# overview
We are interested in studying the interaction between microbes and host systems, in the context of antibiotic resistance, infection, and the innate immune response.

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5 Development Of Treatments And Therapeutic Interventions

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2.2 Factors Relating To The Physical Environment

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2.2 Factors Relating To The Physical Environment

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1.1 Normal Biological Development And Functioning

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Intracellular Signaling Peptides And Proteins

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Peking University - (Beijing, Beijing, China)

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Princeton University - (Princeton, New Jersey, United States)

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Brookhaven National Laboratory - (Upton, New York, United States)

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Characterization of the ligand and DNA binding properties of a putative archaeal regulator ST1710.

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Effect of crowding by Ficolls on OmpA and OmpT refolding and membrane insertion.

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Accessibility from the Cytoplasm Is Critical for ssrA Tag-Mediated Degradation of Integral Membrane Proteins by ClpXP Protease.

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Nanoparticle-mediated remote control of enzymatic activity.

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Biotinylation as a Tool to Enhance Uptake of Compounds in Gramnegative Bacteria

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Probing a myth: does the younger generation of scientists have it easier?

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Study of Multidrug Efflux System Protein Degradation in E. coli Using Transposons Library

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Direct fluorescence polarization assay for the detection of glycopeptide antibiotics.

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Structure of inorganic pyrophosphatase from Staphylococcus aureus reveals conformational flexibility of the active site.

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Detection of protein-DNA interaction and regulation using gold nanoparticles.

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Probing the Dynamic Aspects of AcrB Function through Disulfide Bond Formation

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Characterization of a recombinant thermostable dehalogenase isolated from the hot spring thermophile Sulfolobus tokodaii.

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Purification of an Engineered Membrane Protein FhuA for Size-Dependent Separation

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Enabling technologies in discovery: the 2009 Nobel Prize and its implications in antibiotic design.

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A monoadduct generating Ru(ii) complex induces ribosome biogenesis stress and is a molecular mimic of phenanthriplatin.

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Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis.

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Comparison of in vitro and in vivo oligomeric states of a wild type and mutant trimeric inner membrane multidrug transporter.

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A bioluminescent molecular switch for glucose.

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Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics.

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Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes.

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Gasdermin D (GSDMD) as a new target for the treatment of infection.

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Synthesis and biological evaluation of stilbene-based peptoid mimics against the phytopathogenic bacterium Xanthomonas citri pv. citri.

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Differentiating surface and bulk interactions using localized surface plasmon resonances of gold nanorods.

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The ssrA-Tag Facilitated Degradation of an Integral Membrane Protein.

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Site specific and reversible protein immobilization facilitated by a DNA binding fusion tag.

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Using U-Shaped Localized Surface Plasmon Resonance Sensors to Compensate for Nonspecific Interactions

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Institute of Electrical and Electronics Engineers (IEEE)

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Functional Relevance of Unstructured Regions of AcrA, the Periplasmic Adaptor of the Major Multidrug Efflux System in E. coli

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Oligomeric state of the Escherichia coli metal transporter YiiP.

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Probing the Functional Relevance of the Tip-to-Tip Acrab-Tolc Structural Model

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Increasing Salt Rejection of Polybenzimidazole Nanofiltration Membranes via the Addition of Immobilized and Aligned Aquaporins.

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Binding and transport of metal ions at the dimer interface of the Escherichia coli metal transporter YiiP.

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Glucose responsive hydrogel networks based on protein recognition.

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Insight into the MultidrugEfflux Pump AcrB Oligomerization Process

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Insight into the AcrAB-TolC Complex Assembly Process Learned from Competition Studies.

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Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection.

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A dimorphism shift of hepatitis B virus capsids in response to ionic conditions.

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Detection of halogenated organic compounds using immobilized thermophilic dehalogenase.

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Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice.

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Role of Protein Charge Density on Hepatitis B Virus Capsid Formation.

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Cysteine residue is not essential for CPM protein thermal-stability assay.

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Distribution of fluoroquinolones in the two aqueous compartments of Escherichia coli.

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Role of a conserved residue R780 in Escherichia coli multidrug transporter AcrB.

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Optimal self-referenced sensing using long- and short- range surface plasmons.

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AcrB trimer stability and efflux activity, insight from mutagenesis studies.

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Assembling of AcrB trimer in cell membrane.

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Extracellular histones trigger disseminated intravascular coagulation by lytic cell death

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Inflammasome Activation Promotes Deep Vein Thrombosis through Pyroptosis

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Subcellular Accumulation of Fluoroquinolones in E. coli

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Observations of Compound Penetration in Escherichia coli using Ethidium Bromide as a Model Compound

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Corrigendum to Assembling of AcrB Trimer in Cell Membrane [J. Mol. Biol. 423(1) (2012) 123134]

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Selective metal binding to a membrane-embedded aspartate in the Escherichia coli metal transporter YiiP (FieF).

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Insights into the function and structural flexibility of the periplasmic molecular chaperone SurA.

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Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB.

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Correlation between AcrB trimer association affinity and efflux activity.

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Layer-by-layer Assembled Membranes with Immobilized Porins.

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Biotinylation as a tool to enhance the uptake of small molecules in Gram-negative bacteria.

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Accumulation and efflux of polychlorinated biphenyls in Escherichia coli.

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Dissecting the function of a protruding loop in AcrB trimerization.

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Probing the Dynamics of AcrB Through Disulfide Bond Formation.

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Abstract 487: Extracellularhistonestrigger Disseminated Intravascular Coagulation By Lytic Cell Death

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Oriented immobilization of proteins on hydroxyapatite surface using bifunctional bisphosphonates as linkers.

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Emergence of two AcrB substitutions conferring multidrug resistance to Salmonella spp.

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Small globular protein motif forms particulate hydrogel under various pH conditions.

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Diverse sequences are functional at the C-terminus of the E. coli periplasmic chaperone SurA.

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Novel model of brain metastasis formation: the influence of polychlorinated biphenyls on bloodbrain barrier integrity and brain metastasis

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Study of the degradation of a multidrug transporter using a non-radioactive pulse chase method.

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Application of Fluorescence in Studying Therapeutic Enzymes.

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Inflammasome activation promotes venous thrombosis through pyroptosis.

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Abstract 038: Inflammasome Activation Triggers Blood Coagulation Through Pyroptosis

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A Bioluminescent Molecular Switch For Glucose

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Functional relevance of AcrB Trimerization in pump assembly and substrate binding.

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Unfolding study of a trimeric membrane protein AcrB.

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Transport Across Two Membrane Bilayers in E. coli by Efflux Pumps of Different Dimensions.

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Folding of AcrB Subunit Precedes Trimerization.

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Multi-mode Localized Surface Plasmon Resonance Sensors for Compensation of Interfering Effects

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

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Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death.

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Periplasmic Targets for the Development of Effective Antimicrobials against Gram-Negative Bacteria.

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Data on spectrum-based fluorescence resonance energy transfer measurement of E. coli multidrug transporter AcrB.