# overview
Our lab is predominantly interested in the neuropathogenesis of HIV and drug abuse. We are elucidating the role of HIV and drugs of abuse in energy dysregulation, which ultimately may lead the neurodegeneration. We examine the metabolic signatures through inflammasome profiles, mitochondrial biogenesis, and epigenetics. We use in vitro, ex vivo and a transgenic rat model system in our experiments. Our goal is to develop novel diagnostics tests and treatments for neuroAIDs and neurologic damage related to drugs of abuse.

# keywords[]
Tat Gene Products, Human Immunodeficiency Virus

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

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Sterol Regulatory Element Binding Proteins

# keywords[]
Tat Gene Products, Human Immunodeficiency Virus

# keywords[]
Tat Gene Products, Human Immunodeficiency Virus

# keywords[]
Tat Gene Products, Human Immunodeficiency Virus

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Serotonin Plasma Membrane Transport Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Tat Gene Products, Human Immunodeficiency Virus

# keywords[]
Tat Gene Products, Human Immunodeficiency Virus

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptors, Thromboxane A2, Prostaglandin H2

# keywords[]
NLR Family, Pyrin Domain-Containing 3 Protein

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
University of Madras - (Chennai, Tamil Nadu, India)

# publications[].label
ASHWAGANDHA (WITHANIA SOMNIFERA) REVERSES B-AMYLOID INDUCED NEURONAL TOXICITY: IMPLICATIONS IN HAND

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Development of TIMP1 magnetic nanoformulation for regulation of synaptic plasticity in HIV-1 infection.

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Alpha thrombin rapidly induces tyrosine phosphorylation of glucose regulated protein-75 related stress protein(s) in lung fibroblast cells

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Oxidative Stress in HIV Infection and Alcohol Use: Role of Redox Signals in Modulation of Lipid Rafts and ATP-Binding Cassette Transporters.

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Ashwagandha (Withania somnifera) reverses HIV-1 induced neurodegeneration via attenuation of beta-Amyloid plaques: Implications in HIV-Associated Neurocognitive Disorders (HAND)

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Differential expression and functional role of cannabinoid genes in alcohol users.

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Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury.

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HIV-1 Tat upregulates expression of histone deacetylase-2 in human neurons: Implication for HAND

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Modulation of glial cells of adolescent mice given binge treatment with ethanol

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Differential regulation of neurotoxin in HIV clades: role of cocaine and methamphetamine.

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HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration.

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Toxic effect of methacrylonitrile on rat lung

# publications[].publisher
The Society for Free Radical Research Japan

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Association of Dopamine Receptor D2 C957T Gene SNP in Learning and Memory Among HIV-Positive Alcohol Abusers

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Epigenetics and Mitochondrial Biogenesis: The Role of Sirtuins in HIV Neuropathogenesis.

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Haematological and erythrocyte membrane changes induced by methacrylonitrile.

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Differential Effects of HIV-1 Clade B and Clade C Tat Protein on Expression of Pro- and Anti-inflammatory Cytokines by Primary Monocytes

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Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS.

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HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation.

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Circadian disruption and psychostimulants dysregulates plasma acute-phase proteins and circulating cell-free mitochondrial DNA.

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Activation of the Antioxidant Defensive Enzymes Against HIV-1 gp120 are Mediated by Oxidative Stress and Elevated Intracellular Calcium Levels

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Cannabinoid Agonists Regulate Alcohol-induced Inflammation in Human Dendritic Cells

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Immunopathogenesis of HIV-1 Infection in Cocaine users: Role of Arachidonic Acid

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-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A.

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Role of Dendritic Cells in HIV Infection: DC-SIGN and Novel Therapeutic Approaches

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HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND).

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Immunoneuropathogenesis of HIV-1 clades B and C: role of redox expression and thiol modification.

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Methamphetamine treatment and HIV-1 infection dysregulate Synaptic plasticity in SKNMC neuronal cells

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Inflammasome Gene Expression and their role in HIV and Cocaine Induced Apoptosis

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Pulmonary phospholipid changes induced by butylated hydroxy toluene, an antioxidant, in rats.

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Modulation of glial cells of adolescent mice given binge treatment with ethanol

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Differential Regulation of Neuroplasticity Associated Genes by HIV-1B and C Clades

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Differential effects of HIV type 1 clade B and clade C Tat protein on expression of proinflammatory and antiinflammatory cytokines by primary monocytes.

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Neuroprotective Effect of Piracetam against Cocaine-Induced Neuro Epigenetic Modification of DNA Methylation in Astrocytes.

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Role of HDAC2 and miR-485 in regulation of synaptic plasticity genes in HIV infection: Implication in HAND

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HIV infection and drugs of abuse: role of acute phase proteins.

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HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.

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EFFECT OF NICOTINE ON SYNAPTIC PLASTICITY GENE EXPRESSION IN HIV-1 INFECTION: IMPLICATION IN HAND.

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Glucose mediated downregulation of human angiotensin typel receptor gene expression in proximal tubule epithelial cells is induced by PKC epsilon

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HIV Subtypes B and C gp120 and Methamphetamine Interaction: Dopaminergic System Implicates Differential Neuronal Toxicity.

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Effects of alcohol on histone deacetylase 2 (HDAC2) and the neuroprotective role of trichostatin A (TSA).

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Proteomics Profiling with SWATH-MS Quantitative Analysis of Changes in the Human Brain with HIV Infection Reveals a Differential Impact on the Frontal and Temporal Lobes.

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Differential Expression of Cannabinoid Genes in Alcoholics

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Effects of Alcohol on Cannabinoid (CB2) and Serotonin (5-HT3) Receptors in the Human Neuroblastoma Cell Line, SK-N-MC, and the Role of Histone Deacetylase 2 (HDAC2).

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HIV-1 gp120 induces antioxidant response element-mediated expression in primary astrocytes: role in HIV associated neurocognitive disorder.

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HIV-1 Tat and cocaine impact astrocytic energy reservoirs and epigenetic regulation by influencing the LINC01133-hsa-miR-4726-5p-NDUFA9 axis.

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Cell cycle checkpoints and pathogenesis of HIV-1 infection: a brief overview.

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Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line.

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Synaptic Plasticity and Neurological Disorders in Neurotropic Viral Infections.

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IMMUNOPATHOGENIC MECHANISMS OF HIV-1 CLADE B AND C: ROLE OF DOPAMINERGIC SYSTEM.

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DUAL MECHANISM ENHANCED BBB CROSSING BY TRANSFERRIN CONJUGATED FLUORESCENT MAGNETIC LIPOSOME.

# publications[].label
Effect of methacrylonitrile on rat lung antioxidant enzymes.

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Effect of human immunodeficiency virus on blood-brain barrier integrity and function: an update.

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Interactive role of human immunodeficiency virus type 1 (HIV-1) clade-specific Tat protein and cocaine in blood-brain barrier dysfunction: implications for HIV-1-associated neurocognitive disorder.

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Molecular Mechanism of Immunosuppression by Cocaine in HIV-1 Infected Subjects: Role of TLR3

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Histone Deacetylase Activity in Development of HIV-Associated Neurocognitive Disorder.

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Effects of Drugs of Abuse on the Blood-Brain Barrier: A Brief Overview.

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Immunopathogenesis of HIV infection in cocaine users: role of arachidonic acid.

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BINGE DRINKING CONTRIBUTING TO OPIOID USE DISORDERS

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Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC).

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Proteomics Profiling and Cytotoxic Effect of Curcuma longa on Prostate Cancer

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Psychostimulants influence oxidative stress and redox signatures: the role of DNA methylation.

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HIV-1 Clade B and C Tat differentially Induces Indoleamine-2, 3-Dioxygenase (IDO) and Serotonin in Immature Dendritic Cells (IDC): Implications for Neuro-AIDS

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beta-Amyloid, HIV-1 Infection and Drugs of Abuse Induced Neurodegeneration and Protective Effects of Ashwagandha

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Cocaine and HIV Upregulate Glycolytic Enzymes and Mitochondrial Biogenesis in Astrocytes

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Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview.

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Vorinostat positively regulates synaptic plasticity genes expression and spine density in HIV infected neurons: role of nicotine in progression of HIV-associated neurocognitive disorder.

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Hyperglycemia alters angiotensin type 1 receptor expression through MAP-kinase signaling pathway in liver cells

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Polydrug mediated effects on HIV Nef plus exosome release and neuropathogenesis is modulated by Nef peptide magnetic nanocarriers

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Influence of psychostimulants and opioids on epigenetic modification of class III histone deacetylase (HDAC)-sirtuins in glial cells.

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Human Immunodeficiency Virus type-1 Glade B and C gp120 Inhibit NMDA-receptor mediated induction of Arachidonic Acid: Implications on Neuro-AIDS

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Chemopreventive potential of an ethyl acetate fraction from Curcuma longa is associated with upregulation of p57(kip2) and Rad9 in the PC-3M prostate cancer cell line.

# publications[].publisher
Asian Pacific Organization for Cancer Prevention

# publications[].label
Ashwagandha (Withania somnifera) reverses -amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND).

# publications[].label
Proteomic Fingerprints of Primary Human Neurons treated with HIV-1 Clade B and C Proteins: Implications for Neuro-AIDS

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Profile of Class I Histone Deacetylases (HDAC) by Human Dendritic Cells after Alcohol Consumption and In Vitro Alcohol Treatment and Their Implication in Oxidative Stress: Role of HDAC Inhibitors Trichostatin A and Mocetinostat.

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HIV- Tat and Cocaine Impact Astrocytic DNA Methylation

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A simple vapour phase decomposition (VPD) of quartz powder in a polypropylene vessel and determination of phosphorus by spectrophotometry.

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HIV and Morphine: Oxidative Stress Impact Cell Cycle Regulation and Neurodegeneration

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EXPRESSION OF HISTONE DEACETYLASE 2 (HDAC2) IN HUMAN MONOCYTE-DERIVED DENDRITIC CELLS (MDDCS) TREATED WITH ALCOHOL

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Neuropathogenic Mechanisms by HIV-1 Clade B And C: Role of Lipid Rafts.

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Glucose induced activation of mitogen activated protein kinases and downstream molecular events in human proximal tubular epithelial cells

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Comparative Immunovirological Study between Buprenorphine and Methadone Using Human Lymphocytes and Glial Cells

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Sensitization to morphine's anti-nociception in C57BL/6J mice having binge exposure to ethanol

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Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.

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HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation.

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HIV NEUROPATHOGENESIS: ROLE OF NEF plus EXOSOMES (EXNEF), METHAMPHETAMINE AND OPIATES

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HIV-1 Tat and cocaine coexposure impacts piRNAs to affect astrocyte energy metabolism.

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Epigenetic signature of N-terminal acetyltransferases: a probable mediator of immune and neuropathogenesis in HIV infection.

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HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling.

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Differential Regulation of Thiol Modification by HIV-1 Clade B and C Protein

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Effect of Cocaine on HIV Infection and Inflammasome Gene Expression Profile in HIV Infected Macrophages.

# publications[].label
Sensitization to morphine's anti-nociception in C57BL/6J mice having binge exposure to ethanol

# publications[].label
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF-Transcriptional Mediated Neurodegeneration

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Development of hybrid nanocarrier (Au/Fe3O4) for active drug delivery to brain to eliminate HIV-1 persistence

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MAGNETIC NANOPARTICLE FOR TARGETTED ANTI-HIV DRUG DELIVERY IN IN VIVO MODEL

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Neuropathogenic Mechanisms of HIV-1 Clade B and C: Role of Methamphetamine (METH).

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Enhanced blood-brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation.

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HIV-1 Tat and cocaine impact astrocytic energy reservoir influence on miRNA epigenetic regulation.

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Sleep Disorder and Cocaine Abuse Impact Purine and Pyrimidine Nucleotide Metabolic Signatures.

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Commentary of Drugs of Abuse and HIV Infection in South Florida, USA

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Differential regulation of indoleamine-2,3-dioxygenase (IDO) by HIV type 1 clade B and C Tat protein.

# publications[].label
Effect of methacrylonitrile on rat lung mitochondria and microsomes

# publications[].label
Psychostimulants and opioids differentially influence the epigenetic modification of histone acetyltransferase and histone deacetylase in astrocytes.

# researcherOn[].label
Cocaine and HIV Influence Mitochondrial Epigenetics in Astrocytic Networks

# researcherOn[].awardedBy.label
National Institute on Drug Abuse - (Bethesda, Maryland, United States)

# inTheNews[].label
Psychostimulant and Opioid Drugs Can Epigenetically Influence HATs & HDACs