# overview
The Raghavan lab utilizes biomaterials and regenerative engineering strategies to create engineered microenvironments - these engineered niches allow the study of cancer stem cell, neural cell and immune interactions as it pertains to cancer metastasis and inflammation.

# keywords[]
12 Responsible Consumption And Production

# keywords[]
Carcinoma Associated Mesenchymal Stem Cells (ca-msc)

# keywords[]
12 Responsible Consumption And Production

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
12 Responsible Consumption And Production

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Anna University, Chennai - (Chennai, Tamil Nadu, India)

# educationAndTraining[].field
Instrumentation and Control Systems Engineering

# educationAndTraining[].organization.label
University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States)

# educationAndTraining[].field
High-Impact Principles and Practices for STEM Education

# educationAndTraining[].organization.label
University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States)

# educationAndTraining[].organization.label
Virginia Tech - Wake Forest University - (Blacksburg, Virginia, United States)

# awardsAndHonors[].label
Cells, Tissues, Organs - Young Investigator Award

# publications[].label
Neuronal Progenitor Cells Undergo Oxidant Injury Following Cryopreservation

# publications[].label
Rapid Prototypable Biomimetic Peristalsis Bioreactor Capable of Concurrent Shear and Multi-Axial Strain.

# publications[].label
Restoration of Adult-Like Colonic Motility in Aged Transgenic Mice Expressing Phosphomimic HSP27

# publications[].label
S1797 Co-Culture of Enteric Neuronal Cells with Bioengineered Three-Dimensional Colonic Circular Smooth Muscle Constructs

# publications[].tags
12 Responsible Consumption and Production

# publications[].label
The appendix as a viable source of neural progenitor cells to functionally innervate bioengineered gastrointestinal smooth muscle tissues.

# publications[].label
Carcinoma-Associated Mesenchymal Stem Cells Promote Chemoresistance in Ovarian Cancer Stem Cells via PDGF Signaling.

# publications[].label
Su1874 Tubular Esophageal Tissue Construct Bioengineered From Isolated Esophageal Circular Smooth Muscle Cells

# publications[].tags
12 Responsible Consumption and Production

# publications[].label
IAS Smooth Muscle Cells Direct the Differentiation of Neuronal Progenitor Cells Into Mature Neurons

# publications[].label
HSP27 Mediated Maintenance of Neural Integrity in Aged Transgenic Mice Expressing Phosphomimic HSP27

# publications[].label
Self-Renewal and CSCs In Vitro Enrichment: Growth as Floating Spheres.

# publications[].label
Rapid generation of multiplexed cell cocultures using acoustic droplet ejection followed by aqueous two-phase exclusion patterning.

# publications[].label
Sa2055 Neuronal Progenitor Cells Undergo Oxidant Injury Following Cryopreservation

# publications[].label
Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells.

# publications[].label
Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering.

# publications[].label
Mo1826 FISH Oil Aids in Treatment of Colonic Dysmotility in Mice With DSS-Induced Colitis

# publications[].label
Immuno-modulation of macrophages by ovarian cancer stem cells in an in vitro 3D spheroid platform

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
TISSUE-ENGINEERED INTESTINES CAN NEO-INNERVATE EXPERIMENTALLY DENERVATED INTESTINES WITH FUNCTIONAL NITRERGIC NEURONS

# publications[].label
660 Successful Implantation of Physiologically Functional Bioengineered Mouse Internal Anal Sphincter

# publications[].label
Bioengineering of physiologically functional intrinsically innervated human internal anal sphincter constructs.

# publications[].label
Longitudinal Muscle Physiological Specificity Correlates With the Differences in Expression and Phosphorylation of Contractile Proteins

# publications[].label
Abstract A33: Patient-specific evaluation of chemoresistance and tumor recurrence using ovarian cancer stem cell spheroids

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
How inclusive are cell lines in preclinical engineered cancer models?

# publications[].label
Successful Implantation of Physiologically Functional Bioengineered Mouse Internal Anal Sphincter

# publications[].label
Tissue engineering of the gastrointestinal tract: the historic path to translation.

# publications[].label
Near Infrared Labeling and Detection of Enteric Nerves: Tracking of Differentiating Neural Progenitor Cells and Tissue Innervation

# publications[].label
Chapter 35 Advances in Neo-Innervation of the Gut

# publications[].label
Su2060 HSP27 Mediated Maintenance of Neural Integrity in Aged Transgenic Mice Expressing Phosphomimic HSP27

# publications[].label
Manufacturing a Gastrointestinal Hollow Organ Using Novel Biodegradable Chitosan Scaffold With Physiologically Functional Circular Smooth Muscle Layer

# publications[].tags
12 Responsible Consumption and Production

# publications[].label
Tubular Esophageal Tissue Construct Bioengineered From Isolated Esophageal Circular Smooth Muscle Cells

# publications[].label
In Situ Implantation Preserves Myogenic and Neuronal Characteristics of Intrinsically Innervated Bioengineered Human Internal Anal Sphincter (IAS)

# publications[].label
The Intersection of Biomaterials, Tissue Engineering and Immuno-Oncology

# publications[].label
Dissecting Transcriptomic Heterogeneity in Patient-Derived Pancreatic Ductal Adenocarcinoma With Single-Nucleus RNA-seq

# publications[].label
114  Tissue-Engineered Intestines Can Neo-Innervate Experimentally Denervated Intestines with Functional Nitrergic Neurons

# publications[].label
Integrated cancer tissue engineering models for precision medicine.

# publications[].label
Decellularized organ biomatrices facilitate quantifiable in vitro 3D cancer metastasis models.

# publications[].label
Su2010 Near Infrared Labeling and Detection of Enteric Nerves: Tracking of Differentiating Neural Progenitor Cells and Tissue Innervation

# publications[].label
S2071 Phosphorylated Heat Shock Protein 20 (HSP20) Inhibits PKC and Non-PKC Mediated Force Generation in Bioengineered Colonic Circular Smooth Muscle Constructs

# publications[].label
In vivo growth of a bioengineered internal anal sphincter: comparison of growth factors for optimization of growth and survival.

# publications[].label
Printing of small molecular medicines from the vapor phase.

# publications[].label
A Bioengineered Segment of Colonic Smooth Muscle Tissue Demonstrates the Capabilities of Expansion and Decompression Similar to Native Tissue

# publications[].label
M2032 Longitudinal Muscle Physiological Specificity Correlates With the Differences in Expression and Phosphorylation of Contractile Proteins

# publications[].label
Contraction of Colonic Longitudinal Smooth Muscle is Dependent on PKC-Mediated Phosphorylation of Tropomyosin

# publications[].label
Comparison of Angiogenic Growth Factors to Optimize Physiological Function of Implanted Tissue Engineered Internal Anal Sphincter (IAS)

# publications[].label
171 Physiology of Intrinsically Innervated Bioengineered Construct From Human Internal Anal Sphincter Smooth Muscle Cells

# publications[].label
The influence of extracellular matrix composition on the differentiation of neuronal subtypes in tissue engineered innervated intestinal smooth muscle sheets.

# publications[].label
Co-Culture of Enteric Neuronal Cells with Bioengineered Three-Dimensional Colonic Circular Smooth Muscle Constructs

# publications[].label
S1241 Development of a Three-Dimensional Physiological Model of Colonic Longitudinal Smooth Muscle In Vitro Lined Up in Longitudinal Axis

# publications[].label
FISH Oil Aids in Treatment of Colonic Dysmotility in Mice With DSS- Induced Colitis

# publications[].label
Stem cell therapy for GI neuromuscular disorders.

# publications[].label
Restoration of Adult-Like Colonic Motility in Aged Transgenic Mice Expressing Phosphomimic HSP27

# publications[].label
Chapter 13 The Intersection of Biomaterials, Tissue Engineering, and Immuno-oncology

# publications[].label
Bioengineered three-dimensional physiological model of colonic longitudinal smooth muscle in vitro.

# publications[].label
Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance

# publications[].label
Neo-Innervation of a Bioengineered Smooth Muscle Construct by an Intrinsically Innervated Construct Located on the Same Scaffold

# publications[].label
264 Extracellular Matrix Directs Differentiation of Motor Neuronal Subtypes in Tissue Engineered Innervated Intestinal Smooth Muscle

# publications[].label
166 Successful Implantation of Intrinsically Innervated Physiologically Functional Bioengineered Human Internal Anal Sphincter (IAS)

# publications[].label
Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells

# publications[].label
Breast cancer cells exhibit enhanced proliferation, invasion, PLAU expression and chemoresistance when exposed to fluid shear stress in an innovative 3D bioreactor

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Inclusive Engagement in an Undergraduate Core Biomaterials Course for Enhanced Reflective Learning.

# publications[].label
Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells.

# publications[].label
Macrophage Checkpoint Nanoimmunotherapy Has the Potential to Reduce Malignant Progression in Bioengineered In Vitro Models of Ovarian Cancer.

# publications[].label
Phosphorylated Heat Shock Protein 20 (HSP20) Inhibits PKC and Non-PKC Mediated Force Generation in Bioengineered Colonic Circular Smooth Muscle Constructs

# publications[].label
Acute Exposure to Pyridostigmine Bromide Disrupts Cholinergic Myenteric Neuroimmune Function in Mice.

# publications[].label
601 The Appendix As a Viable Source of Neural Progenitor Cells to Functionally Innervate Bioengineered Gastrointestinal Smooth Muscle Tissues

# publications[].label
IMAGE AND VIDEO ACQUISITION AND PROCESSING FOR CLINICAL APPLICATIONS.

# publications[].label
Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays for preclinical drug sensitivity assays.

# publications[].label
Protection by therapeutic oral vaccination with inactivated bacteria in a mouse model Helicobacter pylori infection.

# publications[].label
In Situ Implantation of Autologous Biosphincter (TM) Re-Instates Continence in a Large Animal Model of Passive Fecal Incontinence

# publications[].label
Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis.

# publications[].label
Surgical implantation of a bioengineered internal anal sphincter.

# publications[].label
Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut.

# publications[].label
In Situ Implantation Preserves Myogenic and Neuronal Characteristics of Intrinsically Innervated Bioengineered Human Internal Anal Sphincter (IAS)

# publications[].label
Modulation of Adult Enteric Neuroglial Differentiation by Varying Extracellular Matrix Composition

# publications[].label
Tu1368 A Bioengineered Segment of Colonic Smooth Muscle Tissue Demonstrates the Capabilities of Expansion and Decompression Similar to Native Tissue

# publications[].label
Comparison of Angiogenic Growth Factors to Optimize Physiological Function of Implanted Tissue Engineered Internal Anal Sphincter (IAS)

# publications[].label
Design and Implementation of Privilege for Sale, a JEDI Activity for a Biomedical Engineering Introductory Course

# publications[].label
Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness

# publications[].label
Abstract A52: Serially passaging ovarian cancer spheroids as an in situ model for emergence of chemoresistance and enrichment of cancer stem cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Bioengineering and regeneration of gastrointestinal tissue: where are we now and what comes next?

# publications[].label
Liquid crystal elastomer based dynamic device for urethral support: Potential treatment for stress urinary incontinence.

# publications[].label
72 In Situ Implanted Bioengineered Human Internal Anal Sphincter Innervated With Human Enteric Neuronal Progenitor Cells Maintain Myogenic and Neurogenic Physiological Functionality

# publications[].label
Expansion of Circulating Tumor Cells from Patients with Locally Advanced Pancreatic Cancer Enable Patient Derived Xenografts and Functional Studies for Personalized Medicine.

# publications[].label
Advances in cancer mechanobiology: Metastasis, mechanics, and materials.

# publications[].label
Successful implantation of physiologically functional bioengineered mouse internal anal sphincter.

# publications[].label
785 IAS Smooth Muscle Cells Direct the Differentiation of Neuronal Progenitor Cells Into Mature Neurons

# publications[].label
Macrophage activation in response to shape memory polymer foam-coated aneurysm occlusion devices.

# publications[].label
Personalized Medicine-Based Approach to Model Patterns of Chemoresistance and Tumor Recurrence Using Ovarian Cancer Stem Cell Spheroids.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
600 In Situ Implantation of Autologous Biosphincter Re-Instates Continence in a Large Animal Model of Passive Fecal Incontinence

# publications[].label
Tissue engineering in the gut: developments in neuromusculature.

# publications[].label
576 Contraction of Colonic Longitudinal Smooth Muscle is Dependent on PKC-Mediated Phosphorylation of Tropomyosin

# publications[].label
Successful Implantation of Intrinsically Innervated Physiologically Functional Bioengineered Human Internal Anal Sphincter (IAS)

# publications[].label
Degrees of macrophage-facilitated healing in aneurysm occlusion devices.

# publications[].label
Development of a Three-Dimensional Physiological Model of Colonic Longitudinal Smooth Muscle In Vitro Lined Up in Longitudinal Axis

# publications[].label
Chapter 34 Intestinal Regeneration The Bioengineering Approach

# publications[].label
The Future of ctDNA-Defined Minimal Residual Disease: Personalizing Adjuvant Therapy in Colorectal Cancer.

# publications[].label
Extracellular Matrix Directs Differentiation of Motor Neuronal Subtypes in Tissue Engineered Innervated Intestinal Smooth Muscle

# publications[].label
Sa2054 Modulation of Adult Enteric Neuroglial Differentiation by Varying Extracellular Matrix Composition

# publications[].label
Abstract AP22: CHEMORESISTANCE, TUMOR INITIATION AND TUMOR REEMERGENCE TRENDS IN MALIGNANT ASCITESDERIVED OVARIAN CANCER STEM CELL SPHEROIDS

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments.

# publications[].label
Neuroglial differentiation of adult enteric neuronal progenitor cells as a function of extracellular matrix composition.

# publications[].label
Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Chapter 17 Cellular Physiology of Gastrointestinal Smooth Muscle

# publications[].label
In Situ Implanted Bioengineered Human Internal Anal Sphincter Innervated With Human Enteric Neuronal Progenitor Cells Maintain Myogenic and Neurogenic Physiological Functionality

# publications[].label
The Proteolytic Landscape of Ovarian Cancer: Applications in Nanomedicine.

# publications[].label
Neo-innervation of a bioengineered intestinal smooth muscle construct around chitosan scaffold.

# publications[].label
Physiology of Intrinsically Innervated Bioengineered Construct From Human Internal Anal Sphincter Smooth Muscle Cells

# publications[].label
Upregulation of COX-2 in MCF7 Breast Cancer Cells When Exposed to Shear Stress

# publications[].label
Enteric neural differentiation in innervated, physiologically functional, smooth muscle constructs is modulated by bone morphogenic protein 2 secreted by sphincteric smooth muscle cells.

# publications[].label
The Appendix As a Viable Source of Neural Progenitor Cells to Functionally Innervate Bioengineered Gastrointestinal Smooth Muscle Tissues

# publications[].label
857 Neo-Innervation of a Bioengineered Smooth Muscle Construct by an Intrinsically Innervated Construct Located on the Same Scaffold

# publications[].label
Successful implantation of bioengineered, intrinsically innervated, human internal anal sphincter.

# publications[].label
Comparative analysis of tumor spheroid generation techniques for differential in vitro drug toxicity.

# researcherOn[].label
Nano-immunotherapy targeting macrophages to arrest liver metastasis in ovarian cancer

# researcherOn[].awardedBy.label
Houston Methodist - (Houston, Texas, United States)

# researcherOn[].label
Bioengineered intestines can evaluate neuro-immune pathobiology of Gulf War Illness-related gastrointestinal dysfunction

# researcherOn[].awardedBy.label
Congressionally Directed Medical Research Programs - (Frederick, Maryland, United States)

# researcherOn[].label
Engineered enteric nerve plexi to improve predictive preclinical screens in early-stage colorectal adenocarcinomas

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Microphysiological Leads Optimization and Toxicity Screening facility

# researcherOn[].awardedBy.label
Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States)

# researcherOn[].label
Longitudinal macrophage immunomodulation in 3D tumor organoids for immunotherapy screening

# researcherOn[].awardedBy.label
Texas A&M University - (College Station, Texas, United States)

# streetAddress
3120 TAMU; 5016 Emerging Technologies Building; 

# inTheNews[].label
Texas A&M researchers using bioengineering of gut tissue to find answers to Gulf War Illness

# inTheNews[].label
A&M researchers work tirelessly to cure Gulf War Illness, help our Veterans

# inTheNews[].label
Innovations in gut research could help veterans with Gulf War Illness