# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
Our goal is to understand how microorganisms interact in complex communities. Specifically, we study how small molecules produced in a microbial community affect the growth, development and metabolic output of the organisms. We use a combination of microbiology, genetic, genomic, and biochemical approaches to dissect complex interspecies interactions. Currently, our research focuses on the interactions of the soil bacteria Bacillus subtilis and members of the genus Streptomyces, known for their prolific production of bioactive small molecules and development of aerial structures and spores.

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
2.2 Factors Relating To The Physical Environment

# educationAndTraining[].organization.label
University of Colorado Boulder - (Boulder, Colorado, United States)

# educationAndTraining[].organization.label
Lewis & Clark College - (Portland, Oregon, United States)

# awardsAndHonors[].label
Faculty Early Career Development (CAREER) Program

# publications[].label
Interactions between Streptomyces coelicolor and Bacillus subtilis: Role of surfactants in raising aerial structures.

# publications[].label
Linearmycins Activate a Two-Component Signaling System Involved in Bacterial Competition and Biofilm Morphology.

# publications[].label
Imaging secondary metabolism of Streptomyces sp. Mg1 during cellular lysis and colony degradation of competing Bacillus subtilis.

# publications[].label
Bacterial competition reveals differential regulation of the pks genes by Bacillus subtilis.

# publications[].label
De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using PacBio Single-Molecule Sequencing.

# publications[].label
Simultaneous Two- and Three-Photon Deep Imaging of Autofluorescence in Bacterial Communities.

# publications[].label
Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Mps1 and Ipl1/Aurora B Act Sequentially to Correctly Orient Chromosomes on the Meiotic Spindle of Budding Yeast

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Imaging Mass Spectrometry, Metabolism, and New Views of the Microbial World

# publications[].label
Translating metabolic exchange with imaging mass spectrometry.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display.

# publications[].label
Activity Screening of Carrier Domains within Nonribosomal Peptide Synthetases Using Complex Substrate Mixtures and Large Molecule Mass Spectrometry †

# publications[].label
ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain.

# publications[].label
Chloramphenicol-mobilized Bacillus subtilis transiently expresses resistance to multiple antibiotics, including the glycopeptides phleomycin and bleomycin.

# publications[].label
A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and Bacterial Membrane Physiology.

# publications[].label
Bacterial Communities: Interactions to Scale.

# publications[].label
LoaP is a broadly conserved antiterminator protein that regulates antibiotic gene clusters in Bacillus amyloliquefaciens.

# publications[].label
MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions.

# publications[].label
Facile Detection of Acyl and Peptidyl Intermediates on Thiotemplate Carrier Domains via Phosphopantetheinyl Elimination Reactions during Tandem Mass Spectrometry †

# publications[].label
Enzymatic resistance to the lipopeptide surfactin as identified through imaging mass spectrometry of bacterial competition.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Interspecies Chemical Communication in Bacterial Development

# publications[].label
Bacillaene and sporulation protect Bacillus subtilis from predation by Myxococcus xanthus.

# publications[].label
Escape from Lethal Bacterial Competition through Coupled Activation of Antibiotic Resistance and a Mobilized Subpopulation.

# publications[].label
Antibiotic Stimulation of a Bacillus subtilis Migratory Response.

# publications[].label
A singular enzymatic megacomplex from Bacillus subtilis

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Mps1p regulates meiotic spindle pole body duplication in addition to having novel roles during sporulation.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes.

# publications[].label
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis

# publications[].publisher
Proceedings of the National Academy of Sciences

# researcherOn[].label
CAREER: Essential functions of secondary metabolic networks for bacterial competition

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# streetAddress
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences

# etdChairOf[].label
Gorzelnik, Karl V (2014-05). Competition-Mediated Identification of the First Environmental Protein Responsible for the Degradation of the Lipopeptide Surfactin. Master's Thesis.

# etdChairOf[].label
Stubbendieck, Reed Michael (2017-05). Discovering Linearmycins in Bacterial Competition: Lysis, Autolysis, and Resistance. Doctoral Dissertation.