# overview
Our lab studies various herpesviruses but the major focus of our research is on the study of cytomegalovirus (CMV) which is a common pathogen that establish a life long infection in a mainly latent state. CMV causes disease in transplant patients and is a leading cause of congenital disease in newborns where the virus crosses the placenta and infects the fetus in utero. Congenitally infected newborns can have severe disease that causes cognitive impairment, hearing loss and vision problems. There is no vaccine against congenital CMV and our research seeks to understand the disease and develop interventions strategies.

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2.2 Factors Relating To The Physical Environment

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Reverse Transcriptase Polymerase Chain Reaction

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Receptor, Platelet-derived Growth Factor Alpha

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Receptor, Platelet-derived Growth Factor Alpha

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University of Glasgow - (Glasgow, United Kingdom)

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University of Glasgow - (Glasgow, United Kingdom)

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Cincinnati Children's Hospital Medical Center - (Cincinnati, Ohio, United States)

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Correction: Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus.

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Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model.

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Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model.

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Genotypic analysis of two hypervariable human cytomegalovirus genes.

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Insertional Mutagenesis of the Guinea Pig Cytomegalovirus (GPCMV) Genome: Stable Expression of the Green Fluorescent Protein (GFP) Gene and Application to In Vivo Pathogenesis Studies

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A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus.

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Molecular characterization of the guinea pig cytomegalovirus UL83 (pp65) protein homolog.

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The Guinea Pig Model of Congenital Cytomegalovirus Infection

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The impact of genome length on replication and genome stability of the herpesvirus guinea pig cytomegalovirus.

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Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease.

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Antiviral and vaccine strategies against cytomegalovirus: Current therapies and future directions

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An Attenuated CMV Vaccine with a Deletion in Tegument Protein GP83 (pp65 Homolog) Protects against Placental Infection and Improves Pregnancy Outcome in a Guinea Pig Challenge Model.

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Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein.

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The non-nucleoside antiviral, BAY 38-4766, protects against cytomegalovirus (CMV) disease and mortality in immunocompromised guinea pigs.

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Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV.

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Current and new cytomegalovirus antivirals and novel animal model strategies.

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Prospects for prevention of Salmonella infection in children through vaccination.

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Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir.

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Identification of essential and non-essential genes of the guinea pig cytomegalovirus (GPCMV) genome via transposome mutagenesis of an infectious BAC clone.

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Vaccination as an Antiviral Strategy for Control of Cytomegalovirus (CMV) Disease: A Vectored Vaccine Approach Targeting the UL83 (pp65) Homolog Protects Against Congenital CMV Disease in the Guinea Pig Model

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A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary.

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Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells.

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Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins.

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Design and development of antivirals and intervention strategies against human herpesviruses using high-throughput approach.

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Guinea pig cytomegalovirus trimer complex gH/gL/gO uses PDGFRA as universal receptor for cell fusion and entry.

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A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs.

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Molecular cloning of the guinea pig cytomegalovirus (GPCMV) genome as an infectious bacterial artificial chromosome (BAC) in Escherichia coli.

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Protection against congenital cytomegalovirus (CMV) disease, conferred by a replication-disabled, bacterial artificial chromosome (BAC)-based DNA vaccine.

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Cytomegalovirus antivirals and development of improved animal models.

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A Chimeric Guinea Pig Cytomegalovirus (GPCMV) Encoding Wild Type or Mutant HCMV UL97 Renders GPCMV Susceptible or Resistant to Ganciclovir while Retaining an Ability to Disseminate in the Animal Host

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Guinea pig cytomegalovirus protective T cell antigen GP83 is a functional pp65 homolog for innate immune evasion and pentamer dependent virus tropism.

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Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model.

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Recent advances in herpesvirus genetics using bacterial artificial chromosomes.

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A bright future for bioluminescent imaging in viral research.

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Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig.

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Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection.

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Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome.

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Molecular, biological, and in vivo characterization of the guinea pig cytomegalovirus (CMV) homologs of the human CMV matrix proteins pp71 (UL82) and pp65 (UL83).

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Chapter 37 Human Herpesviruses and Animal Models

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Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus.

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Genetically engineered live-attenuated cytomegalovirus (CMV) vaccines improve pregnancy outcome in the guinea-pig model of congenital CMV infection

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Transposon and Transposome Mutagenesis of Plasmids, Cosmids, and BACs

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A Novel Non-Replication-Competent Cytomegalovirus Capsid Mutant Vaccine Strategy Is Effective in Reducing Congenital Infection.

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The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.

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Neutralizing antibodies to gB based CMV vaccine requires full length antigen but reduced virus neutralization on non-fibroblast cells limits vaccine efficacy in the guinea pig model.

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Cloning the complete guinea pig cytomegalovirus genome as an infectious bacterial artificial chromosome with excisable origin of replication.

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Transposon and transposome mutagenesis of plasmids, cosmids, and BACs.

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Placental Trophoblast Infection and TLR Mediated Response to Congenital CMV

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of Allergy and Infectious Diseases

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CMV Pentameric Complex Based Vaccine Strategies for Prevention of Congenital CMV

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-Eunice Kennedy Shriver National Institute of Child Health & Human Development

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Development of a universal DISC vaccine strategy against congenital cytomegalovirus

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National Institutes of Health - (Bethesda, Maryland, United States)

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Development of an Effective DISC Vaccine Strategy Against Congenital CMV

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# streetAddress
Dept. Microbial Path & Immunol. COM; 8447 Riverside Pkwy, MREB2, Rm 3209; Dept. Microbial Path & Immunol. COM, 8447 Riverside Pkwy, MREB2, Rm 3209