# positions[].label
Associate Professor and Director of Graduate Studies

# overview
1. Obesity associated metabolic syndrome (MetS) is both a US and a worldwide epidemic and a major burden to healthcare system. Chronic low-grade inflammation (CLGI) is a well-established characteristic of the obese-human condition and though, the gastrointestinal (GI) mucosa is the first tissue that interacts with dietary components and luminal microbiota both of which are known to regulate obesity, the research on the role of GI-mucosa in obesity associated MetS is lacking. Findings from my lab support a key role of Janus kinase 3 (Jak3), a non-receptor tyrosine kinase, in intestinal and systemic CLGI associated obesity and diabetes in both an animal-model and in humans. Our publications, and unpublished data indicate that Jak3 regulates; colonic and systemic CLGI, and multiple symptoms of metabolic syndrome. Our goal is to determine the associated underlying mechanisms. Our current focus is on tissue-specific roles of Jak3 and associated signaling complexes in CLGI-onset as a precursor for; (a) obesity and diabetes, (b) Obesity and Alzheimer's disease, and (c) inflammatory bowel disease.

2. Inflammatory bowel disease (IBD) that includes Crohn's disease and Ulcerative colitis is a chronic inflammatory condition of gastrointestinal tract. Annual death from these diseases are over 70,000.00, and the incidences of new cases have been rising over the years. Because the repairs of intestinal mucosa (Restitution) are compromised during IBD, the research focus of our lab is to dissect the roles of intestinal epithelial, intestinal immune cells and gut microbiota in mucosal restitution. Our lab was pioneered the functions of Jak3 in intestinal epithelial mucosa. We show that IL-2 (a cytokine produced during intestinal inflammation) promotes mucosal wound repair through Jak3 complexed with villin, ShcA, and ?-catenin. Studies are underway to define the tissue-specific Jak3-mediated signaling pathways that regulate CLGI as a precursor for the onset of IBD.

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Src Homology 2 Domain-Containing, Transforming Protein 1

# keywords[]
Atp-binding Cassette Subfamily 2 Junior Blood Group (abcg2)

# keywords[]
Atp Binding Cassette Transporter, Subfamily G, Member 2

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
University of Tennessee Health Science Center - (Memphis, Tennessee, United States)

# educationAndTraining[].organization.label
Indian Institute of Technology Kharagpur - (Kharagpur, India)

# publications[].label
Regulation of cell motility by tyrosine phosphorylated villin.

# publications[].publisher
American Society for Cell Biology (ASCB)

# publications[].label
Drug-induced liver injury and prospect of cytokine based therapy; A focus on IL-2 based therapies.

# publications[].label
Villin regulates intestinal epithelial cell motility

# publications[].label
Simulation and modeling of continuous H2 production process by Enterobacter cloacae IIT-BT 08 using different bioreactor configuration

# publications[].label
Structure and Function of Jak3- SH2 Domain

# publications[].label
Adriamycin analogues. Synthesis of the and anomers of 7-O-(3-amino-3,5-dideoxy-D-ribofuranosyl)adriamycinone and some related compounds

# publications[].label
Chronic Low-grade Inflammation in Obesity and Diabetes associated Colorectal Cancer Development

# publications[].label
Adapter protein Shc regulates Janus kinase 3 phosphorylation.

# publications[].label
Janus kinase 3 regulates interleukin 2-induced mucosal wound repair through tyrosine phosphorylation of villin.

# publications[].label
Modeling and simulation of clean fuel production by Enterobacter cloacae IIT-BT 08

# publications[].label
Identification of molecular switch regulating interactions of Janus kinase 3 with cytoskeletal proteins.

# publications[].label
Electron microscopy of hydrogen producing immobilized E. cloacae IIT-BT 08 on natural polymers

# publications[].label
Inflammatory Bowel Disease Therapeutics: A Focus on Probiotic Engineering.

# publications[].label
Role of Janus-Kinase 3 in Lung Inflammation

# publications[].label
Role of Janus kinase 3 in mucosal differentiation and predisposition to colitis.

# publications[].label
Mucosal Epithelial Jak Kinases in Health and Diseases.

# publications[].label
Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier

# publications[].label
Isolation and molecular characterization of hydrogenase gene from a high rate of hydrogen-producing bacterial strain Enterobacter cloacae IIT-BT 08

# publications[].label
Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis.

# publications[].label
Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer

# publications[].label
Deep eutectic solvents' ability to solubilize lignin, cellulose, and hemicellulose; thermal stability; and density.

# publications[].label
Role of Janus-Kinase 3 in Lung Inflammation

# publications[].label
Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments.

# publications[].label
Optimization of fermentation parameters using response surface methodology for biohydrogen production from urban waste

# publications[].label
Continuous hydrogen production by immobilized Enterobacter cloacae IIT-BT 08 using lignocellulosic materials as solid matrices

# publications[].label
JANUS KINASE 3 REGULATES COLONIC DIFFERENTIATION

# publications[].publisher
Federation of American Societies for Experimental Biology

# publications[].label
Identification of Molecular Switch Regulating Intestinal Breast Cancer Resistance Protein (BCRP) Mediated Drug Efflux in Obesity

# publications[].label
Methods of Screening for Janus Kinase 3 Interacting Compounds

# publications[].label
Continuous hydrogen production by immobilized Enterobacter cloacae IIT-BT 08 using lignocellulosic materials as solid matrices

# publications[].label
Identification of a functional switch for actin severing by cytoskeletal proteins.

# publications[].label
Production and purification of -amylase from hydrogen producing Enterobacter cloacae IIT-BT 08

# publications[].label
Redirection of biochemical pathways for the enhancement of H2 production by Enterobacter cloacae

# publications[].label
Training the defense system for modern-day warfare: the horizons for immunotherapy and vaccines for cancer

# publications[].label
Role of breast cancer resistance protein in obesity associated chronic low grade inflammation

# publications[].label
N-terminal phosphorylation of Jak3 regulates Jak3-villin interaction.

# publications[].label
Molecular dynamics study of thrombin capture by aptamers TBA26 and TBA29 coupled to a DNA origami

# publications[].label
Changes in Jak3 Expression during the Differentiation of Intestinal epithelial cells

# publications[].publisher
Federation of American Societies for Experimental Biology

# publications[].label
Isolation and molecular characterization of hydrogenase gene from a high rate of hydrogen-producing bacterial strain Enterobacter cloacae IIT-BT 08

# publications[].label
Functional dissection and molecular characterization of calcium-sensitive actin-capping and actin-depolymerizing sites in villin.

# publications[].label
Role of Janus Kinase 3 in Predisposition to Obesity-associated Metabolic Syndrome.

# publications[].label
Tu1898 Jak3 Expression Regulates Colonic Hypoxia Mediated Severity of DSS Induced Colitis

# publications[].label
Regulation of actin dynamics by tyrosine phosphorylation: identification of tyrosine phosphorylation sites within the actin-severing domain of villin.

# publications[].label
Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through -catenin.

# publications[].label
Regulation of epithelial to mesenchymal transition by the actin-binding protein villin

# publications[].label
Association of villin with phosphatidylinositol 4,5-bisphosphate regulates the actin cytoskeleton.

# publications[].label
Intestinal breast cancer resistance protein (BCRP) requires Janus kinase 3 activity for drug efflux and barrier functions in obesity.

# publications[].label
Role of Jak3 in hepatic inflammation during ulcerative colitis

# publications[].label
Increased severity of high molecular weight DSS induced colitis in aged mice

# publications[].label
Molecular cloning, characterization, and overexpression of a novel [Fe]-hydrogenase isolated from a high rate of hydrogen producing Enterobacter cloacae IIT-BT 08.

# publications[].label
Enhancement of hydrogen production by Enterobacter cloacae IIT-BT 08

# researcherOn[].label
Role of Cytokine Signaling In Intestinal Restitution

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

# inTheNews[].label
How might diabetes lead to Alzheimer’s? Study suggests the liver is key

# inTheNews[].label
Type 3 Diabetes’: High-Fat Diet Could Increase Alzheimer’s Risk