# overview
My research activities at the College of Dentistry (COD) have a focus on (1) the development of translational and clinical research in dentistry and (2) research on the development and biomechanics of mineralized tissues from a translational and organismal perspective. Research in my laboratory includes studies of phenotypic assessment of skeletal tissues, with an emphasis on material properties, gross and micro structure, biomechanics, and temporal and evolutionary adaptations. Methods that we use include techniques for determining 3D material properties (ultrasound, nanoindentation), 2D and 3D bone histomorphometry, 3D scanning technologies (cone beam CT, micro CT), and various biomechanical modeling techniques, such as finite element analysis. Recent projects have included studies of cranial bone adaptation during wound healing and distraction osteogenesis, and studies of phenotypic adaptations in mouse genetic models related to alterations of pathways associated with Wnt/?-catenin signaling in osteoblasts (with J. Feng) and osteoclasts (with Y. Wan).

Mentoring Experience: 4 Postdocs; 18 PhD; 21 MS; 22 Undergrad DDS Research; 8 Undergrad BS Research; 53 Grad Advisor (as Graduate Program Director); 2 KL2 scholars

# hrJobTitle
Retired Professor Associate Dean and Interim Department Head

# keywords[]
Intercellular Signaling Peptides And Proteins

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National Institute Of Dental And Craniofacial Research (u.s.)

# keywords[]
Intercellular Signaling Peptides And Proteins

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Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Chronic Kidney Disease-mineral And Bone Disorder

# keywords[]
Intercellular Signaling Peptides And Proteins

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1.1 Normal Biological Development And Functioning

# keywords[]
National Institute Of Dental And Craniofacial Research (u.s.)

# keywords[]
Chronic Kidney Disease-mineral And Bone Disorder

# keywords[]
Intracellular Signaling Peptides And Proteins

# educationAndTraining[].organization.label
University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States)

# educationAndTraining[].organization.label
University of Chicago - (Chicago, Illinois, United States)

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University of Pennsylvania - (Philadelphia, Pennsylvania, United States)

# publications[].label
Short-term stability and muscle adaptation after mandibular advancement surgery with and without suprahyoid myotomy in juvenile Macaca mulatta.

# publications[].label
Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss.

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BIOMECHANICAL RATIONALE FOR SURGICAL-ORTHODONTIC EXPANSION OF THE ADULT MAXILLA - DISCUSSION

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Biomechanical strain and morphologic changes with age in rat calvarial bone and sutures.

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An investigation of the oral pathologies occurring in bulimia nervosa

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Determinants of feeding behavior and food material properties on the deformations of the macaque mandible

# publications[].label
The structural rigidity of the cranium of Australopithecus africanus: implications for diet, dietary adaptations, and the allometry of feeding biomechanics.

# publications[].label
Occlusal force after mandibular advancement in adult rhesus monkeys.

# publications[].label
Elastic properties and masticatory bone stress in the macaque mandible.

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In vivo bone strain and finite-element modeling of the craniofacial haft in catarrhine primates.

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Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible.

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Additional fossil Theropithecus from Hopefield, South Africa: a comparison with other African sites and a reevaluation of its taxonomic status.

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Accuracy of elastic property measurement in mandibular cortical bone is improved by using cylindrical specimens.

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Divided Zygomatic Bone in Primates With Implications of Skull Morphology and Biomechanics.

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Biphasic and dosage-dependent regulation of osteoclastogenesis by -catenin.

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Elevation of a full-thickness mucoperiosteal flap alone accelerates orthodontic tooth movement.

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Meckel's cartilage directly contributes to early mandibular formation

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The mandibles of castrated male rhesus macaques (Macaca mulatta): The effects of orchidectomy on bone and teeth.

# publications[].label
Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles.

# publications[].label
Strain regimes in the ramus of Macaca mulatta estimated using finite element modeling

# publications[].label
Creating an evidence-based dentistry culture at Baylor College of Dentistry: the winds of change.

# publications[].label
Modeling masticatory muscle force in finite element analysis: sensitivity analysis using principal coordinates analysis.

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Probabilistic finite element analysis of a craniofacial finite element model.

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Dentate transport discs can be used to reconstruct large segmental mandibular defects.

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Occlusal force and craniofacial biomechanics during growth in rhesus monkeys.

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A novel way to statistically analyze morphologic changes in Dmp1-null osteocytes.

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Ontogeny and diachronic changes in sexual dimorphism in the craniofacial skeleton of rhesus macaques from Cayo Santiago, Puerto Rico.

# publications[].label
Electromyography of the suprahyoid musculature following mandibular advancement with and without rigid fixation.

# publications[].label
Edentulation alters material properties of cortical bone in the human craniofacial skeleton: functional implications for craniofacial structure in primate evolution.

# publications[].label
Human feeding biomechanics: performance, variation, and functional constraints

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Biomechanical implications of intraspecific shape variation in chimpanzee crania: moving toward an integration of geometric morphometrics and finite element analysis.

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THE EFFECT OF DIET TEXTURE ON HEALING FOLLOWING TEMPOROMANDIBULAR-JOINT DISCECTOMY IN RABBITS - DISCUSSION

# publications[].label
Three-dimensional evaluation of mandibular bone regenerated by bone transport distraction osteogenesis.

# publications[].label
Relationship Between Three-Dimensional Microstructure and Elastic Properties of Cortical Bone in the Human Mandible and Femur

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Mechanical compensation in the evolution of the early hominin feeding apparatus.

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Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation.

# publications[].label
Elastic properties and masticatory bone stress in the macaque mandible

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Mechanical evidence that Australopithecus sediba was limited in its ability to eat hard foods.

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New roles and mechanism of action of BMP4 in postnatal tooth cytodifferentiation.

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A comparison of stimulated bite force after mandibular advancement using rigid and nonrigid fixation.

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Osseointegration of dental implants placed into canine mandibular bone regenerated by bone transport distraction osteogenesis.

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How does the rate of dentoalveolar distraction affect the bone regenerate produced?

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Fusion patterns of craniofacial sutures in rhesus monkey skulls of known age and sex from Cayo Santiago.

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Age changes in skinfold thickness among upper class school children of differing ethnic backgrounds residing in Guatemala.

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Elastic Properties of Chimpanzee Craniofacial Cortical Bone.

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Principles of evidence-based dental practice (EBDP).

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Changes in biomechanical strain and morphology of rat calvarial sutures and bone after Tgf-3 inhibition of posterior interfrontal suture fusion.

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Regional material heterogeneity in craniofacial cortical bone of the genus Pan

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Estimation of body weights from craniometric variables in baboons.

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Variations in cortical material properties throughout the human dentate mandible.

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PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.

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Review of In Vivo Bone Strain Studies and Finite Element Models of the Zygomatic Complex in Humans and Nonhuman Primates: Implications for Clinical Research and Practice.

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Normal masticatory performance in young adults and children.

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Human feeding biomechanics: performance, variation, and functional constraints.

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Osteocyte morphology in the human craniofacial skeleton

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How does the amount of surgical insult affect bone around moving teeth?

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Mechanical Properties of the Masticatory System in Recent Northern Chinese populations

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor .

# publications[].publisher
Proceedings of the National Academy of Sciences

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The Biomechanics of Bony Facial "Buttresses" in South African Australopiths: An Experimental Study Using Finite Element Analysis.

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Supernumerary Sutures in the Zygoma and their Impacts on Skull Modularity and Biomechanics

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Bone strain following application of a rigid bone plate: an in vitro study in human mandibles.

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HDAC7 inhibits osteoclastogenesis by reversing RANKL-triggered -catenin switch.

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Elastic properties of external cortical bone in the craniofacial skeleton of the rhesus monkey.

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The Vulnerability of the Temporomandibular Joint in Recent Northern China Populations

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The feeding biomechanics and dietary ecology of Paranthropus boisei.

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Elastic properties of human supraorbital and mandibular bone.

# publications[].label
Particle size and shape of calcium hydroxide.

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Human feeding biomechanics: performance, variation, and functional constraints

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Development of the nose and soft tissue profile.

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Laser-treated stainless steel mini-screw implants: 3D surface roughness, bone-implant contact, and fracture resistance analysis.

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Errata: The Structural Rigidity of the Cranium of Australopithecus africanus: Implications for Diet, Dietary Adaptations, and the Allometry of Feeding Biomechanics

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Supernumerary Sutures in the Zygoma and their Impacts on Skull Modularity and Biomechanics

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Biomechanical characteristics of cortical bone regenerate after mandibular distraction osteogenesis in dogs

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The digital reconstruction process and the assessment of hard tissue structure and mechanics

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Adaptations in the temporalis muscles of rabbits after masseter muscle removal.

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Growth of the maxillary sinus in children and adolescents: A longitudinal study.

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Effects of latency on the quality and quantity of bone produced by dentoalveolar distraction osteogenesis.

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A comparison of cortical elastic properties in the craniofacial skeletons of three primate species and its relevance to the study of human evolution.

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The winds of change revisited: progress towards building a culture of evidence-based dentistry.

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Material properties of mandibular cortical bone in the American alligator, Alligator mississippiensis.

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Recovery of jaw muscle function following injection of a myotoxic agent (lidocaine-epinephrine).

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Biomechanics of the mandible of Macaca mulatta during the power stroke of mastication: Loading, deformation, and strain regimes and the impact of food type.

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Material properties of the inner and outer cortical tables of the human parietal bone.

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Patients' perception of pain during ultrasonic debridement: a comparison between piezoelectric and magnetostrictive scalers.

# publications[].label
Biomechanical implications of cortical elastic properties of the macaque mandible.

# publications[].label
A method of bite force measurement in primates.

# publications[].label
Modeling elastic properties in finite-element analysis: how much precision is needed to produce an accurate model?

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Development, Structure, and Function of the Zygomatic Bones: What is New and Why Do We Care?

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The effects of bisphosphonates on osteoblasts in vitro.

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Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration.

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Effect of phosphate treatment of Acid-etched implants on mineral apposition rates near implants in a dog model.

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Biomechanical characteristics of regenerated cortical bone in the canine mandible.

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Two distalization methods compared in a novel patient-specific finite element analysis.

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In Vitro Mechanical Evaluation of Mandibular Bone Transport Devices

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Post-natal effect of overexpressed DKK1 on mandibular molar formation.

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Divided Zygomata in Neolithic and Dynastic Northern Chinese Populations

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AN INVESTIGATION OF THE ORAL PATHOLOGIES OCCURRING IN BULIMIA-NERVOSA

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Effect of force on alveolar bone surrounding miniscrew implants: a 3-dimensional microcomputed tomography study.

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Divided zygoma in Holocene human populations from Northern China.

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Force level and strain patterns during bilateral mandibular osteodistraction.

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Odontogenic abscesses in rhesus macaques (Macaca mulatta) of Cayo Santiago.

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Vacuum-induced Suction Stimulates Increased Numbers of Blood Vessels in Healthy Dog Gingiva.

# publications[].label
Osteoclast progenitors reside in the peroxisome proliferator-activated receptor -expressing bone marrow cell population.

# publications[].label
Internal Bone Structure and Orientation in the Browridge of Homo, Pan, Gorilla, Papio, and Cebus

# publications[].label
The feeding biomechanics and dietary ecology of Australopithecus africanus.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A pilot histologic comparison of bone-to-implant contact between phosphate-coated and control titanium implants in the canine model.

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In vitro strain measurements in the condylar process of the human mandible.

# publications[].label
Viewpoints: diet and dietary adaptations in early hominins: the hard food perspective.

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VEGF-C promotes the development of lymphatics in bone and bone loss.

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Masticatory biomechanics and its relevance to early hominid phylogeny: an examination of palatal thickness using finite-element analysis.

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Skulls of Orangutans with unilateral divided zygoma

# publications[].label
Surface Strain on Bone and Sutures in a Monkey Facial Skeleton: An In Vitro Approach and its Relevance to Finite Element Analysis

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Repression of osteocyte Wnt/-catenin signaling is an early event in the progression of renal osteodystrophy.

# publications[].label
Comparison of the effects of phosphate-coated and sandblasted acid-etched titanium implants on osseointegration: a microcomputed tomographic examination in the canine model.

# publications[].label
PGC1 beta Mediates PPAR gamma Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss (vol 11, pg 503, 2010)

# publications[].label
Understanding human craniofacial bone properties and biomechanics - a perspective on macaques, baboons, and beyond

# publications[].label
Changes in Mandibular Cortical Bone Density and Elastic Properties during Growth

# publications[].label
Material properties of the dentate maxilla.

# publications[].label
Adaptation of the suprahyoid muscle complex to mandibular advancement surgery.

# publications[].label
Internal Bone Architecture in the Zygoma of Human and Pan.

# publications[].label
Regional, ontogenetic, and sex-related variations in elastic properties of cortical bone in baboon mandibles.

# publications[].label
Osteocyte Morphology in the Primate Craniofacial Skeleton

# publications[].label
Edentulation alters material properties of cortical bone in the human mandible.

# publications[].label
Advancement genioplasty with and without soft tissue pedicle: An experimental investigation.

# publications[].label
Elastic anisotropy and off-axis ultrasonic velocity distribution in human cortical bone.

# publications[].label
The evidence-based dentistry initiative at Baylor College of Dentistry.

# publications[].label
Effects of miniscrew orientation on implant stability and resistance to failure.

# publications[].label
In vivo bone strain and finite element modeling of a rhesus macaque mandible during mastication.

# publications[].label
Material properties of the human cranial vault and zygoma.

# publications[].label
A finite element analysis of masticatory stress hypotheses.

# publications[].label
Considering the constrained lever model: Feeding biomechanics of OH 5 assessed using finite element analysis

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Rigid fixation and strain patterns in the pig zygomatic arch and suture - Discussion

# publications[].label
Masticatory properties in pre-modern Holocene populations from Northern China.

# publications[].label
Biomechanics of the canine mandible during bone transport distraction osteogenesis.

# publications[].label
Inheritance of sutural pattern at the pterion in Rhesus monkey skulls.

# publications[].label
Masticatory exercise as an adjunctive treatment for hyperdivergent patients.

# publications[].publisher
The Angle Orthodontist (EH Angle Education & Research Foundation)

# publications[].label
Role of TGF- in a mouse model of high turnover renal osteodystrophy.

# publications[].label
Microwear, mechanics and the feeding adaptations of Australopithecus africanus.

# publications[].label
Finite element analysis in functional morphology.

# publications[].label
Osteocyte Morphology in the Primate Craniofacial Skeleton

# publications[].label
Architecture and microstructure of cortical bone in reconstructed canine mandibles after bone transport distraction osteogenesis.

# publications[].label
Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action.

# publications[].label
Structural properties of mandibular bone following application of a bone plate.

# publications[].label
Biomechanical effects of fixed partial denture therapy on strain patterns of the mandible.

# streetAddress
Texas A&M University College of Dentistry; Academic Affairs; 3302 Gaston Avenue

# etdChairOf[].label
Pryor, Leslie Claire (2015-08). Trabecular Bone Structure and Cellular Morphology in the Primate Craniofacial Skeleton. Doctoral Dissertation.

# etdChairOf[].label
Spann, Stephanie (2014-08). Sleep Disorders Treatment Survey. Master's Thesis.