# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Research Interests: Understanding pathophysiology and developing treatment strategies for neurodegenerative conditions including Gulf War Illness, Traumatic Brain Injury, Aging, Alzheimer's Disease and Temporal Lobe Epilepsy,

Expertise: Developing experimental models for Gulf War Illness, Traumatic Brain Injury, and Temporal Lobe Epilepsy, Survival surgeries for transplantation of cells and chronic EEG recordings, isolation of microglia and astrocytes from rodent brains, functional assessment in rodents by neurocognitive tests, investigation of modulation of neuroinflammation and neurogenesis at the cellular and molecular level, human mesenchymal stem cell cultures and isolation of extracellular Vesicles.

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Human Mesenchymal Stem Cell-derived Extracellular Vesicles

# keywords[]
Glial-cell Line Derived Neurotrophic Factor

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Cyclic Amp Response-element Binding Protein

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Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Human

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Janus Kinase/signal Transducers And Activators Of The Transcription (jak/stat) Signaling

# keywords[]
Nod-, Lrr- And Pyrin Domain-containing Protein 3 (nlrp3) Inflammasomes

# educationAndTraining[].organization.label
Acharya Nagarjuna University - (Guntur, Andhra Pradesh, India)

# educationAndTraining[].organization.label
Kasturba Medical College - (Manipala, Karnataka, India)

# educationAndTraining[].organization.label
Kasturba Medical College - (Manipala, Karnataka, India)

# publications[].label
Intranasal Administration of MSC-Derived Exosomes Modulate Status Epilepticus Induced Abnormal Plasticity of Newly Born Neurons and Microglial Activation in the Hippocampus

# publications[].label
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Prolonged Low-Level Inflammation Due to Exposure to Gulf War Illness Related Chemicals Increases Susceptibility to Cholestatic Liver Injury by Enhancing CD11b+ Macrophage/Monocyte Infiltration into the Liver

# publications[].label
Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.

# publications[].label
Montelukast Treatment Attenuates Cognitive Dysfunction in a Model of Chronic Gulf War Illness With Modulation of Leukotriene Signaling and NLRP3-Inflammasome Activation

# publications[].label
Neural Stem Cell or Human Induced Pluripotent Stem Cell-Derived GABA-ergic Progenitor Cell Grafting in an Animal Model of Chronic Temporal Lobe Epilepsy.

# publications[].label
Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet?

# publications[].label
Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus.

# publications[].label
Serum protein profile studies of cervical cancers in monitoring of tumor response to radiotherapy using HPLC-LIF: A pilot study

# publications[].label
A SINGLE INTRANASAL DOSE OF HUMAN NSC-DERIVED EXTRACELLULAR VESICLES AFTER TBI INHIBITS PROINFLAMMATORY TRANSCRIPTOMIC SIGNATURES IN ASTROCYTES

# publications[].label
Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves.

# publications[].label
Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory.

# publications[].label
Neuroimmune mechanisms of cognitive impairment in a mouse model of Gulf War illness.

# publications[].label
Emerging Anti-Aging Strategies - Scientific Basis and Efficacy.

# publications[].label
Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness.

# publications[].label
Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy.

# publications[].label
Promise of metformin for preventing age-related cognitive dysfunction.

# publications[].label
Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression.

# publications[].label
Intranasally Administered Human MSC-Derived Extracellular Vesicles Pervasively Incorporate into Neurons and Microglia in both Intact and Status Epilepticus Injured Forebrain.

# publications[].label
CHOLESTATIC LIVER INJURY IS EXACERBATED BY PRIOR EXPOSURE TO GULF WAR ILLNESS-RELATED CHEMICALS

# publications[].label
Brain Dysfunction in a Model of Gulf War Illness Continues into Middle Age with Elevated Oxidative Stress and Waned Mitochondrial Activity

# publications[].label
Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice.

# publications[].label
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus.

# publications[].label
Resveratrol Treatment after Status Epilepticus Restrains Neurodegeneration and Abnormal Neurogenesis with Suppression of Oxidative Stress and Inflammation.

# publications[].label
Gulf war illness-related chemicals increase CD11b/c+ monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model.

# publications[].label
Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation.

# publications[].label
Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction.

# publications[].label
Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans.

# publications[].label
Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood.

# publications[].label
Exposure to gulf war illness-related chemicals increases susceptibility to cholestatic liver injury by enhancing CD11b+macrophage/monocyte infiltration into the liver

# publications[].label
Innate immune signaling and sex differences contribute to neurocognitive impairment, neuroinflammation, and mitochondrial rewiring in a mouse model of Gulf War illness

# publications[].label
Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus.

# publications[].label
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB signaling.

# publications[].label
Extracellular Vesicles in the Forebrain Display Reduced miR-346 and miR-331-3p in a Rat Model of Chronic Temporal Lobe Epilepsy.

# publications[].label
Rhythms of Core Clock Genes and Spontaneous Locomotor Activity in Post-Status Epilepticus Model of Mesial Temporal Lobe Epilepsy.

# publications[].label
Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness.

# publications[].label
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus.

# publications[].label
REPEATED CLOSED HEAD INJURY LEADS TO LONGTERM COGNITIVE AND MOOD IMPAIRMENTS WITH ELEVATED OXIDATIVE STRESS, NEUROINFLAMMATION AND REDUCED HIPPOCAMPAL NEUROGENESIS

# publications[].label
Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer's Model.

# publications[].label
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus.

# publications[].label
Transient CSF1R Inhibition in the Early Stage of AD Retains Homeostatic Microglia with Reduced Inflammasomes and Increased autophagy in the 5XFAD Model

# publications[].label
Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness.

# publications[].label
Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and enhanced neurogenesis in the hippocampus.

# publications[].label
Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness.

# publications[].label
Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties.

# publications[].label
A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology.

# publications[].label
Unilateral Moderate Controlled Cortical Impact Traumatic Brain Injury Induces Enduring Deficits in Spatial, Object Location, Object Recognition and Pattern Separation Memory, and Mood Function

# publications[].label
Predictive and prognostic significance of glutathione levels and DNA damage in cervix cancer patients undergoing radiotherapy.

# publications[].label
Moderate Running Exercise Improves Cognitive, Memory, and Mood Function With Increased Neurogenesis in a Gulf War Illness Model

# publications[].label
FDA-approved cannabidiol [Epidiolex] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis.

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine