?

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QIP, a component of the vegetative RNA silencing pathway, is essential for meiosis and suppresses meiotic silencing in Neurospora crassa.

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Effect of heritable symbionts on maternally-derived embryo transcripts

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A Re-Analysis of an Existing Drosophila melanogaster Dataset Reveals a New Set of Genes Involved in Post-Mating Response

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An argonaute-like protein is required for meiotic silencing.

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The genome sequence of the filamentous fungus Neurospora crassa.

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Rapid molecular evolution of Spiroplasma symbionts of Drosophila.

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Synaptic vesicles isolated from the electric organ of Torpedo californica and from the central nervous system of Mus musculus contain small ribonucleic acids (sRNAs).

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The G1 cyclin Cln3p controls vacuolar biogenesis in Saccharomyces cerevisiae.

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DNA methylation affects meiotic trans-sensing, not meiotic silencing, in Neurospora.

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Translocation of Neurospora crassa transcription factor NUC-1 into the nucleus is induced by phosphorus limitation.

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Ribosome profiling the cell cycle: lessons and challenges.

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Translate to divide: ontrol of the cell cycle by protein synthesis.

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Plant SET domain-containing proteins: structure, function and regulation.

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Gene replacements at the his-3 locus of Neurospora crassa

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Construction of strains for rapid homokaryon purification after integration of constructs at the histidine-3 ( his-3) locus of Neurospora crassa.

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Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.

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Coupling of Protein Synthesis with Cell Division

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of General Medical Science

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National Science Foundation - (Arlington, Virginia, United States)

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Bennett, Chloe (2022-12). Exploring the RNA Landscape of the Post-Mating Response in Drosophila melanogaster. Doctoral Dissertation.

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Suescún Torres, Ana Victoria (2014-08). Sexual Development and Meiotic Silencing in Neurospora crassa. Doctoral Dissertation.

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Clanton, Ryan Michael (2017-12). Targeting Locoregional Characteristics of Neoplasms. Doctoral Dissertation.