# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
Our laboratory is interested in elucidating novel plant immune signaling pathways as well as studying the myriad actions of pathogen virulence factors that intercept host immune responses. In order to provide a complete view of host-microbe interactions, we are using cellular, functional genomic, genetic, biochemical and bioinformatic approaches. In addition, plant immunity is inextricably linked with plant development and environmental stresses. We are also interested in understanding the signaling crosstalk that orchestrates plant responses to different extrinsic and intrinsic signals. Ultimately, knowledge gained from studying model plants, such as Arabidopsis, will be applied to improve crop plants for resistance against different biotic and abiotic stresses.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Mitogen-activated Protein (map) Kinase Cascade

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Pathogen- Or Microbe-associated Molecular Patterns (pamps Or Mamps)

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Bak1-interacting Receptor-like Kinase 1 (bir1)

# keywords[]
Brassinosteroid Insensitive 1-associated Receptor Kinase 1 (bak1)

# keywords[]
Somatic Embryogenesis Receptor Kinases (serks)

# keywords[]
Vascular Endothelial Growth Factor Receptor-1

# educationAndTraining[].organization.label
Institute of Genetics and Developmental Biology - (Beijing, China)

# educationAndTraining[].organization.label
Arkansas State University - (Jonesboro, Arkansas, United States)

# educationAndTraining[].organization.label
China Agricultural University - (Beijing, China)

# awardsAndHonors[].label
Faculty Early Career Development (CAREER) Program

# awardsAndHonors[].label
Enhancing Development and Generating Excellence in Scholarship (EDGES) Fellow

# publications[].label
The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity.

# publications[].label
Cleave and Unleash: Metacaspases Prepare Peps for Work.

# publications[].label
The cloak, dagger, and shield: proteases in plant-pathogen interactions.

# publications[].label
Big roles of small kinases: the complex functions of receptor-like cytoplasmic kinases in plant immunity and development.

# publications[].label
Inverse modulation of plant immune and brassinosteroid signaling pathways by the receptor-like cytoplasmic kinase BIK1.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity.

# publications[].label
Ubiquitylome analysis reveals a central role for the ubiquitin-proteasome system in plant innate immunity.

# publications[].label
Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant innate immunity.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Elicitation and suppression of microbe-associated molecular pattern-triggered immunity in plant-microbe interactions.

# publications[].label
Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity.

# publications[].label
RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Differential Function of Arabidopsis SERK Family Receptor-like Kinases in Stomatal Patterning.

# publications[].label
Regulation of cotton (Gossypiumhirsutum) drought responses by mitogen-activated protein (MAP) kinase cascade-mediated phosphorylation of GhWRKY59.

# publications[].label
A gain-of-function mutation in Msl10 triggers cell death and wound-induced hyperaccumulation of jasmonic acid in Arabidopsis.

# publications[].label
Modulation of RNA polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity.

# publications[].label
Cloning and characterization of a cDNA encoding 14-3-3 protein with leaf and stem-specific expression from wheat.

# publications[].label
Phytocytokine signalling reopens stomata in plant immunity and water loss.

# publications[].label
Transcriptional Regulation of Pattern-Triggered Immunity in Plants.

# publications[].label
A trimeric CrRLK1L-LLG1 complex genetically modulates SUMM2-mediated autoimmunity.

# publications[].label
Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity.

# publications[].label
The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment.

# publications[].label
Construction of a cotton VIGS library for functional genomics study.

# publications[].label
Regulation of Arabidopsis brassinosteroid receptor BRI1 endocytosis and degradation by plant U-box PUB12/PUB13-mediated ubiquitination.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
From Chaos to Harmony: Responses and Signaling upon Microbial Pattern Recognition.

# publications[].label
Activation of a COI1-dependent pathway in Arabidopsis by Pseudomonas syringae type III effectors and coronatine.

# publications[].label
A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum.

# publications[].label
Microbial signature-triggered plant defense responses and early signaling mechanisms.

# publications[].label
Protein ADP-Ribosylation Takes Control in Plant-Bacterium Interactions.

# publications[].label
Silencing GhNDR1 and GhMKK2 compromises cotton resistance to Verticillium wilt.

# publications[].label
Detecting drought regulators using stochastic inference in Bayesian networks.

# publications[].label
The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes.

# publications[].label
Cotton GhBAK1 mediates Verticillium wilt resistance and cell death.

# publications[].label
A 'GLoRy' Battle for Cotton against Fusarium.

# publications[].label
The dominant negative ARM domain uncovers multiple functions of PUB13 in Arabidopsis immunity, flowering, and senescence.

# publications[].label
The Pseudomonas syringae effector HopF2 suppresses Arabidopsis immunity by targeting BAK1.

# publications[].label
One for all: the receptor-associated kinase BAK1.

# publications[].label
Return of old foes - recurrence of bacterial blight and Fusarium wilt of cotton.

# publications[].label
Overexpression of Pti5 in tomato potentiates pathogen-induced defense gene expression and enhances disease resistance to Pseudomonas syringae pv. tomato.

# publications[].label
Tyrosine phosphorylation of protein kinase complex BAK1/BIK1 mediates Arabidopsis innate immunity.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Agrobacterium-mediated virus-induced gene silencing assay in cotton.

# publications[].label
Ubiquitination of plant immune receptors.

# publications[].label
Bifurcation of Arabidopsis NLR immune signaling via Ca-dependent protein kinases.

# publications[].label
Endless HideandSeek: Dynamic Coevolution in PlantBacterium Warfare

# publications[].label
RNA Interference-Based Screen Reveals Concerted Functions of MEKK2 and CRCK3 in Plant Cell Death Regulation.

# publications[].label
Bacterial effectors target BAK1-associated receptor complexes: One stone two birds.

# publications[].label
Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation.

# publications[].label
Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses.

# publications[].label
Pipped at the Post: Pipecolic Acid Derivative Identified as SAR Regulator.

# publications[].label
60 years of development of the journal of integrative plant biology.

# publications[].label
SlBBX20 interacts with the COP9 signalosome subunit SlCSN5-2 to regulate anthocyanin biosynthesis by activating SlDFR expression in tomato.

# publications[].label
Functions of Calcium-Dependent Protein Kinases in Plant Innate Immunity.

# publications[].label
Proteolytic Processing of SERK3/BAK1 Regulates Plant Immunity, Development, and Cell Death.

# publications[].label
Loss-of-function of Arabidopsis receptor-like kinase BIR1 activates cell death and defense responses mediated by BAK1 and SOBIR1.

# publications[].label
More than an on-and-off switch: Post-translational modifications of plant pattern recognition receptor complexes.

# publications[].label
The oral secretion from Cotton Boll Weevil (Anthonomus grandis) induces defense responses in cotton (Gossypium spp) and Arabidopsis thaliana

# publications[].label
Bacterial effectors target the common signaling partner BAK1 to disrupt multiple MAMP receptor-signaling complexes and impede plant immunity.

# publications[].label
Coordinated regulation of plant immunity by poly(ADP-ribosyl)ation and K63-linked ubiquitination.

# publications[].label
Nuclear dynamics of Arabidopsis calcium-dependent protein kinases in effector-triggered immunity.

# publications[].label
A Cysteine-Rich Protein Kinase Associates with a Membrane Immune Complex and the Cysteine Residues Are Required for Cell Death.

# publications[].label
The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding.

# publications[].label
A phospho-switch constrains BTL2-mediated phytocytokine signaling in plant immunity.

# publications[].label
Plant cell surface molecular cypher: Receptor-like proteins and their roles in immunity and development.

# publications[].label
The use of protoplasts to study innate immune responses.

# publications[].label
Bacterial effector HopF2 suppresses arabidopsis innate immunity at the plasma membrane.

# publications[].label
Ligand-Induced Receptor-like Kinase Complex Regulates Floral Organ Abscission in Arabidopsis.

# publications[].label
Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity.

# publications[].label
Plant immune response to pathogens differs with changing temperatures.

# publications[].label
The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity.

# publications[].label
Ligand-induced monoubiquitination of BIK1 regulates plant immunity.

# publications[].label
Multiple intramolecular trafficking signals in RESISTANCE TO POWDERY MILDEW 8.2 are engaged in activation of cell death and defense.

# publications[].label
The Pseudomonas syringae type III effector AvrRpt2 promotes pathogen virulence via stimulating Arabidopsis auxin/indole acetic acid protein turnover.

# publications[].label
Phosphorylation of receptor-like cytoplasmic kinases by bacterial flagellin.

# publications[].label
TAL effector driven induction of a SWEET gene confers susceptibility to bacterial blight of cotton.

# publications[].label
PAMP-induced monoubiquitination of PRR-associated kinase BIK1 by an E3 ligase LUCKY positively regulates plant innate immunity

# publications[].label
Stress-induced activation of receptor signaling by protease-mediated cleavage.

# publications[].label
Intercepting host MAPK signaling cascades by bacterial type III effectors.

# publications[].label
A nonproteinaceous Fusarium cell wall extract triggers receptor-like protein-dependent immune responses in Arabidopsis and cotton.

# publications[].label
Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Nuclear actions in innate immune signaling.

# publications[].label
PARylation of the forkhead-associated domain protein DAWDLE regulates plant immunity.

# publications[].label
Malectin-like receptor kinases as protector deities in plant immunity.

# publications[].label
Differential Regulation of Two-Tiered Plant Immunity and Sexual Reproduction by ANXUR Receptor-Like Kinases.

# publications[].label
Differential innate immune signalling via Ca(2+) sensor protein kinases.

# publications[].label
Plant plasma membrane-resident receptors: Surveillance for infections and coordination for growth and development.

# publications[].label
Nuclear dynamics of Arabidopsis calcium-dependent protein kinases in effector-triggered immunity

# publications[].label
MiR133b is involved in endogenous hydrogen sulfide suppression of sFlt-1 production in human placenta.

# publications[].label
A receptor-like cytoplasmic kinase, BIK1, associates with a flagellin receptor complex to initiate plant innate immunity.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
It takes two to tango - molecular links between plant immunity and brassinosteroid signalling.

# publications[].label
Stack Heterotrimeric G Proteins and MAPK Cascades on a RACK.

# publications[].label
Analysis of Cf-12 tomato transcriptome profile in response to Cladosporium fulvum infection with Hisat, StringTie and Ballgown

# publications[].label
A cluster of mutations disrupt the avirulence but not the virulence function of AvrPto.

# researcherOn[].label
Protein phosphorylation and poly(ADP-ribosyl)ation in cotton drought stress

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Differential regulation of plant innate immunity

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Differential Regulation of Plant Innate Immunity

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Molecular dissection of protein poly(ADP-ribosyl)ation in plant immunity and pathogen-induced DNA damage

# researcherOn[].awardedBy.label
Directorate for Biological Sciences - (Arlington, Virginia, United States)

# researcherOn[].label
Cotton Functional Genomics In Biotic and Abiotic Stress Responses

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
USDA-National Institute of Food And Agriculture

# researcherOn[].label
Enhancing Resistance in Upland Cotton by Dissecting the Disease Mechanism of Fusarium oxysporum f. sp. Vasinfectum race 4

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
USDA-National Institute of Food And Agriculture

# researcherOn[].label
CAREER: Orchestrating transcriptional reprogramming by combinatorial complexity of general transcriptional regulation and specific immune responses

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# streetAddress
Texas A&M University; Biochemistry & Biophysics; 2123 TAMU

# schools[]
College of Agriculture and Life Sciences

# inTheNews[].label
Texas A&M University Announces 2020 EDGES Fellows

# inTheNews[].label
Plant science discovery may help treat allergies and immune deficiencies

# inTheNews[].label
Plant Science Discovery May Help Treat Allergies and Immune Deficiencies

# etdChairOf[].label
Cheng, Cheng (2013-11). Genetic and Biochemical Analysis of Innate Immunity in Arabidopsis thaliana. Doctoral Dissertation.

# etdChairOf[].label
Xu, Guangyuan (2016-08). Genetic Dissection and Functional Analysis of Suppressors of Receptor-Like Kinase BAK1 Family-Mediated Cell Death. Doctoral Dissertation.

# etdChairOf[].label
Zhou, Jinggeng (2013-07). Bacterial Effector HopF2 Suppresses Arabidopsis Immunity by Targeting BAK1. Master's Thesis.

# etdChairOf[].label
Ma, Xiyu (2017-12). Exploring Plant Innate Immune Signaling Network: Layered Post-translational Modifications in Play. Doctoral Dissertation.