# overview
My research activities at the College of Dentistry (COD) have a focus on (1) the development of translational and clinical research in dentistry and (2) research on the development and biomechanics of mineralized tissues from a translational and organismal perspective. Research in my laboratory includes studies of phenotypic assessment of skeletal tissues, with an emphasis on material properties, gross and micro structure, biomechanics, and temporal and evolutionary adaptations. Methods that we use include techniques for determining 3D material properties (ultrasound, nanoindentation), 2D and 3D bone histomorphometry, 3D scanning technologies (cone beam CT, micro CT), and various biomechanical modeling techniques, such as finite element analysis. Recent projects have included studies of cranial bone adaptation during wound healing and distraction osteogenesis, and studies of phenotypic adaptations in mouse genetic models related to alterations of pathways associated with Wnt/?-catenin signaling in osteoblasts (with J. Feng) and osteoclasts (with Y. Wan).

Mentoring Experience: 4 Postdocs; 18 PhD; 21 MS; 22 Undergrad DDS Research; 8 Undergrad BS Research; 53 Grad Advisor (as Graduate Program Director); 2 KL2 scholars

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Retired Professor Associate Dean and Interim Department Head

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Intercellular Signaling Peptides And Proteins

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Vascular Endothelial Growth Factor Receptor-3

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National Institute Of Dental And Craniofacial Research (u.s.)

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Intracellular Signaling Peptides And Proteins

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Intercellular Signaling Peptides And Proteins

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Intercellular Signaling Peptides And Proteins

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Chronic Kidney Disease-mineral And Bone Disorder

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1.1 Normal Biological Development And Functioning

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Chronic Kidney Disease-mineral And Bone Disorder

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National Institute Of Dental And Craniofacial Research (u.s.)

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University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States)

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University of Chicago - (Chicago, Illinois, United States)

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University of Pennsylvania - (Philadelphia, Pennsylvania, United States)

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Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible.

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Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement.

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Masticatory exercise as an adjunctive treatment for hyperdivergent patients.

# publications[].publisher
The Angle Orthodontist (EH Angle Education & Research Foundation)

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Review of In Vivo Bone Strain Studies and Finite Element Models of the Zygomatic Complex in Humans and Nonhuman Primates: Implications for Clinical Research and Practice.

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Relationship Between Three-Dimensional Microstructure and Elastic Properties of Cortical Bone in the Human Mandible and Femur

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Microwear, mechanics and the feeding adaptations of Australopithecus africanus.

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Effects of latency on the quality and quantity of bone produced by dentoalveolar distraction osteogenesis.

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Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles.

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Three-dimensional evaluation of mandibular bone regenerated by bone transport distraction osteogenesis.

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BIOMECHANICAL RATIONALE FOR SURGICAL-ORTHODONTIC EXPANSION OF THE ADULT MAXILLA - DISCUSSION

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Force level and strain patterns during bilateral mandibular osteodistraction.

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Principles of evidence-based dental practice (EBDP).

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Biomechanical characteristics of cortical bone regenerate after mandibular distraction osteogenesis in dogs

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An investigation of the oral pathologies occurring in bulimia nervosa

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Rigid fixation and strain patterns in the pig zygomatic arch and suture - Discussion

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Biomechanics of the canine mandible during bone transport distraction osteogenesis.

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Modeling elastic properties in finite-element analysis: how much precision is needed to produce an accurate model?

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A comparison of cortical elastic properties in the craniofacial skeletons of three primate species and its relevance to the study of human evolution.

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Edentulation alters material properties of cortical bone in the human craniofacial skeleton: functional implications for craniofacial structure in primate evolution.

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Additional fossil Theropithecus from Hopefield, South Africa: a comparison with other African sites and a reevaluation of its taxonomic status.

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Development, Structure, and Function of the Zygomatic Bones: What is New and Why Do We Care?

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A finite element analysis of masticatory stress hypotheses.

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The effects of bisphosphonates on osteoblasts in vitro.

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Viewpoints: diet and dietary adaptations in early hominins: the hard food perspective.

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Biomechanical implications of cortical elastic properties of the macaque mandible.

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Elastic Properties of Chimpanzee Craniofacial Cortical Bone.

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Electromyography of the suprahyoid musculature following mandibular advancement with and without rigid fixation.

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Comparison of the effects of phosphate-coated and sandblasted acid-etched titanium implants on osseointegration: a microcomputed tomographic examination in the canine model.

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Dentate transport discs can be used to reconstruct large segmental mandibular defects.

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Structural properties of mandibular bone following application of a bone plate.

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Regional material heterogeneity in craniofacial cortical bone of the genus Pan

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Patients' perception of pain during ultrasonic debridement: a comparison between piezoelectric and magnetostrictive scalers.

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A comparison of stimulated bite force after mandibular advancement using rigid and nonrigid fixation.

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Vacuum-induced Suction Stimulates Increased Numbers of Blood Vessels in Healthy Dog Gingiva.

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Estimation of body weights from craniometric variables in baboons.

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Biomechanical strain and morphologic changes with age in rat calvarial bone and sutures.

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Determinants of feeding behavior and food material properties on the deformations of the macaque mandible

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Edentulation alters material properties of cortical bone in the human mandible.

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Surface Strain on Bone and Sutures in a Monkey Facial Skeleton: An In Vitro Approach and its Relevance to Finite Element Analysis

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor .

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Proceedings of the National Academy of Sciences

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Divided zygoma in Holocene human populations from Northern China.

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Human feeding biomechanics: performance, variation, and functional constraints

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The Vulnerability of the Temporomandibular Joint in Recent Northern China Populations

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Post-natal effect of overexpressed DKK1 on mandibular molar formation.

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Particle size and shape of calcium hydroxide.

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In vivo bone strain and finite element modeling of a rhesus macaque mandible during mastication.

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Skulls of Orangutans with unilateral divided zygoma

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Development of the nose and soft tissue profile.

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Mechanical compensation in the evolution of the early hominin feeding apparatus.

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VEGF-C promotes the development of lymphatics in bone and bone loss.

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Regional, ontogenetic, and sex-related variations in elastic properties of cortical bone in baboon mandibles.

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AN INVESTIGATION OF THE ORAL PATHOLOGIES OCCURRING IN BULIMIA-NERVOSA

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Modeling masticatory muscle force in finite element analysis: sensitivity analysis using principal coordinates analysis.

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How does the rate of dentoalveolar distraction affect the bone regenerate produced?

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Masticatory biomechanics and its relevance to early hominid phylogeny: an examination of palatal thickness using finite-element analysis.

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Divided Zygomata in Neolithic and Dynastic Northern Chinese Populations

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Accuracy of elastic property measurement in mandibular cortical bone is improved by using cylindrical specimens.

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Internal Bone Structure and Orientation in the Browridge of Homo, Pan, Gorilla, Papio, and Cebus

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Effects of miniscrew orientation on implant stability and resistance to failure.

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The mandibles of castrated male rhesus macaques (Macaca mulatta): The effects of orchidectomy on bone and teeth.

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Normal masticatory performance in young adults and children.

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Recovery of jaw muscle function following injection of a myotoxic agent (lidocaine-epinephrine).

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A novel way to statistically analyze morphologic changes in Dmp1-null osteocytes.

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Two distalization methods compared in a novel patient-specific finite element analysis.

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PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.

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Osseointegration of dental implants placed into canine mandibular bone regenerated by bone transport distraction osteogenesis.

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The evidence-based dentistry initiative at Baylor College of Dentistry.

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In vitro strain measurements in the condylar process of the human mandible.

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Bone strain following application of a rigid bone plate: an in vitro study in human mandibles.

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THE EFFECT OF DIET TEXTURE ON HEALING FOLLOWING TEMPOROMANDIBULAR-JOINT DISCECTOMY IN RABBITS - DISCUSSION

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Elastic properties and masticatory bone stress in the macaque mandible

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In vivo bone strain and finite-element modeling of the craniofacial haft in catarrhine primates.

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The feeding biomechanics and dietary ecology of Paranthropus boisei.

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New roles and mechanism of action of BMP4 in postnatal tooth cytodifferentiation.

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Odontogenic abscesses in rhesus macaques (Macaca mulatta) of Cayo Santiago.

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Advancement genioplasty with and without soft tissue pedicle: An experimental investigation.

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In Vitro Mechanical Evaluation of Mandibular Bone Transport Devices

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Age changes in skinfold thickness among upper class school children of differing ethnic backgrounds residing in Guatemala.

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Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action.

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Human feeding biomechanics: performance, variation, and functional constraints.

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Fusion patterns of craniofacial sutures in rhesus monkey skulls of known age and sex from Cayo Santiago.

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Short-term stability and muscle adaptation after mandibular advancement surgery with and without suprahyoid myotomy in juvenile Macaca mulatta.

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Growth of the maxillary sinus in children and adolescents: A longitudinal study.

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Biomechanical effects of fixed partial denture therapy on strain patterns of the mandible.

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Osteocyte Morphology in the Primate Craniofacial Skeleton

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The digital reconstruction process and the assessment of hard tissue structure and mechanics

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Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss.

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Ontogeny and diachronic changes in sexual dimorphism in the craniofacial skeleton of rhesus macaques from Cayo Santiago, Puerto Rico.

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Biomechanical implications of intraspecific shape variation in chimpanzee crania: moving toward an integration of geometric morphometrics and finite element analysis.

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Material properties of the inner and outer cortical tables of the human parietal bone.

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A method of bite force measurement in primates.

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Architecture and microstructure of cortical bone in reconstructed canine mandibles after bone transport distraction osteogenesis.

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Mechanical evidence that Australopithecus sediba was limited in its ability to eat hard foods.

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Osteoclast progenitors reside in the peroxisome proliferator-activated receptor -expressing bone marrow cell population.

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Understanding human craniofacial bone properties and biomechanics - a perspective on macaques, baboons, and beyond

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Occlusal force after mandibular advancement in adult rhesus monkeys.

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Human feeding biomechanics: performance, variation, and functional constraints

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Repression of osteocyte Wnt/-catenin signaling is an early event in the progression of renal osteodystrophy.

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Strain regimes in the ramus of Macaca mulatta estimated using finite element modeling

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Biomechanical characteristics of regenerated cortical bone in the canine mandible.

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Material properties of mandibular cortical bone in the American alligator, Alligator mississippiensis.

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Finite element analysis in functional morphology.

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PGC1 beta Mediates PPAR gamma Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss (vol 11, pg 503, 2010)

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Meckel's cartilage directly contributes to early mandibular formation

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Effect of force on alveolar bone surrounding miniscrew implants: a 3-dimensional microcomputed tomography study.

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Material properties of the human cranial vault and zygoma.

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Considering the constrained lever model: Feeding biomechanics of OH 5 assessed using finite element analysis

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Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration.

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Adaptation of the suprahyoid muscle complex to mandibular advancement surgery.

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Elastic properties of external cortical bone in the craniofacial skeleton of the rhesus monkey.

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Biphasic and dosage-dependent regulation of osteoclastogenesis by -catenin.

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Masticatory properties in pre-modern Holocene populations from Northern China.

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Material properties of the dentate maxilla.

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HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered -catenin switch.

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Laser-treated stainless steel mini-screw implants: 3D surface roughness, bone-implant contact, and fracture resistance analysis.

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Elastic properties of human supraorbital and mandibular bone.

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Occlusal force and craniofacial biomechanics during growth in rhesus monkeys.

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Errata: The Structural Rigidity of the Cranium of Australopithecus africanus: Implications for Diet, Dietary Adaptations, and the Allometry of Feeding Biomechanics

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Effect of phosphate treatment of Acid-etched implants on mineral apposition rates near implants in a dog model.

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Elastic anisotropy and off-axis ultrasonic velocity distribution in human cortical bone.

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The winds of change revisited: progress towards building a culture of evidence-based dentistry.

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Changes in Mandibular Cortical Bone Density and Elastic Properties during Growth

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Adaptations in the temporalis muscles of rabbits after masseter muscle removal.

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How does the amount of surgical insult affect bone around moving teeth?

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The Biomechanics of Bony Facial "Buttresses" in South African Australopiths: An Experimental Study Using Finite Element Analysis.

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Role of TGF- in a mouse model of high turnover renal osteodystrophy.

# publications[].label
Elastic properties and masticatory bone stress in the macaque mandible.

# publications[].label
Osteocyte morphology in the human craniofacial skeleton

# publications[].label
Probabilistic finite element analysis of a craniofacial finite element model.

# publications[].label
The feeding biomechanics and dietary ecology of Australopithecus africanus.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Osteocyte Morphology in the Primate Craniofacial Skeleton

# publications[].label
Divided Zygomatic Bone in Primates With Implications of Skull Morphology and Biomechanics.

# publications[].label
Internal Bone Architecture in the Zygoma of Human and Pan.

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Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type.

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Changes in biomechanical strain and morphology of rat calvarial sutures and bone after Tgf-3 inhibition of posterior interfrontal suture fusion.

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Supernumerary Sutures in the Zygoma and their Impacts on Skull Modularity and Biomechanics

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The structural rigidity of the cranium of Australopithecus africanus: implications for diet, dietary adaptations, and the allometry of feeding biomechanics.

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Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation.

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Creating an evidence-based dentistry culture at Baylor College of Dentistry: the winds of change.

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Inheritance of sutural pattern at the pterion in Rhesus monkey skulls.

# publications[].label
Mechanical Properties of the Masticatory System in Recent Northern Chinese populations

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Variations in cortical material properties throughout the human dentate mandible.

# publications[].label
A pilot histologic comparison of bone-to-implant contact between phosphate-coated and control titanium implants in the canine model.

# publications[].label
Supernumerary Sutures in the Zygoma and their Impacts on Skull Modularity and Biomechanics

# streetAddress
Texas A&M University College of Dentistry; Academic Affairs; 3302 Gaston Avenue

# etdChairOf[].label
Pryor, Leslie Claire (2015-08). Trabecular Bone Structure and Cellular Morphology in the Primate Craniofacial Skeleton. Doctoral Dissertation.

# etdChairOf[].label
Spann, Stephanie (2014-08). Sleep Disorders Treatment Survey. Master's Thesis.