# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# overview
My laboratory is interested in the role played by cytoskeletal remodeling in development and disease, particularly, angiogenesis and tumor progression and invasion. The long-term goal of our research is to understand how extracellular signals that alter tyrosine phosphorylation and the metabolism of inositol phospholipids modulate actin dynamics and cell motility. Areas of interest include the biogenesis of actin-based structures of invasion, intracellular trafficking, and three-dimensional tissue morphogenesis in vitro. Our research employs a combination of molecular genetics, cell biology, proteomics, and high-resolution optical imaging.

# keywords[]
Insulin-like Growth Factor Binding Protein 4

# keywords[]
Insulin-like Growth Factor Binding Protein 5

# keywords[]
Insulin-like Growth Factor Binding Protein 2

# keywords[]
Rho Guanine Nucleotide Dissociation Inhibitor Alpha

# keywords[]
Protein Tyrosine Phosphatase, Non-receptor Type 12

# keywords[]
Insulin-like Growth Factor Binding Protein 4

# keywords[]
Insulin-like Growth Factor Binding Protein 2

# keywords[]
Insulin-like Growth Factor Binding Protein 5

# keywords[]
Insulin-like Growth Factor Binding Protein 4

# keywords[]
Insulin-like Growth Factor Binding Protein 5

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Receptor, Platelet-Derived Growth Factor Beta

# keywords[]
Insulin-like Growth Factor Binding Protein 4

# educationAndTraining[].organization.label
Cornell University - (Ithaca, New York, United States)

# educationAndTraining[].organization.label
University of Connecticut Health Center - (Farmington, Connecticut, United States)

# educationAndTraining[].organization.label
National University of Rio Cuarto - (Córdoba, Argentina)

# educationAndTraining[].organization.label
National University of Mar del Plata - (Mar del Plata, Argentina)

# publications[].label
Protein tyrosine phosphatase-PEST and 8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.

# publications[].label
Ovarian follicular wave synchronization and induction of ovulation in postpartum beef cows.

# publications[].label
Differentiation of dominant versus subordinate follicles in cattle.

# publications[].label
Correction: Stoichiometry of Nck-dependent actin polymerization in living cells.

# publications[].label
Seasonality of estrus and ovulation in Creole goats of Argentina

# publications[].label
Nck Is Required for Focal Adhesion Maturation and Polarized Cell Motility.

# publications[].label
Nck deficiency is associated with delayed breast carcinoma progression and reduced metastasis.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
Selective regulation of cytoskeletal tension and cell-matrix adhesion by RhoA and Src.

# publications[].label
Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics.

# publications[].label
n-3 polyunsaturated fatty acids suppress CD4(+) T cell proliferation by altering phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2] organization.

# publications[].label
A potential role for insulin-like growth factor binding protein-4 proteolysis in the establishment of ovarian follicular dominance in cattle.

# publications[].label
Proteolysis of insulin-like growth factor binding proteins -4 and -5 in bovine follicular fluid: implications for ovarian follicular selection and dominance.

# publications[].label
Advancement of ovulation and oestrus after temporary calf removal and FSH supplementation in postpartum beef cows

# publications[].label
Selection of the dominant follicle and insulin-like growth factor (IGF)-binding proteins: evidence that pregnancy-associated plasma protein A contributes to proteolysis of IGF-binding protein 5 in bovine follicular fluid.

# publications[].label
Follicular development: the role of the follicular microenvironment in selection of the dominant follicle.

# publications[].label
The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency.

# publications[].label
A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors.

# publications[].label
Development of codominant follicles in cattle is associated with a follicle-stimulating hormone-dependent insulin-like growth factor binding protein-4 protease.

# publications[].label
Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization.

# publications[].label
Stoichiometry of Nck-dependent actin polymerization in living cells.

# publications[].label
Neuropilin 1 balances 8 integrin-activated TGF signaling to control sprouting angiogenesis in the brain.

# publications[].label
The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Actin remodeling by Nck regulates endothelial lumen formation.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.

# publications[].label
Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1.

# publications[].label
A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells.

# publications[].label
n-3 polyunsaturated fatty acids suppress phosphatidylinositol 4,5-bisphosphate-dependent actin remodelling during CD4+ T-cell activation.

# researcherOn[].label
Signaling integration in endothelial and vascular morphogenesis

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Role of intimal stiffness in endothelial-mesenchymal transition and atherosclerosis progression

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].label
Regulation of the endothelial translatome by arterial stiffening in atherosclerosis

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# streetAddress
Texas A&M University; Vet Med Pathobiology; 4467 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US