# overview
My research focuses on the roles of genetic diversity on neurological conditions resulting from environmental agents, such as viral infections. We use Theiler's Murine Encephalomyelitis virus (TMEV), a neurotropic virus affecting mice, and the genetically diverse Collaborative Cross mouse resource, to study the mechanisms underlying neuropathological outcomes to infection.

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1.1 Normal Biological Development And Functioning

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30 Agricultural, Veterinary And Food Sciences

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Theiler's Murine Encephalomyelitis Virus, (tmev)

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Golden Retriever Muscular Dystrophy (grmd)

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C57BL/6J mice exposed to perfluorooctanoic acid demonstrate altered immune responses and increased seizures after Theiler's murine encephalomyelitis virus infection.

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Additive, epistatic, and environmental effects through the lens of expression variability QTL in a twin cohort.

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A 1.3-Mb interval map of equine homologs of HSA2.

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Comparative Genomics of X-linked Muscular Dystrophies: The Golden Retriever Model.

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Unexpected Structural Features of the Equine Major Histocompatibility Complex

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The genome sequence of taurine cattle: a window to ruminant biology and evolution.

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American Association for the Advancement of Science (AAAS)

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Baseline Gait and Motor Function Predict Long-Term Severity of Neurological Outcomes of Viral Infection.

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RNA-seq of serial kidney biopsies obtained during progression of chronic kidney disease from dogs with X-linked hereditary nephropathy.

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Consequences of perinatal bisphenol A exposure in a mouse model of multiple sclerosis.

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A high-resolution physical map of equine homologs of HSA19 shows divergent evolution compared with other mammals.

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Genome-wide association study to identify potential genetic modifiers in a canine model for Duchenne muscular dystrophy.

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Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background.

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Genetic and immunological contributors to virus-induced paralysis.

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Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures.

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GRMD cardiac and skeletal muscle metabolism gene profiles are distinct.

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A BAC contig map over the proximal approximately 3.3 Mb region of horse chromosome 21.

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A conserved segmental duplication within ELA.

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Translating golden retriever muscular dystrophy microarray findings to novel biomarkers for cardiac/skeletal muscle function in Duchenne muscular dystrophy.

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Expression profiling of disease progression in canine model of Duchenne muscular dystrophy.

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Resilience in Long-Term Viral Infection: Genetic Determinants and Interactions.

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Microsatellite variation in the equine MHC.

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A high resolution RH map of the bovine major histocompatibility complex.

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Population-level expression variability of mitochondrial DNA-encoded genes in humans.

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Antecedent presentation of neurological phenotypes in the Collaborative Cross reveals four classes with complex sex-dependencies.

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Exceptional conservation of horse-human gene order on X chromosome revealed by high-resolution radiation hybrid mapping.

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Proceedings of the National Academy of Sciences

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Pharmacologic management of Duchenne muscular dystrophy: target identification and preclinical trials.

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Host genetic background influences diverse neurological responses to viral infection in mice.

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A 4,103 marker integrated physical and comparative map of the horse genome.

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Aging Shapes the Population-Mean and -Dispersion of Gene Expression in Human Brains.

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Host genetic diversity drives variable central nervous system lesion distribution in chronic phase of Theiler's Murine Encephalomyelitis Virus (TMEV) infection.

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Genetic risk factors for insidious equine recurrent uveitis in Appaloosa horses.

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Host Genetic Determinants of Diversity in Viral-Induced Neuropathology

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of Neurological Disorders and Stroke

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Regulatory Science in Environmental Health and Toxicology

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National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

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DHHS-NIH-National Institute of Environmental Health Sciences

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TEX-VAL: Texas A&M Tissue Chip Validation Consortium

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National Institutes of Health - (Bethesda, Maryland, United States)

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Comprehensive Tools and Models for Addressing Exposure to Mixtures During Environmental Emergency-Related Contamination Events

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National Institute of Environmental Health Sciences - (Durham, North Carolina, United States)

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DHHS-NIH-National Institute of Environmental Health Sciences

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IMSD at Texas A&M University:  Initiative for Maximizing Student Diversity in Biomedical Sciences

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of General Medical Science

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Texas A&M University School of Public Health; Environmental and Occupational Health; 1266 TAMU