# preferredTitle
R.L. Bricker Professor in Cancer Immunology

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
T cell biology

T cell-based immunotherapy

Cell metabolism

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Hypoxia-Inducible Factor 1, Alpha Subunit

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Human

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Non-human

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
Gag Gene Products, Human Immunodeficiency Virus

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Stem Cell Research - Nonembryonic - Human

# keywords[]
Tumor Necrosis Factor Receptor Superfamily, Member 7

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Non-human

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Human

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Tumor Necrosis Factor Ligand Superfamily Member 14

# keywords[]
Receptors, Tumor Necrosis Factor, Member 14

# keywords[]
Tumor Necrosis Factor Receptor Superfamily, Member 7

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Human

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Human

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell

# keywords[]
Stem Cell Research - Nonembryonic - Non-human

# keywords[]
Stem Cell Research - Induced Pluripotent Stem Cell - Human

# keywords[]
Stem Cell Research - Nonembryonic - Human

# educationAndTraining[].organization.label
La Jolla Institute For Allergy & Immunology - (San Diego, California, United States)

# educationAndTraining[].organization.label
Third Military Medical University - (Chongqing, China)

# publications[].label
In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
mRNA Vaccines: The Dawn of a New Era of Cancer Immunotherapy.

# publications[].label
Regulation of c-Myc/survivin from notch signaling modulates T cell differentiation (HEM2P.250)

# publications[].label
Directed Differentiation of Induced Pluripotent Stem Cells towards T Lymphocytes

# publications[].label
Comparative effects of pulsatile and nonpulsatile flow on plasma fibrinolytic balance in pediatric patients undergoing cardiopulmonary bypass.

# publications[].label
Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase.

# publications[].label
Brucella activates the host RIDD pathway to subvert BLOS1-directed immune defense.

# publications[].label
A metabolically engineered bacterium controls autoimmunity and inflammation by remodeling the pro-inflammatory microenvironment.

# publications[].label
TGF--Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism.

# publications[].label
Current advances and outlooks in immunotherapy for pancreatic ductal adenocarcinoma.

# publications[].label
Impact of Pulsatile Flow on Vital Organ Recovery During Cardiopulmonary Bypass in Neonates and Infants.

# publications[].label
Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis.

# publications[].label
Erratum to: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development

# publications[].label
Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents.

# publications[].label
Identification of elongation factor2 as a novel regulator of mitochondrial fission

# publications[].label
Erratum: Corrigendum: The costimulation-regulated duration of PKB activation controls T cell longevity

# publications[].label
Intracellular signals of T cell costimulation.

# publications[].label
ILC3 cells promote the proliferation and invasion of pancreatic cancer cells through IL-22/AKT signaling.

# publications[].label
The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.

# publications[].label
In Vitro Differentiation of T Cells from Murine Pluripotent Stem Cells.

# publications[].label
In vivo programming tumor Ag-specific CTL

# publications[].label
Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion.

# publications[].label
Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
NAC1 confines virus-specific memory formation of CD4+ T cells through the ROCK1-mediated pathway.

# publications[].label
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice.

# publications[].label
Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells.

# publications[].label
Regulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity.

# publications[].label
A metabolically engineered bacterial vaccine protects against arthritis in mice

# publications[].label
Engineering live attenuated vaccines: Old dogs learning new tricks.

# publications[].label
Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1 axis.

# publications[].label
Programming of induced pluripotent stem cells into regulatory T cell for arthritis prevention (107.6)

# publications[].label
Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival.

# publications[].label
Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells.

# publications[].label
The serine-threonine kinase inositol-requiring enzyme 1 (IRE1) promotes IL-4 production in T helper cells.

# publications[].label
Melanoma Immunotherapy in Mice Using Genetically Engineered Pluripotent Stem Cells.

# publications[].label
Bacterial Therapeutics: Addressing the Affordability Gap in Cancer Therapy.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HIV Replication and PD-1 Expression on CD4+ T Cells.

# publications[].label
Laboratory Evaluation of Hemolysis and Systemic Inflammatory Response in Neonatal Nonpulsatile and Pulsatile Extracorporeal Life Support Systems.

# publications[].label
Directed differentiation of induced pluripotent stem cells towards T lymphocytes.

# publications[].label
Stem Cell-Based Cellular Therapy in Rheumatoid Arthritis

# publications[].label
NAC1 modulates autoimmunity by suppressing regulatory T cell-mediated tolerance.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
NAC1 promotes stemness and regulates myeloid-derived cell status in triple-negative breast cancer.

# publications[].label
Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity.

# publications[].label
HVEM regulates effector versus memory cell fate decisions following respiratory poxvirus infection

# publications[].label
A metabolically engineered bacterium controls autoimmunity by remodeling the pro-inflammatory microenvironment

# publications[].label
Expression of NAC1 Restrains the Memory Formation of CD8+ T Cells during Viral Infection.

# publications[].label
OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation.

# publications[].label
Utilizing regulatory T cells against rheumatoid arthritis.

# publications[].label
Hepatitis B Virus Immunopathology, Model Systems, and Current Therapies.

# publications[].label
Identification of Elongation Factor-2 as a Novel Regulator of Mitochondrial Fission

# publications[].label
An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells.

# publications[].label
Heat Shock Proteins in Cancer Immunotherapy.

# publications[].label
Innate Lymphoid Cells: A Promising New Regulator in Fibrotic Diseases.

# publications[].label
Metabolic Reprogramming and Reactive Oxygen Species in T Cell Immunity.

# publications[].label
The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice.

# publications[].label
The costimulation-regulated duration of PKB activation controls T cell longevity.

# publications[].label
C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection.

# publications[].label
Generation of Tumor Antigen-Specific Cytotoxic T Lymphocytes from Pluripotent Stem Cells.

# publications[].label
Harnessing Bacterial Agents to Modulate the Tumor Microenvironment and Enhance Cancer Immunotherapy.

# publications[].label
Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells.

# publications[].label
eEF2K promotes PD-L1 stabilization through inactivating GSK3 in melanoma.

# publications[].label
T lineage differentiation from induced pluripotent stem cells.

# publications[].label
Development of Auto Antigen-specific Regulatory T Cells for Diabetes Immunotherapy.

# publications[].label
Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression.

# publications[].label
Metabolic Fitness of NAC1-Deficient Regulatory T Cells in the Tumor Microenvironment Fuels Tumor Growth.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Protective Cancer Vaccine Using Genetically Modified Hematopoietic Stem Cells.

# publications[].label
SET domain containing 1B gene is mutated in primary hepatic neuroendocrine tumors.

# publications[].label
FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development.

# publications[].label
Correction: Nac1 promotes stemness and regulates myeloidderived cell status in triplenegative breast cancer.

# publications[].label
[A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii].

# publications[].label
Activation of NFkB1 by OX40 contributes to antigendriven T cell expansion and survival

# publications[].label
Co-Targeting Nucleus Accumbens Associate 1 and NF-B Signaling Synergistically Inhibits Melanoma Growth.

# publications[].label
Hepatitis B virus X protein-induced aberrant epigenetic modifications contributing to human hepatocellular carcinoma pathogenesis.

# publications[].label
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity.

# publications[].label
Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals.

# publications[].label
Programming of antigen-specific CTLs from induced pluripotent stem cells for tumor protection (156.1)

# publications[].label
T Cell Response to SARS-CoV-2 Coinfection and Comorbidities.

# publications[].label
Role of T Cells in Microbial Pathogenesis.

# publications[].label
Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase.

# publications[].label
Telbivudine treatment corrects HBV-induced epigenetic alterations in liver cells of patients with chronic hepatitis B.

# publications[].label
Identification of a NACC1-Regulated Gene Signature Impli-Cated in the Features of Triple-Negative Breast Cancer

# publications[].label
Chicken-derived CD20 antibodies with potent B-cell depletion activity.

# publications[].label
The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection.

# publications[].label
Adoptive Cell Transfer: Is it a Promising Immunotherapy for Colorectal Cancer?

# publications[].label
Identification of a NACC1-Regulated Gene Signature Implicated in the Features of Triple-Negative Breast Cancer.

# publications[].label
Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HBV Replication through Production of IFN- and TNF-.

# publications[].label
Immunotherapy for triple-negative breast cancer: Existing challenges and exciting prospects.

# publications[].label
Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity.

# publications[].label
USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.

# publications[].label
Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion.

# publications[].label
HVEM Imprints Memory Potential on Effector CD8 T Cells Required for Protective Mucosal Immunity.

# publications[].label
The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes.

# publications[].label
Development of CAR-T Cell Persistence in Adoptive Immunotherapy of Solid Tumors.

# publications[].label
Regulation of CD8+T-lymphocytes by eEF-2K

# publications[].label
OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells.

# publications[].label
Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8+ T cells.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation.

# publications[].label
Chapter 14 Current development in iPSC-based therapy for autoimmune diseases

# publications[].label
Apolipoprotein E levels in pediatric patients undergoing cardiopulmonary bypass.

# publications[].label
eEF-2K Deficiency Boosts the Virus-Specific Effector CD8+ T Cell Responses During Viral Infection.

# publications[].label
Autophagy in T-cell differentiation, survival and memory.

# publications[].label
eEF-2 Kinase-targeted miR-449b confers radiation sensitivity to cancer cells.

# publications[].label
Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T cells and inhibits spontaneous systemic autoimmunity.

# publications[].label
Innate lymphoid cells as novel regulators of obesity and its-associated metabolic dysfunction.

# publications[].label
Modulation of autoimmune diseases by iPS cells.

# publications[].label
The regulation of FoxP3-expressing regulatory T cells.

# publications[].label
Identification of Elongation Factor-2 as a Novel Regulator of Mitochondrial Fission

# publications[].label
NAC1 Modulates Autoimmunity by Suppressing Regulatory T Cell-Mediated Tolerance

# publications[].label
Live attenuated bacterium limits cancer resistance to CAR-T therapy by remodeling the tumor microenvironment.

# publications[].label
Generation of Antigen-Specific T Lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy

# publications[].label
Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.

# publications[].label
Targeting Stem Cell-Derived Tissue-Associated Regulatory T Cells for Type 1 Diabetes Immunotherapy.

# publications[].label
Stem cell-derived tissue- associated regulatory T cells ameliorate the development of autoimmune arthritis

# publications[].label
Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKK Phosphorylation.

# researcherOn[].awardedBy.label
National Cancer Institute - (Rockville, Maryland, United States)

# researcherOn[].label
Stem cell-derived regulatory T cells for therapeutic use in arthritis

# researcherOn[].awardedBy.label
National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)

# researcherOn[].label
Role of Stem Cell-Derived T Lymphocytes in Chronic HBV Infection

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine