# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# overview
My research program integrates digital pathology, gastrointestinal (GI) pathology, and experimental pathology using animal models to advance scientific understanding of disease mechanisms and improve diagnostic and translational research outcomes. As an experimental pathologist, I bridge basic science and clinical medicine by applying quantitative tissue analysis, rigorous histopathology, and advanced imaging technologies to investigate inflammatory, infectious, and neoplastic diseases--particularly those affecting the GI tract, but I am experienced in multiple tissues in many animal models. These three focus areas reinforce each other: digital pathology provides analytical precision, GI pathology offers a biologically rich and clinically relevant system, and animal models serve as essential platforms for mechanistic discovery and therapeutic evaluation.

# keywords[]
Platelet Endothelial Cell Adhesion Molecule-1

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Receptors, Tumor Necrosis Factor, Type I

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Hypoxia-inducible Factor 1, Alpha Subunit

# keywords[]
Fusion Regulatory Protein 1, Light Chains

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
American College of Veterinary Pathologists - (Madison, Wisconsin, United States)

# educationAndTraining[].organization.label
American College of Veterinary Pathologists - (Madison, Wisconsin, United States)

# educationAndTraining[].organization.label
Talladega College - (Talladega, Alabama, United States)

# educationAndTraining[].organization.label
Michigan State University - (East Lansing, Michigan, United States)

# educationAndTraining[].organization.label
Tuskegee University - (Tuskegee, Alabama, United States)

# awardsAndHonors[].label
1,000 Inspiring Black Scientists in America

# publications[].label
Combining vitamin E metabolite 13'-carboxychromanol and a lactic acid bacterium synergistically mitigates colitis and colitis-associated dysbiosis in mice.

# publications[].label
Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography.

# publications[].label
Tissue expression of steroid hormone receptors is associated with differential immune responsiveness.

# publications[].label
Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling.

# publications[].label
Innate immune response modulators control inflammation and improve survival in viral encephalitis

# publications[].label
Role of Myd88-mediated signaling in the prevention of colon adenocarcinomas

# publications[].label
Implementing Digital Pathology into Veterinary Academics and Research.

# publications[].label
Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi.

# publications[].label
Changes in fatty acid profile indicate a chemo-preventive response to navy bean extract in an inflammation-associated colorectal cancer mouse model

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Vitamin E delta-tocotrienol and metabolite 13'-carboxychromanol inhibit colitis-associated colon tumorigenesis and modulate gut microbiota in mice.

# publications[].label
Hypoxia-inducible-factors differentially contribute to clinical disease and viral replication during RSV infection.

# publications[].label
Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases.

# publications[].label
Viral Clearance and Neuroinflammation in Acute TMEV Infection Vary by Host Genetic Background.

# publications[].label
Induction of acute graft vs. host disease in lymphopenic mice.

# publications[].label
Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota.

# publications[].label
Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung disease: an association study.

# publications[].label
Plasmid Acquisition Alters Vancomycin Susceptibility in Clostridioides difficile.

# publications[].label
Association between hTERT rs2736100 polymorphism and sensitivity to anti-cancer agents.

# publications[].label
Pro-Inflammatory and Anti-Inflammatory Cytokine Expression in Tnf-/- and WT Mice with Chronic Colitis

# publications[].label
Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity.

# publications[].label
Correction: Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease.

# publications[].label
Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease.

# publications[].label
Prevalence of Neospora caninum Exposure in Wild Pigs (Sus scrofa) from Oklahoma with Implications of Testing Method on Detection.

# publications[].label
Peliod hepatocellular carcinoma in a domesticated ferret (Mustela putorius furo).

# publications[].label
Delta-tocotrienol 13-Carboxychromanol, a Vitamin E Metabolite, Interacts With Gut Microbes As Indicated by Its Anti-colitis Synergy With a Lactic Acid Bacterium in Mice

# publications[].label
Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study.

# publications[].label
Combining gamma-tocopherol and aspirin synergistically suppresses colitis-associated colon tumorigenesis and modulates the gut microbiota in mice, and inhibits the growth of human colon cancer cells.

# publications[].label
Micro-CT Features of Lung Consolidation, Collagen Deposition and Inflammation in Experimental RSV Infection Are Aggravated in the Absence of Nrf2.

# publications[].label
Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis.

# publications[].label
Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors.

# publications[].label
The effect of TNF on the colonic microbiome and acute colitis

# publications[].label
P13-045-23 Combining Gamma-Tocopherol (T) and Aspirin Synergistically Suppresses Colitis-Associated Colon Tumorigenesis and Modulates Gut Microbiota in Mice

# publications[].label
Folic Acid-Conjugated Radioluminescent Calcium Tungstate Nanoparticles as Radio-Sensitizers for Cancer Radiotherapy.

# publications[].label
Deletion of P2Y2 receptor reveals a role for lymphotoxin- in fatty streak formation.

# publications[].label
Citrulline and ADI-PEG20 reduce inflammation in a juvenile porcine model of acute endotoxemia.

# publications[].label
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.

# publications[].label
Concurrent bullous emphysema, bronchointerstitial pneumonia with necrosis, and tension pneumothorax in an 8-week-old puppy.

# publications[].label
Articular gout and suspected pseudogout in a Basilisk lizard (Basilicus plumifrons).

# publications[].publisher
American Association of Zoo Veterinarians

# publications[].label
Supplementation of polyphenol-rich grapes attenuates colitis, colitis-associated colon cancer, and disease-associated dysbiosis in mice, but fails to mitigate colitis in antibiotic-treated mice.

# publications[].label
Computed tomographic features of confirmed gallbladder pathology in 34 dogs.

# publications[].label
Digital pathology in academia: Implementation and impact.

# publications[].label
Time Release Ion Matrix Regenerates Dystrophic Skeletal Muscle.

# publications[].label
Subclinical ketosis in postpartum dairy cows alters the adipose tissue immunological profile in a depot-specific manner.

# publications[].label
Nested PCR Detection of Pythium sp. from Formalin-Fixed, Paraffin-Embedded Canine Tissue Sections.

# publications[].label
Gamma-tocopherol but not mixed tocopherols attenuates moderate colon inflammation and inflammation-promoted colon tumorigenesis in mice

# publications[].label
LILRB4 regulates circadian disruption-induced mammary tumorigenesis via non-canonical WNT signaling pathway.

# publications[].label
Interleukin-1 Role in Human Th17 Responses, Dendritic Cell Activation, and Epithelial Cell Transformation

# publications[].label
Engineering Abaloparatide to Accumulate Locally in Fracture Calluses Following Systemic Administration

# publications[].label
Micro-Ct Features of Lung Consolidation, Collagen Deposition and Inflammation in Experimental RSV Infection Are Aggravated in the Absence of Nrf2

# publications[].label
Feasibility of a mini-pig model of radiation-induced brain injury to one cerebral hemisphere.

# publications[].label
Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice.

# publications[].label
Association between MUC5B and TERT polymorphisms and different interstitial lung disease phenotypes.

# publications[].label
Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and -catenin.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Role of Hypoxia-Inducible Factors in Respiratory Syncytial Virus Infection-Associated Lung Disease.

# publications[].label
In Vivo Evaluation of Biodegradability and Biocompatibility of Fe30Mn Alloy.

# publications[].label
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN- production by repressing -catenin activation in dendritic cells.

# publications[].label
Parental Alcohol Use Disrupts Offspring Mitochondrial Activity, Promoting Susceptibility to Toxicant-Induced Liver Cancer.

# publications[].label
Healing efficacy of fracture-targeted GSK3 inhibitor-loaded micelles for improved fracture repair.

# publications[].label
The Intersection of TNF, IBD and the Microbiome.

# publications[].label
Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease.

# publications[].label
An engineered dual function peptide to repair fractured bones.

# publications[].label
Soft, stretchable conductive hydrogels for high-performance electronic implants.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Chemopreventive Effects of Delta-tocotrienol (TE) in a Mouse Model Bearing Key Genetic Mutations Resembling Sporadic Colorectal Cancer

# publications[].label
Comparative pathobiology of low and high pathogenicity H7N3 Chilean avian influenza viruses in chickens.

# publications[].publisher
American Association of Avian Pathologists (AAAP)

# publications[].label
Respiratory Distress in Hypophosphatasia: The Case for Defects in Lung and Diaphragm in HPP Sheep

# publications[].label
Vitamin E alpha- and gamma-tocopherol mitigate colitis, protect intestinal barrier function and modulate the gut microbiota in mice.

# publications[].label
A zero-inflated non-negative matrix factorization for the deconvolution of mixed signals of biological data.

# publications[].label
Influence of Housing Temperature and Genetic Diversity on Allogeneic T Cell-Induced Tissue Damage in Mice.

# publications[].label
Gamma-tocopherol attenuates moderate but not severe colitis and suppresses moderate colitis-promoted colon tumorigenesis in mice.

# publications[].label
TNF Modulates The Gut Microbiota And Drives Inflammation

# publications[].label
SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection.

# publications[].label
Age, sex, and TNF associated differences in the gut microbiota of mice and their impact on acute TNBS colitis.

# publications[].label
Engineering Abaloparatide to Accumulate Locally in Fracture Calluses Following Systemic Administration

# publications[].label
Antibiotic administration exacerbates acute graft vs. host disease-induced bone marrow and spleen damage in lymphopenic mice.

# publications[].label
Evaluation of 25% Poloxamer As a Slow Release Carrier for Morphine in a Rat Model.

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Extracellular Vesicles Derived from Mesenchymal Stem Cells as a Medical Countermeasure against Ocular Injuries Induced by Mustard Agents

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Regulation of RNA degradation and translation, and viral infection by vaccinia virus decapping enzyme D10

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Self-wrapping, MRI-compatible nerve cuffs for stable neural stimulation and recording

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Research Development Fund –Recurring Funds Grant

# researcherOn[].awardedBy.label
Texas A&M University - (College Station, Texas, United States)

# researcherOn[].label
Molecular Factors Contributing to Carcinogenesis by Low-Dose Arsenic

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# inTheNews[].label
100 inspiring Black scientists in America

# inTheNews[].label
9 Current And Former Texas A&M University System Faculty Members Earn Spots On Black Scientists List

# inTheNews[].label
Texas A&M Researcher Named To National List Of Inspiring Black Scientists

# inTheNews[].label
Committee Announced to Find Next President of Texas A&M

# inTheNews[].label
CVM Researcher Recognized on National List of Inspiring Black Scientists

# inTheNews[].label
A Sweet Solution for Safer Diagnosis and Treatment

# inTheNews[].label
CVMBS Veterinary Pathologist Promotes Diversity, Inclusion Within Veterinary Medicine

# inTheNews[].label
Highlight: Digital Pathology In Veterinary Academics