# overview
Dr. Tanmay Lele's research is in the area of mechanobiology with a focus on cancer mechanobiology. His lab is interested in the molecular mechanisms by which cell generated mechanical forces and associated signaling pathways enable cell and tissue functions, and how these relationships become altered in cancer. Current research projects in the laboratory include quantitative measurements of nuclear forces, the effect of mechanical stresses on nuclear functions and gene expression, cellular adaptation to mechanical properties of the extracellular matrix, and the mechanics of cancer tissue development.

Lele is a scholar in cancer research at the Cancer Prevention and Research Institute of Texas.

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1.1 Normal Biological Development And Functioning

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Intracellular Signaling Peptides And Proteins

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1.1 Normal Biological Development And Functioning

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Model A-type Lamins B-type Lamins Nuclear Lamina

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1.1 Normal Biological Development And Functioning

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Endosomal Sorting Complexes Required For Transport

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Stem Cell Research - Induced Pluripotent Stem Cell - Human

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Stem Cell Research - Induced Pluripotent Stem Cell

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Stem Cell Research - Nonembryonic - Human

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Stem Cell Research - Nonembryonic - Non-human

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1.1 Normal Biological Development And Functioning

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1.1 Normal Biological Development And Functioning

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35 Commerce, Management, Tourism And Services

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1.1 Normal Biological Development And Functioning

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1.1 Normal Biological Development And Functioning

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5102 Atomic, Molecular And Optical Physics

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4009 Electronics, Sensors And Digital Hardware

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1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Purdue University - (West Lafayette, Indiana, United States)

# publications[].label
The LINC complex controls global breast acini architecture through connections to the actin cytoskeleton

# publications[].label
Nanoscale Control of CellSubstrate Adhesion

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An improved mathematical approach for determination of molecular kinetics in living cells with FRAP.

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Imaging mechanical properties of cancer cells during metastasis with Brillouin microspectroscopy

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation.

# publications[].label
Macrophage Adhesion and Viability on Zinc Oxide Nanorods

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A method for direct imaging of x-z cross-sections of fluorescent samples.

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A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.

# publications[].publisher
American Association for Cancer Research (AACR)

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Genetic variation drives cancer cell adaptation to ECM stiffness.

# publications[].publisher
Proceedings of the National Academy of Sciences

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Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs.

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Subsurface oxygen formation on Pt(100): Experiments and modeling

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Editorial: Nuclear morphology in development and disease.

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Low Hg(II) ion concentration electrical detection with AlGaN/GaN high electron mobility transistors

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Reverse Plasticity Underlies Rapid Evolution by Clonal Selection within Populations of Fibroblasts Propagated on a Novel Soft Substrate.

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Brushes, cables, and anchors: recent insights into multiscale assembly and mechanics of cellular structural networks.

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Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading.

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An unresolved LINC in the nuclear envelope.

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When the Nucleus Disconnects, Cells Lose Their Way.

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Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells.

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Tools to study cell mechanics and mechanotransduction.

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Gene screen reveals chromatin proteins influence abnormal nuclear morphology associated with breast cancer cell models

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AlGaN/GaN HEMT And ZnO Nanorod Based Sensors for Chemical and Bio-Applications

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Contributions of surface topography and cytotoxicity to the macrophage response to zinc oxide nanorods.

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A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton.

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Fast electrical detection of Hg(II) ions with AlGaN/GaN high electron mobility transistors

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Local, transient tensile stress on the nuclear membrane causes membrane rupture.

# publications[].publisher
American Society for Cell Biology (ASCB)

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ZnO Nanorods for Controlling Cell Behavior

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A predictive unifying explanation for nuclear shapes based on a simple geometric principle

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The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts.

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How Dynein and Microtubules Rotate the Nucleus.

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The study of low temperature hydrothermal growth of ZnO nanorods on stents and its applications of cell adhesion and viability

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The Elephant in the Cell: Nuclear Mechanics and Mechanobiology.

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Dynein-generated forces bend and reorient microtubules by acting upon stationary pinning points.

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Spatiotemporal patterns during CO oxidation on Pt(100) at elevated pressures

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Actomyosin pulls to advance the nucleus in a migrating tissue cell.

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Conformable coating of SiO2 on hydrothermally grown ZnO nanorods

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FLUCTUATING MOTOR FORCES BEND GROWING MICROTUBULES.

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Viscous shaping of the compliant cell nucleus.

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High-throughput gene screen reveals modulators of nuclear shape.

# publications[].publisher
American Society for Cell Biology (ASCB)

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Nucleocytoplasmic transport is regulated by forces on the nucleus

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New sensors offer promise of bedside diagnosis

# publications[].publisher
SPIE, the international society for optics and photonics

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Ultradonut Topology of the Nuclear Envelope

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Investigation of in vivo microtubule and stress fiber mechanics with laser ablation.

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Evidence for Drop-Like Nuclear Deformation in Sheared Endothelial Monolayers.

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Mechanical Stabilization of the Glandular Acinus by Linker of Nucleoskeleton and Cytoskeleton Complex.

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Nuclear shapes are geometrically determined by the excess surface area of the nuclear lamina.

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The role of glycans in the mechanobiology of cancer.

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Geometry of the nuclear envelope determines its flexural stiffness.

# publications[].publisher
American Society for Cell Biology (ASCB)

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Macrophage Response to Zinc Oxide Nanorod Surfaces -Topography and Toxicity

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Abstract 6225: Tumor evolution through selection by ECM stiffness

# publications[].publisher
American Association for Cancer Research (AACR)

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New approaches for understanding the nuclear force balance in living, adherent cells.

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Cytoplasmic dynein: tension generation on microtubules and the nucleus.

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Rho activation drives luminal collapse and eversion in epithelial acini.

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Intracellular Concentration Gradients That Mirror External Gradients in Microfluidic Flows: A Computational Analysis.

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Brillouin spectroscopy imaging of cell phototoxic damage

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Modulation of Nuclear Shape by Substrate Rigidity.

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How dynein and microtubules rotate the nucleus.

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Direct Force Probe for Nuclear Mechanics.

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Chemical Engineering Principles in the Field of Cell Mechanics

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Prostate specific antigen detection using AlGaN/GaN high electron mobility transistors

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Apical cell protrusions cause vertical deformation of the soft cancer nucleus.

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Abstract 6224: Drop-like deformation of nuclei in cancer patient tissue

# publications[].publisher
American Association for Cancer Research (AACR)

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Nuclear shapes are geometrically determined by lamina excess area

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A new function for nuclear lamins: providing surface tension to the nuclear drop.

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Real-time detection of botulinum toxin with AlGaN/GaN high electron mobility transistor

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Matrix stiffness drives drop like nuclear deformation and lamin A/C tension-dependent YAP nuclear localization.

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The control of cell adhesion and viability by zinc oxide nanorods.

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A Skeptic's Guide to Bacterial Mechanosensing.

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Extreme wrinkling of the nuclear lamina is a morphological marker of cancer.

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Effects of Molecular Motors on Microtubule Mechanics.

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Randomly oriented, upright SiO2 coated nanorods for reduced adhesion of mammalian cells.

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Penetrating living cells using semiconductor nanowires.

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Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell.

# publications[].publisher
Proceedings of the National Academy of Sciences

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Tools to study cell mechanics and mechanotransduction

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Transient Pinning and Pulling: A Mechanism for Bending Microtubules.

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Nucleocytoplasmic transport is regulated by forces on the nucleus

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Hydrothermally Grown ZnO Nanorods as Cell Adhesion Control Coating for Implant Devices

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Botulinum toxin detection using AlGaN/GaN high electron mobility transistors

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Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability.

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Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias in Helicobacter pylori.

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Dynamic, mechanical integration between nucleus and cell- where physics meets biology.

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Cellular micromasonry: biofabrication with single cell precision.

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Toward in situ biochemistry: combining chemical kinetics approaches with biomolecular imaging in living cells.

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The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells.

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The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C

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Dynamically Cross-Linked Granular Hydrogels for 3D Printing and Therapeutic Delivery.

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Cyto-Mechanics of Microtubular Buckling and Centering of Centrosome

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GaN and ZnO-Based Sensors for Gas, Nuclear Materials and Chemical Detection

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Nuclear size changes caused by local motion of cell boundaries unfold the nuclear lamina and dilate chromatin and intranuclear bodies.

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A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton

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The Nucleus Bypasses Obstacles by Deforming Like a Drop with Surface Tension Mediated by Lamin A/C.

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Concentration Sensing by the Moving Nucleus in Cell Fate Determination: A Computational Analysis.

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Sarcomere mechanics in capillary endothelial cells.

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The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C

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Gene screen reveals chromatin proteins influence abnormal nuclear morphology associated with breast cancer cell models.

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A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP).

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Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching.

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Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactions.

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Rapid Electrical Detection of Hg(II) Ions with AlGaN/GaN High Electron Mobility Transistors

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Coordinated Dynamics of RNA Splicing Speckles in the Nucleus.

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Real-time Detection of Botulinum Toxin with AlGaN/GaN High Electron Mobility Transistors

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Molecular cancer cell responses to solid compressive stress and interstitial fluid pressure.

# publications[].label
Mechanical principles of nuclear shaping and positioning.

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CYTOSKELETAL PROTEINS AT THE LIPID MEMBRANE

# publications[].label
Stamp wound assay for studying coupled cell migration and cell debris clearance.

# publications[].label
Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblasts propagated on a novel soft substrate

# publications[].label
Low Temperature Hydrothermal Growth of ZnO Nanorods and its Applications

# publications[].label
Repair of nuclear ruptures requires barrier-to-autointegration factor

# publications[].label
Rethinking nuclear shaping: insights from the nuclear drop model.

# publications[].label
Nuclei sense complex tissue shape and direct intestinal stem cell fate.

# publications[].label
Rho activation drives luminal collapse and eversion in epithelial acini

# publications[].label
AlGaN/GaN HEMT And ZnO Nanorod Based Sensors for Chemical and Bio-Applications

# publications[].label
An epigenetic small molecule screen to target abnormal nuclear morphology in human cells.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
Rapid Electrical Detection of Hg(II) Ions with AlGaN/GaN High Electron Mobility Transistors

# publications[].label
Actomyosin tug-of-war advances the nucleus in a migrating tissue cell

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Optimizing COVID-19 testing capabilities and clinical management using pathology informatics.

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The effect of cyclic mechanical strain on activation of dendritic cells cultured on adhesive substrates.

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Introduction to soft matter aspects of cancer.

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Mathematical analysis of physicochemical processes on catalytic surfaces

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A multi-modular tensegrity model of an actin stress fiber.

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Selective detection of Hg (II) ions from Cu(II) and Pb(II) using AlGaN/GaN high electron mobility transistors

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Fast detection of a protozoan pathogen, Perkinsus marinus, using AlGaN/GaN high electron mobility transistors

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Fast Detection of Perkinsus Marinus, a Prevalent Pathogen of Oysters and Clams from Sea Waters

# publications[].label
Ultradonut topology of the nuclear envelope.

# publications[].publisher
Proceedings of the National Academy of Sciences

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Nuclear Morphological Abnormalities in Cancer: A Search for Unifying Mechanisms.

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Emerging Concepts and Tools in Cell Mechanomemory.

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Modulating malignant epithelial tumor cell adhesion, migration and mechanics with nanorod surfaces.

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A Monte-Carlo method for portfolio optimization under partially observed stochastic volatility

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

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Micropost Arrays to Model ECM Fiber Obstacles During Cell Migration in Confinement.

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Biosensors Using Functionalized ZnO and GaN Surfaces

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FRAP analysis: accounting for bleaching during image capture.

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Dynamic Adaptation in Extant Porins Facilitates Antibiotic Tolerance in Energetic Escherichia coli.

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Vertical uniformity of cells and nuclei in epithelial monolayers.

# publications[].label
Sarcomere length fluctuations and flow in capillary endothelial cells.

# publications[].label
c-erbB-2 Sensing Using AlGaN/GaN High Electron Mobility Transistors For Breast Cancer Detection

# publications[].label
Excess surface area of the nuclear lamina enables unhindered cell migration through constrictions.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Barrier to autointegration factor (BAF) regulates the cellular response to nuclear rupture.

# publications[].label
The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity.

# publications[].label
Chapter Eight Cytoskeletal Proteins at the Lipid Membrane

# publications[].label
Effects of dynein on microtubule mechanics and centrosome positioning.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
Nucleocytoplasmic transport rates are regulated by cellular processes that modulate GTP availability.

# publications[].label
S2046 Reducing Tumor Growth On Stents Using Nanorods: Nanotechnology for the Prevention of Cell Adhesion and Migration

# publications[].label
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics.

# publications[].label
Loss of mechanical homeostasis drives epithelial acinar eversion

# publications[].label
Spatio-temporal pattern formation during CO oxidation on Pt(100) at low and intermediate pressures: A comparative study.

# publications[].label
c-erbB-2 Sensing using AlGaN/GaN High Electron Mobility Transistors for Breast Cancer Detection

# publications[].label
Anisotropic random walks reveal chemotaxis signaling output in run-reversing bacteria

# publications[].label
Multi-omics investigation reveals molecular determinants of cancer cell evolution on soft extracellular matrix.

# publications[].label
GaN and ZnO-Based Sensors for Gas, Nuclear Materials and Chemical Detection

# publications[].label
Local nuclear deformation in response to transient tensile stress can cause membrane rupture.

# publications[].label
Insights developed into nuclear mechanics by live cell imaging

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
The nucleus is an intracellular propagator of actomyosin forces in NIH 3T3 fibroblasts.

# publications[].label
AlGaN/GaN HEMT And ZnO nanorod-based sensors for chemical and bio-applications

# publications[].publisher
SPIE, the international society for optics and photonics

# publications[].label
Actomyosin tension exerted on the nucleus through nesprin-1 connections influences endothelial cell adhesion, migration, and cyclic strain-induced reorientation (vol 99, pg 115, 2010)

# publications[].label
Mechanical Characterization of Glandular Acini Using a Micro-indentation Instrument.

# publications[].label
Investigating complexity of protein-protein interactions in focal adhesions.

# publications[].label
Focal Adhesions: Self-Assembling Nanoscale Mechanochemical Machines that Control Cell Function

# publications[].label
c-erbB-2 sensing using AlGaN/GaN high electron mobility transistors for breast cancer detection

# publications[].label
Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts.

# publications[].label
Estrogen-receptor- exchange and chromatin dynamics are ligand- and domain-dependent

# researcherOn[].label
RoL: FELS: EAGER Rules for cellular adaptation to the mechanical properties of their environment

# researcherOn[].awardedBy.label
Directorate for Biological Sciences - (Arlington, Virginia, United States)

# researcherOn[].label
Nuclear Dysfunction in Cancer: The Role of Mechanical Stresses Transmitted by the LINC Complex

# researcherOn[].awardedBy.label
National Cancer Institute - (Rockville, Maryland, United States)

# streetAddress
Department of Biomedical Engineering; Emerging Technologies Building, Room #5062, 101 Bizzell Street,; Texas A&M University

# inTheNews[].label
Biomedical Engineering Researcher Receives $5 Million Grant To Further Cancer Studies

# inTheNews[].label
UChicago Medicine receives $10M to develop a center for cellular therapy

# etdChairOf[].label
Katiyar, Aditya (2022-08). Studying Nuclear Deformation During Migration of Cells through Confining Environments. Doctoral Dissertation.

# etdChairOf[].label
Purkayastha, Purboja (2022-12). Cell and Tissue Adaptation to Mechanical Alterations. Doctoral Dissertation.