# overview
Dr. Tanmay Lele's research is in the area of mechanobiology with a focus on cancer mechanobiology. His lab is interested in the molecular mechanisms by which cell generated mechanical forces and associated signaling pathways enable cell and tissue functions, and how these relationships become altered in cancer. Current research projects in the laboratory include quantitative measurements of nuclear forces, the effect of mechanical stresses on nuclear functions and gene expression, cellular adaptation to mechanical properties of the extracellular matrix, and the mechanics of cancer tissue development.

Lele is a scholar in cancer research at the Cancer Prevention and Research Institute of Texas.

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Stem Cell Research - Nonembryonic - Human

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Endosomal Sorting Complexes Required For Transport

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1.1 Normal Biological Development And Functioning

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Intracellular Signaling Peptides And Proteins

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1.1 Normal Biological Development And Functioning

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Model A-type Lamins B-type Lamins Nuclear Lamina

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Purdue University - (West Lafayette, Indiana, United States)

# publications[].label
Conformable coating of SiO2 on hydrothermally grown ZnO nanorods

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Local nuclear deformation in response to transient tensile stress can cause membrane rupture.

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Nucleocytoplasmic transport is regulated by forces on the nucleus

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Brillouin spectroscopy imaging of cell phototoxic damage

# publications[].publisher
SPIE, the international society for optics and photonics

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Viscous shaping of the compliant cell nucleus.

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Anisotropic random walks reveal chemotaxis signaling output in run-reversing bacteria

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Tools to study cell mechanics and mechanotransduction.

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Low Hg(II) ion concentration electrical detection with AlGaN/GaN high electron mobility transistors

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Chemical Engineering Principles in the Field of Cell Mechanics

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Low Temperature Hydrothermal Growth of ZnO Nanorods and its Applications

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Mechanical principles of nuclear shaping and positioning.

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Mechanical Characterization of Glandular Acini Using a Micro-indentation Instrument.

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Emerging Concepts and Tools in Cell Mechanomemory.

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Cyto-Mechanics of Microtubular Buckling and Centering of Centrosome

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Coordinated Dynamics of RNA Splicing Speckles in the Nucleus.

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Investigating complexity of protein-protein interactions in focal adhesions.

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Macrophage Response to Zinc Oxide Nanorod Surfaces -Topography and Toxicity

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Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation (vol 99, pg 115, 2010)

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Rapid Electrical Detection of Hg(II) Ions with AlGaN/GaN High Electron Mobility Transistors

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An epigenetic small molecule screen to target abnormal nuclear morphology in human cells.

# publications[].publisher
American Society for Cell Biology (ASCB)

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Modulation of Nuclear Shape by Substrate Rigidity.

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Rho activation drives luminal collapse and eversion in epithelial acini.

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The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity.

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Fast electrical detection of Hg(II) ions with AlGaN/GaN high electron mobility transistors

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Editorial: Nuclear morphology in development and disease.

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Estrogen-receptor- exchange and chromatin dynamics are ligand- and domain-dependent

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Imaging mechanical properties of cancer cells during metastasis with Brillouin microspectroscopy

# publications[].publisher
SPIE, the international society for optics and photonics

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The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts.

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Apical cell protrusions cause vertical deformation of the soft cancer nucleus.

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Hydrothermally Grown ZnO Nanorods as Cell Adhesion Control Coating for Implant Devices

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A Skeptic's Guide to Bacterial Mechanosensing.

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Macrophage Adhesion and Viability on Zinc Oxide Nanorods

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ZnO Nanorods for Controlling Cell Behavior

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New sensors offer promise of bedside diagnosis

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Mathematical analysis of physicochemical processes on catalytic surfaces

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Gene screen reveals chromatin proteins influence abnormal nuclear morphology associated with breast cancer cell models.

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A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.

# publications[].publisher
American Association for Cancer Research (AACR)

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A Monte-Carlo method for portfolio optimization under partially observed stochastic volatility

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Institute of Electrical and Electronics Engineers (IEEE)

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A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton.

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A method for direct imaging of x-z cross-sections of fluorescent samples.

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Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching.

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Selective detection of Hg (II) ions from Cu(II) and Pb(II) using AlGaN/GaN high electron mobility transistors

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CYTOSKELETAL PROTEINS AT THE LIPID MEMBRANE

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A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP).

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Fast detection of a protozoan pathogen, Perkinsus marinus, using AlGaN/GaN high electron mobility transistors

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The control of cell adhesion and viability by zinc oxide nanorods.

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Tools to study cell mechanics and mechanotransduction

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Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability.

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Spatio-temporal pattern formation during CO oxidation on Pt(100) at low and intermediate pressures: A comparative study.

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Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Reverse Plasticity Underlies Rapid Evolution by Clonal Selection within Populations of Fibroblasts Propagated on a Novel Soft Substrate.

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Transient Pinning and Pulling: A Mechanism for Bending Microtubules.

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Biosensors Using Functionalized ZnO and GaN Surfaces

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Enhanced Cell Growth, Function, and Differentiation by TiO2 Nanotube Surface Structuring

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The Elephant in the Cell: Nuclear Mechanics and Mechanobiology.

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Sarcomere length fluctuations and flow in capillary endothelial cells.

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A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton

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Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori.

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An improved mathematical approach for determination of molecular kinetics in living cells with FRAP.

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Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex.

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How Dynein and Microtubules Rotate the Nucleus.

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S2046 Reducing Tumor Growth On Stents Using Nanorods: Nanotechnology for the Prevention of Cell Adhesion and Migration

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c-erbB-2 sensing using AlGaN/GaN high electron mobility transistors for breast cancer detection

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c-erbB-2 Sensing Using AlGaN/GaN High Electron Mobility Transistors For Breast Cancer Detection

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Loss of mechanical homeostasis drives epithelial acinar eversion

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Modulating malignant epithelial tumor cell adhesion, migration and mechanics with nanorod surfaces.

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FLUCTUATING MOTOR FORCES BEND GROWING MICROTUBULES.

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The effect of cyclic mechanical strain on activation of dendritic cells cultured on adhesive substrates.

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Subsurface oxygen formation on Pt(100): Experiments and modeling

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Rho activation drives luminal collapse and eversion in epithelial acini

# publications[].label
The study of low temperature hydrothermal growth of ZnO nanorods on stents and its applications of cell adhesion and viability

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Gene screen reveals chromatin proteins influence abnormal nuclear morphology associated with breast cancer cell models

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Brushes, cables, and anchors: recent insights into multiscale assembly and mechanics of cellular structural networks.

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An unresolved LINC in the nuclear envelope.

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AlGaN/GaN HEMT And ZnO Nanorod Based Sensors for Chemical and Bio-Applications

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Prostate specific antigen detection using AlGaN/GaN high electron mobility transistors

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AlGaN/GaN HEMT And ZnO nanorod-based sensors for chemical and bio-applications

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Ultradonut topology of the nuclear envelope.

# publications[].publisher
Proceedings of the National Academy of Sciences

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Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina.

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The nucleus is an intracellular propagator of actomyosin forces in NIH 3T3 fibroblasts.

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Repair of nuclear ruptures requires barrier-to-autointegration factor

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Cellular micromasonry: biofabrication with single cell precision.

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Toward in situ biochemistry: combining chemical kinetics approaches with biomolecular imaging in living cells.

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Focal Adhesions: Self-Assembling Nanoscale Mechanochemical Machines that Control Cell Function

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The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C

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AlGaN/GaN HEMT And ZnO Nanorod Based Sensors for Chemical and Bio-Applications

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The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells.

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Intracellular Concentration Gradients That Mirror External Gradients in Microfluidic Flows: A Computational Analysis.

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Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery.

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Dynamic Adaptation in Extant Porins Facilitates Antibiotic Tolerance in Energetic Escherichia coli.

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Botulinum toxin detection using AlGaN/GaN high electron mobility transistors

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Nucleocytoplasmic transport is regulated by forces on the nucleus

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Actomyosin tug-of-war advances the nucleus in a migrating tissue cell

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c-erbB-2 Sensing using AlGaN/GaN High Electron Mobility Transistors for Breast Cancer Detection

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Cytoplasmic dynein: tension generation on microtubules and the nucleus.

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Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts.

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Effects of dynein on microtubule mechanics and centrosome positioning.

# publications[].publisher
American Society for Cell Biology (ASCB)

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Optimizing COVID-19 testing capabilities and clinical management using pathology informatics.

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Contributions of surface topography and cytotoxicity to the macrophage response to zinc oxide nanorods.

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Direct Force Probe for Nuclear Mechanics.

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Molecular cancer cell responses to solid compressive stress and interstitial fluid pressure.

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Investigation of in vivo microtubule and stress fiber mechanics with laser ablation.

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FRAP analysis: accounting for bleaching during image capture.

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Actomyosin pulls to advance the nucleus in a migrating tissue cell.

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The role of glycans in the mechanobiology of cancer.

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Sarcomere mechanics in capillary endothelial cells.

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How dynein and microtubules rotate the nucleus.

# publications[].label
Real-time Detection of Botulinum Toxin with AlGaN/GaN High Electron Mobility Transistors

# publications[].label
Fast Detection of Perkinsus Marinus, a Prevalent Pathogen of Oysters and Clams from Sea Waters

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Insights developed into nuclear mechanics by live cell imaging

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
GaN and ZnO-Based Sensors for Gas, Nuclear Materials and Chemical Detection

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Effects of Molecular Motors on Microtubule Mechanics.

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Rapid Electrical Detection of Hg(II) Ions with AlGaN/GaN High Electron Mobility Transistors

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Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactions.

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Penetrating living cells using semiconductor nanowires.

# publications[].label
Local, transient tensile stress on the nuclear membrane causes membrane rupture.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
Vertical uniformity of cells and nuclei in epithelial monolayers.

# publications[].label
Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation.

# publications[].label
Randomly oriented, upright SiO2 coated nanorods for reduced adhesion of mammalian cells.

# publications[].label
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells.

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Barrier to autointegration factor (BAF) regulates the cellular response to nuclear rupture.

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High-throughput gene screen reveals modulators of nuclear shape.

# publications[].publisher
American Society for Cell Biology (ASCB)

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GaN and ZnO-Based Sensors for Gas, Nuclear Materials and Chemical Detection

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New approaches for understanding the nuclear force balance in living, adherent cells.

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Dynamic, mechanical integration between nucleus and cell- where physics meets biology.

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Chapter Eight Cytoskeletal Proteins at the Lipid Membrane

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Nuclear shapes are geometrically determined by lamina excess area

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Dynein-generated forces bend and reorient microtubules by acting upon stationary pinning points.

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Stamp wound assay for studying coupled cell migration and cell debris clearance.

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Introduction to soft matter aspects of cancer.

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Geometry of the nuclear envelope determines its flexural stiffness.

# publications[].publisher
American Society for Cell Biology (ASCB)

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A multi-modular tensegrity model of an actin stress fiber.

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Nuclear Morphological Abnormalities in Cancer: A Search for Unifying Mechanisms.

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A new function for nuclear lamins: Providing surface tension to the nuclear drop

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The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C

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A predictive unifying explanation for nuclear shapes based on a simple geometric principle

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Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics.

# publications[].label
Concentration Sensing by the Moving Nucleus in Cell Fate Determination: A Computational Analysis.

# publications[].label
Spatiotemporal patterns during CO oxidation on Pt(100) at elevated pressures

# publications[].label
Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.

# publications[].label
Ultradonut Topology of the Nuclear Envelope

# publications[].label
The LINC complex controls global breast acini architecture through connections to the actin cytoskeleton

# publications[].label
The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C.

# publications[].label
Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblasts propagated on a novel soft substrate

# publications[].label
Nuclear size changes caused by local motion of cell boundaries unfold the nuclear lamina and dilate chromatin and intranuclear bodies.

# publications[].label
Real-time detection of botulinum toxin with AlGaN/GaN high electron mobility transistor

# researcherOn[].label
Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmitted by the LINC Complex

# researcherOn[].awardedBy.label
National Cancer Institute - (Rockville, Maryland, United States)

# researcherOn[].label
RoL: FELS: EAGER Rules for cellular adaptation to the mechanical properties of their environment

# researcherOn[].awardedBy.label
Directorate for Biological Sciences - (Arlington, Virginia, United States)

# streetAddress
Department of Biomedical Engineering; Emerging Technologies Building, Room #5062, 101 Bizzell Street,; Texas A&M University

# inTheNews[].label
UChicago Medicine receives $10M to develop a center for cellular therapy

# inTheNews[].label
Biomedical Engineering Researcher Receives $5 Million Grant To Further Cancer Studies

# etdChairOf[].label
Purkayastha, Purboja (2022-08). Cell and Tissue Adaptation to Mechanical Alterations. Doctoral Dissertation.

# etdChairOf[].label
Katiyar, Aditya (2022-05). Studying Nuclear Deformation During Migration of Cells through Confining Environments. Doctoral Dissertation.