# overview
Dr. Fatima Alshbool is an Assistant Professor, who joined the Rangel College of Pharmacy in February 2020. She is a pharmacist and a pharmacologist by training, having received her Pharm.D. degree (2006) from Jordan University of Science & Technology and her PhD degree (2014) from Loma Linda University. Dr. Alshbool's research program is focused on studying cardiovascular/thromboembolic disorders, such as heart attacks and stroke, particularly as they relate to platelet activation and signal transduction, including in the context of environmental health. One of her laboratory's main areas of focus has been investigating the impact of a relatively new form of tobacco smoking, namely e-cigarettes on platelet biology and associated diseases. She is also interested in defining the structural biology of platelet G-protein Coupled Receptors; amongst others. Dr. Alshbool's ultimate goal is to identify new therapeutic agents for the prevention or treatment of cardiovascular disease, and to gain insight into the negative impact of "tobacco" exposure on cardiovascular health.

# keywords[]
Perinatal Period - Conditions Originating In Perinatal Period

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Conditions Affecting The Embryonic And Fetal Periods

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Receptors, Thromboxane A2, Prostaglandin H2

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Mucosa-associated Lymphoid Tissue Lymphoma Translocation 1 Protein

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3201 Cardiovascular Medicine And Haematology

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1.1 Normal Biological Development And Functioning

# keywords[]
Perinatal Period - Conditions Originating In Perinatal Period

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Conditions Affecting The Embryonic And Fetal Periods

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# educationAndTraining[].organization.label
Jordan University of Science and Technology - (Irbid, Irbid, Jordan)

# educationAndTraining[].organization.label
Loma Linda University - (Loma Linda, California, United States)

# publications[].label
Exposure of Mice to Thirdhand Smoke Modulates In Vitro and In Vivo Platelet Responses.

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A Novel Antibody Targeting the Second Extracellular Loop of the Serotonin 5-HT2A Receptor Inhibits Platelet Function.

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Co-expression Analysis to Identify Key Modules and Hub Genes Associated With COVID19 in Platelets

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Exposure to Nicotine Vapor Produced by an Electronic Nicotine Delivery System Causes Short-Term Increases in Impulsive Choice in Adult Male Rats.

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The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis.

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Investigation of the impact of thirdhand e-cigarette exposure on platelet function: A pre-clinical study.

# publications[].label
Abstract 156: Prenatal Exposure To Electronic Delivery Systems Modulates Platelet Reactivity, Epigenetics And Gene Expression In Mice

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Author Correction: Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine.

# publications[].label
The effect of emerging tobacco related products and their toxic constituents on thrombosis.

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The Prothrombotic Phenotype of Thirdhand Electronic Cigarette Exposure is Sex Independent and Involves Systemic Mediated Effects on Platelet Function: Evidence from a Mouse Model.

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Short-Term E-Cigarette Exposure Increases the Risk of Thrombogenesis and Enhances Platelet Function in Mice.

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Investigation of a Thromboxane A2 Receptor-Based Vaccine for Managing Thrombogenesis.

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Role of IB kinase  in regulating the remodeling of the CARMA1-Bcl10-MALT1 complex.

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P2Y12 antibody inhibits platelet activity and protects against thrombogenesis.

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Impact of Electronic Cigarettes on the Cardiovascular System.

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The effects of hookah/waterpipe smoking on general health and the cardiovascular system.

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Arhgef1 Plays a Vital Role in Platelet Function and Thrombogenesis.

# publications[].label
Recipients of the 2021 Early Career Investigator Awards.

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Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis.

# publications[].label
In utero thirdhand smoke exposure modulates platelet function in a sex-dependent manner.

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Emerging multifunctional roles of Claudin tight junction proteins in bone.

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Vaping while high: Factors associated with vaping marijuana among youth in the United States.

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The Antidepressant Duloxetine Inhibits Platelet Function and Protects against Thrombosis

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The Antidepressant Duloxetine Inhibits Platelet Function and Protects against Thrombosis.

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Predicting thrombotic cardiovascular outcomes induced by waterpipe-associated chemicals using comparative toxicogenomic database: Genes, phenotypes, and pathways.

# publications[].label
Investigation of the Mechanistic Impact of Prenatal Exposure to Thirdhand Smoke on Platelet Activation

# publications[].label
The Impact of Maternal/In Utero Exposure of Novel Tobacco Products on the Offspring Cardiovascular Health.

# publications[].label
A high-calcium diet failed to rescue an osteopenia phenotype in claudin-18 knockout mice.

# publications[].label
Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.

# publications[].label
In Utero Thirdhand Smoke Modulates Platelet Gene Expression in Exposed Mice

# publications[].label
Abstract 126: Exposure To Thirdhand Hookah Smoke Elevates The Risk Of Thrombogenesis By Enhancing Platelet Function

# publications[].label
Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.

# publications[].label
The JUUL E-Cigarette Elevates the Risk of Thrombosis and Potentiates Platelet Activation.

# publications[].label
The G-protein  subunits regulate platelet function.

# publications[].label
Third-hand Smoke: Impact on Hemostasis and Thrombogenesis.

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Investigation of Novel Inhibitor for the Serotonin 5HT2A Receptor

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Abstract 13598: The G-protein BetaGamma Subunits Regulate Platelet Function

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CXCL12 regulates platelet activation via the regulator of G-protein signaling 16.

# publications[].label
Short-Term Exposure to Waterpipe/Hookah Smoke Triggers a Hyperactive Platelet Activation State and Increases the Risk of Thrombogenesis.

# publications[].label
Mouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function.

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Managing Thrombus Formation with EL2-5HTVac: A Selective Vaccination-Based Approach Targeting the Platelet Serotonin 5-HT2AR

# publications[].label
Co-expression analysis to identify key modules and hub genes associated with COVID19 in Platelets

# publications[].label
Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine.

# publications[].label
Co-expression analysis to identify key modules and hub genes associated with COVID-19 in platelets.

# publications[].label
Regulator of G-Protein Signaling 16 Is a Negative Modulator of Platelet Function and Thrombosis.

# publications[].label
Acute exposure to nicotine vapor causes short-term increases in impulsive choice in rats

# researcherOn[].label
The Impact of Third-Hand E#Cigarette Exposure on Platelet Function and Thrombogenesis

# researcherOn[].awardedBy.label
National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)