# overview
Salmonella is a leading cause of food borne illness, causing an estimated 1.4 million cases per year in the United States. Serovar Typhimurium is responsible for about 26% of these cases (CDC, 1998).  The vast majority of Salmonella infections in mammals and birds are the result of infection with S. enterica subspecies I serovars, yet very few genetic factors that are necessary for intestinal persistence in these reservoirs have been described. Intestinal persistence is critical for shedding and transmission of serovar Typhimurium in mammals and birds, yet this phenomenon and interaction of the organism with the host immune system during persistent infection is poorly understood. The long-term goal of our work is to understand the genetic basis of persistence and host range restriction of Salmonella enterica serovar Typhimurium in its mammalian hosts.

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2.2 Factors Relating To The Physical Environment

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Intercellular Signaling Peptides And Proteins

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1.1 Normal Biological Development And Functioning

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2.2 Factors Relating To The Physical Environment

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Reverse Transcriptase Polymerase Chain Reaction

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2.2 Factors Relating To The Physical Environment

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30 Agricultural, Veterinary And Food Sciences

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2.2 Factors Relating To The Physical Environment

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2.2 Factors Relating To The Physical Environment

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Receptors, Tumor Necrosis Factor, Type I

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3205 Medical Biochemistry And Metabolomics

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Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Brown University - (Providence, Rhode Island, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Texas A&M Health Science Center - (College Station, Texas, United States)

# educationAndTraining[].organization.label
Tufts University - (Medford, Massachusetts, United States)

# awardsAndHonors[].label
Junior Faculty Research Excellence Award

# publications[].label
Genomic diversity of Salmonella enterica -The UoWUCC 10K genomes project

# publications[].label
Genetic Determinants of Salmonella enterica Serovar Typhimurium Proliferation in the Cytosol of Epithelial Cells.

# publications[].label
Defined single-gene and multi-gene deletion mutant collections in Salmonella enterica sv Typhimurium.

# publications[].label
Using the collaborative cross to identify the role of host genetics in defining the murine gut microbiome.

# publications[].label
Silencing the alarm: insights into the interaction between host and pathogen. Conference on Microbial Pathogenesis: Mechanisms of Infectious Disease.

# publications[].label
Abrogation of the twin arginine transport system in Salmonella enterica serovar Typhimurium leads to colonization defects during infection.

# publications[].label
The ferric enterobactin transporter Fep is required for persistent Salmonella enterica serovar typhimurium infection.

# publications[].label
The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer bacterial resistance to antimicrobial peptide.

# publications[].label
Taxonomic and Metagenomic Analyses Define the Development of the Microbiota in the Chick.

# publications[].label
A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

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Formation of a fibrous structure on the surface of Legionella pneumophila associated with exposure of DotH and DotO proteins after intracellular growth.

# publications[].label
Taming the elephant: Salmonella biology, pathogenesis, and prevention.

# publications[].label
Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross

# publications[].label
The type VI secretion systems encoded in Salmonella pathogenicity islands SPI-6 and SPI-19 contribute to intestinal colonization of chickens and systemic spread by Salmonella enterica serotype Typhimurium

# publications[].label
CsgA is a pathogen-associated molecular pattern of Salmonella enterica serotype Typhimurium that is recognized by Toll-like receptor 2.

# publications[].label
A Salmonella Regulator Modulates Intestinal Colonization and Use of Phosphonoacetic Acid.

# publications[].label
'Form variation' of the O12 antigen is critical for persistence of Salmonella Typhimurium in the murine intestine.

# publications[].label
Using the Collaborative Cross to identify the role of host genetics in defining the murine gut microbiome

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Contribution of Asparagine Catabolism to Salmonella Virulence.

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High-throughput Screening to Determine the Genetic Requirements for Salmonella Survival Under Different Growth Conditions

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Only one of the two type VI secretion systems encoded in the Salmonella enterica serotype Dublin genome is involved in colonization of the avian and murine hosts.

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Subspecies IIIa and IIIb Salmonellae are defective for colonization of murine models of salmonellosis compared to Salmonella enterica subsp. I serovar typhimurium.

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Phage proteins block and trigger retron toxin/antitoxin systems

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The EAL domain containing protein STM2215 (rtn) is needed during Salmonella infection and has cyclic di-GMP phosphodiesterase activity.

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Novel genetic tools for studying food-borne Salmonella.

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Presynaptic glutamate receptors regulate noradrenaline release from isolated nerve terminals.

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Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.

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An Oxidative Central Metabolism Enables Salmonella to Utilize Microbiota-Derived Succinate.

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The Salmonella type-3 secretion system-1 and flagellar motility influence the neutrophil respiratory burst.

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Respiration of Microbiota-Derived 1,2-propanediol Drives Salmonella Expansion during Colitis.

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Deciphering the Enzymatic Function of the Bovine Enteric Infection-Related Protein YfeJ from Salmonella enterica Serotype Typhimurium.

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Novel Two-Step Hierarchical Screening of Mutant Pools Reveals Mutants under Selection in Chicks.

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De novo pyrimidine synthesis is necessary for intestinal colonization of Salmonella Typhimurium in chicks.

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Requirement of siderophore biosynthesis for plant colonization by Salmonella enterica.

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SipA, SopA, SopB, SopD, and SopE2 contribute to Salmonella enterica serotype typhimurium invasion of epithelial cells.

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Molecular pathogenesis of Salmonella enterica serotype typhimurium-induced diarrhea.

# publications[].label
Analysis of Two Complementary Single-Gene Deletion Mutant Libraries of Salmonella Typhimurium in Intraperitoneal Infection of BALB/c Mice.

# publications[].label
Identification of novel factors involved in modulating motility of Salmonella enterica serotype typhimurium.

# publications[].label
A rapid change in virulence gene expression during the transition from the intestinal lumen into tissue promotes systemic dissemination of Salmonella.

# publications[].label
Elucidating Mechanisms of Tolerance to Salmonella Typhimurium Across Long-Term Infections Using the Collaborative Cross

# publications[].label
The ABC-type efflux pump MacAB protects Salmonella enterica serovar typhimurium from oxidative stress.

# publications[].label
Bacterial retrons encode tripartite toxin/antitoxin systems

# publications[].label
The type VI secretion system encoded in SPI-6 plays a role in gastrointestinal colonization and systemic spread of Salmonella enterica serovar Typhimurium in the chicken.

# publications[].label
Analysis of pools of targeted Salmonella deletion mutants identifies novel genes affecting fitness during competitive infection in mice.

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Mathematical methods for visualization and anomaly detection in telemetry datasets.

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Module representatives for refining gene co-expression modules.

# publications[].label
Elucidating Mechanisms of Tolerance to Salmonella Typhimurium across Long-Term Infections Using the Collaborative Cross.

# publications[].label
High-throughput comparison of gene fitness among related bacteria.

# publications[].label
Salmonella Pathogenicity Island 1 Is Expressed in the Chicken Intestine and Promotes Bacterial Proliferation.

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Contribution of the type VI secretion system encoded in SPI-19 to chicken colonization by Salmonella enterica serotypes Gallinarum and Enteritidis.

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Host restriction of Salmonella enterica serotype Typhimurium pigeon isolates does not correlate with loss of discrete genes.

# publications[].label
A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium.

# publications[].label
Multicopy Single-Stranded DNA Directs Intestinal Colonization of Enteric Pathogens.

# publications[].label
Live attenuated S. Typhimurium vaccine with improved safety in immuno-compromised mice.

# publications[].label
Genomic diversity of Salmonella enterica -The UoWUCC 10K genomes project.

# publications[].label
High-throughput assay to phenotype Salmonella enterica Typhimurium association, invasion, and replication in macrophages.

# publications[].label
In vivo identification, expression and function of Salmonella virulence genes

# publications[].label
Genetic background influences survival of infections with Salmonella enterica serovar Typhimurium in the Collaborative Cross.

# publications[].label
Taxonomic and metagenomic analyses define the development of the microbiota in the chick

# publications[].label
Linearized Siderophore Products Secreted via MacAB Efflux Pump Protect Salmonella enterica Serovar Typhimurium from Oxidative Stress.

# publications[].label
Spontaneous excision of the Salmonella enterica serovar Enteritidis-specific defective prophage-like element phiSE14.

# publications[].label
Novel determinants of intestinal colonization of Salmonella enterica serotype typhimurium identified in bovine enteric infection.

# publications[].label
High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages

# publications[].label
L-asparaginase II produced by Salmonella typhimurium inhibits T cell responses and mediates virulence.

# publications[].label
Morphologic and cytokine profile characterization of Salmonella enterica serovar typhimurium infection in calves with bovine leukocyte adhesion deficiency.

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Salmonella enterica serotype Typhimurium and its host-adapted variants.

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Deciphering the Aldolase Function of STM3780 from a Bovine Enteric Infection-Related Gene Cluster in Salmonella enterica Serotype Typhimurium.

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Host restriction of Salmonella enterica serotype Typhi is not caused by functional alteration of SipA, SopB, or SopD.

# publications[].label
Infection of mice by Salmonella enterica serovar Enteritidis involves additional genes that are absent in the genome of serovar Typhimurium.

# publications[].label
A comparison of cecal colonization of Salmonella enterica serotype Typhimurium in white leghorn chicks and Salmonella-resistant mice.

# researcherOn[].label
Defining the molecular mechanisms of competitive exclusion to reduce Salmonella burden in poultry

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
USDA-National Institute of Food And Agriculture

# researcherOn[].label
Tolerance Mechanisms Through Innovative Population Analysis

# researcherOn[].awardedBy.label
United States Department of Defense - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Definition of targets to inhibit Salmonella colonization of the intestine

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
USDA-National Institute of Food And Agriculture

# researcherOn[].label
Identification of Salmonella Genes Important for Systemic Colonization

# researcherOn[].awardedBy.label
National Institute of Allergy and Infectious Diseases - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
National Institute of Infectious Diseases

# researcherOn[].label
Defining the molecular mechanisms of MacAB in protection of Salmonella from oxidative stress

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 8447 Riverside Parkway

# etdChairOf[].label
Elfenbein, Johanna R (2014-07). Novel Mechanisms Used by Salmonella Typhimurium to Colonize the Intestine. Doctoral Dissertation.

# etdChairOf[].label
Sivula, Christine Patricia (2009-05). Comparison of cecal colonization of Salmonella enterica serotype Typhimurium in white leghorn chicks and Salmonella-resistant mice. Master's Thesis.