# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
The long-term goal of my laboratory is to understand the molecular basis of pathogenesis of Marek's disease virus (MDV), a potent oncogenic herpesvirus that causes T-cell tumors in chickens. MDV codes for a protein (Meq), which shares significant resemblance with the Jun/Fos family of transcriptional factors. We have shown that this gene plays a critical role in latency and transformation of T-lymphocytes. Understanding the basic mechanism of viral pathogenesis will aid in the development of improved vaccine. We are also interested in other important poultry disease like avian influenza.

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# educationAndTraining[].organization.label
Andhra University - (Visakhapatnam, Andhra Pradesh, India)

# educationAndTraining[].organization.label
University of Maryland, College Park - (College Park, Maryland, United States)

# educationAndTraining[].organization.label
University of Maryland, College Park - (College Park, Maryland, United States)

# publications[].label
In vitro characterization of the Meq proteins of Marek's disease virus vaccine strain CVI988.

# publications[].label
Marek's disease virus-encoded vIL-8 gene is involved in early cytolytic infection but dispensable for establishment of latency.

# publications[].label
Selection of a recombinant Marek's disease virus in vivo through expression of the Marek's EcoRI-Q (Meq)-encoded oncoprotein: characterization of an rMd5-based mutant expressing the Meq of strain RB-1B.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Cloning, sequence analysis and expression of the major outer capsid protein gene of an aquareovirus.

# publications[].label
Deletion of Marek's disease virus large subunit of ribonucleotide reductase impairs virus growth in vitro and in vivo.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Analysis of the ovine respiratory syncytial virus (RSV) G glycoprotein gene defines a subgroup of ungulate RSV.

# publications[].label
Latency of Marek's Disease Virus (MDV) in a Reticuloendotheliosis Virustransformed T-cell Line. I: Uptake and Structure of the Latent MDV Genome

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Recombinant Marek's disease virus (MDV) lacking the Meq oncogene confers protection against challenge with a very virulent plus strain of MDV.

# publications[].label
Isolation of subgroup J avian leukosis virus in Korea.

# publications[].label
Avian influenza virus surveillance in hunter-harvested waterfowl, Texas coast, September 2009-January 2010.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Properties of a meq-Deleted rMd5 Marek's Disease Vaccine: Protection Against Virulent MDV Challenge and Induction of Lymphoid Organ Atrophy Are Simultaneously Attenuated by Serial Passage In Vitro

# publications[].label
RNA-seq analysis revealed novel genes and signaling pathway associated with disease resistance to avian influenza virus infection in chickens

# publications[].publisher
Oxford University Press (OUP): Policy B - Oxford Open Option F

# publications[].label
Characterization of a very virulent Marek's disease virus mutant expressing the pp38 protein from the serotype 1 vaccine strain CVI988/Rispens.

# publications[].label
Recombinant turkey herpesvirus vaccines and uses thereof

# publications[].label
Protein-coding content of the sequence of Marek's disease virus serotype 1.

# publications[].label
Simultaneous detection of avian influenza virus NP and H5 antibodies in chicken sera using a fluorescence microsphere immunoassay.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Characterization and evaluation of avian influenza NS1 mutant virus as a potential live and killed DIVA (differentiating between infected and vaccinated animals) vaccine for chickens.

# publications[].label
Homodimerization of Marek's disease virus-encoded Meq protein is not sufficient for transformation of lymphocytes in chickens.

# publications[].label
The enhancement effect of pp38 gene product on the activity of its upstream bi-directional promoter in Marek's disease virus.

# publications[].label
Varicella-zoster virus ORF57, unlike its pseudorabies virus UL3.5 homolog, is dispensable for viral replication in cell culture.

# publications[].label
Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach.

# publications[].label
Differential attenuation of Marek's disease virus-induced tumours and late-Marek's disease virus-induced immunosuppression.

# publications[].label
Cell culture attenuation eliminates rMd5Meq-induced bursal and thymic atrophy and renders the mutant virus as an effective and safe vaccine against Marek's disease.

# publications[].label
Marek's disease virus-encoded Meq gene is involved in transformation of lymphocytes but is dispensable for replication.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Characterization of LORF11, a unique gene common to the three Marek's disease virus serotypes.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach (vol 11, pg 373, 2010)

# publications[].label
Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. II: expression of the latent MDV genome.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Deletion of LORF9 but not LORF10 attenuates Marek's disease virus pathogenesis.

# publications[].label
A multiplexed immunoassay for detection of antibodies against avian influenza virus.

# publications[].label
A Novel Effective and Safe Vaccine for Prevention of Marek's Disease Caused by Infection with a Very Virulent Plus (vv+) Marek's Disease Virus.

# publications[].label
Glycoproteins E and I of Marek's disease virus serotype 1 are essential for virus growth in cultured cells.

# publications[].label
Chapter 20 Practical Aspects of Poultry Vaccination

# publications[].label
Identification and structural analysis of a MDV gene encoding a protein kinase.

# publications[].label
Highly virulent Marek's disease virus strains affect T lymphocyte function and viability of splenocytes in commercial meat-type chickens.

# publications[].label
Integrated analysis of microRNA expression and mRNA transcriptome in lungs of avian influenza virus infected broilers.

# publications[].label
High virus titer in feather pulp of chickens infected with subgroup J avian leukosis virus.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Use of avian bornavirus isolates to induce proventricular dilatation disease in conures.

# publications[].publisher
Centers for Disease Control and Prevention (CDC)

# publications[].label
Rescue of a pathogenic Marek's disease virus with overlapping cosmid DNAs: use of a pp38 mutant to validate the technology for the study of gene function.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Cloning of a Very Virulent Plus, 686 Strain of Marek's Disease Virus as a Bacterial Artificial Chromosome

# publications[].label
Development of DIVA (differentiation of infected from vaccinated animals) vaccines utilizing heterologous NA and NS1 protein strategies for the control of triple reassortant H3N2 influenza in turkeys.

# publications[].label
CHARACTERIZATION OF LORF11, A UNIQUE GENE COMMON TO THE THREE MAREK'S DISEASE VIRUS SEROTYPES

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Characterization of the chromosomal binding sites and dimerization partners of the viral oncoprotein Meq in Marek's disease virus-transformed T cells.

# publications[].label
Effects of combined viral-bacterial challenge with or without supplementation of Saccharomyces cerevisiae boulardii strain CNCM I-1079 on immune upregulation and DMI in beef heifers.

# publications[].label
Standardization of a model to study revaccination against Marek's disease under laboratory conditions.

# publications[].label
The role of Meq-vIL8 in regulating Marek's disease virus pathogenesis.

# publications[].label
Deletion of Marek's Disease Virus Large Subunit of Ribonucleotide Reductase Impairs Virus Growth In Vitro and In Vivo

# publications[].label
Marek's disease virus infection in the brain: virus replication, cellular infiltration, and major histocompatibility complex antigen expression.

# publications[].label
Protection and synergism by recombinant fowl pox vaccines expressing multiple genes from Marek's disease virus.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Insertion of Reticuloendotheliosis Virus Long Terminal Repeat into the Genome of CVI988 Strain of Marek's Disease Virus Results in Enhanced Growth and Protection

# publications[].label
Sequence variability of the glycoprotein gene of bovine respiratory syncytial virus.

# publications[].label
Marek's disease virus vaccine compositions and methods of using thereof

# publications[].label
Comparative evaluation of vaccine efficacy of recombinant Marek's disease virus vaccine lacking Meq oncogene in commercial chickens.

# publications[].label
RNA-seq analysis revealed novel genes and signaling pathway associated with disease resistance to avian influenza virus infection in chickens.

# publications[].label
Evaluation of Factors Affecting Vaccine Efficacy of Recombinant Marek's Disease Virus Lacking the Meq Oncogene in Chickens

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.

# publications[].label
Marek's Disease Virus Cluster 3 miRNAs Restrict Virus' Early Cytolytic Replication and Pathogenesis.

# publications[].label
Latest Insights into Unique Open Reading Frames Encoded by Unique Long (UL) and Short (US) Regions of Marek's Disease Virus.

# publications[].label
Structural difference in the fusion protein among strains of bovine respiratory syncytial virus.

# publications[].label
Analysis of polypeptides synthesized in bovine respiratory syncytial virus-infected cells.

# publications[].label
A Marek's disease virus vIL-8 deletion mutant has attenuated virulence and confers protection against challenge with a very virulent plus strain.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Role of Marek's Disease Virus (MDV)-Encoded US3 Serine/Threonine Protein Kinase in Regulating MDV Meq and Cellular CREB Phosphorylation.

# publications[].label
Mapping the domains on the phosphoprotein of bovine respiratory syncytial virus required for N-P interaction using a two-hybrid system.

# publications[].label
Marek's disease vaccines: Current status, and strategies for improvement and development of vector vaccines.

# publications[].label
Phenotypic Characterization of Recombinant Marek's Disease Virus in Live Birds Validates Polymorphisms Associated with Virulence.

# publications[].label
Sequence analysis of genome segment 10 encoding the major outer capsid protein (VP7) of genogroup B aquareovirus and its relationship with the VP7 protein of genogroup A aquareovirus.

# publications[].label
US3 Serine/Threonine Protein Kinase from MDV-1, MDV-2, and HVT Differentially Regulate Viral Gene Expression and Replication.

# publications[].label
Latency of Marek's disease virus (MDV) in a reticuloendotheliosis virus-transformed T-cell line. I: uptake and structure of the latent MDV genome.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Properties of a meq-deleted rmd5 Marek's disease vaccine: protection against virulent MDV challenge and induction of lymphoid organ atrophy are simultaneously attenuated by serial passage in vitro.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Evaluation of factors affecting vaccine efficacy of recombinant Marek's disease virus lacking the Meq oncogene in chickens.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Marek's disease virus US3 protein kinase phosphorylates chicken HDAC 1 and 2 and regulates viral replication and pathogenesis.

# publications[].label
Simultaneous Detection of Avian Influenza Virus NP and H5 Antibodies in Chicken Sera Using a Fluorescence Microsphere Immunoassay

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Preliminary study for evaluation of avian influenza virus inactivation in contaminated poultry products using electron beam irradiation.

# publications[].label
Sequence comparison between the phosphoprotein mRNAs of human and bovine respiratory syncytial viruses identifies a divergent domain in the predicted protein.

# publications[].label
Marek's Disease Virus (MDV) Meq Oncoprotein Plays Distinct Roles in Tumor Incidence, Distribution, and Size.

# publications[].label
Methods for the Manipulation of Herpesvirus Genome and the Application to Marek's Disease Virus Research.

# publications[].label
Avian influenza virus investigation in wild bobwhite quail from Texas.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Effects of Live Yeast Supplementation on Complete Blood Cell Count and Febrile Responses in Heifers after Viral-Bacterial Respiratory Challenge.

# publications[].label
Marek's disease virus Meq oncoprotein interacts with chicken HDAC 1 and 2 and mediates their degradation via proteasome dependent pathway.

# publications[].label
Manipulation of Promyelocytic Leukemia Protein Nuclear Bodies by Marek's Disease Virus Encoded US3 Protein Kinase.

# publications[].label
Evaluation and Identification of Marek's Disease Virus BAC Clones as Standardized Reagents for Research.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
The role of pp38 in regulation of Marek's disease virus bi-directional promoter between pp38 and 1.8-kb mRNA.

# publications[].label
Telomeric repeats in the commercial SB-1 vaccine facilitate viral integration and contribute to vaccine efficacy.

# publications[].label
Identification and in vitro characterization of a Marek's disease virus-encoded Ribonucleotide reductase.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Latency of Marek's Disease Virus (MDV) in a Reticuloendotheliosis Virustransformed T-cell Line. II: Expression of the Latent MDV Genome

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Cloning of a very virulent plus, 686 strain of Marek's disease virus as a bacterial artificial chromosome.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Varicella-zoster virus (VZV) ORF32 encodes a phosphoprotein that is posttranslationally modified by the VZV ORF47 protein kinase.

# publications[].label
Coinfection of specific-pathogen-free chickens with Marek's disease virus (MDV) and chicken infectious anemia virus: effect of MDV pathotype.

# publications[].label
Recombinant turkey herpesvirus vaccines and uses thereof

# publications[].label
Expansion of a unique region in the Marek's disease virus genome occurs concomitantly with attenuation but is not sufficient to cause attenuation.

# publications[].label
Insertion of reticuloendotheliosis virus long terminal repeat into the genome of CVI988 strain of Marek's disease virus results in enhanced growth and protection.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Practical Aspects of Poultry Vaccination

# publications[].label
The pp38 gene of Marek's disease virus (MDV) is necessary for cytolytic infection of B cells and maintenance of the transformed state but not for cytolytic infection of the feather follicle epithelium and horizontal spread of MDV.

# publications[].label
Differential attenuation of the induction by Marek's disease virus of transient paralysis and persistent neurological disease: a model for pathogenesis studies.

# publications[].label
Biocharacteristics shared by highly protective vaccines against Marek's disease.

# publications[].label
Development of a quantitative-competitive polymerase chain reaction assay for serotype 1 Marek's disease virus.

# publications[].label
Selection of a Recombinant Marek's Disease Virus In Vivo Through Expression of the Marek's EcoRI-Q (Meq)Encoded Oncoprotein: Characterization of an rMd5-Based Mutant Expressing the Meq of Strain RB-1B

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Expression of a uracil DNA glycosylase (UNG) inhibitor in mammalian cells: varicella-zoster virus can replicate in vitro in the absence of detectable UNG activity.

# publications[].label
Recombinant turkey herpesvirus vaccines and uses thereof

# publications[].label
Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers.

# researcherOn[].label
Methods for control of economically important viral diseases of poultry

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Characterization of avian herpesvirus vector vaccines capable of protecting against multiple diseases in chickens

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Vet Med Pathobiology; 4467 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
School of Veterinary Medicine and Biomedical Sciences

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
School of Veterinary Medicine and Biomedical Sciences

# etdChairOf[].label
Bajwa, Kanika (2020-12). Role of Meq-vIL8 in the Pathogenesis of Marek’s Disease Virus. Doctoral Dissertation.

# etdChairOf[].label
Liao, Yifei (2021-03). Functional Interaction between Marek's Disease Virus US3 and Meq with Chicken CREB and Histone Deacetylases. Doctoral Dissertation.