# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].parent[].label
School of Veterinary Medicine and Biomedical Sciences

# overview
My research interests involve the pathogenesis of kidney disease and investigation of novel biomarkers in dogs and cats with chronic kidney disease and their relation to conventional measures of renal function. In our lab, we are actively exploring urinary proteins, mRNAs, and miRNAs in dogs with naturally occurring glomerular disease in order to determine their ability to serve as early markers of renal disease, specific markers of certain types of renal disease and disease progression, and targets for novel therapies. Our goal is to improve our understanding of the development and progression of kidney disease and to develop and validate testing methods in order to more effectively diagnosis and monitor renal disease in companion animals and humans.

# hrJobTitle
Associate Department Head for Clinical Services

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Cornell University - (Ithaca, New York, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
University of Nebraska–Lincoln - (Lincoln, United States)

# publications[].label
New Frontiers: Approaches to Understand the Mechanistic Basis of Renal Toxicity.

# publications[].label
Trypanosoma cruzi discrete typing unit TcIV implicated in a case of acute disseminated canine Chagas disease.

# publications[].label
Eosinophilic leukemia in three African pygmy hedgehogs ( Atelerix albiventris) and validation of Luna stain.

# publications[].label
Day-to-Day variation of the urine protein: creatinine ratio in female dogs with stable glomerular proteinuria caused by X-linked hereditary nephropathy.

# publications[].label
Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

# publications[].label
Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI.

# publications[].label
X-Linked Hereditary Nephropathy in Navasota Dogs: Clinical Pathology, Morphology, and Gene Expression During Disease Progression.

# publications[].label
Advances in the evaluation of canine renal disease.

# publications[].label
What is your diagnosis? Lingual mass in a dog.

# publications[].label
De novo expression of human leukocyte antigen-DR (HLA-DR) and loss of beta-catenin expression in tubular epithelial cells: a possible event in epithelial-mesenchymal transition in canine renal diseases.

# publications[].label
Correlation of Urine and Serum Biomarkers with Renal Damage and Survival in Dogs with Naturally Occurring Proteinuric Chronic Kidney Disease.

# publications[].label
Re-evaluating urine dipstick protein in dogs: when should you be concerned?

# publications[].label
EFFECTS OF THE LEVEL OF DIETARY PROTEIN ON RENAL INDICES IN NORMAL ADULT CATS

# publications[].label
An atypical case of Trypanosoma cruzi infection in a young English Mastiff.

# publications[].label
Characterization of the genetic basis for autosomal recessive hereditary nephropathy in the English Springer Spaniel.

# publications[].label
Evaluation of biomarkers of kidney injury following 4% succinylated gelatin and 6% hydroxyethyl starch 130/0.4 administration in a canine hemorrhagic shock model.

# publications[].label
ASVCP guidelines: Allowable total error hematology.

# publications[].label
Evaluation of a catalase-based urine test for the detection of urinary tract infection in dogs and cats.

# publications[].label
What's your diagnosis? Skin impression smear from a Bearded Dragon.

# publications[].label
What is your diagnosis? Unusual urinary crystals from a cat.

# publications[].label
Safety of masitinib mesylate in healthy cats.

# publications[].label
SURFACE ENHANCED LASER DESORPTION IONIZATION (SELDI) ANALYSIS OF URINE FROM MALE DOGS IN EARLY STAGES OF PROGRESSIVE TUBULOINTERSTITIAL INJURY DUE TO X-LINKED HEREDITARY NEPHROPATHY

# publications[].label
Chapter 17 Blood and bone marrow toxicity

# publications[].label
RNA-seq of serial kidney biopsies obtained during progression of chronic kidney disease from dogs with X-linked hereditary nephropathy.

# publications[].label
Comparison of the performance of the IDEXX SediVue Dx with manual microscopy for the detection of cells and 2 crystal types in canine and feline urine.

# publications[].label
DNP-KLH Yields Changes in Leukocyte Populations and Immunoglobulin Isotype Use with Different Immunization Routes in Zebrafish.

# publications[].label
B-cell lymphoma with Mott cell differentiation in two young adult dogs.

# publications[].label
A next generation setup for pre-fractionation of non-denatured proteins reveals diverse albumin proteoforms each carrying several post-translational modifications.

# publications[].label
Expression profiling of disease progression in canine model of Duchenne muscular dystrophy.

# publications[].label
Sodium hypochlorite bleach ingestion in two dogs

# publications[].label
Serum 1-proteinase inhibitor concentrations in dogs with exocrine pancreatic disease, chronic hepatitis or proteinuric chronic kidney disease.

# publications[].label
Masitinib-associated minimal change disease with acute tubular necrosis resulting in acute kidney injury in a dog.

# publications[].label
Use of urinary biomarkers of renal ischemia in a lamb preclinical left ventricular assist device model.

# publications[].label
Traditional Renal Biomarkers and New Approaches to Diagnostics.

# publications[].label
Correlation of electrophoretic urine protein banding patterns with severity of renal damage in dogs with proteinuric chronic kidney disease.

# publications[].label
Urinary biomarkers of renal disease in dogs with X-linked hereditary nephropathy.

# publications[].label
Proteomic analysis of urine from male dogs during early stages of tubulointerstitial injury in a canine model of progressive glomerular disease.

# publications[].label
Comparison of RNA isolation and library preparation methods for small RNA sequencing of canine biofluids.

# publications[].label
Chapter 22 Blood and bone marrow toxicity

# publications[].label
WEEK-TO-WEEK VARIABILITY OF IOHEXOL CLEARANCE, SERUM CREATININE, AND SYMMETRIC DIMETHYLARGININE IN DOGS WITH STABLE CHRONIC RENAL DISEASE

# publications[].label
Spontaneous echocardiographic contrast in three dogs.

# publications[].label
Effects of dietary protein content on renal parameters in normal cats.

# publications[].label
Urinary neutrophil gelatinase-associated lipocalin concentration changes after acute haemorrhage and colloid-mediated reperfusion in anaesthetized dogs.

# publications[].label
Abnormal Expression of miR-21 in Kidney Tissue of Dogs With X-Linked Hereditary Nephropathy: A Canine Model of Chronic Kidney Disease.

# publications[].label
X-Linked Alport Dogs Demonstrate Mesangial Filopodial Invasion of the Capillary Tuft as an Early Event in Glomerular Damage.

# publications[].label
Characteristics associated with bacterial growth in urine in 451 proteinuric dogs (2008-2018).

# publications[].label
24 Male Reproductive Tract Prostate, Testes, Penis, and Semen

# publications[].label
CORRELATION OF SYMMETRIC DIMETHYLARGININE WITH GLOMERULAR FILTRATION RATE IN DOGS WITH CHRONIC PROGRESSIVE RENAL DISEASE

# publications[].label
COMPARISON OF URINE SODIUM DODECYL SULFATE-POLYACRYLAMIDE GEL ELECTROPHORESIS (SDS-PAGE) WITH RENAL HISTOLOGIC FINDINGS IN DOGS WITH RENAL DISEASE

# publications[].label
Symmetric Dimethylarginine Assay Validation, Stability, and Evaluation as a Marker for the Early Detection of Chronic Kidney Disease in Dogs.

# publications[].label
Prevalence of immune-complex glomerulonephritides in dogs biopsied for suspected glomerular disease: 501 cases (2007-2012).

# publications[].label
ASVCP guidelines: allowable total error guidelines for biochemistry.

# researcherOn[].label
Characterization of Kidney Disease in Dalmatians

# researcherOn[].awardedBy.label
American Kennel Club Canine Health Foundation - (Raleigh, North Carolina, United States)

# researcherOn[].label
AAV2- CRiSPR/Cas9 preclinical trial on a naturally occurring ATS dog model

# researcherOn[].awardedBy.label
Alport Syndrome Foundation - (Phoenix, Arizona, United States)

# researcherOn[].label
MicroRNA profiling in dogs with chronic kidney disease caused by glomerular diseases

# researcherOn[].awardedBy.label
American Kennel Club Canine Health Foundation - (Raleigh, North Carolina, United States)

# researcherOn[].label
FDA Vet-LIRN Site Application –Agrilife and the Texas  A&M University System

# researcherOn[].awardedBy.label
United States Food and Drug Administration - (Silver Spring, Maryland, United States)

# researcherOn[].label
Correlation of urine biomarkers with chronic renal disease progression in dogs

# researcherOn[].awardedBy.label
Morris Animal Foundation - (Denver, Colorado, United States)

# researcherOn[].label
Investigation of microRNAs as non-invasive biomarkers of chronic kidney disease in dogs

# researcherOn[].awardedBy.label
American Kennel Club Canine Health Foundation - (Raleigh, North Carolina, United States)

# researcherOn[].label
Characterization of Renal Disease in American Boxer Dogs

# researcherOn[].awardedBy.label
American Kennel Club Canine Health Foundation - (Raleigh, North Carolina, United States)

# researcherOn[].label
Urinary protein and gene expression characterization and comparison with renal biopsy findings and clinical data in dogs with proteinuric renal diseases

# researcherOn[].awardedBy.label
American Kennel Club Canine Health Foundation - (Raleigh, North Carolina, United States)

# streetAddress
Texas A&M University; Vet Med Pathobiology; 4467 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
School of Veterinary Medicine and Biomedical Sciences

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
School of Veterinary Medicine and Biomedical Sciences