# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# overview
I am an anatomic veterinary pathologist from Bern, Switzerland with broad experience in macroscopical and histological evaluation of tissues from various animal species. I am specialized in Dermatopathology and I provide diagnostic service in the Dermatopathology Speciality Service as well as diagnostic service to the Veterinary Medical Teaching Hospital at TAMU. My research focuses on understanding the pathogenesis of non-inflammatory alopecia in dogs. I am investigating the molecular pathways involved in the activation of follicular stem cells and the regulation of the hair cycle. Our research group in Bern could establish a method to investigate the colony forming capacity of canine follicular stem cells and transit amplifying cells. In Utrecht, The Netherlands, I established the culturing of canine skin organoids (derived from interfollicular epidermis and hair follicles). This model system recapitulates in vitro skin stratification more faithfully than currently used 2D lines. These organoid lines provide the basis to explore epidermal function, to investigate culture conditions necessary for the development of organoids with a HF signature and to address cutaneous disorders in dogs and potentially human patients.

# keywords[]
Insulin-like Growth Factor Binding Protein 5

# keywords[]
Platelet Endothelial Cell Adhesion Molecule-1

# educationAndTraining[].organization.label
University of Bern - (Bern, Switzerland)

# educationAndTraining[].organization.label
University of Bern - (Bern, Switzerland)

# awardsAndHonors[].label
Veterinary Medical Teaching Hospital (VMTH) Clinical Service Award

# publications[].label
Stem Cell-Associated Marker Expression in Canine Hair Follicles.

# publications[].label
Staphylococcus felis C4 exhibits invitro antimicrobial activity against methicillin-resistant Staphylococcus pseudintermedius in a novel canine skin explant model.

# publications[].label
Estradiol-induced alopecia in five dogs after contact with a transdermal gel used for the treatment of postmenopausal symptoms in women.

# publications[].label
Novel insights into the pathways regulating the canine hair cycle and their deregulation in alopecia X.

# publications[].label
Long-term expansion and differentiation of adult murine epidermal stem cells in 3D organoid cultures.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Cetacean Morbillivirus Infection in a Killer Whale (Orcinus orca) from Brazil.

# publications[].label
The Hair Follicle: A Comparative Review of Canine Hair Follicle Anatomy and Physiology.

# publications[].label
Comparative assessment of a canine-specific medium to support colony formation from canine hair follicular keratinocytes.

# publications[].label
Abnormal keratinocyte differentiation in the nasal planum of Labrador Retrievers with hereditary nasal parakeratosis (HNPK).

# publications[].label
Histologic features of hair follicle neoplasms and cysts in dogs and cats: a diagnostic guide.

# publications[].publisher
American Veterinary Medical Association (AVMA)

# publications[].label
Establishment and characterization of a canine keratinocyte organoid culture system.

# publications[].label
Surgical and oncologic outcomes in dogs with malignant peripheral nerve sheath tumours arising from the brachial or lumbosacral plexus.

# publications[].label
Synergistic inhibition in cell-cell fusion mediated by the matrix and nucleocapsid protein of canine distemper virus.

# publications[].label
A case of necrotizing fasciitis with septic shock in a cat caused by Acinetobacter baumannii.

# publications[].label
Cutaneous lesions associated with dual infection caused by canine distemper virus and orthopoxvirus in a domestic cat.

# publications[].label
Pathologic and flow cytometric features of a case of canine ventral cervical lymphangiosarcoma.

# publications[].label
Investigation of a unique short open reading frame within the 3' untranslated region of the canine distemper virus matrix messenger RNA.

# publications[].label
Common superficial and deep cutaneous bacterial infections in domestic animals: A review.

# publications[].label
Thyroblastoma in a rhesus macaque (Macaca mulatta): A case report.

# publications[].label
Bald thigh syndrome in sighthounds-Revisiting the cause of a well-known disease.

# publications[].label
Long-term expanding human airway organoids for disease modeling.

# publications[].label
Cutaneous Amelanotic Signet-Ring Melanoma in a Siberian Tiger (Panthera tigris altaica).

# publications[].label
Spatial Distribution of Stem Cell-Like Keratinocytes in Dissected Compound Hair Follicles of the Dog.

# publications[].label
Post mortem computed tomography and core needle biopsy in comparison to autopsy in eleven Bernese mountain dogs with histiocytic sarcoma.

# publications[].label
A de novo variant in the ASPRV1 gene in a dog with ichthyosis.

# publications[].label
Canine sterile neutrophilic dermatosis (resembling Sweet's syndrome) with severe extracutaneous manifestations.

# publications[].label
Novel Features of the Prenatal Horn Bud Development in Cattle (Bos taurus).

# publications[].label
Reassessing Stephanofilaria stilesi dermatitis in cattle, with characterization of molecular markers for confirming diagnosis.

# publications[].label
Intragenic PNPLA1 duplication in Labrador retrievers with nonepidermolytic ichthyosis.

# publications[].label
New Zealand White Rabbits Effectively Clear Borrelia burgdorferi B31 despite the Bacterium's Functional vlsE Antigenic Variation System.

# publications[].label
ABHD5 frameshift deletion in Golden Retrievers with ichthyosis.

# publications[].label
Pollakisuria in a dwarf goat due to pathologic enlargement of the uterus.

# publications[].label
The First Immunocompetent Mouse Model of Strictly Human Pathogen, Borrelia recurrentis.

# publications[].label
Two domains of the V protein of virulent canine distemper virus selectively inhibit STAT1 and STAT2 nuclear import.

# publications[].label
A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation.

# publications[].label
Evaluation of canine epidermis and keratinocytoids (keratinocytic organoids) by transmission electron microscopy.

# publications[].label
Clinical and histological characterization of hair coat and glandular tissue of Chinese crested dogs.

# publications[].label
Characterization of canine epidermal organoid cultures by immunohistochemical analysis and quantitative PCR.

# publications[].label
Positive effects of hyperbaric oxygen therapy in a cat with cutaneous nocardiosis.

# publications[].label
FAM83G/Fam83g genetic variants affect canine and murine hair formation.

# publications[].label
Signal peptide and helical bundle domains of virulent canine distemper virus fusion protein restrict fusogenicity.

# publications[].label
Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state.

# publications[].label
Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis.

# publications[].label
Granulomatous Rhinitis in a Horse due to Mycobacterium intracellulare Infection.

# publications[].label
Pyogranulomatous panniculitis in a domestic cat associated with Pseudomonas luteola infection.

# publications[].label
Sores of boreal moose reveal a previously unknown genetic lineage of parasitic nematode within the genus Onchocerca.

# publications[].label
Carotid pseudoaneurysm in a kitten after accidental puncture with a needle.

# streetAddress
664 Raymond Stotzer Parkway; 4467 TAMU; 664 Raymond Stotzer Parkway, 4467 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US