# overview
The Karpac Lab is broadly interested in the origins of signaling networks that provide animals with metabolic flexibility, and thus the capacity to balance energy homeostasis. These ancient networks, under intense evolutionary pressure, both respond to and are shaped by diverse inputs, such as nutrient availability, pathogens, and aging. We primarily use the fruit fly Drosophila melanogaster as a genetic model to investigate the function and integration of these signaling networks at multiple levels of biological organization: from molecules, to cells and tissues, to inter-organ communication, to organismal physiology and aging.

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Intracellular Signaling Peptides And Proteins

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Intracellular Signaling Peptides And Proteins

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Reverse Transcriptase Polymerase Chain Reaction

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Reverse Transcriptase Polymerase Chain Reaction

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Reverse Transcriptase Polymerase Chain Reaction

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Intercellular Signaling Peptides And Proteins

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1.1 Normal Biological Development And Functioning

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Grove City College - (Grove City, Pennsylvania, United States)

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Oklahoma Medical Research Foundation - (Oklahoma City, Oklahoma, United States)

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Buck Institute for Research on Aging - (Novato, California, United States)

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University of Rochester - (Rochester, New York, United States)

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A virus-acquired host cytokine controls systemic aging by antagonizing apoptosis.

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Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection

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Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila.

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Promoting longevity by maintaining metabolic and proliferative homeostasis.

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Insulin and JNK: optimizing metabolic homeostasis and lifespan.

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Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage.

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NF-B Shapes Metabolic Adaptation by Attenuating Foxo-Mediated Lipolysis in Drosophila.

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Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction.

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Regulation of Drosophila lifespan by JNK signaling.

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Proopiomelanocortin heterozygous and homozygous null mutant mice develop pituitary adenomas.

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Dietary Adaptation of Microbiota in Drosophila Requires NF-B-Dependent Control of the Translational Regulator 4E-BP.

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The Drosophila midgut and the systemic coordination of lipid-dependent energy homeostasis.

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Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila.

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Lifespan extension by preserving proliferative homeostasis in Drosophila.

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A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila.

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JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila.

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Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila.

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PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan.

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Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis.

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Development, maintenance, and function of the adrenal gland in early postnatal proopiomelanocortin-null mutant mice.

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Diet-MEF2 interactions shape lipid droplet diversification in muscle to influence Drosophila lifespan.

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Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage.

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Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition.

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American Association for Cancer Research (AACR)

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Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors.

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Effects on hippocampus of lifelong absence of glucocorticoids in the pro-opiomelanocortin null mutant mouse reveal complex relationship between glucocorticoids and hippocampal structure and function.

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Metabolic homeostasis: HDACs take center stage.

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Integrin-ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium.

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Adaptive physiology drives ageing plasticity in locusts.

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Membrane therapy using DHA suppresses epidermal growth factor receptor signaling by disrupting nanocluster formation.

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Pro-opiomelanocortin peptides and the adrenal gland.

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Targeting plasma membrane spatial dynamics to suppress aberrant Wnt signaling

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National Cancer Institute - (Rockville, Maryland, United States)

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Foxo/NFkB Interactions in the Regulation of Metabolic Homeostasis

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

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National Institutes of Health - (Bethesda, Maryland, United States)

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DHHS-NIH-National Institute of Diabetes and Digestive and Kidney Disorders

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Inter-organ communication in the systemic control of aging

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American Federation for Aging Research - (New York, New York, United States)

# streetAddress
Texas A&M University College of Medicine; Dept. of Molecular And Cellular Medicine; 8447 Riverside Parkway, MREB II