# overview
Cell/Developmental Biology. Developmental Genetics. Intracellular differentiation of eukaryotes, especially ciliates. General interests in: intracellular pattern formation and morphogenesis; molecular aspects of gene expression in ciliate protozoa; development of organelles, including intracellular motility and organelle localization. Specific interests in: signal transduction, regulation of cytoskeletal organization, and motility in the social amoeba Dictyostelium; organization, patterning and morphogenesis of surface-related cytoskeletal and membranous structures of ciliates, especially Paramecium; applications of laser optical force trap technology to developmental problems in Paramecium tetraurelia and Tetrahymena thermophila; 2 molecular aspects of serotype gene expression in P. tetraurelia; development of exocytotic organelles (the trichocysts) in P. tetraurelia. General approach involves use of classical and modern light and electron microscopic techniques, integrated with genetic, molecular, mechanical or physiological manipulations of the cells.

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Indiana University System - (Bloomington, Indiana, United States)

# educationAndTraining[].organization.label
University of Iowa - (Iowa City, Iowa, United States)

# educationAndTraining[].organization.label
University of Minnesota - (Minneapolis, Minnesota, United States)

# educationAndTraining[].organization.label
University of Minnesota - (Minneapolis, Minnesota, United States)

# educationAndTraining[].organization.label
University of Minnesota - (Minneapolis, Minnesota, United States)

# awardsAndHonors[].label
Association of Former Students College-Level Teaching Distinguished Achievement Award, The

# publications[].label
Trichocyst phenotype transformation induced by macronuclear transplantation in Paramecium tetraurelia.

# publications[].label
Identification of the basal bodies and kinetodesmal fibers in living cells of Paramecium tetraurelia Sonneborn, 1975 and Paramecium sonneborni Aufderheide, Daggett & Nerad, 1983.

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Refinements of and commentary on the silver staining techniques of Fernndez-Galiano.

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Motility events of trichocyst insertion in Paramecium tetraurelia.

# publications[].label
Formation and positioning of surface-related structures in protozoa.

# publications[].label
A microfluidic-enabled mechanical microcompressor for the immobilization of live single- and multi-cellular specimens.

# publications[].label
Control of exocytotic processes: cytological and physiological studies of trichocyst mutants in Paramecium tetraurelia.

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The conjusome, a novel organelle in the ciliate tetrahymena thermophila

# publications[].label
Analyses of inverted ciliary rows in Paramecium. Combined light and election microscopic observations

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Directed positioning of micronuclei in Paramecium tetraurelia with laser tweezers: absence of detectible damage after manipulation.

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Cytoplasmic inheritance in Saccharomyces cerevisiae: comparison of first zygotic budsite to mitochondrial inheritance patterns.

# publications[].label
Clonal aging in Paramecium tetraurelia. II. Evidence of functional changes in the macronucleus with age.

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IFT57 stabilizes the assembled intraflagellar transport complex and mediates transport of motility-related flagellar cargo.

# publications[].label
Synchrony of division in mass cultures of Paramecium tetraurelia by a selective density-labelling technique.

# publications[].label
The Conjusome-A Transient Organelle Linking Genome Rearrangements in the Parental and Developing Macronuclei.

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PARAMECIUM-SONNEBORNI N-SP, A NEW MEMBER OF THE PARAMECIUM-AURELIA SPECIES-COMPLEX

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Genetic aspects of intracellular motility: cortical localization and insertion of trichocysts in Paramecium tetraurelia.

# publications[].label
AN IMPROVEMENT IN THE PROTARGOL TECHNIQUE OF NG AND NELSEN

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Autonomous replication and addition of telomerelike sequences to DNA microinjected into Paramecium tetraurelia macronuclei.

# publications[].label
The conjusome: a novel structure in Tetrahymena found only during sexual reorganization.

# publications[].label
A mechanical microcompressor for high resolution imaging of motile specimens.

# publications[].label
Cytoplasmic inheritance in Saccharomyces cerevisiae: comparison of zygotic mitochondrial inheritance patterns.

# publications[].label
Macronuclear transformation with specific DNA fragments controls the content of the new macronuclear genome in Paramecium tetraurelia.

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Mitochondrial associations with specific microtubular components of the cortex of Tetrahymena thermophila. I. Cortical patterning of mitochondria.

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Migration of Dictyostelium discoideum to the Chemoattractant Folic Acid.

# publications[].label
The effective site of the lesion resulting from a trichocyst non-discharge stable differentiation of somatic nuclei in Paramecium tetraurelia.

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THE NON-CYTOTACTIC NATURE OF METACHRONY IN PARAMECIUM-TETRAURELIA

# publications[].label
In vitro enhancement of cell clumping by surface region fractions.

# publications[].label
Mitochondrial Associations with Specific Components of the Cortex of Tetrahymena thermophila Nanney & McCoy, 1976: Microtubules and the Epiplasm1

# publications[].label
Clonal aging in Paramecium tetraurelia. Absence of evidence for a cytoplasmic factor.

# publications[].label
ASSOCIATIONS OF CORTICAL MITOCHONDRIA WITH CORTICAL MICROTUBULES AND WITH THE EPIPLASM OF TETRAHYMENA-THERMOPHILA

# publications[].label
The effective sites of some mutations affecting exocytosis in Paramecium tetraurelia

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Saltatory motility of uninserted trichocysts and mitochondria in Paramecium tetraurelia.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses.

# publications[].label
The conjusome: A novel organelle in Tetrahymena harboring the chromodomain protein Pdd1p

# publications[].label
An overview of techniques for immobilizing and viewing living cells.

# publications[].label
Transformation of Paramecium by microinjection of a cloned serotype gene.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
A critical period of ear development controlled by distinct populations of ciliated cells in the zebrafish.

# publications[].label
Mitochondrial associations with specific microtubular components of the cortex of Tetrahymena thermophila. II. Response of the mitochondrial pattern to changes in the microtubule pattern.

# publications[].label
PHENOTYPIC CHANGES INDUCED BY MACRONUCLEAR TRANSPLANTATION IN PARAMECIUM-TETRAURELIA

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Phenotypes associated with early clonal death in Paramecium tetraurelia.

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MITOCHONDRIAL ASSOCIATIONS WITH SPECIFIC COMPONENTS OF THE CORTEX OF TETRAHYMENA-THERMOPHILA NANNEY AND MCCOY, 1976 - MICROTUBULES AND THE EPIPLASM

# publications[].label
COMPARISON OF AGING CHARACTERISTICS OF WILD-TYPE AND MUTANT STRAINS OF PARAMECIUM-TETRAURELIA

# publications[].label
DIRECTED POSITIONING OF NUCLEI IN LIVING PARAMECIUM-TETRAURELIA - USE OF THE LASER OPTICAL FORCE TRAP FOR DEVELOPMENTAL BIOLOGY

# publications[].label
STUDY OF THE CAUSES OF CLONAL AGING IN PARAMECIUM-TETRAURELIA USING MICRO-INJECTION

# publications[].label
Cellular aspects of pattern formation: the problem of assembly.

# streetAddress
Texas A&M University; Biology; 3258 TAMU

# etdChairOf[].label
Gamble, Debra Natalie (1994-04). Aging in wild-type and early death mutants of Paramecium tetraurelia. Master's Thesis.