# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
The long-term goal of my research program is to understand how activated (proliferating) cholangiocytes participate in the progression of cholestatic liver diseases and eventual development of cholangiocarcinoma. My research is focused on elucidating the factors (such as, mechanical stress) and intracellular signaling mechanisms that regulate cholangiocyte proliferation and biliary fibrosis during extrahepatic cholestasis.

# keywords[]
Perinatal Period - Conditions Originating In Perinatal Period

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Receptors, Transforming Growth Factor Beta

# keywords[]
Receptor, Transforming Growth Factor-beta Type I

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptor, Fibroblast Growth Factor, Type 2

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
GTP-Binding Protein Alpha Subunits, Gi-Go

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Cyclic AMP Response Element-Binding Protein

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Vascular Endothelial Growth Factor Receptor-3

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptor, Transforming Growth Factor-beta Type Ii

# keywords[]
Receptors, Vascular Endothelial Growth Factor

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Atp Binding Cassette Transporter, Subfamily B

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M Health Science Center - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# publications[].label
Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells.

# publications[].label
Biliary atresia: is lack of innate immune response tolerance key to pathogenesis?

# publications[].label
Nicotine Promotes Cholangiocarcinoma Growth in Xenograft Mice.

# publications[].label
Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes.

# publications[].label
Heterogeneity of the intrahepatic biliary epithelium.

# publications[].label
Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal-7 microRNA.

# publications[].label
Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion.

# publications[].label
Lin28 and let-7: roles and regulation in liver diseases.

# publications[].label
Mechanisms of biliary carcinogenesis and growth.

# publications[].label
Recent advances in understanding bile duct remodeling and fibrosis.

# publications[].label
Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function.

# publications[].label
Regulation of adipose tissue inflammation by adenosine 2A receptor in obese mice.

# publications[].label
Sa1700 The Secretin/Secretin Receptor Axis Modulates Biliary Proliferation Following Cholestatic Injury Through Changes in Menin Expression

# publications[].label
Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis.

# publications[].label
Caveolin and 1-integrin coordinate angiotensinogen expression in cardiac myocytes.

# publications[].label
Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver.

# publications[].label
Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth.

# publications[].label
Tu1619 Blockade of Substance P Receptor attenuates Cellular Senescence and Liver Fibrosis in the Mdr2/ Mouse Model of Primary Sclerosing Cholangitis

# publications[].label
Cholangiocyte proliferation and liver fibrosis.

# publications[].label
Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury.

# publications[].label
Sa1699 Local Inhibition of Hepatic GnRH by Vivo-Morpholino Reduces Biliary Proliferation and Ameliorates the Expression of Fibrotic Markers in Cholestatic Rats

# publications[].label
Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice.

# publications[].label
Morphological and functional heterogeneity of the mouse intrahepatic biliary epithelium.

# publications[].label
Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP.

# publications[].label
The role of the secretin/secretin receptor axis in inflammatory cholangiocyte communication via extracellular vesicles.

# publications[].label
236 miR-34a Regulates Cellular Senescence in Activated Hepatic Stellate Cells During Alcohol Induced Hepatic Injury

# publications[].label
Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity.

# publications[].label
Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats.

# publications[].label
Knockout of -calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes.

# publications[].label
Alfa and beta estrogen receptors and the biliary tree.

# publications[].label
Estrogens and the pathophysiology of the biliary tree.

# publications[].label
Gastrin inhibits cholangiocyte growth in bile duct-ligated rats by interaction with cholecystokinin-B/Gastrin receptors via D-myo-inositol 1,4,5-triphosphate-, Ca(2+)-, and protein kinase C alpha-dependent mechanisms.

# publications[].label
Hepatic nervous system and neurobiology of the liver.

# publications[].label
Regulation of Cellular Senescence by miR-34a in Alcoholic Liver Injury.

# publications[].label
Cholangiocyte lipoapoptosis: implications for biliary damage during nonalcoholic fatty liver disease.

# publications[].label
Ca2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts.

# publications[].label
750 Melatonin Therapy Reduces Biliary Proliferation and Hepatic Fibrosis in the Mdr2/ Mouse Model of Primary Sclerosing Cholangitis (PSC) By Decreased Expression of miR-200b and Angiogenic Factors

# publications[].label
Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer.

# publications[].label
The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis.

# publications[].label
Pathogenesis of Kupffer Cells in Cholestatic Liver Injury.

# publications[].label
Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets.

# publications[].label
Regulation of cholangiocyte bile secretion.

# publications[].label
Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.

# publications[].label
Endothelin inhibits cholangiocarcinoma growth by a decrease in the vascular endothelial growth factor expression.

# publications[].label
Sa1719 Dark Therapy Protects Mdr2/- Mice From Cholestatic Liver Injury Through miR-34a Regulation of the p53/SIRT-1 Signaling Pathway

# publications[].label
Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.

# publications[].label
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities.

# publications[].label
Taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway.

# publications[].label
Activation of the renin-angiotensin system stimulates biliary hyperplasia during cholestasis induced by extrahepatic bile duct ligation.

# publications[].label
Paracrine communication between mechanically stretched myocytes and fibroblasts

# publications[].label
Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b.

# publications[].label
Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Molecular pathology of biliary tract cancers.

# publications[].label
Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms.

# publications[].label
Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation.

# publications[].label
The secretin/secretin receptor axis modulates liver fibrosis through changes in transforming growth factor-1 biliary secretion in mice.

# publications[].label
Endothelin-1 inhibits secretin-stimulated ductal secretion by interacting with ETA receptors on large cholangiocytes.

# publications[].label
Tauroursodeoxycholate inhibits human cholangiocarcinoma growth via Ca2+-, PKC-, and MAPK-dependent pathways.

# publications[].label
Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt.

# publications[].label
Vasopressin regulates the growth of the biliary epithelium in polycystic liver disease.

# publications[].label
Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.

# publications[].label
Sa1698 Downregulation of Menin by Mir-24-1 Increases Cholangiocarcinoma Proliferation

# publications[].label
Functional analysis of microRNAs in human hepatocellular cancer stem cells.

# publications[].label
Melatonin inhibits hypothalamic gonadotropin-releasing hormone release and reduces biliary hyperplasia and fibrosis in cholestatic rats.

# publications[].label
Epigenetic regulation of miR-34a expression in alcoholic liver injury.

# publications[].label
Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity.

# publications[].label
HFD feeding for seven months abolishes STING disruption-driven but not female sex-based protection against hepatic steatosis and inflammation in mice.

# publications[].label
Leptin enhances cholangiocarcinoma cell growth.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.

# publications[].label
459 Inhibition of the Secretin/Secretin Receptor Axis Attenuates Biliary Fibrosis During Cholestasis

# publications[].label
Examination of the cellular mechanisms by which marinobufagenin inhibits cytotrophoblast function.

# publications[].label
Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances.

# publications[].label
Thyroid hormone inhibits biliary growth in bile duct-ligated rats by PLC/IP(3)/Ca(2+)-dependent downregulation of SRC/ERK1/2.

# publications[].label
510 microRNA-21 Increases Liver Fibrosis via Modulation of TGF-1/SMAD Signaling in Bile Duct Ligated (BDL) Mice

# publications[].label
Regulatory mechanisms of ductal bile secretion.

# publications[].label
Neuropeptide Y inhibits biliary hyperplasia of cholestatic rats by paracrine and autocrine mechanisms.

# publications[].label
Erratum: (Journal of Clinical Investigation (September 1997) 100:6 (1349-1362))

# publications[].label
Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis.

# publications[].label
Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes.

# publications[].label
Lin28 and let-7: Roles and regulation in liver diseases

# publications[].label
Corrigendum to "Exosomes in liver pathology".

# publications[].label
Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.

# publications[].label
gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Tannic acid inhibits cholangiocyte proliferation after bile duct ligation via a cyclic adenosine 5',3'-monophosphate-dependent pathway.

# publications[].label
Regulation of biliary proliferation by neuroendocrine factors: implications for the pathogenesis of cholestatic liver diseases.

# publications[].label
Adenylyl cyclases in the digestive system.

# publications[].label
Functional role of cellular senescence in biliary injury.

# publications[].label
Regrowth of the rat biliary tree after 70% partial hepatectomy is coupled to increased secretin-induced ductal secretion.

# publications[].label
After damage of large bile ducts by gamma-aminobutyric acid, small ducts replenish the biliary tree by amplification of calcium-dependent signaling and de novo acquisition of large cholangiocyte phenotypes.

# publications[].label
Differential transcriptional characteristics of small and large biliary epithelial cells derived from small and large bile ducts.

# publications[].label
Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice.

# publications[].label
Tu1616 miR-125b Negatively Regulates Menin Expression and Protects from Liver Fibrosis

# publications[].label
Mechanisms of cholangiocyte responses to injury.

# publications[].label
Role of apoptosis in development of primary biliary cirrhosis.

# publications[].label
Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion.

# publications[].label
Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors.

# publications[].label
Antitumor Activity of a Novel Fibroblast Growth Factor Receptor Inhibitor for Intrahepatic Cholangiocarcinoma.

# publications[].label
Functional role of microvesicles in gastrointestinal malignancies.

# publications[].label
Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism.

# publications[].label
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion.

# publications[].label
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice.

# publications[].label
Differentially expressed adenylyl cyclase isoforms mediate secretory functions in cholangiocyte subpopulation.

# publications[].label
Intercellular Communication between Hepatic Cells in Liver Diseases.

# publications[].label
The function of alkaline phosphatase in the liver: regulation of intrahepatic biliary epithelium secretory activities in the rat.

# publications[].label
Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes.

# publications[].label
Isolated neonatal rat papillary muscles: a new model to translate neonatal rat myocyte signaling into contractile mechanics.

# publications[].label
Cholinergic system modulates growth, apoptosis, and secretion of cholangiocytes from bile duct-ligated rats.

# publications[].label
Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts.

# publications[].label
Secretin activation of the apical Na+-dependent bile acid transporter is associated with cholehepatic shunting in rats.

# publications[].label
Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver.

# publications[].label
Role of cholangiocytes in primary biliary cirrhosis.

# publications[].label
GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.

# publications[].label
Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies.

# publications[].label
Evaluation of differential gene expression by microarray analysis in small and large cholangiocytes isolated from normal mice.

# publications[].label
The role of the renin-angiotensin system in liver fibrosis.

# publications[].label
Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats.

# publications[].label
Bile acid interactions with cholangiocytes.

# publications[].label
Tu1694 Regulation of Cellular Senescence Associated Liver Fibrosis By Melatonin in Cholestatic Liver Injury

# publications[].label
Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone.

# publications[].label
698 Signal Transducer and Activator of Transcription (STAT)-3 Regulates MicroRNA Gene Expression in Alcoholic Steatohepatitis

# publications[].label
Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages.

# publications[].label
gamma-Interferon inhibits secretin-induced choleresis and cholangiocyte proliferation in a murine model of cirrhosis.

# publications[].label
Hepatitis C Virus Infection and Cholangiocarcinoma: An Insight into Epidemiologic Evidences and Hypothetical Mechanisms of Oncogenesis.

# publications[].label
p38 MAPK inhibits stretch-induced JNK activation in cardiac myocytes through MKP-1.

# publications[].label
Pinealectomy or light exposure exacerbates biliary damage and liver fibrosis in cholestatic rats through decreased melatonin synthesis.

# publications[].label
Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma.

# publications[].label
Pleiotropic effects of CD5L in hepatic inflammation and fibrosis.

# publications[].label
Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha.

# publications[].label
Knockout of alpha-calcitonin gene-related peptide reduces cholangiocyte proliferation in bile duct ligated mice.

# publications[].label
Production of spontaneously beating neonatal rat heart tissue for calcium and contractile studies

# publications[].label
Development and functional characterization of extrahepatic cholangiocyte lines from normal rats.

# publications[].label
Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation.

# publications[].label
The Hippo signaling functions through the Notch signaling to regulate intrahepatic bile duct development in mammals.

# publications[].label
Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway.

# publications[].label
Increased susceptibility of cholangiocytes to tumor necrosis factor-alpha cytotoxicity after bile duct ligation.

# publications[].label
Inhibition of the apelin/apelin receptor axis decreases cholangiocarcinoma growth.

# publications[].label
7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.

# publications[].label
Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms.

# publications[].label
Chronic nicotine exposure stimulates biliary growth and fibrosis in normal rats.

# publications[].label
Marinobufagenin inhibits proliferation and migration of cytotrophoblast and CHO cells.

# publications[].label
Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats.

# publications[].label
653 microRNA-34a Regulates Alcoholic Hepatitis Through SIRT1/NF-kappa;B Pathway

# publications[].label
Gastrin reverses established cholangiocyte proliferation and enhanced secretin-stimulated ductal secretion of BDL rats by activation of apoptosis through increased expression of Ca2+- dependent PKC isoforms.

# publications[].label
Sa1700 Inhibition of the Substance P/Neurokinin 1 Receptor Signaling Axis Reduces Cholangiocarcinoma Growth In Vivo

# publications[].label
Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease.

# publications[].label
Knockout of microRNA-21 attenuates alcoholic hepatitis through the VHL/NF-B signaling pathway in hepatic stellate cells.

# publications[].label
Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1.

# publications[].label
Heat shock factor-1 knockout enhances cholesterol 7-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis.

# publications[].label
Vascular factors, angiogenesis and biliary tract disease.

# publications[].label
Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis.

# publications[].label
Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats.

# publications[].label
The immunophysiology of biliary epithelium.

# publications[].label
Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin.

# publications[].label
The functional role of microRNAs in alcoholic liver injury.

# publications[].label
Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha.

# publications[].label
The physiological roles of secretin and its receptor.

# publications[].label
287 Senescence of Activated Hepatic Stellate Cells Limits Liver Fibrosis During Alcoholic Liver Injury

# publications[].label
Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes.

# publications[].label
Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats.

# publications[].label
803 microRNA Regulation of Functional Heterogeneity in Human Cholangiocytes

# publications[].label
A Review of the Scaffold Protein Menin and its Role in Hepatobiliary Pathology.

# publications[].label
Ischemia reperfusion of the hepatic artery induces the functional damage of large bile ducts by changes in the expression of angiogenic factors.

# publications[].label
Mechanical Stretch Stimulates Cholangiocyte Proliferation and Profibrotic Gene Expression

# publications[].label
H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway.

# publications[].label
Cardiac fibroblast physiology and pathology.

# publications[].label
Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis.

# publications[].label
Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis.

# publications[].label
Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes.

# publications[].label
Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.

# publications[].label
Tu1618 Treatment of Biliary Injury With Small Cholangiocyte Therapy Decreases Stellate Cell Activation via Mediation of Cellular Senescence

# publications[].label
Biliary epithelium: A neuroendocrine compartment in cholestatic liver disease.

# publications[].label
Dual Role of Bile Acids on the Biliary Epithelium: Friend or Foe?

# publications[].label
Autocrine regulation of biliary pathology by activated cholangiocytes.

# publications[].label
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells.

# publications[].label
Role of stem cells during diabetic liver injury.

# publications[].label
Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis.

# publications[].label
Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor.

# publications[].label
The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.

# publications[].label
Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium.

# publications[].label
Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2-/- mice.

# publications[].label
Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver.

# publications[].label
Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes.

# publications[].label
Divergent allosteric patterns verify the regulatory paradigm for aspartate transcarbamylase.

# publications[].label
Author Correction: The role of the secretin/secretin receptor axis in inflammatory cholangiocyte communication via extracellular vesicles.

# publications[].label
Tu1698 Modulation of Epithelial Mesenchymal Transition by miRNA125b in Cholestatic Bile Duct Ligated (BDL) Mice

# publications[].label
Functional heterogeneity of the intrahepatic biliary epithelium.

# publications[].label
Tu1613 Cranial Infusion of Melatonin in a Rat Model of Extrahepatic Cholestasis Reduces Biliary Proliferation and Liver Fibrosis

# publications[].label
Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth.

# publications[].label
Sa1715 Regulation of Cellular Senescence by the microRNA-34a/p53 Axis During Alcoholic Liver Injury

# publications[].label
Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1.

# publications[].label
Prolonged administration of secretin to normal rats increases biliary proliferation and secretin-induced ductal secretory activity.

# publications[].label
Taurocholate feeding prevents CCl4-induced damage of large cholangiocytes through PI3-kinase-dependent mechanism.

# publications[].label
Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration.

# publications[].label
Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes.

# publications[].label
Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.

# publications[].label
Development and characterization of secretin-stimulated secretion of cultured rat cholangiocytes.

# publications[].label
Cholangiocyte injury and ductopenic syndromes.

# publications[].label
Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity.

# publications[].label
Activation of the cholehepatic shunt as a potential therapy for primary sclerosing cholangitis.

# publications[].label
2. FUNCTIONAL HETEROGENEITY OF INTRAHEPATIC CHOLANGIOCYTES

# publications[].label
457 Impact of MT2 Melatonin Receptor Deletion on Cellular Senescence in Cholangiocytes Isolated From Mice After Cholestatic Liver Injury

# publications[].label
Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity.

# publications[].label
745 Inhibition of Hepatic Stellate Cell Activation by Stem Cell Derived Extracellular Vesicles and microRNAs During Cholestatic Liver Injury

# publications[].label
Novel -catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis.

# publications[].label
Mechanosensing and Regulation of Cardiac Function.

# publications[].label
Forkhead box A2 regulates biliary heterogeneity and senescence during cholestatic liver injury in mice.

# publications[].label
Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats.

# publications[].label
Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from BDL rat liver.

# publications[].label
Recent advances in the morphological and functional heterogeneity of the biliary epithelium.

# publications[].label
Sa1718 C-Myc-Regulated Biliary Cellular Senescence and Functional Heterogeneity During Cholestatic Liver Injury

# publications[].label
Complex bile duct network formation within liver decellularized extracellular matrix hydrogels.

# publications[].label
cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway.

# publications[].label
Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats.

# publications[].label
Probiotic Bifidobacterium species: potential beneficial effects in diarrheal disorders. Focus on "Probiotic Bifidobacterium species stimulate human SLC26A3 gene function and expression in intestinal epithelial cells".

# publications[].label
The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor-1-Mediated Biliary Senescence.

# publications[].label
miR-24 Inhibition Increases Menin Expression and Decreases Cholangiocarcinoma Proliferation.

# researcherOn[].label
Regulation Of Biliary Growth And Fibrosis By Melatonin

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# researcherOn[].label
The Role of Stem Cell Derived Microvesicles in Cholestatic Liver Injury

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# researcherOn[].label
Neuroendocrine Regulation of Biliary Growth and Fibrosis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# researcherOn[].label
Growth Regulation of the Intrahepatic Biliary Tree

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# researcherOn[].label
Role of Sensory Neuropeptides in the Regulation of Biliary Function

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Role Of Stem Cell Derived Microvesicles In Alcoholic Liver Injury

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute on Alcohol Abuse and Alcoholism (NIAAA)

# researcherOn[].label
Regulation of Bile Duct Growth in Bile Duct Ligated Rats

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# streetAddress
Texas A&M University School of Medicine; Department of Medical Physiology; 

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Natural Compound In Vegetables Helps Fight Fatty Liver Disease

# inTheNews[].label
Natural compound in vegetables helps fight fatty liver disease