# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
The Liu Lab at Texas A&M University is specialized in several research frontiers in the ubiquitin-proteasome pathway proteomics, phage display-based techniques for macrocyclic peptide and nanobody drug discovery, and medicinal chemistry for the small molecule and proteasome-targeting chimera (PROTAC) therapeutic development. In the ubiquitin-proteasome pathway proteomic research, we are specialized in the synthesis of ubiquitin and ubiquitin-like protein-based activity-based probes for profiling active ubiquitin and ubiquitin-like protein-targeting enzymes. For the phage display research front, we have developed phage display techniques integrated with genetically encoded noncanonical amino acids and/or uniquely chemically modified macrocyclic peptides for drug discovery. In medicinal chemistry, we are targeting both epigenetic enzymes, epigenetic readers, cell surface receptors, and ubiquitin- and ubiquitin-like protein-targeting enzymes for the development of small molecules and PROTACs as therapeutics. Our lab was previously active on the synthesis of chromatin with posttranslational modifications for the understanding of their functions and the development of antivirals for SARS-CoV-2. Dr. Liu is also directing the Texas A&M Drug Discovery Center that houses a high-throughput screening instrument suite.

# keywords[]
3403 Macromolecular And Materials Chemistry

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3403 Macromolecular And Materials Chemistry

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
United States Food And Drug Administration

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# keywords[]
3404 Medicinal And Biomolecular Chemistry

# educationAndTraining[].organization.label
University of California, Davis - (Davis, California, United States)

# educationAndTraining[].organization.label
Beijing University of Technology - (Beijing, Beijing, China)

# awardsAndHonors[].label
Faculty Early Career Development (CAREER) Program

# publications[].label
Stepwise Assembly of Turn-on Fluorescence Sensors in Multicomponent Metal-Organic Frameworks for inVitro Cyanide Detection.

# publications[].label
Genetic incorporation of twelve meta-substituted phenylalanine derivatives using a single pyrrolysyl-tRNA synthetase mutant.

# publications[].label
Zinc thiotropolone combinations as inhibitors of the SARS-CoV-2 main protease.

# publications[].label
Protein Synthesis via Activated Cysteine-Directed Protein Ligation.

# publications[].label
A genetically encoded aldehyde for rapid protein labelling.

# publications[].label
tRNAPyl: Structure, function, and applications.

# publications[].label
Synthesis and incorporation of 1,2-alkanolamine-functionalized lysine as a non-canonical amino acid into GFP

# publications[].label
Genetic incorporation of an aliphatic keto-containing amino acid into proteins for their site-specific modifications.

# publications[].label
Site specific post-translational modifications of protein by expanding the genetic code: Protein methylation and structure enrichment

# publications[].label
A genetically encoded acrylamide functionality.

# publications[].label
Towards reassigning the rare AGG codon in Escherichia coli.

# publications[].label
Engineering the N-terminal domain of pyrrolysyl-tRNA synthetase: Optimizing genetic incorporation of non-canonical amino acids

# publications[].label
The molecular basis of tight nuclear tethering and inactivation of cGAS.

# publications[].label
Near-cognate suppression of amber, opal and quadruplet codons competes with aminoacyl-tRNAPyl for genetic code expansion.

# publications[].label
Expanding the chemical diversity of lasso peptide MccJ25 with genetically encoded noncanonical amino acids.

# publications[].label
The nitrilimine-alkene cycloaddition is an ultra rapid click reaction.

# publications[].label
A Click Chemistry Approach to Reveal the chromatin-Dependent Histone H3 K36 Deacetylase Nature of SIRT7

# publications[].label
Titelbild: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. 10/2022)

# publications[].label
Epigenetic reader chromodomain as a potential therapeutic target.

# publications[].label
Ubiquitin Azapeptide Esters as Next-Generation Activity-Based Probes for Cysteine Enzymes in the Ubiquitin Signal Pathway.

# publications[].label
Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir.

# publications[].label
A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells**

# publications[].label
Mycobacterium tuberculosis fluorescent and bioluminescent imaging technologies: addressing the issue of sensitivity.

# publications[].label
From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and UbiquitinLike Proteins

# publications[].label
Expressed Protein Ligation without Intein

# publications[].label
Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors.

# publications[].label
Genetic incorporation of unnatural amino acids into proteins in mammalian cells.

# publications[].label
Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2.

# publications[].label
The "-Clamp" Offers a New Strategy for Site-Selective Protein Modification.

# publications[].label
The Pyrrolysyl-tRNA Synthetase Activity can be Improved by a P188 Mutation that Stabilizes the Full-Length Enzyme.

# publications[].label
Genetic incorporation of a benzaldehyde residue for rapid bioorthogonal labeling at neutral pH

# publications[].label
Cellular Activities of SARS-CoV-2 Main Protease Inhibitors Reveal Their Unique Characteristics

# publications[].label
A rationally designed pyrrolysyl-tRNA synthetase mutant with a broad substrate spectrum.

# publications[].label
Novel luminescence-based assay for deubiquitinases inhibitors discovery

# publications[].label
Proteins with Site-Specific Lysine Methylation.

# publications[].label
SARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme.

# publications[].label
Alternative codon study for genetic code expansion in Escherichia coli

# publications[].label
The Effects of Site Specific Histone Modifications on Nucleosomal DNA Accessibility

# publications[].label
Kinetic and thermodynamic analysis of the interaction of cations with dialkylglycine decarboxylase.

# publications[].label
Bepridil is potent against SARS-CoV-2 in vitro.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Phage-assisted, active site-directed ligand evolution of a potent and selective histone deacetylase 8 inhibitor.

# publications[].label
Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Using Amber and Ochre Nonsense Codons to Code Two Different Noncanonical Amino Acids in One Protein Gene.

# publications[].label
Advancing Genetically Encoded Lysine (GEK) Chemistry: From Precision Modulation to Therapeutic Innovation.

# publications[].label
Pyrrolysyl-tRNA synthetase: An ordinary enzyme but an outstanding genetic code expansion tool

# publications[].label
A Versatile Approach for SiteSpecific Lysine Acylation in Proteins

# publications[].label
Genetic incorporation of seven ortho-substituted phenylalanine derivatives

# publications[].label
Expressed Protein Ligation without Intein.

# publications[].label
An amber obligate active site-directed ligand evolution technique for phage display.

# publications[].label
Effects of End Group Termination on Salting-Out Constants for Triglycine.

# publications[].label
Manipulating protein pi-pi interactions by site-specific incorporation of fluorinated phenylalanine analogs

# publications[].label
Catalyst-free and site-specific one-pot dual-labeling of a protein directed by two genetically incorporated noncanonical amino acids.

# publications[].label
Facile system for genetic incorporation of two different noncanonical amino acids into one protein in Escherichia coli

# publications[].label
Chemical biology approach for dimethyllysine incorporation into proteins

# publications[].label
Genetically encoded fluorophenylalanines enable insights into the recognition of lysine trimethylation by an epigenetic reader.

# publications[].label
E1-catalyzed ubiquitin C-terminal amidation for the facile synthesis of deubiquitinase substrates.

# publications[].label
E1-catalyzed ubiquitin C-terminal amidation for the facile syntheses of deubiquitinase substrates

# publications[].label
Structural Basis for the Recognition of paraBenzoylLphenylalanine by Evolved AminoacyltRNA Synthetases

# publications[].label
Sirtuins 1 and 2 Are Universal Histone Deacetylases.

# publications[].label
A click chemistry approach to site-specific immobilization of a small laccase enables efficient direct electron transfer in a biocathode.

# publications[].label
An amber-encoding helper phage for more efficient phage display of noncanonical amino acids.

# publications[].label
Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease.

# publications[].label
From nicotine to SARS-CoV-2 antivirals with potent in vivo efficacy and a broad anti-coronavirus spectrum.

# publications[].label
Evolving the N-Terminal Domain of Pyrrolysyl-tRNA Synthetase for Improved Incorporation of Noncanonical Amino Acids.

# publications[].label
A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems.

# publications[].label
Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome.

# publications[].label
A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals.

# publications[].label
A Reversible Chemogenetic Switch for Chimeric Antigen Receptor TCells.

# publications[].label
Front Cover: MPI8 is Potent against SARSCoV2 by Inhibiting Dually and Selectively the SARSCoV2 Main Protease and the Host Cathepsin L (ChemMedChem 1/2022)

# publications[].label
A Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2

# publications[].label
A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes.

# publications[].label
RESVERATROL BINDS NUCLEAR RECEPTOR 4A1 (NR4A1) AND ACTS AS AN NR4A1 ANTAGONIST IN LUNG CANCER CELLS.

# publications[].label
Diversification of Phage-Displayed Peptide Libraries with Noncanonical Amino Acid Mutagenesis and Chemical Modification.

# publications[].label
Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases.

# publications[].label
An Enhanced Hybrid Screening Approach to Identify Potent Inhibitors for the SARS-CoV-2 Main Protease From the NCI Compound Library.

# publications[].label
Aminophosphonate inhibitors of dialkylglycine decarboxylase: structural basis for slow binding inhibition.

# publications[].label
The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives.

# publications[].label
Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay.

# publications[].label
Expressed Protein Ligation Without Intein

# publications[].label
Drug Repurposing for the SARS-CoV-2 Papain-Like Protease

# publications[].label
Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics.

# publications[].label
Genetically encoded photocaged Ne-methyl-L-lysine

# publications[].label
Pyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion tool.

# publications[].label
An optimal "Click" formulation strategy for antibody-drug conjugate synthesis.

# publications[].label
MPI8 is Potent Against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L

# publications[].label
Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1.

# publications[].label
Increasing insulin yield by fusion with superfolder green fluorescing protein

# publications[].label
A genetically encoded bidentate, metal-binding amino acid.

# publications[].label
Cover Feature: Covalent Inhibition in Drug Discovery (ChemMedChem 9/2019)

# publications[].label
Stepwise Assembly of Turnon Fluorescence Sensors in Multicomponent MetalOrganic Frameworks for in Vitro Cyanide Detection

# publications[].label
A Genetically Encoded Allysine for the Synthesis of Proteins with SiteSpecific Lysine Dimethylation

# publications[].label
Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main Protease Inhibitor, in Rat Plasma in Pharmacokinetic Studies.

# publications[].label
A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*.

# publications[].label
Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors.

# publications[].label
Nitrilimine-alkene cycloaddition as an ultra rapid click reaction for protein labeling

# publications[].label
A genetically encoded diazirine photocrosslinker in Escherichia coli.

# publications[].label
Reversal of the hofmeister series: specific ion effects on peptides.

# publications[].label
Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain.

# publications[].label
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.

# publications[].label
Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor

# publications[].label
Structural insights into the -- stacking mechanism and DNA-binding activity of the YEATS domain.

# publications[].label
Reports from the Chemical Biology of Texas Symposium at the 69th Southwest Regional Meeting of the American Chemical Society.

# publications[].label
Sirtuin 2 inhibitors identified by phage display with an expanded genetic code

# publications[].label
A Genetically Encoded BoronateContaining Amino Acid

# publications[].label
A genetically encoded boronate-containing amino acid.

# publications[].label
Improving the bioactivity of rHirudin with boronophenylalanine site-specific modification.

# publications[].label
From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin-Like Proteins.

# publications[].label
Development of Chemical Tools for the Human YEATS Domain.

# publications[].label
Role of Q52 in catalysis of decarboxylation and transamination in dialkylglycine decarboxylase.

# publications[].label
A strategy for dual inhibition of the proteasome and fatty acid synthase with belactosin C-orlistat hybrids.

# publications[].label
Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Orally Available Drug Candidates for Acute Myeloid Leukemia.

# publications[].label
A Simple, Quick, and Scalable Route to Fluorogenic Ubiquitin and Ubiquitin-Like Protein Substrates for Assessing Activities of Deubiquitinases and Ubiquitin-Like Protein-Specific Proteases.

# publications[].label
Cover Picture: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. Int. Ed. 10/2022)

# publications[].label
Drug Repurposing for the SARS-CoV-2 Papain-Like Protease.

# publications[].label
Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases.

# publications[].label
A Speedy Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors.

# publications[].label
MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L.

# publications[].label
Synthesis of proteins with defined posttranslational modifications using the genetic noncanonical amino acid incorporation approach.

# publications[].label
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV.

# publications[].label
Deacetylase substrate specificity analysis: Decoding the histone language

# publications[].label
Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease.

# publications[].label
A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds.

# publications[].label
Probing the active site of alanine racemase by incorporation of non-canonical amino acids

# publications[].label
Directed Evolution of Candidatus Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase for the Genetic Incorporation of Two Different Noncanonical Amino Acids in One Protein.

# publications[].label
A Versatile Approach for Site-Specific Lysine Acylation in Proteins.

# publications[].label
A facile method to synthesize histones with posttranslational modification mimics.

# publications[].label
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.

# publications[].label
Systematic studies of nonsense suppression abilities of Methanosarcina mazei pyrrolysyl-tRNA synthetase-tRNAPyl pair in Escherichia coli

# publications[].label
A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease.

# publications[].label
Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes.

# publications[].label
Site specific protein labeling of genetically encoded strained alkene/alkyne functionalities in vivo via rapid catalyst-free click chemistry

# publications[].label
Nonsense and sense suppression abilities of original and derivative Methanosarcina mazei pyrrolysyl-tRNA synthetase-tRNA(Pyl) pairs in the Escherichia coli BL21(DE3) cell strain.

# publications[].label
The Construction of a Genetically Encoded, Phage-Displayed Cyclic-Peptide Library.

# publications[].label
Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes (vol 50, pg 13085, 2014)

# publications[].label
A Genetically Encoded, PhageDisplayed CyclicPeptide Library

# publications[].label
A Novel Y-Shaped, S-O-N-O-S-Bridged Cross-Link between Three Residues C22, C44, and K61 Is Frequently Observed in the SARS-CoV-2 Main Protease.

# publications[].label
A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease

# publications[].label
Frontispiece: Proteins with SiteSpecific Lysine Methylation

# publications[].label
Genetically encoded acrylamide functionality directs diverse bioorthogonal protein modifications

# publications[].label
Repurposing Halicin as a Potent Covalent Inhibitor for the SARS-CoV-2 Main Protease

# publications[].label
Bepridil is potent against SARS-CoV-2 In Vitro.

# publications[].label
A facile system for genetic incorporation of two different noncanonical amino acids into one protein in Escherichia coli.

# publications[].label
Genetic code expansion: Synthetases pick up the PACE.

# publications[].label
The genetic incorporation of thirteen novel non-canonical amino acids.

# publications[].label
Computational Model-Assisted Development of a Nonenzymatic Fluorescent Glucose-Sensing Assay.

# publications[].label
A convenient method for genetic incorporation of multiple noncanonical amino acids into one protein in Escherichia coli.

# publications[].label
Genetic incorporation of unnatural amino acids into proteins in mammalian cells

# publications[].label
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV.

# publications[].label
Allosteric Regulation of E3 Ligase Parkin Studied by HydrogenDeuterium Exchange Measured by Mass Spectrometry (nsHX-MS) and Single Molecule FRET (smFRET)

# publications[].label
Selecting folded proteins from a library of secondary structural elements.

# publications[].label
Probing the Catalytic Charge-Relay System in Alanine Racemase with Genetically Encoded Histidine Mimetics.

# publications[].label
Fluorinated Aromatic Amino Acids Distinguish Cation- Interactions from Membrane Insertion.

# publications[].label
Repurposing Halicin as a potent covalent inhibitor for the SARS-CoV-2 main protease.

# publications[].label
Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid.

# publications[].label
A Genetically Encoded Bidentate, MetalBinding Amino Acid

# publications[].label
Corrigendum: Drug Repurposing for the SARS-CoV-2 Papain-Like Protease.

# publications[].label
Phospha-Michael Addition as a New Click Reaction for Protein Functionalization.

# publications[].label
A Recurring Chemogenetic Switch for Chimeric Antigen Receptor T Cells

# publications[].label
Phage-Assisted, Active Site-Directed Ligand Evolution with a Genetically Encoded N-Butyryl-L-Lysine to Identify a Cellularly Potent and Selective Inhibitor for the ENL YEATS Domain as an Anti-Leukemia Agent

# publications[].label
BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease.

# publications[].label
Genetically encoded unstrained olefins for live cell labelling with tetrazine dyes

# publications[].label
A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation.

# publications[].label
Site Specific Lysine Acetylation of Histones for Nucleosome Reconstitution using Genetic Code Expansion in Escherichia coli.

# publications[].label
Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid.

# publications[].label
Kinetic and crystallographic analysis of active site mutants of Escherichia coli gamma-aminobutyrate aminotransferase.

# publications[].label
Probing the catalytic charge relay system in alanine racemase enzyme with genetically encoded histidine mimetics

# publications[].label
Genetic encoding of methyl- and acetyl-lysine analogs into proteins

# publications[].label
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation.

# publications[].label
Two rapid catalyst-free click reactions for in vivo protein labeling of genetically encoded strained alkene/alkyne functionalities.

# publications[].label
Front Cover: Evolving the NTerminal Domain of PyrrolysyltRNA Synthetase for Improved Incorporation of Noncanonical Amino Acids (ChemBioChem 1/2018)

# researcherOn[].label
The Preparation of Novel Phage-Displayed Macrocyclic Peptide Libraries for the Identification of Anticancer Agents

# researcherOn[].awardedBy.label
Cancer Prevention and Research Institute of Texas - (Austin, Texas, United States)

# researcherOn[].label
Studying Reversible Histone Acylations in Nucleosome Contexts

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Phage Display With Two Genetically Incorporated Noncanonical Amino Acids

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Develop General Methods for the Synthesis of Proteins with Posttranslational Lysine Modifications

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Career: Site-Specific Dual-Labeling of A Protein Through Two Genetically Incorporated Noncanonical Amino Acids

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# streetAddress
Texas A&M University; Chemistry Department; 3255 TAMU

# organizations[]
College of Agriculture and Life Sciences

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
College of Agriculture and Life Sciences

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
TAMU researchers say potential COVID-19 treatment could be a 'gamechanger'

# inTheNews[].label
The federal government shipped remdesivir to hospitals this week, but North Texas received none

# inTheNews[].label
Paving the way for new peptide-based therapeutics with novel method of phage display

# inTheNews[].label
X-Grants Program Provides Funding for Eight Interdisciplinary Projects

# inTheNews[].label
New 'genetic code' coronavirus vaccine in the works

# inTheNews[].label
Novel phage display technique could lead to new therapeutics

# inTheNews[].label
Texas A&M scientist discovers first COVID-19 treatment drug

# inTheNews[].label
The US spent a lot of money on Remdesivir. What is it?

# inTheNews[].label
Chemist Remains Optimistic About Succes of Antiviral in Treating COVID-19

# inTheNews[].label
How known drugs could be applied to the current coronavirus outbreak

# inTheNews[].label
The Molecular Basis of Tight Nuclear Tethering and Inactivation of CGAS

# inTheNews[].label
Texas A&M researchers are working on multiple new drugs to fight COVID-19

# inTheNews[].label
Texas A&M chemists working on drugs to treat COVID-19

# inTheNews[].label
Lessons from a cancer diagnosis, and what it teaches us about surviving the COVID-19 pandemic

# inTheNews[].label
Texas A&M professor identified COVID-19 treatment now used in Texas hospitals

# etdChairOf[].label
Deonarine-Chihak, Sasha Mala (2016-12). A Tetrazine-Terminal Alkene System for Profiling Protein Fatty Acylation Modifications. Master's Thesis.

# etdChairOf[].label
Odoi, Keturah Amarkie (2016-12). Protein Engineering: Amending Proteins with Chemical Functionalities. Doctoral Dissertation.

# etdChairOf[].label
Hsu, Willie Weili (2017-08). The Investigation of Sirtuin Activities on Short-Chained Mono-Acylated Histone H3 Tetramers and Nucleosomes. Doctoral Dissertation.

# etdChairOf[].label
Sharma, Vangmayee (2017-08). The Engineering and Optimization of Pyrrolysyl-Synthetase as a Tool for Noncanonical Amino Acid Incorporation. Doctoral Dissertation.

# etdChairOf[].label
Wang, Xiaoshan (2018-05). The Nitrilimine-Alkene Cycloaddition Mechanism and Phage-displayed Cyclic Peptide Libraries for Drug Discovery. Doctoral Dissertation.

# etdChairOf[].label
Wang, Zhipeng (2018-05). The Chemical Synthetic Investigation of Proteins with Sitespecific Lysine Post-Translational Modifications. Doctoral Dissertation.

# etdChairOf[].label
Wu, Bo (2014-08). Synthesis of Proteins with Homogenous Chemical and Posttranslational Modifications. Doctoral Dissertation.

# etdChairOf[].label
Lee, Yan-Jiun (2015-12). Expanding the Genetic Code for Synthesis of Proteins with Native Biological Modifications and Novel Chemical, Biophysical Probes. Doctoral Dissertation.

# etdChairOf[].label
Odoi, Keturah (2012-05). Orthogonality and Codon Preference of the Pyrrolysyl-tRNA Synthetase-tRNAPyl pair in Escherichia coli for the Genetic Code Expansion. Master's Thesis.

# etdChairOf[].label
Huang, Ying (2012-05). Genetic Incorporation of Noncanonical Amino Acids into Proteins for Protein Function Investigation. Doctoral Dissertation.