# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Our lab studies various herpesviruses but the major focus of our research is on the study of cytomegalovirus (CMV) which is a common pathogen that establish a life long infection in a mainly latent state. CMV causes disease in transplant patients and is a leading cause of congenital disease in newborns where the virus crosses the placenta and infects the fetus in utero. Congenitally infected newborns can have severe disease that causes cognitive impairment, hearing loss and vision problems. There is no vaccine against congenital CMV and our research seeks to understand the disease and develop interventions strategies.

# keywords[]
Receptor, Platelet-derived Growth Factor Alpha

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptor, Platelet-derived Growth Factor Alpha

# keywords[]
Receptor, Platelet-derived Growth Factor Alpha

# keywords[]
2.2 Factors Relating To The Physical Environment

# educationAndTraining[].organization.label
University of Glasgow - (Glasgow, United Kingdom)

# educationAndTraining[].organization.label
Cincinnati Children's Hospital Medical Center - (Cincinnati, Ohio, United States)

# educationAndTraining[].organization.label
University of Glasgow - (Glasgow, United Kingdom)

# publications[].label
Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein.

# publications[].label
The Guinea Pig Model of Congenital Cytomegalovirus Infection

# publications[].label
A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs.

# publications[].label
Transposon and Transposome Mutagenesis of Plasmids, Cosmids, and BACs

# publications[].label
Guinea pig cytomegalovirus GP84 is a functional homolog of the human cytomegalovirus (HCMV) UL84 gene that can complement for the loss of UL84 in a chimeric HCMV.

# publications[].label
The guinea pig as a relevant preclinical model in the rat race for a vaccine against congenital cytomegalovirus infection.

# publications[].label
Knockout of key receptors (PDGFRA and NRP2) in the guinea pig model blocks direct and endocytic pathways of CMV cell entry.

# publications[].label
An Attenuated CMV Vaccine with a Deletion in Tegument Protein GP83 (pp65 Homolog) Protects against Placental Infection and Improves Pregnancy Outcome in a Guinea Pig Challenge Model.

# publications[].label
The impact of genome length on replication and genome stability of the herpesvirus guinea pig cytomegalovirus.

# publications[].label
Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease.

# publications[].label
Molecular characterization of the guinea pig cytomegalovirus UL83 (pp65) protein homolog.

# publications[].label
Recent advances in herpesvirus genetics using bacterial artificial chromosomes.

# publications[].label
Design and development of antivirals and intervention strategies against human herpesviruses using high-throughput approach.

# publications[].label
Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model.

# publications[].label
Vaccination as an Antiviral Strategy for Control of Cytomegalovirus (CMV) Disease: A Vectored Vaccine Approach Targeting the UL83 (pp65) Homolog Protects Against Congenital CMV Disease in the Guinea Pig Model

# publications[].label
Genetically engineered live-attenuated cytomegalovirus (CMV) vaccines improve pregnancy outcome in the guinea-pig model of congenital CMV infection

# publications[].label
Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model.

# publications[].label
Chapter 37 Human Herpesviruses and Animal Models

# publications[].label
A Novel Non-Replication-Competent Cytomegalovirus Capsid Mutant Vaccine Strategy Is Effective in Reducing Congenital Infection.

# publications[].label
Genotypic analysis of two hypervariable human cytomegalovirus genes.

# publications[].label
A Chimeric Guinea Pig Cytomegalovirus (GPCMV) Encoding Wild Type or Mutant HCMV UL97 Renders GPCMV Susceptible or Resistant to Ganciclovir while Retaining an Ability to Disseminate in the Animal Host

# publications[].label
Protection against congenital cytomegalovirus (CMV) disease, conferred by a replication-disabled, bacterial artificial chromosome (BAC)-based DNA vaccine.

# publications[].label
Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus.

# publications[].label
Guinea pig cytomegalovirus trimer complex gH/gL/gO uses PDGFRA as universal receptor for cell fusion and entry.

# publications[].label
Prospects for prevention of Salmonella infection in children through vaccination.

# publications[].label
Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells.

# publications[].label
Neutralizing antibodies to gB based CMV vaccine requires full length antigen but reduced virus neutralization on non-fibroblast cells limits vaccine efficacy in the guinea pig model.

# publications[].label
Cytomegalovirus antivirals and development of improved animal models.

# publications[].label
Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins.

# publications[].label
Insertional Mutagenesis of the Guinea Pig Cytomegalovirus (GPCMV) Genome: Stable Expression of the Green Fluorescent Protein (GFP) Gene and Application to In Vivo Pathogenesis Studies

# publications[].label
A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary.

# publications[].label
Cloning the complete guinea pig cytomegalovirus genome as an infectious bacterial artificial chromosome with excisable origin of replication.

# publications[].label
Current and new cytomegalovirus antivirals and novel animal model strategies.

# publications[].label
T cell inducing vaccine against cytomegalovirus immediate early 1 (IE1) protein provides high level cross strain protection against congenital CMV.

# publications[].label
Molecular cloning of the guinea pig cytomegalovirus (GPCMV) genome as an infectious bacterial artificial chromosome (BAC) in Escherichia coli.

# publications[].label
Expression of the human cytomegalovirus UL97 gene in a chimeric guinea pig cytomegalovirus (GPCMV) results in viable virus with increased susceptibility to ganciclovir and maribavir.

# publications[].label
Transposon and transposome mutagenesis of plasmids, cosmids, and BACs.

# publications[].label
Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome.

# publications[].label
A bright future for bioluminescent imaging in viral research.

# publications[].label
Guinea pig cytomegalovirus protective T cell antigen GP83 is a functional pp65 homolog for innate immune evasion and pentamer dependent virus tropism.

# publications[].label
Molecular, biological, and in vivo characterization of the guinea pig cytomegalovirus (CMV) homologs of the human CMV matrix proteins pp71 (UL82) and pp65 (UL83).

# publications[].label
The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting.

# publications[].label
Identification of essential and non-essential genes of the guinea pig cytomegalovirus (GPCMV) genome via transposome mutagenesis of an infectious BAC clone.

# publications[].label
Preconceptual administration of an alphavirus replicon UL83 (pp65 homolog) vaccine induces humoral and cellular immunity and improves pregnancy outcome in the guinea pig model of congenital cytomegalovirus infection.

# publications[].label
Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig.

# publications[].label
The non-nucleoside antiviral, BAY 38-4766, protects against cytomegalovirus (CMV) disease and mortality in immunocompromised guinea pigs.

# publications[].label
A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus.

# publications[].label
Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model.

# publications[].label
Correction: Viral Glycoprotein Complex Formation, Essential Function and Immunogenicity in the Guinea Pig Model for Cytomegalovirus.

# publications[].label
Antiviral and vaccine strategies against cytomegalovirus: Current therapies and future directions

# researcherOn[].label
Development of a universal DISC vaccine strategy against congenital cytomegalovirus

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Placental Trophoblast Infection and TLR Mediated Response to Congenital CMV

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
Development of an Effective DISC Vaccine Strategy Against Congenital CMV

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
CMV Pentameric Complex Based Vaccine Strategies for Prevention of Congenital CMV

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-Eunice Kennedy Shriver National Institute of Child Health & Human Development

# streetAddress
Dept. Microbial Path & Immunol. COM; 8447 Riverside Pkwy, MREB2, Rm 3209; Dept. Microbial Path & Immunol. COM, 8447 Riverside Pkwy, MREB2, Rm 3209

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine