# preferredTitle
Professor and Presidential Impact Fellow and Chancellor EDGES Fellow

# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
The long-term goal of our research is to study the molecular mechanisms of insulin signal transduction, insulin resistance and associated cardiovascular dysfunction, aiming at nutritional and therapeutic intervention for control of metabolic and cardiovascular disorders. My laboratory is focused on the study of cellular signaling and gene transcriptional regulation of metabolic homeostasis that are governed by the PI3K->Akt->FoxO pathway, with the hope of understanding how dysregulation of this pathway in insulin/IGF-1 action causes liver damage, cardiovascular dysfunction, and pancreatic beta cell failure, resulting in diabetes, obesity, and organ failure.

# keywords[]
Insulin-like Growth Factor Binding Protein 1

# keywords[]
Electron Transport Chain Complex Proteins

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Growth Hormone Secretagogue Receptor (ghs-r)

# keywords[]
Growth Hormone Secretagogue Receptor (ghs-r)

# keywords[]
Pancreatic And Duodenal Homeobox 1 (pdx1)

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Growth Hormone Secretagogue Receptor (ghsr)

# keywords[]
Insulin-like Growth Factor Binding Protein 1

# keywords[]
Hypoxia-inducible Factor 1, Alpha Subunit

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Insulin-like Growth Factor Binding Protein 1

# keywords[]
Mechanistic Target Of Rapamycin Complex 1

# keywords[]
Insulin-like Growth Factor Binding Protein 1

# keywords[]
Mechanistic Target Of Rapamycin Complex 1

# keywords[]
Insulin-like Growth Factor Binding Protein 1

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Growth Hormone Secretagogue Receptor (ghs-r)

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Peking University - (Beijing, Beijing, China)

# educationAndTraining[].organization.label
Huazhong Agricultural University - (Wuhan, China)

# publications[].label
Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice.

# publications[].label
Rubisco activities and the small subunit gene cloning and functional analysis of Aegilops squarrosa

# publications[].label
A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice

# publications[].label
Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis.

# publications[].label
Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in hypothalamus.

# publications[].label
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.

# publications[].label
Estrogen Protects Cardiac Function and Energy Metabolism in Dilated Cardiomyopathy Induced by Loss of Cardiac IRS1 and IRS2.

# publications[].label
Cover Picture: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. Int. Ed. 10/2022)

# publications[].label
Activation of Foxo1 by insulin resistance promotes cardiac dysfunction and -myosin heavy chain gene expression.

# publications[].label
A Recurring Chemogenetic Switch for Chimeric Antigen Receptor T Cells

# publications[].label
Insulin receptor substrate signaling controls cardiac energy metabolism and heart failure.

# publications[].label
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.

# publications[].label
Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta.

# publications[].label
Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice.

# publications[].label
Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis.

# publications[].label
1508-P: ZnPP-Laden Nanoparticles Improve Glucose Homeostasis and Chronic Inflammation during Obesity

# publications[].label
Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1.

# publications[].label
Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells.

# publications[].label
Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation.

# publications[].label
Abstract 177: Insulin Resistance and Mechanisms of Heart Failure

# publications[].label
AKT-independent protection of prostate cancer cells from apoptosis mediated through complex formation between the androgen receptor and FKHR.

# publications[].label
RTEF-1 attenuates blood glucose levels by regulating insulin-like growth factor binding protein-1 in the endothelium.

# publications[].label
Ginsenoside Rg2 inhibits adipogenesis in 3T3-L1 preadipocytes and suppresses obesity in high-fat-diet-induced obese mice through the AMPK pathway.

# publications[].label
Suppression of FOXO1 attenuates inflamm-aging and improves liver function during aging.

# publications[].label
Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice.

# publications[].label
Foxo1 integrates insulin signaling with mitochondrial function in the liver.

# publications[].label
Metformin Targets Foxo1 to Control Glucose Homeostasis.

# publications[].label
Mice lacking adenosine 2A receptor reveal increased severity of MCD-induced NASH.

# publications[].label
Abstract P253: Transcriptional Regulation of the IGFBP-1 Gene by RTEF-1 in Endothelial Cells

# publications[].label
Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia.

# publications[].label
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.

# publications[].label
Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis.

# publications[].label
Molecular Basis of Insulin Resistance: The Role of IRS and Foxo1 in the Control of Diabetes Mellitus and Its Complications.

# publications[].label
Cell GHS-R Regulates Insulin Secretion and Sensitivity.

# publications[].label
Titelbild: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. 10/2022)

# publications[].label
A Reversible Chemogenetic Switch for Chimeric Antigen Receptor TCells.

# publications[].label
Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus.

# publications[].label
Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.

# publications[].label
Cardiac Myocyte KLF5 Regulates Ppara Expression and Cardiac Function.

# publications[].label
Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets.

# publications[].label
The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling.

# publications[].label
Transcription Factor Forkhead Box O1 Mediates Transforming Growth Factor-1-Induced Apoptosis in Hepatocytes.

# publications[].label
Reciprocal Regulation of Hepatic TGF-1 and Foxo1 Controls Gluconeogenesis and Energy Expenditure.

# publications[].label
Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases.

# publications[].label
ZnPP-laden nanoparticles improve glucose homeostasis and chronic inflammation during obesity.

# publications[].label
A structural and functional analogue of a Bowman-Birk-type protease inhibitor from Odorrana schmackeri.

# publications[].label
Activation of AMPK restricts coxsackievirus B3 replication by inhibiting lipid accumulation.

# publications[].label
Myocardial Activation of p38 alpha MAPK Results in Cardiac Insulin Resistance by Chronic Insulin Signaling

# publications[].label
Suppression of Ghrelin Receptor in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis

# publications[].label
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.

# publications[].label
Sample preparation for the metabolomics investigation of poly-gamma-glutamate-producing Bacillus licheniformis by GC-MS.

# publications[].label
Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.

# publications[].label
Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention.

# publications[].label
GHSR Deletion in -Cells of Male Mice: Ineffective in Obesity, but Effective in Protecting against Streptozotocin-Induced -Cell Injury in Aging.

# publications[].label
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.

# publications[].label
Estrogen Improves Insulin Sensitivity and Suppresses Hepatic Glucose Production via the Transcription Factor Foxo1

# publications[].label
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.

# publications[].label
Structural and functional analysis of the related transcriptional enhancer factor-1 and NF-B interaction.

# publications[].label
A Murine Pancreatic Islet Cell-based Screening for Diabetogenic Environmental Chemicals.

# publications[].label
GHS-R in brown fat potentiates differential thermogenic responses under metabolic and thermal stresses.

# publications[].label
Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity.

# publications[].label
FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression.

# publications[].label
Novel gene expressed during early embryogenesis of zebrafish identified by mRNA differential display

# publications[].label
Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38 MAPK during insulin resistance.

# publications[].label
Identification of an ionic mechanism for ER-mediated rapid excitation in neurons.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Mechanisms of Heart Failure in Type 2 Diabetes Mellitus.

# publications[].label
A nucleoprotein complex containing CCAAT/enhancer-binding protein beta interacts with an insulin response sequence in the insulin-like growth factor-binding protein-1 gene and contributes to insulin-regulated gene expression.

# publications[].label
Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms.

# publications[].label
Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity.

# publications[].label
Gene- and activation-specific mechanisms for insulin inhibition of basal and glucocorticoid-induced insulin-like growth factor binding protein-1 and phosphoenolpyruvate carboxykinase transcription. Roles of forkhead and insulin response sequences.

# publications[].label
Epigallocatechin Gallate Inhibits Hepatic Glucose Production in Primary Hepatocytes via Downregulating PKA Signaling Pathways and Transcriptional Factor FoxO1.

# publications[].label
A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice.

# publications[].label
TGF-1 Signaling Impairs Metformin Action on Glycemic Control.

# publications[].label
Hepatic p38 MAPK controls gluconeogenesis via FOXO1 phosphorylation at S273 during glucagon signalling in mice.

# publications[].label
Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation.

# publications[].label
Amino Acids in Autophagy: Regulation and Function.

# publications[].label
Near-Infrared Model and Its Robustness as Affected by Fruit Origin for 'Dangshan' Pear Soluble Solids Content and pH Measurement

# publications[].label
Etiology of Metabolic Syndrome and Dietary Intervention.

# publications[].label
Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice.

# publications[].label
Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin.

# publications[].label
Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis viaReducing Inflammation and TGF-1-mediated HSC Activation.

# publications[].label
A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells**

# publications[].label
FoxO1 Deficiency Enhances Cell Proliferation and Survival Under Normoglycemia and Promotes Angiogenesis Under Hyperglycemia in the Placenta.

# publications[].label
Nucleotide sequence of a cDNA encoding the small subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase from Aegilops squarrosa.

# publications[].label
Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R.

# publications[].label
Activation of the canonical ER stress IRE1-XBP1 pathway by insulin regulates glucose and lipid metabolism.

# publications[].label
Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence.

# publications[].label
Ubiquitin Azapeptide Esters as Next-Generation Activity-Based Probes for Cysteine Enzymes in the Ubiquitin Signal Pathway.

# publications[].label
Insulin Resistance and Mechanisms of Heart Failure

# publications[].label
An estrogen receptor -derived peptide improves glucose homeostasis during obesity.

# publications[].label
Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis.

# publications[].label
Echocardiographic assessment of Gprotein coupled estrogen receptor (GPER) activation on coronary blood flow and cardiac function in mice

# publications[].label
ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration.

# publications[].label
FoxO1 Promotes Liver Fibrosis through TGF1 mediated Hepatic Stellate Cell Activation

# publications[].label
Regulation of Macronutrients in Insulin Resistance and Glucose Homeostasis during Type 2 Diabetes Mellitus.

# publications[].label
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.

# publications[].label
APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.

# publications[].label
Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis.

# publications[].label
The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor.

# publications[].label
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK.

# publications[].label
Novel mechanism of blood pressure regulation by forkhead box class O1-mediated transcriptional control of hepatic angiotensinogen.

# publications[].label
Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1.

# publications[].label
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

# publications[].label
DPP-4 Inhibitors Improve Diabetic Wound Healing via Direct and Indirect Promotion of Epithelial-Mesenchymal Transition and Reduction of Scarring.

# publications[].label
Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1.

# publications[].label
Ghrelin Signaling in Immunometabolism and Inflamm-Aging.

# publications[].label
Expression pattern of a 2 tubulin gene in zebrafish embryos identified by whole mountin situ hybridization

# publications[].label
Ex Vivo Smooth Muscle Pharmacological Effects of a Novel Bradykinin-Related Peptide, and Its Analogue, from Chinese Large Odorous Frog, Odorrana livida Skin Secretions.

# publications[].label
Sexual Dimorphism in Control of Heart Failure in Insulin Resistance

# researcherOn[].label
The role of GHS-R in macrophage reprogramming during meta-inflammation.

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# researcherOn[].label
Transcriptional Regulation of Metabolic and Hepatic Homeostasis By Foxo Signaling

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Transcriptional Regulation of Metabolic and Hepatic Homeostasis by Fox0Signaling

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Nutrient-sensing GHS-R in macrophage reprogramming and inflamm-aging

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Targeting Insulin Resistance by Estrogen Receptor in Control of Type 2 Diabetes Mellitus

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# researcherOn[].label
The role of GHS-R in macrophage reprogramming during meta-inflammation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# researcherOn[].label
Control of liver fibrosis and failure by insulin resistance and FoxO signaling

# researcherOn[].awardedBy.label
American Diabetes Association - (Alexandria, Virginia, United States)

# streetAddress
Texas A&M University; Department of Nutrition; 123A-Cater-Mattil Hall; 2253 TAMU

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences

# inTheNews[].label
National Diabetes Month time to learn more about diabetes

# etdChairOf[].label
Jiang, Wen (2021-05). The Role of Hepatic Estrogen Receptor Alpha in Control of Insulin Signaling Pathway and Glucose Homeostasis. Master's Thesis.

# etdChairOf[].label
Shen, Zheng (2021-12). The Role of Autophagy in Control of Glucose Homeostasis. Doctoral Dissertation.

# etdChairOf[].label
Pan, Quan (2020-12). The Role of Hepatic Transforming Growth Factor Beta 1 in Glucose and Energy Metabolism. Doctoral Dissertation.

# etdChairOf[].label
Yang, Wanbao (2020-12). P38 Αlpha MAPK Regulates Foxo1 and Hepatic Glucose Production in Health and Disease. Doctoral Dissertation.