# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
It has been long recognized that glycans play a wide spectrum of essential roles in metazoan organisms, while defects in glycosylation are involved in numerous human diseases and abnormalities, from cancer to brain malformation and defects of immune system. However, the complexity of glycosylation pathways and limitations of genetic and in vivo approaches available for studying glycosylation in higher animals significantly impede the research in mammals. We are using the advantages of Drosophila model system, including its decreased genetic redundancy, powerful arsenal of molecular genetic approaches, and comprehensively characterized development, to elucidate mechanisms underlying the function of glycosylation in development and physiology. We employ a multidisciplinary approach to study the roles of several novel glycosyltransferase genes at molecular, cellular, and organismal levels. Currently, our laboratory is involved in two main projects: one project focuses on studying the function of sialylation in the central nervous system, while another project is aimed at elucidation of molecular mechanisms of protein O-mannosylation.

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Moscow State University - (Moscow, Russia)

# publications[].label
Interrelation of hierarchic compactization levels as a basis of chromatin functional organization

# publications[].label
Protein tyrosine phosphatase 69D is a substrate of protein O-mannosyltransferases 1-2 that is required for the wiring of sensory axons in Drosophila.

# publications[].label
A relatively small 5' regulatory region of esterase S gene of Drosophila virilis determines the specific expression as revealed in transgenic experiments.

# publications[].label
The in vivo function of Drosophila CMP-Sialic acid synthetase

# publications[].label
NATURE OF NANOSECOND KINETICS OF HIGHER-PLANT FLUORESCENCE - THEORETICAL-MODEL

# publications[].label
Flexibility of DNA within transcriptionally active nucleosomes: analysis by circular dichroism measurements.

# publications[].label
[Increase in the degree of histone acetylation in the nucleosome sheath leads to unfolding of a 30-nm nucleosome fibril].

# publications[].label
THE THEORETICAL DESCRIPTION OF RECOMBINATION FLUORESCENCE OF PHOTOSYNTHETIC ORGANISMS BY MASTER EQUATION

# publications[].label
Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats.

# publications[].label
Protein O-mannosylation in animal development and physiology: from human disorders to Drosophila phenotypes.

# publications[].label
Interrelation of hierarchic compactization levels as a basis of chromatin functional organization

# publications[].label
THE INCREASE IN ACETYLATION LEVEL OF CORE HISTONES LEADS TO THE UNFOLDING OF 30 NM NUCLEOSOMAL FIBER

# publications[].label
O-Mannosylation of Drosophila Dystroglycan by Protein O-Mannosyltransferases, Rotate Abdomen and Twisted

# publications[].label
RELAXATION INVOLVEMENT IN THE PRIMARY PROCESSES OF THE PHOTOSYSTEM-II CHARGE SEPARATION - THEORETICAL-MODEL

# publications[].label
[Molecular genetic mechanisms of regulating activity of the estS gene in transgenic Drosophila].

# publications[].label
Analysis of chromatin decondensation by means of gel electrophoresis in low-density agarose

# publications[].label
Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers.

# publications[].label
Influence of specific nucleotide sequences on the transcriptional activity of the avian retroviral long terminal repeats

# publications[].label
Elucidating the role of sialylation in cardiac function using a Drosophila model

# publications[].label
The role of Drosophila cytidine monophosphate-sialic acid synthetase in the nervous system.

# publications[].label
[Study of the process of chromatin decondensation using low density agar gel electrophoresis].

# publications[].label
The expression of esterase S gene of Drosophila virilis in Drosophila melanogaster.

# publications[].label
Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A METHOD OF ELECTROPHORESIS IN LOW-DENSITY AGAROSE GELS FOR ANALYSIS OF CHROMATIN CONDENSATION

# publications[].label
The role of CMP-Sialic acid synthetase in Drosophila neural transmission

# publications[].label
[An electrophoresis method in low density agarose gel for analyzing the chromatin condensation process].

# publications[].label
Notch ligands Delta and Serrate can be glycosylated by Fringe.

# publications[].label
Developmental roles and pathogenic mechanisms associated with protein O-mannosylation in Drosophila

# publications[].label
An O-fucose site in the ligand binding domain inhibits Notch activation.

# publications[].label
The Role of Protein O-Mannosylation in Drosophila Development

# publications[].label
Drosophila Dystroglycan is a target of O-mannosyltransferase activity of two protein O-mannosyltransferases, Rotated Abdomen and Twisted.

# publications[].label
TISSUE-SPECIFICITY OF ESTS GENE-EXPRESSION IN THE TRANSGENIC DROSOPHILA

# publications[].label
fringe modulates Notch signalling: Identifying the molecular basis of this interaction.

# publications[].label
Fringe is a glycosyltransferase that modifies Notch.

# publications[].label
A simple and reproducible method for analysis of chromatin condensation.

# publications[].label
THE THEORETICAL INVESTIGATION OF THE RADICAL PAIR WATER-PROTEIN SURROUNDINGS RELAXATIONS INFLUENCE ON THE PHOTOSYSTEM-2 FLUORESCENCE KINETICS

# publications[].label
Pathogenic mechanisms associated with abnormal protein O-mannosylation: Cell culture and Drosophila models

# publications[].label
The putative sialyltransferase gene of Drosophila melanogaster: The study of its expression, activity and functioning during development

# publications[].label
TEMPERATURE-DEPENDENCE OF CHROMATIN CONDENSATION AT DIFFERENT IONIC-STRENGTH OF THE MEDIUM - A STUDY BY THE MEANS OF ELECTROPHORESIS IN AGAROSE GELS OF LOW-DENSITY

# publications[].label
Function of Sialyltransferase in Drosophila CNS

# publications[].label
[The purine-pyrimidine tract activates transcription of the minimal retroviral promotor].

# publications[].label
[Interconnection of hierarchical compactization levels as the basis for functional organization of chromatin].

# publications[].label
Sialyltransferase regulates nervous system function in Drosophila.

# publications[].label
Protein O-Mannosyltransferases Affect Sensory Axon Wiring and Dynamic Chirality of Body Posture in the Drosophila Embryo.

# publications[].label
Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo.

# publications[].label
N-glycosylation in regulation of the nervous system.

# publications[].label
Requirement for O-Mannosylation in Drosophila Development

# publications[].label
Protein O-mannosylation in metazoan organisms.

# publications[].label
[Acetylation of histones in vitro causes chromatin decompactization].

# publications[].label
[Tissue-specific expression of the estS gene in transgenic Drosophila].

# publications[].label
Protein O-mannosylation in metazoan organisms.

# publications[].label
Glycomic studies of Drosophila melanogaster embryos.

# publications[].label
Influence of Specific Nucleotide Sequences on the Transcriptional Activity of the Avian Retro viral Long Terminal Repeats

# publications[].label
DESCRIPTION OF RECOMBINATION KINETICS OF THE RADICAL PAIR IN BACTERIA REACTION CENTERS TAKING INTO ACCOUNT THE DYNAMICS OF PROTEIN SURROUNDING

# publications[].label
[Condensation of nucleosome fibrils at increased temperature].

# publications[].label
Identification of a novel enzyme responsible for O-fucosylation of Thrombospondin Type 1 repeats.

# publications[].label
Characterization of Drosophila CMP-sialic acid synthetase activity reveals unusual enzymatic properties.

# publications[].label
Modulation of signal transduction by differential receptor glycosylation: The role of O-linked fucose in notch signaling

# publications[].label
Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe.

# publications[].label
CHROMATIN DECOMPACTIZATION IS CAUSED BY ACETYLATION OF HISTONES IN-VITRO

# publications[].label
APPLICATION OF LOW-DENSITY AGAROSE-GEL ELECTROPHORESIS IN STUDIES OF CHROMATIN CONDENSATION

# publications[].label
Genetic Interactions Between Drosophila sialyltransferase and 1,4-N-acetylgalactosaminyltransferase-A Genes Indicate Their Involvement in the Same Pathway.

# publications[].label
[Effect of specific nucleotide sequences on the transcription activity of long terminal repeats of avian retroviruses].

# publications[].label
RANDOM-WALK APPROACH DESCRIPTION OF FLUORESCENCE KINETICS IN THE PROCESS OF ENERGY-TRANSFER BY LIGHT-HARVESTING MATRIX IN THE MODEL OF THE PIGMENT-PROTEIN COMPLEX

# publications[].label
Dorsal-ventral signaling in the Drosophila eye.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster.

# publications[].label
The expression and function of Drosophila sialyltransferase in the central nervous system

# publications[].label
The role of protein N-glycosylation in neural transmission.

# publications[].label
[Dependence of the chromatin condensation process on the temperature and ionic strength of the media: investigation using gel electrophoresis in low density agarose].

# publications[].label
Sweet rescue or surrender of the failing heart?

# publications[].label
Role of sialyltransferase in the nervous system development of Drosophila

# publications[].label
Brillouin spectroscopy reveals changes in muscular viscoelasticity in Drosophila POMT mutants

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Characterization of N-linked glycans on the Drosophila sialyltransferase protein, DSiaT by mass spectrometry

# publications[].label
Role of relaxations in the primary processes of charge separation of photosystem II: Theoretical model

# publications[].label
Acetylation of core histones causes the unfolding of 30 nm chromatin fiber: analysis by agarose gel electrophoresis.

# publications[].label
Sialylation in protostomes: a perspective from Drosophila genetics and biochemistry.

# publications[].label
A novel approach to study in vivo sialyltransferase protein expression in Drosophila melanogaster

# publications[].label
The twisted gene encodes Drosophila protein O-mannosyltransferase 2 and genetically interacts with the rotated abdomen gene encoding Drosophila protein O-mannosyltransferase 1.

# publications[].label
Novel Regulatory Mechanisms Controlling Sialylation in Drosophila Nervous System

# publications[].label
CONDENSATION OF THE NUCLEOSOMAL FIBER IN RESPONSE TO TEMPERATURE INCREASE

# publications[].label
Genetic and Functional Mechanisms of Drosophila Sialylation

# publications[].label
Characterization of Sialylation Pathway in Drosophila

# researcherOn[].label
Protein glycosylation in development, physiology and disease: Revealing functional mechanisms usingDrosophila model

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Protein glycosylation in development, physiology and disease: Revealing functional mechanisms using Drosophila model

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Functional mechanisms underlying Dystroglycan-dependent and independent roles of protein O-mannosylation in the nervous system

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Neurological Disorders and Stroke

# researcherOn[].label
The Control On Neural Transmission By Glycosylation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences

# etdChairOf[].label
Lyalin, Dmitry (2011-08). The Role of O-mannosyl Glycans in Drosophila Development. Doctoral Dissertation.

# etdChairOf[].label
Carnahan, Mindy (2011-08). Elucidating the Functions of the Sialylation Pathway in Drosophila melanogaster. Master's Thesis.

# etdChairOf[].label
Repnikova, Elena Aleksandrovna (2009-08). Role of Sialylation in the Nervous System Development of Drosophila melanogaster. Doctoral Dissertation.

# etdChairOf[].label
Baker, Ryan Andrew (2016-12). The Role of Protein O-MannosylTransferase in the Development of Drosophila Torsion Phenotypes. Doctoral Dissertation.

# etdChairOf[].label
Scott, Hilary Anne (2017-08). Regulation of Sialylation in the Drosophila Nervous System. Doctoral Dissertation.