# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
Research in my laboratory focuses on better understanding the molecular mechanisms of pathogenesis of Marek's disease virus, a chicken oncogenic alphaherpesvirus. We study gene function using biochemical techniques and by introducing mutations into the viral genome. The knowledge obtained from these studies is used to develop vaccines to control this critical poultry pathogen. In addition, we are investigating the use of Marek's disease vaccines as viral vectors to control other viral diseases of poultry.

# hrJobTitle
Professor and Interim Associate Dean for Research School of Nursing

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Helicoverpa Zea Reproductive Virus (HzRV)

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3507 Strategy, Management And Organisational Behaviour

# keywords[]
35 Commerce, Management, Tourism And Services

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
University of Santiago de Compostela - (Santiago de Compostela, Spain)

# educationAndTraining[].organization.label
University of Maryland, College Park - (College Park, Maryland, United States)

# educationAndTraining[].organization.label
Michigan State University - (East Lansing, Michigan, United States)

# awardsAndHonors[].label
Fellow, SEC Academic Leadership Development Program

# awardsAndHonors[].label
Accountability, Climate and Equity (ACE)  Women’s Progress Award

# publications[].label
In vitro characterization of the Meq proteins of Marek's disease virus vaccine strain CVI988.

# publications[].label
Cloning, sequence analysis and expression of the major outer capsid protein gene of an aquareovirus.

# publications[].label
Deletion of Marek's disease virus large subunit of ribonucleotide reductase impairs virus growth in vitro and in vivo.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Detection and characterization of a distinct bornavirus lineage from healthy Canada geese (Branta canadensis).

# publications[].label
Genetic manipulation of a very virulent strain of Marek's disease virus

# publications[].label
PTIE : Reflections on university strategic planning & holistic faculty evaluation

# publications[].label
Recombinant Marek's disease virus (MDV) lacking the Meq oncogene confers protection against challenge with a very virulent plus strain of MDV.

# publications[].label
Avian influenza virus surveillance in hunter-harvested waterfowl, Texas coast, September 2009-January 2010.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Properties of a meq-Deleted rMd5 Marek's Disease Vaccine: Protection Against Virulent MDV Challenge and Induction of Lymphoid Organ Atrophy Are Simultaneously Attenuated by Serial Passage In Vitro

# publications[].label
Development and use of a PCR assay for detection of the reproductive virus in wild populations of helicoverpa zea (Lepidoptera: noctuidae).

# publications[].label
RNA-seq analysis revealed novel genes and signaling pathway associated with disease resistance to avian influenza virus infection in chickens

# publications[].publisher
Oxford University Press (OUP): Policy B - Oxford Open Option F

# publications[].label
Characterization of a very virulent Marek's disease virus mutant expressing the pp38 protein from the serotype 1 vaccine strain CVI988/Rispens.

# publications[].label
Recombinant turkey herpesvirus vaccines and uses thereof

# publications[].label
Protein-coding content of the sequence of Marek's disease virus serotype 1.

# publications[].label
Wild Birds, a Source of Reticuloendotheliosis Virus Infection for the Endangered Attwater's Prairie-Chicken ( Tympanuchus cupido attwateri)?

# publications[].label
Simultaneous detection of avian influenza virus NP and H5 antibodies in chicken sera using a fluorescence microsphere immunoassay.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Cost-benefit analysis of avian influenza control in Nepal.

# publications[].publisher
O.I.E (World Organisation for Animal Health)

# publications[].label
Characterization and evaluation of avian influenza NS1 mutant virus as a potential live and killed DIVA (differentiating between infected and vaccinated animals) vaccine for chickens.

# publications[].label
Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens.

# publications[].label
Evaluation of a 384-well format for high-throughput real-time reverse transcription polymerase chain reaction for avian influenza testing.

# publications[].label
Comparison of Real-Time Reverse TranscriptionPCR and Virus Isolation for Estimating Prevalence of Avian Influenza Virus in Hunter-Harvested Wild Birds at Waterfowl Wintering Grounds Along the Texas MidGulf Coast (20052006 Through 20082009)

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Detection of aquareovirus RNA in fish tissues by nucleic acid hybridization with a cloned cDNA probe.

# publications[].label
Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach.

# publications[].label
Role of nonmigratory mottled ducks (Anas fulvigula) as sentinels for avian influenza surveillance.

# publications[].publisher
American Association of Zoo Veterinarians

# publications[].label
Cell culture attenuation eliminates rMd5Meq-induced bursal and thymic atrophy and renders the mutant virus as an effective and safe vaccine against Marek's disease.

# publications[].label
Further characterization of the gonad-specific virus of corn earworm, Helicoverpa zea.

# publications[].label
Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach (vol 11, pg 373, 2010)

# publications[].label
Ingestion of lead and nontoxic shot by Green-winged Teal (Anas crecca) and Northern Shovelers (Anas clypeata) from the mid-Gulf Coast of Texas, USA.

# publications[].label
Deletion of LORF9 but not LORF10 attenuates Marek's disease virus pathogenesis.

# publications[].label
ADVANCE: Promoting Success of Women Faculty Through a Psychologically Healthy Workplace

# publications[].label
A multiplexed immunoassay for detection of antibodies against avian influenza virus.

# publications[].label
A Novel Effective and Safe Vaccine for Prevention of Marek's Disease Caused by Infection with a Very Virulent Plus (vv+) Marek's Disease Virus.

# publications[].label
Chapter 20 Practical Aspects of Poultry Vaccination

# publications[].label
Genetic analysis of aquareoviruses using RNA-RNA blot hybridization.

# publications[].label
Heterogeneity in the genome RNAs and polypeptides of five members of a novel group of rotavirus-like viruses isolated from aquatic animals.

# publications[].label
Integrated analysis of microRNA expression and mRNA transcriptome in lungs of avian influenza virus infected broilers.

# publications[].label
Rescue of a pathogenic Marek's disease virus with overlapping cosmid DNAs: use of a pp38 mutant to validate the technology for the study of gene function.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Cloning of a Very Virulent Plus, 686 Strain of Marek's Disease Virus as a Bacterial Artificial Chromosome

# publications[].label
H7N9 influenza A virus in turkeys in Minnesota.

# publications[].label
INFLUENCE OF THE TEMPERATURE AND CELL-LINE ON THE ADSORPTION AND REPLICATION OF 5 FISH ROTAVIRUSES

# publications[].label
Development of DIVA (differentiation of infected from vaccinated animals) vaccines utilizing heterologous NA and NS1 protein strategies for the control of triple reassortant H3N2 influenza in turkeys.

# publications[].label
Cross-sectional serosurvey of avian influenza antibodies presence in domestic ducks of Kathmandu, Nepal.

# publications[].label
Geographical Information Systems: A Tool to Map and Analyze Disease Spread

# publications[].label
The role of Meq-vIL8 in regulating Marek's disease virus pathogenesis.

# publications[].label
Fish viral infections in northwest of Spain.

# publications[].label
Deletion of Marek's Disease Virus Large Subunit of Ribonucleotide Reductase Impairs Virus Growth In Vitro and In Vivo

# publications[].label
Acquisition, persistence, and species susceptibility of the Hz-2V virus.

# publications[].label
ADVANCE: Promoting Success of Women Faculty Through a Psychologically Healthy Workplace

# publications[].label
A GENETIC PROBE FOR IDENTIFICATION OF THE TURBOT AQUAREOVIRUS IN INFECTED CELL-CULTURES

# publications[].label
Proteolytic bacteria in the lower digestive tract of poultry may affect avian influenza virus pathogenicity.

# publications[].label
Insertion of Reticuloendotheliosis Virus Long Terminal Repeat into the Genome of CVI988 Strain of Marek's Disease Virus Results in Enhanced Growth and Protection

# publications[].label
A duplex real-time polymerase chain reaction assay for the simultaneous detection of long terminal repeat regions and envelope protein gene sequences of Reticuloendotheliosis virus in avian blood samples.

# publications[].label
Marek's disease virus down-regulates surface expression of MHC (B Complex) Class I (BF) glycoproteins during active but not latent infection of chicken cells.

# publications[].label
Multiyear surveillance for avian influenza virus in waterfowl from wintering grounds, Texas coast, USA.

# publications[].publisher
Centers for Disease Control and Prevention (CDC)

# publications[].label
Marek's disease virus vaccine compositions and methods of using thereof

# publications[].label
Conceptualizations of Teaching and Learning in Impact Statements for Tenure and Promotion

# publications[].label
Exploratory spatial analysis of Lyme disease in Texas -what can we learn from the reported cases?

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Comparative evaluation of vaccine efficacy of recombinant Marek's disease virus vaccine lacking Meq oncogene in commercial chickens.

# publications[].label
RNA-seq analysis revealed novel genes and signaling pathway associated with disease resistance to avian influenza virus infection in chickens.

# publications[].label
Evaluation of Factors Affecting Vaccine Efficacy of Recombinant Marek's Disease Virus Lacking the Meq Oncogene in Chickens

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.

# publications[].label
Biochemical and serological characterization of Carnobacterium spp. isolated from farmed and natural populations of striped bass and catfish.

# publications[].label
Investigation of the utility of the Simport-Matrix Chaperones for Avian Influenza Virus sample storage and transportation

# publications[].label
VIBRIO-MIMICUS AND VIBRIO-CHOLERAE NON-01 ISOLATED FROM WILD AND HATCHERY-REARED FISH

# publications[].label
Marek's Disease Virus Cluster 3 miRNAs Restrict Virus' Early Cytolytic Replication and Pathogenesis.

# publications[].label
Latest Insights into Unique Open Reading Frames Encoded by Unique Long (UL) and Short (US) Regions of Marek's Disease Virus.

# publications[].label
A Marek's disease virus vIL-8 deletion mutant has attenuated virulence and confers protection against challenge with a very virulent plus strain.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Role of Marek's Disease Virus (MDV)-Encoded US3 Serine/Threonine Protein Kinase in Regulating MDV Meq and Cellular CREB Phosphorylation.

# publications[].label
Pathogenicity of two recombinant avian leukosis viruses.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Mapping the domains on the phosphoprotein of bovine respiratory syncytial virus required for N-P interaction using a two-hybrid system.

# publications[].label
Marek's disease vaccines: Current status, and strategies for improvement and development of vector vaccines.

# publications[].label
Sequence analysis of genome segment 10 encoding the major outer capsid protein (VP7) of genogroup B aquareovirus and its relationship with the VP7 protein of genogroup A aquareovirus.

# publications[].label
US3 Serine/Threonine Protein Kinase from MDV-1, MDV-2, and HVT Differentially Regulate Viral Gene Expression and Replication.

# publications[].label
Properties of a meq-deleted rmd5 Marek's disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Evaluation of factors affecting vaccine efficacy of recombinant Marek's disease virus lacking the Meq oncogene in chickens.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
PHENOTYPIC AND PATHOBIOLOGICAL PROPERTIES OF CORYNEBACTERIUM-AQUATICUM ISOLATED FROM DISEASED STRIPED BASS

# publications[].label
Marek's disease virus US3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis.

# publications[].label
Simultaneous Detection of Avian Influenza Virus NP and H5 Antibodies in Chicken Sera Using a Fluorescence Microsphere Immunoassay

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Avian influenza surveillance in hunter-harvested waterfowl from the Gulf Coast of Texas (November 2005-January 2006).

# publications[].label
Preliminary study for evaluation of avian influenza virus inactivation in contaminated poultry products using electron beam irradiation.

# publications[].label
Marek's Disease Virus (MDV) Meq Oncoprotein Plays Distinct Roles in Tumor Incidence, Distribution, and Size.

# publications[].label
Methods for the Manipulation of Herpesvirus Genome and the Application to Marek's Disease Virus Research.

# publications[].label
Avian influenza virus investigation in wild bobwhite quail from Texas.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Marek's disease virus Meq oncoprotein interacts with chicken HDAC 1 and 2 and mediates their degradation via proteasome dependent pathway.

# publications[].label
Manipulation of Promyelocytic Leukemia Protein Nuclear Bodies by Marek's Disease Virus Encoded US3 Protein Kinase.

# publications[].label
Diagnosis of myeloid leukosis induced by a recombinant avian leukosis virus in commercial white leghorn egg laying flocks.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Characterization of 2 aquareovirus proteins.

# publications[].label
SERRATIA-MARCESCENS - A POTENTIAL PATHOGEN FOR FISH

# publications[].label
Identification and in vitro characterization of a Marek's disease virus-encoded Ribonucleotide reductase.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
New syndrome of mixed bacterial and viral etiology in cultured turbot scophthalmus maximus

# publications[].label
MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A NATURALLY 0CCURRING RECOMBINANT SUBGROUP B AVIAN LEUKOSIS VIRUS (ALV) WITH A SUBGROUP J-LIKE LONG TERMINAL REPEAT (LTR)

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Cloning of a very virulent plus, 686 strain of Marek's disease virus as a bacterial artificial chromosome.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Molecular and biological characterization of a naturally occurring recombinant subgroup B avian leukosis virus with a subgroup J-like long terminal repeat.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
ASSOCIATION OF STREPTOCOCCUS SP WITH FISH MORTALITIES IN THE CHESAPEAKE BAY AND ITS TRIBUTARIES

# publications[].label
Recombinant turkey herpesvirus vaccines and uses thereof

# publications[].label
Expansion of a unique region in the Marek's disease virus genome occurs concomitantly with attenuation but is not sufficient to cause attenuation.

# publications[].label
Insertion of reticuloendotheliosis virus long terminal repeat into the genome of CVI988 strain of Marek's disease virus results in enhanced growth and protection.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Practical Aspects of Poultry Vaccination

# publications[].label
Identification and characterization of recombinant subgroup J avian leukosis viruses (ALV) expressing subgroup A ALV envelope.

# publications[].label
Effects of bacterial microflora of the lower digestive tract of free-range waterfowl on influenza virus activation.

# publications[].label
Characterization of the US/TRS junction region of different MDV pathotypes

# publications[].label
Avian influenza viral nucleocapsid and hemagglutinin proteins induce chicken CD8+ memory T lymphocytes.

# publications[].label
IDENTIFICATION OF THE ANGELFISH, POMACANTHUS-SEMICIRCULATUS AQUAREOVIRUS AS A MEMBER OF AQUAREOVIRUS GENOGROUP-A USING RNA-RNA BLOT HYBRIDIZATION

# publications[].label
Comparison of real-time reverse transcription-PCR and virus isolation for estimating prevalence of avian influenza virus in hunter-harvested wild birds at waterfowl wintering grounds along the Texas mid-Gulf Coast (2005-2006 through 2008-2009).

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Recombinant turkey herpesvirus vaccines and uses thereof

# publications[].label
Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers.

# publications[].label
Molecular characterization of avian influenza viruses isolated in Texas

# researcherOn[].label
The role of post-translational modifications of Meq oncoprotein in Marek's disease virus pathogenesis

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Production and Characterization of Novel Reagents for the Development of Diagnostic Technologies for Rift Valley Fever

# researcherOn[].awardedBy.label
United States Department of Homeland Security - (New York, New York, United States)

# researcherOn[].label
Promoting Success of Women Faculty Through A Psychologically Healthy Workplace

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# streetAddress
Texas A&M University; Department of Veterinary Pathobiology; 4467 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
School of Veterinary Medicine and Biomedical Sciences

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
School of Veterinary Medicine and Biomedical Sciences

# inTheNews[].label
Actualización de los diferentes tipos de vacunas recombinantes en puesta

# inTheNews[].label
La vacuna Prevexxion RN, protagonista de aviForum Puesta 2022

# inTheNews[].label
Texas A&M Leadership To The Aggie Community: 'Be An Ally'

# etdChairOf[].label
Bajwa, Kanika (2020-12). Role of Meq-vIL8 in the Pathogenesis of Marek’s Disease Virus. Doctoral Dissertation.

# etdChairOf[].label
Liao, Yifei (2021-03). Functional Interaction between Marek's Disease Virus US3 and Meq with Chicken CREB and Histone Deacetylases. Doctoral Dissertation.