# overview
Our group specializes in determining the cellular and molecular mechanisms of beneficial effects of mesenchymal stem cells (MSCs) in diseases that include heart disease, diabetes, and peritonitis. The goal is to develop a cellular therapy for human diseases either (a) with adult stem/progenitor cells (MSCs), or (b) with therapeutic factors that MSCs produce in response to signals from injured tissues.

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

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Stem Cell Research - Embryonic - Non-human

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Stem Cell Research - Nonembryonic - Non-human

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1.1 Normal Biological Development And Functioning

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Reverse Transcriptase Polymerase Chain Reaction

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Stem Cell Research - Induced Pluripotent Stem Cell

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5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Pusan National University - (Busan, South Korea)

# educationAndTraining[].organization.label
Tulane University - (New Orleans, Louisiana, United States)

# educationAndTraining[].organization.label
Pusan National University - (Busan, South Korea)

# educationAndTraining[].organization.label
Pusan National University - (Busan, South Korea)

# publications[].label
TSG-6 protects corneal endothelium from transcorneal cryoinjury in rabbits.

# publications[].publisher
Association for Research in Vision and Ophthalmology (ARVO)

# publications[].label
Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-B signaling in resident macrophages.

# publications[].label
Preactivation of human MSCs with TNF- enhances tumor-suppressive activity.

# publications[].label
Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF- stimulated gene/protein 6.

# publications[].label
Expression of aquaporin-5 and its regulation in skeletal muscle cells.

# publications[].label
Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue.

# publications[].label
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.

# publications[].label
Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration.

# publications[].label
Roles of NF-kappaB and bcl-2 in two differential modes of cell death of mouse cortical collecting duct cells.

# publications[].label
Protection against hydrogen peroxide induced injury in renal proximal tubule cell lines by inhibition of poly(ADP-ribose) synthase.

# publications[].label
Effect of brainderived neurotrophic factor in neural differentiation of mouse embryonic stem cells and neural precursor cells

# publications[].label
Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen.

# publications[].label
Pre-activated human mesenchymal stromal cells in combination with doxorubicin synergistically enhance tumor-suppressive activity in mice.

# publications[].label
Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Stanniocalcin-1 attenuates ischemic cardiac injury and response of differentiating monocytes/macrophages to inflammatory stimuli.

# publications[].label
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels.

# publications[].label
Mechanisms of mesenchymal stem/stromal cell function.

# publications[].label
The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice.

# publications[].label
Data against a Common Assumption: Xenogeneic Mouse Models Can Be Used to Assay Suppression of Immunity by Human MSCs.

# publications[].label
Extracellular ATP stimulates Na+ and Cl- transport through the activation of multiple purinergic receptors on the apical and basolateral membranes in M-1 mouse cortical collecting duct cells

# publications[].label
Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-.

# publications[].label
Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It.

# publications[].label
Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells.

# publications[].label
Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response.

# publications[].label
InVitro Macrophage Assay Predicts the InVivo Anti-inflammatory Potential of Exosomes from Human Mesenchymal Stromal Cells.

# publications[].label
Apoptosis induced by inhibition of contact with extracellular matrix in mouse collecting duct cells.

# publications[].label
Changes in expression of sodium cotransporters and aquaporin-2 during ischemia-reperfusion injury in rabbit kidney.

# publications[].label
TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity.

# publications[].label
Identification of the HSPB4/TLR2/NF-B axis in macrophage as a therapeutic target for sterile inflammation of the cornea.

# publications[].label
TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjgren's Syndrome.

# publications[].label
Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: the MSCs are activated to secrete prostaglandin E2.

# publications[].label
Mesenchymal Stromal Cells Inhibit Inflammatory Lymphangiogenesis in the Cornea by Suppressing Macrophage in a TSG-6-Dependent Manner.

# publications[].label
MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Therapeutic factors secreted by mesenchymal stromal cells and tissue repair.

# publications[].label
MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

# publications[].label
Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6.

# publications[].label
Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells.

# researcherOn[].label
Extracellular Vesicles Produced by Mesenchymal Stem Cells as Novel Therapy for Autoimmune Uveitis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Therapeutic Effects of MSC-Derived Extracellular Vesicles on Sjögren's Syndrome

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# streetAddress
Texas A&M Health Science Center; Regenerative Medicine; 1114 TAMUS