# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# overview
The central goal of our research is to understand how oligodendroglial development and function in the mammalian central nervous system is regulated in health and disease. Specifically, we are interested in molecular and cellular mechanisms involved in oligodendrocyte damage/dysfunction in white matter injuries such as multiple sclerosis and cerebral palsy and in aging-related neurodegenerative diseases such as Alzheimer's disease. Because in most CNS diseases, multiple cell types including neurons, glial cells and vascular cells are involved via complex interactions, we investigate, at the cellular and molecular level, the role of microglia and astrocytes in the process of oligodendrocyte development, differentiation and damage. We use a variety of methods including primary cell cultures and transgenic and knockout animals to elucidate cellular pathways mediating oligodendrocyte injury.

The second focus of our laboratory is to elucidate the signals that promote oligodendrocyte survival and regeneration/remyelination after injury, and to study cell-cell interactions that regulate remyelination. These studies should contribute significantly to our understanding of mechanisms of oligodendrocyte development and injury, and provide new clues for potential prevention and treatment of human white matter diseases.

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Receptors, Tumor Necrosis Factor, Type I

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Receptors, Tumor Necrosis Factor, Type I

# educationAndTraining[].organization.label
University of Hawaii at Manoa - (Honolulu, Hawaii, United States)

# educationAndTraining[].organization.label
Beijing Normal University - (Beijing, Beijing, China)

# educationAndTraining[].organization.label
Beijing Normal University - (Beijing, Beijing, China)

# publications[].label
A Three-Dimensional Arrayed Microfluidic Blood-Brain Barrier Model With Integrated Electrical Sensor Array.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation.

# publications[].label
Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling.

# publications[].label
Myeloid caspase-8 restricts RIPK3-dependent proinflammatory IL-1 production and CD4 T cell activation in autoimmune demyelination.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Demyelination and remyelination in anatomically distinct regions of the corpus callosum following cuprizone intoxication.

# publications[].label
Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenase activation in peroxynitrite toxicity to mature rat oligodendrocytes.

# publications[].label
Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi.

# publications[].label
Brain region dependent molecular signatures and myelin repair following chronic demyelination.

# publications[].label
The anti-apoptotic actions of nitric oxide in hepatocytes.

# publications[].label
A multi-compartment CNS neuron-glia Co-culture microfluidic platform.

# publications[].label
Papain proteolysis releases a soluble NADPH dependent diaphorase activity from bovine neutrophil membranes.

# publications[].label
Multi-compartment neuron-glia co-culture platform for localized CNS axon-glia interaction study.

# publications[].label
Astrocyte galectin-9 potentiates microglial TNF secretion.

# publications[].label
Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver.

# publications[].label
Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Galectin-9 is up-regulated in astrocytes by TNF and promotes encephalitogenic T-cell apoptosis

# publications[].label
Impaired autophagy correlates with golden retriever muscular dystrophy phenotype.

# publications[].label
Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes.

# publications[].label
Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation.

# publications[].label
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.

# publications[].label
Microfluidic systems for axonal growth and regeneration research.

# publications[].label
Microfluidic compartmentalized co-culture platform for CNS axon myelination research.

# publications[].label
Activation of oligodendroglial Stat3 is required for efficient remyelination.

# publications[].label
Peroxynitrite-induced neuronal apoptosis is mediated by intracellular zinc release and 12-lipoxygenase activation.

# publications[].label
Glutathione peroxidase-catalase cooperativity is required for resistance to hydrogen peroxide by mature rat oligodendrocytes.

# publications[].label
Neuron aggregate culture platform for in vitro cns myelination study

# publications[].label
The protective role of nitric oxide in hepatocytes during responses to inflammatory mediators and induction of apoptosis

# publications[].label
Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells.

# publications[].label
Preparation of rat brain aggregate cultures for neuron and glia development studies.

# publications[].label
Oxidative and nitrative injury in periventricular leukomalacia: a review.

# publications[].label
Brain-on-a-chip: An in vitro myelination model

# publications[].label
Vicinal sulfhydryl groups involved in neutrophil NADPH oxidase activation

# publications[].label
RIP1 kinase mediates arachidonic acid-induced oxidative death of oligodendrocyte precursors.

# publications[].label
A multi-channel in vitro blood-brain barrier model

# publications[].label
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate.

# publications[].label
Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia.

# publications[].label
p53 is protective against nitric oxide-induced apoptosis in vascular smooth muscle cells.

# publications[].label
Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis.

# publications[].label
STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme).

# publications[].label
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes.

# publications[].label
Isolation and culture of rat and mouse oligodendrocyte precursor cells.

# publications[].label
Aberrant upregulation of astroglial ceramide potentiates oligodendrocyte injury.

# publications[].label
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination.

# publications[].label
Astrocytes promote TNF-mediated toxicity to oligodendrocyte precursors.

# publications[].label
Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis.

# publications[].label
Micro-macro hybrid soft-lithography master (MMHSM) fabrication for lab-on-a-chip applications.

# publications[].label
Axon length quantification microfluidic culture platform for growth and regeneration study.

# publications[].label
Quantitative CNS AXON growth analysis for drug screening in a microfluidic neuron culture platform

# publications[].label
Reactive oxygen species, nitric oxide and apoptosis

# publications[].label
Poly(I:C) promotes TNF/TNFR1-dependent oligodendrocyte death in mixed glial cultures.

# publications[].label
12-Lipoxygenase plays a key role in cell death caused by glutathione depletion and arachidonic acid in rat oligodendrocytes.

# publications[].label
Purified leukocyte cytochrome b558 incorporated into liposomes catalyzes a cytosolic factor dependent diaphorase activity.

# publications[].label
A microchip for quantitative analysis of CNS axon growth under localized biomolecular treatments.

# publications[].label
Islet amyloid polypeptide (IAPP): a second amyloid in Alzheimer's disease.

# publications[].label
Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.

# publications[].label
Direct visualization of membrane architecture of myelinating cells in transgenic mice expressing membrane-anchored EGFP.

# publications[].label
Nitric oxide toxicity to developing ollgodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation

# publications[].label
Developmental up-regulation of MnSOD in rat oligodendrocytes confers protection against oxidative injury.

# publications[].label
Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present.

# publications[].label
Nitric oxide-induced cell death in developing oligodendrocytes is associated with mitochondrial dysfunction and apoptosis-inducing factor translocation.

# publications[].label
High-throughput compartmentalized cns neuron culture platform for axon degeneration/regeneration study

# publications[].label
Galectin-9 increases seizure incidence following acute Theilers murine encephalomyelitis virus infection of C57BL/6 mice.

# publications[].label
22. Galectin-9 is increased during cuprizone intoxication and promotes remyelination

# publications[].label
Microfluidic co-culture platform for CNS axon myelination

# publications[].label
Novel role of vitamin k in preventing oxidative injury to developing oligodendrocytes and neurons.

# publications[].label
Cyclic guanosine monophosphate activates the Akt survival signal pathway and delays apoptosis in primary hepatocytes at a site upstream of caspase-3

# publications[].label
ACTIVATION OF OLIGODENDROGLIAL TNFR1 BY MICROGLIA-DERIVED TNF IS REQUIRED FOR LIPOPOLYSACCHARIDE TOXICITY TO DEVELOPING OLIGODENDROCYTES

# publications[].label
Cyclic nucleotides suppress tumor necrosis factor alpha-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation.

# publications[].label
Nitric oxide inhibits seven members of the caspase family via S-nitrosylation

# researcherOn[].label
Novel role of vitamin K in protecting against white matter injury

# researcherOn[].awardedBy.label
United Cerebral Palsy - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Identification of Novel Small Molecules for Cns Myelin Repair

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Novel role of vitamin K in preventing oxidative injury in developing oligodendrocytes

# researcherOn[].awardedBy.label
Hearst Foundations - (San Francisco, California, United States)

# researcherOn[].label
Role of glial sphingolipid ceramide in aging and Alzheimers disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Glial Interactions In Premyelinating Oligodendrocyte Dest

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Neurological Disorders and Stroke

# researcherOn[].label
Mechanisms of microglia mediated cytotoxicity to oligodendrocytes

# researcherOn[].awardedBy.label
United Cerebral Palsy - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Unlocking BIN1 function in oligodendrocytes and support of axon integrity

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Glial-glial interaction mediates injury to developing oligodendrocytes

# researcherOn[].awardedBy.label
Hearst Foundations - (San Francisco, California, United States)

# researcherOn[].label
STAT3 in myeloid cells: a regulator of autoimmune demyelination

# researcherOn[].awardedBy.label
National Multiple Sclerosis Society - (New York, New York, United States)

# researcherOn[].label
Role of Caspase-8 in Neuroinflammation, Demyelination and Myelin Repair

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
A High-Throughput Microfluidic In Vitro CNS Myelination Model towards Drug Screening

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Role of Galectin-9 in CNS Inflammation, Demyelination and Myelin Repair

# researcherOn[].awardedBy.label
National Multiple Sclerosis Society - (New York, New York, United States)

# streetAddress
VIDI Building Suite 345, TAMU ms4458; Veterinary Integrative Biosciences; 4458 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# etdChairOf[].label
Park, Jaewon (2011-12). Microsystems for In Vitro CNS Neuron Study. Doctoral Dissertation.

# etdChairOf[].label
Thompson, Jeffrey (2012-12). The Role of Caspase-8 in Oligodendrocyte Development and Mechanisms of Oxidative Injury in Neurons and Glia. Master's Thesis.

# etdChairOf[].label
Gomez, Francisco Pascual (2012-08). Estrogen Therapy in a Viral Murine Model of Multiple Sclerosis. Master's Thesis.

# etdChairOf[].label
Lu, Hsueh-Chung (2017-08). The Role of Myeloid STAT3 in Experimental Autoimmune Encephalomyelitis and Postnatal Brain Development. Doctoral Dissertation.

# etdChairOf[].label
Gillis, David Christopher (2015-08). The Role of RIP3 in Neuroinflammation in the Postnatal Mouse Brain. Master's Thesis.