# overview
Research in my laboratory employs multidisciplinary approaches to study the cellular and molecular neurobiology of cell-autonomous circadian clocks and the signal transduction pathway responsible for circadian photoentrainment. The aims of current projects are to study: 1) the role of microRNAs (miRNAs) and other signaling molecules in the local temporal coordination of cell- and tissue-specific circadian clocks; 2) mutual interactions between the circadian clock mechanism, inflammatory signaling and metabolism; and 3) the mechanisms linking circadian rhythm disruption with metabolic disorders such as obesity and diabetes, and with pathological changes in neuroprotective responses to stroke.

# keywords[]
Alzheimer's Disease Including Alzheimer's Disease Related Dementias (ad/adrd)

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Northwestern University - (Evanston, Illinois, United States)

# educationAndTraining[].organization.label
University of Michigan-Ann Arbor - (Ann Arbor, Michigan, United States)

# educationAndTraining[].organization.label
University of Rochester Medical Center - (Rochester, New York, United States)

# educationAndTraining[].organization.label
Northwestern University - (Evanston, Illinois, United States)

# publications[].label
Circadian profiling of the transcriptome in NIH/3T3 fibroblasts: comparison with rhythmic gene expression in SCN2.2 cells and the rat SCN.

# publications[].label
Regulation of basal rhythmicity in protein kinase C activity by melatonin in immortalized rat suprachiasmatic nucleus cells.

# publications[].label
TrkB-deficient mice show diminished phase shifts of the circadian activity rhythm in response to light.

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Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms.

# publications[].label
Cognitive changes and circadian timekeeping disturbances in aging

# publications[].label
Role of brain-derived neurotrophic factor in the circadian regulation of the suprachiasmatic pacemaker by light.

# publications[].label
Effects of developmental alcohol exposure on vasoactive intestinal polypeptide and voltage-dependent calcium channel expression in rat SCN and cerebellum.

# publications[].label
Long-term effects of neonatal alcohol exposure on photic reentrainment and phase-shifting responses of the activity rhythm in adult rats.

# publications[].label
Sex differences in the diathetic effects of shift work schedules on circulating cytokine levels and pathological outcomes of ischemic stroke during middle age.

# publications[].label
The clock genes period 1 and period 2 mediate diurnal rhythms in dioxin-induced Cyp1A1 expression in the mouse mammary gland and liver.

# publications[].label
Melatonin regulates the basal rhythm in protein kinase activity (PKC) generated in SCN2.2 cells

# publications[].label
Responses of the split activity components in hamsters.

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Periodic exposure to a brief light signal stimulates neuroendocrine-gonadal activity in golden hamsters.

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Circadian vasopressin release from perifused rat suprachiasmatic explants in vitro: effects of acute stimulation.

# publications[].label
Role for acetylcholine in mediating effects of light on reproduction.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Effects of altered Clock gene expression on the pacemaker properties of SCN2.2 cells and oscillatory properties of NIH/3T3 cells.

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Cell culture models for oscillator and pacemaker function: recipes for dishes with circadian clocks?

# publications[].label
Amitriptyline Decreases GABAergic Transmission in Basal Forebrain Neurons Using an Optogenetic Model of Aging.

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Neonatal alcohol exposure alters anatomical components of the pathway for photic entrainment in adult rats.

# publications[].label
Rhythmic expression of Fos-related proteins within the rat suprachiasmatic nucleus during constant retinal illumination.

# publications[].label
Neonatal alcohol exposure differentially alters clock gene oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats.

# publications[].label
Saturated fats make some cells lose track of time -- and that's bad

# publications[].label
Shift work cycle-induced alterations of circadian rhythms potentiate the effects of high-fat diet on inflammation and metabolism.

# publications[].label
Development of an age-dependent cognitive index: relationship between impaired learning and disturbances in circadian timekeeping.

# publications[].label
Effects of neonatal alcohol exposure on scn neurotransmitters involved in the light-dark regulation of circadian rhythms

# publications[].label
Expression of brain-derived neurotrophic factor and its cognate receptor, TrkB, in the rat suprachiasmatic nucleus.

# publications[].label
Role of miR-142-3p in the post-transcriptional regulation of the clock gene Bmal1 in the mouse SCN.

# publications[].label
Mitochondrial calcium signaling mediates rhythmic extracellular ATP accumulation in suprachiasmatic nucleus astrocytes.

# publications[].label
Immortal time: circadian clock properties of rat suprachiasmatic cell lines.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Immortalized cells from the rat suprachiasmatic nucleus express functional melatonin receptors.

# publications[].label
Oscillating on borrowed time: diffusible signals from immortalized suprachiasmatic nucleus cells regulate circadian rhythmicity in cultured fibroblasts.

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Circadian rhythm of brain-derived neurotrophic factor in the rat suprachiasmatic nucleus (vol 242, pg 89, 1998)

# publications[].label
Circadian Regulation by the Suprachiasmatic Nucleus

# publications[].label
Circadian rhythms of extracellular ATP accumulation in suprachiasmatic nucleus cells and cultured astrocytes.

# publications[].label
Abstract T MP16: Impact of Circadian Clock Disruption on Infarct Volume in an Ischemic Stroke Model

# publications[].label
Correction to: inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness.

# publications[].label
Role of Proinflammatory Cytokines in Feedback Modulation of Circadian Clock Gene Rhythms by Saturated Fatty Acids.

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Synchronized SCN cell cultures exhibit rhythmic expression of Per1 and TNF alpha mRNAs

# publications[].label
Disruption of clock gene expression alters responses of the aryl hydrocarbon receptor signaling pathway in the mouse mammary gland.

# publications[].publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)

# publications[].label
Circadian rhythms from multiple oscillators: lessons from diverse organisms.

# publications[].label
Maintenance of testicular function in hamsters exposed to short days by intraventricular injections of carbachol during the night

# publications[].label
A cholinergic antagonist, mecamylamine, blocks the phase-shifting effects of light on the circadian rhythm of locomotor activity in the golden hamster.

# publications[].label
Circadian profiling of the transcriptome in immortalized rat SCN cells.

# publications[].label
Splitting of the Circadian Rhythm of Activity in Hamsters

# publications[].label
Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks.

# publications[].label
Specificity of circadian function in transplants of the fetal suprachiasmatic nucleus.

# publications[].label
Neonatal alcohol exposure permanently disrupts the circadian properties and photic entrainment of the activity rhythm in adult rats.

# publications[].label
Circadian clock and cell cycle gene expression in mouse mammary epithelial cells and in the developing mouse mammary gland.

# publications[].label
Neonatal alcohol exposure alters the distribution of retinohypothalamic tract (RHT) fibers innervating the adult rat suprachiasmatic nucleus (SCN).

# publications[].label
Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus.

# publications[].label
Circadian rhythm of brain-derived neurotrophic factor in the rat suprachiasmatic nucleus.

# publications[].label
Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin.

# publications[].label
Disruption of period gene expression alters the inductive effects of dioxin on the AhR signaling pathway in the mouse liver.

# publications[].label
Splitting of the circadian rhythm of activity in hamsters: Effects of exposure to constant darkness and subsequent re-exposure to constant light

# publications[].label
Overlap in the distribution of TrkB immunoreactivity and retinohypothalamic tract innervation of the rat suprachiasmatic nucleus.

# publications[].label
Circadian Rhythms of Melatonin in Intensive Care Unit Patients: Relationships With Delirium

# publications[].label
Developmental alcohol and the regulation of cireadian rhythms

# publications[].label
Effect of one-second light pulses on testicular function and locomotor activity in the golden hamster.

# publications[].label
Circadian rhythms of vasopressin release from individual rat suprachiasmatic explants in vitro.

# publications[].label
Effects of tetrodotoxin on the circadian pacemaker mechanism in suprachiasmatic explants in vitro.

# publications[].label
Immortalized suprachiasmatic nucleus cells express components of multiple circadian regulatory pathways.

# publications[].label
Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.

# publications[].label
Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock.

# publications[].label
Circadian regulation of c-fos expression in the suprachiasmatic pacemaker by light.

# publications[].label
PER2 regulation of mammary gland development.

# publications[].label
Prenatal alcohol, circadian clocks and circadian behavior.

# publications[].label
Developmental alcohol exposure disrupts circadian regulation of BDNF in the rat suprachiasmatic nucleus.

# publications[].label
Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus.

# publications[].label
Overlapping and divergent actions of estrogen and the neurotrophins on cell fate and p53-dependent signal transduction in conditionally immortalized cerebral cortical neuroblasts.

# publications[].label
Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness.

# publications[].label
Establishment and characterization of adenoviral E1A immortalized cell lines derived from the rat suprachiasmatic nucleus.

# publications[].label
MicroRNAs function as cis- and trans-acting modulators of peripheral circadian clocks.

# publications[].label
Expression and rhythmic modulation of circulating microRNAs targeting the clock gene Bmal1 in mice.

# publications[].label
Characterization of melatonin (MLT) receptors in the immortalized rat suprachiasmatic nucleus (SCN) cell line (SCN2.2)

# publications[].label
Developmental alcohol and circadian clock function

# publications[].label
Role of the circadian system in reproductive phenomena.

# publications[].label
Neurochemical basis for the photic control of circadian rhythms and seasonal reproductive cycles: role for acetylcholine.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Developmental alcohol exposure disrupts clock gene rhythms in the rat SCN and cerebellum.

# publications[].label
Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance.

# publications[].label
Real-time analysis of rhythmic gene expression in immortalized suprachiasmatic nucleus cells.

# publications[].label
Photic regulation of c-fos expression in neural components governing the entrainment of circadian rhythms.

# publications[].label
Neonatal alcohol-induced changes in circadian rhythm photoentrainment are coupled with alterations in glutamatergic input systems in the SCN

# publications[].label
Light induces expression of fos-related proteins within gastrin-releasing peptide neurons in the rat suprachiasmatic nucleus.

# publications[].label
Circadian Regulation by the Suprachiasmatic Nucleus

# publications[].label
Immortalized cell lines for real-time analysis of circadian pacemaker and peripheral oscillator properties.

# publications[].label
Developmental alcohol exposure alters light-induced phase shifts of the circadian activity rhythm in rats.

# researcherOn[].label
Circadian Clock Disruption and Ischemic Stroke Outcomes: Age and Sex Differences

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Neurological Disorders and Stroke

# streetAddress
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS

# etdChairOf[].label
Shende, Vikram Ravindra 1982- (2012-11). MicroRNAs Function as Cis- and Trans- Acting Modulators of Clock Gene Expression in SCN and Peripheral Circadian Oscillators. Doctoral Dissertation.

# etdChairOf[].label
Menger, Gus John, III (2009-05). Comparison of circadian gene expression among different oscillator models: identification of critical output signals of the SCN pacemaker. Doctoral Dissertation.

# etdChairOf[].label
Kim, Sammoon (2017-07). Mutual Interactions Between Circadian Clocks, Inflammatory Signaling Pathways and Fatty Acid Metabolism. Doctoral Dissertation.

# etdChairOf[].label
Qu, Xiaoyu (2009-05). Timing Matters: The Role of Circadian Clock Genes In Development and Toxin Responses. Doctoral Dissertation.