# overview
Dr. Mabbott's research focuses on the development of metallic nanoparticles for use in biomedical devices and healthcare settings. Applications include: integration into point of care devices for sensitive detection of disease relevant biomolecules such as circulating miRNA; controlling the nanoparticles light-to-heat conversion (photothermal) efficiency for destruction of diseased tissues (eg. Tumors); localized delivery of miRNA for gene therapy; increasing the therapeutic effect of drugs; biological and chemical signal amplification.

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
Surface Enhanced Raman Spectroscopy (sers)

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
Surface Enhanced Raman Spectroscopy (sers)

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
4.2 Evaluation Of Markers And Technologies

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# educationAndTraining[].organization.label
University of Manchester - (Manchester, Manchester, United Kingdom)

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Towards point-of-care detection of microRNAs using paper-based microfluidics

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SPIE, the international society for optics and photonics

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Detection of cardiovascular disease associated miR-29a using paper-based microfluidics and surface enhanced Raman scattering.

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Exploring the Clinical Utility of Raman Spectroscopy for Point-of-Care Cardiovascular Disease Biomarker Detection.

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Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis.

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Modular and handheld Raman systems for SERS-based point-of-care diagnostics

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Ferric plasmonic nanoparticles, aptamers, and magnetofluidic chips: toward the development of diagnostic surface-enhanced Raman spectroscopy assays.

# publications[].publisher
SPIE, the international society for optics and photonics

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DNA-Directed Formation of Plasmonic Core-Satellite Nanostructures for Quantification of Hepatitis C Viral RNA

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Simultaneous detection and quantification of three bacterial meningitis pathogens by SERS

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From synthetic DNA to PCR product: detection of fungal infections using SERS.

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SERS enhancement of silver nanoparticles prepared by a template-directed triazole ligand strategy.

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SERS active colloidal nanoparticles for the detection of small blood biomarkers using aptamers

# publications[].publisher
SPIE, the international society for optics and photonics

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Lateral Flow Assay for Preeclampsia Screening Using DNA Hairpins and Surface-Enhanced Raman-Active Nanoprobes Targeting hsa-miR-17-5p.

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Thermoresponsive Polymer Micropatterns Fabricated by Dip-Pen Nanolithography for a Highly Controllable Substrate with Potential Cellular Applications.

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Rapid Prototypable Biomimetic Peristalsis Bioreactor Capable of Concurrent Shear and Multi-Axial Strain.

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Spectrally multiplexed assay using gap enhanced nanoparticle for detection of a myocardial infarction biomarker panel.

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Freeze-Driven Synthesis of DNA Hairpin-Conjugated Gold Nanoparticle Biosensors for Dual-Mode Detection.

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Portable, multi-modal Raman and fluorescence spectroscopic platform for point-of-care applications.

# publications[].publisher
SPIE, the international society for optics and photonics

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High Precision Automated Synthesis of Surface-Enhanced (Resonance) Raman Nanotags.

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Summer research in the UK: Unique chemistry in a unique environment

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Correction to Thermoresponsive Polymer Micropatterns Fabricated by Dip-Pen Nanolithography for a Highly Controllable Substrate with Potential Cellular Applications.

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Advances in Biofunctional SERS-Active Nanoparticles for Future Clinical Diagnostics and Therapeutics

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Investigation of surface enhanced Raman scattering activity in silver-coated magnetic nanoparticles

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Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer.

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Through tissue imaging of a live breast cancer tumour model using handheld surface enhanced spatially offset resonance Raman spectroscopy (SESORRS).

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2p or not 2p: tuppence-based SERS for the detection of illicit materials.

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Introducing 12 new dyes for use with oligonucleotide functionalised silver nanoparticles for DNA detection with SERS.

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A locked aptamer-magnetic nanoparticle assay for cardiac troponin I classification to support myocardial infarction diagnosis in resource-limited environments.

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Simultaneous Thermal and Spectroscopic Screening of Morphologically Complex Theranostic Gold Nanoparticles

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Synthesis of SERS-active core-satellite nanoparticles using heterobifunctional PEG linkers.

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Advances in biosensors for diagnosis of Alzheimer's and Parkinson's diseases.

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Comparison of Fe2O3 and Fe2CoO4 core-shell plasmonic nanoparticles for aptamer mediated SERS assays

# publications[].publisher
SPIE, the international society for optics and photonics

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Multiplex imaging of live breast cancer tumour models through tissue using handheld surface enhanced spatially offset resonance Raman spectroscopy (SESORRS).

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Efficient production of uniform gold nanoparticles via a streamlined low-cost, semi-automated, open-source platform.

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Application of surface enhanced Raman scattering to the solution based detection of a popular legal high, 5,6-methylenedioxy-2-aminoindane (MDAI).

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A SERS approach for rapid detection of microRNA-17 in the picomolar range.

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Engineering molecularly-active nanoplasmonic surfaces for DNA detection via colorimetry and Raman scattering

# publications[].publisher
SPIE, the international society for optics and photonics

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Determination of metal ion concentrations by SERS using 2,2'-bipyridyl complexes.

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Indirect sandwich aptamer assay coupled structurally stabilized hairpin assisted hybridization chain reaction for femtomolar detection of cardiac troponin I

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Institute of Electrical and Electronics Engineers (IEEE)

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Fabrication of a 3D-printed electrode applied to electrochemical sensing of lamotrigine

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Analysis of Photothermal Release of Oligonucleotides from Hollow Gold Nanospheres by Surface-Enhanced Raman Scattering

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A low-cost, paper fluidic platform to detect B-type Natriuretic Peptide (BNP) for Congestive Heart Failure (CHF)

# publications[].publisher
SPIE, the international society for optics and photonics

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3D Printed SERS-Active Thin-Film Substrates Used to Quantify Levels of the Genotoxic Isothiazolinone.

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Biomarkers and point of care screening approaches for the management of preeclampsia.

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In vivo Imaging using Surface Enhanced Spatially Offset Raman Spectroscopy (SESORS): Balancing Sampling Frequency to Improve Overall Image Acquisition

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Detection of potentially toxic metals by SERS using salen complexes.

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Paper fluidic platform with dual-optical readouts to detect microRNA-20a (miR-20a) for preeclampsia

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Towards establishing a minimal nanoparticle concentration for applications involving surface enhanced spatially offset resonance Raman spectroscopy (SESORRS) in vivo.

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Through barrier detection of ethanol using handheld Raman spectroscopyConventional Raman versus spatially offset Raman spectroscopy (SORS)

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Paper Microfluidic Device with a Horizontal Motion Valve and a Localized Delay for Automatic Control of a Multistep Assay.

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Objective assessment of SERS thin films: comparison of silver on copper via galvanic displacement with commercially available fabricated substrates

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Undergraduate research in Glasgow, Scotland: A study on magnetic nanoparticles and life beyond the United States

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Organic Semiconductor Laser Platform for the Detection of DNA by AgNP Plasmonic Enhancement.

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Orientation and binding of near infrared absorbing dyes at a gold surface

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The optimisation of facile substrates for surface enhanced Raman scattering through galvanic replacement of silver onto copper.

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Optimization of parameters for the quantitative surface-enhanced Raman scattering detection of mephedrone using a fractional factorial design and a portable Raman spectrometer.