# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Dr. Clark's research seeks to understand how biological and environmental factors shape psychiatric disorders. Specifically, the lab investigates the role of epigenetics in the etiology of psychiatric disorders and identifying (epi)genetic biomarkers. Historically, the lab has focused on alcohol use disorder and this remains a primary outcome of interest. However, alcohol use disorder is highly comorbid with other psychiatric disorders and adversities. As such, the lab has expanded its focus to include other substances of abuse, depression and anxiety along with other personal exposures such as childhood trauma and growing up in neighborhood disadvantage. We approach our research questions using a multidisciplinary perspective that involves utilizing cutting-edge methods and techniques from psychiatry, epigenetics, statistics and bioinformatics. This line of research will eventually lead to the improvement of diagnosis, prognosis and treatment of psychiatric disorders.

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Attention Deficit Hyperactivity Disorder (adhd)

# keywords[]
Diagnostic And Statistical Manual Of Mental Disorders

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
2.3 Psychological, Social And Economic Factors

# keywords[]
4.1 Discovery And Preclinical Testing Of Markers And Technologies

# keywords[]
Machine Learning And Artificial Intelligence

# keywords[]
Networking And Information Technology R&d (nitrd)

# keywords[]
2.3 Psychological, Social And Economic Factors

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Machine Learning And Artificial Intelligence

# keywords[]
2.3 Psychological, Social And Economic Factors

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Attention Deficit Disorder With Hyperactivity

# keywords[]
Health Disparities And Racial Or Ethnic Minority Health Research

# keywords[]
Texas Child Mental Health Care Consortium

# keywords[]
35 Commerce, Management, Tourism And Services

# keywords[]
2.3 Psychological, Social And Economic Factors

# keywords[]
Fagerström Test For Nicotine Dependence (ftnd)

# educationAndTraining[].organization.label
University of California Los Angeles - (Los Angeles, California, United States)

# educationAndTraining[].organization.label
University of California, Berkeley - (Berkeley, California, United States)

# educationAndTraining[].organization.label
University of California Los Angeles - (Los Angeles, California, United States)

# publications[].label
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.

# publications[].label
METHYLOME-WIDE ASSOCIATION STUDY OF ANXIETY DISORDERS

# publications[].label
DNA Methylation Signatures of Alcohol Use Disorder - A large-scale Meta-Analysis in the Psychiatric Genomics Consortium.

# publications[].label
A systematic review of methylome-wide associations with anxiety disorders.

# publications[].label
A COMPREHENSIVE BRAIN METHYLATION AND HYDROXYMETHYLATION STUDY IN ALCOHOL DEPENDENT PATIENTS

# publications[].label
Neuronal-Specific Methylome and Hydroxymethylome Analysis Reveal Replicated and Novel Loci Associated With Alcohol Use Disorder

# publications[].label
Cell type-specific methylome-wide association studies of childhood ADHD symptoms.

# publications[].label
DNA methylation signatures of alcohol use disorder-A large-scale meta-analysis in the PGC-SUD Epigenetics Working Group

# publications[].label
A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies.

# publications[].label
Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study.

# publications[].label
Telomere Length, Epigenetic Aging and Depression in the Netherlands Study of Depression and Anxiety (NESDA)

# publications[].label
MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples.

# publications[].label
Genotype-based ancestral background consistently predicts efficacy and side effects across treatments in CATIE and STAR*D.

# publications[].label
Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder.

# publications[].label
Exploring resource profiles among trauma exposed youth: An identity-focused, cultural, and person-centered approach.

# publications[].label
Enhancing Confidence in Evidence-Based Trauma Care and Implementation Research: Training Program for Clinicians in Ukraine.

# publications[].label
History of interpersonal trauma exposure is a robust risk factor for alcohol and substance use disorders during adolescence.

# publications[].label
Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance.

# publications[].label
Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders.

# publications[].label
Dual methylation and hydroxymethylation study of alcohol use disorder.

# publications[].label
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.

# publications[].label
GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS.

# publications[].label
Analysis of efficacy and side effects in CATIE demonstrates drug response subgroups and potential for personalized medicine.

# publications[].label
Does hair cortisol concentration reflect saliva cortisol levels and/or the regulatory biology of the HPA axis that shapes them in healthy humans?

# publications[].label
Refinement of schizophrenia GWAS loci using methylome-wide association data.

# publications[].label
Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples.

# publications[].label
Sample Size Requirements for Structural Equation Models: An Evaluation of Power, Bias, and Solution Propriety.

# publications[].label
Latent Classes of Adolescent Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Substance Use Predict Clinical Diagnoses at 12-Month Follow-Up.

# publications[].label
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex.

# publications[].label
A longitudinal analysis of social integration, perceived emotional support, and posttraumatic stress in a community sample of sexual assault survivors.

# publications[].label
369. Recurrent Trauma, Symptoms of Post-Traumatic Stress Disorder, and Substance Use Behaviors Among Trauma Exposed Youth

# publications[].label
A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens.

# publications[].label
Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse.

# publications[].label
Testing the temporal relationship between maternal and adolescent depressive and anxiety symptoms in a community sample.

# publications[].label
Patterns of Substance Use Across the First Year of College and Associated Risk Factors.

# publications[].label
PREDICTING THE FUTURE DISEASE STATUS OF DEPRESSED PATIENTS FROM DNA METHYLATION PATTERNS IN BLOOD

# publications[].label
Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.

# publications[].label
School attendance problems and youth psychopathology: structural cross-lagged regression models in three longitudinal data sets.

# publications[].label
DNA methylation biomarkers of alcohol use disorder

# publications[].label
Longitudinal patterns of posttraumatic stress disorder symptoms among sexual assault survivors: A latent transition analysis.

# publications[].label
Evaluating traumatic event scoring schemas for their predictive value to concurrent diagnostic profiles: Texas Childhood Trauma Research Network.

# publications[].label
The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.

# publications[].label
P.4.001 Accelerated biological aging in major depressive disorder: capturing aging patterns in DNA methylation with machine learning methods

# publications[].label
Characterizing patterns of substance use in trauma exposed youth.

# publications[].label
The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood

# publications[].label
Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder.

# publications[].label
Cell-type specific methylome-wide association study of alcohol consumption

# publications[].label
A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens

# publications[].label
Behavioral metabolomics analysis identifies novel neurochemical signatures in methamphetamine sensitization.

# publications[].label
Background Characteristics and Oral Proficiency Development Over Time in Lower-Division College Foreign Language Programs

# publications[].label
Enrichment methods provide a feasible approach to comprehensive and adequately powered investigations of the brain methylome.

# publications[].label
Understanding the Longitudinal Impact of School-Based Health Centers on Student Attendance

# publications[].label
A Large-Scale Methylome-Wide Analysis of Cell-Type Specific Associations With Lifetime Anxiety

# publications[].label
A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue.

# publications[].label
High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction.

# publications[].label
Epigenetic Aging in Major Depressive Disorder.

# publications[].label
Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.

# publications[].label
Does hair cortisol concentration reflect measurable regulatory biology of the HPA axis in healthy humans?

# publications[].label
A large-scale DNA methylation study of alcohol use identified robust associations and cell-type specific insights.

# publications[].label
Cell type-specific methylome-wide association studies of childhood ADHD symptoms.

# publications[].label
255. The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood

# publications[].label
Longitudinal interactions of pain and posttraumatic stress disorder symptoms in U.S. Military service members following blast exposure.

# publications[].label
Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults.

# publications[].label
METHYLOME-WIDE ASSOCIATION STUDIES FOR MAJOR DEPRESSIVE DISORDER IN BLOOD OVERLAP WITH METHYLATION RESULTS FROM BRAIN AND LARGE-SCALE GWAS

# publications[].label
Trajectories of depressive symptoms in response to prolonged stress in medical interns.

# publications[].label
Longitudinal genetic analysis for loneliness in Dutch twins.

# publications[].label
Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder.

# publications[].label
Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex.

# publications[].label
Recurrent Trauma, Symptoms of Post-Traumatic Stress Disorder, and Substance Use Behaviors Among Trauma Exposed Youth

# publications[].label
Dual methylation and hydroxymethylation study of alcohol use disorder

# publications[].label
A systematic review of methylome-wide associations with anxiety disorders.

# publications[].label
Enhancing confidence in evidence-based psychological trauma care and implementation research: training program for clinicians in Ukraine.

# publications[].label
The role of recurrent trauma on post-traumatic stress disorder symptoms and substance use among trauma exposed youth.

# publications[].label
USING STRUCTURAL EQUATION MODELING (SEM) METHODS TO EXAMINE GENOME-WIDE ASSOCIATIONS WITH A LATENT NEUROTICISM FACTOR AND ITEM-SPECIFIC RESIDUALS

# publications[].label
Models and Strategies for Factor Mixture Analysis: An Example Concerning the Structure Underlying Psychological Disorders.

# publications[].label
Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence.

# publications[].label
RaMWAS: fast methylome-wide association study pipeline for enrichment platforms.

# publications[].label
Regime Switching Modeling of Substance Use: Time-Varying and Second-Order Markov Models and Individual Probability Plots.

# publications[].label
Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses.

# publications[].label
Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences.

# publications[].label
Cell-Type Specific Methylome-Wide Association Study of Anxiety Disorders

# publications[].label
Associations of depression and anxiety symptoms in childhood and adolescence with epigenetic aging.

# publications[].label
Methylome-wide association study of anxiety disorders.

# publications[].label
Temporal change in the prevalence and etiology of youth antisocial behavior.

# publications[].label
Predicting Tobacco Use across the First Year of College.

# publications[].label
41. A Large-Scale Methylome-Wide Analysis of Cell-Type Specific Associations With Lifetime Anxiety

# publications[].label
Epigenetic aging in major depressive disorder

# publications[].label
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects.

# publications[].label
Understanding desistance from aggression: A joint interpretation of person-centered and variable-centered approaches.

# publications[].label
Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.

# publications[].label
DUAL METHYLATION AND HYDROXYMETHYLATION STUDY IN BLOOD AND BRAIN IDENTIFIES BAIAP2 AS A MEDIATOR OF GENE EXPRESSION ASSOCIATED WITH ALCOHOL USE DISORDER

# publications[].label
Substance use patterns and mental health comorbidities in youth with a history of depression or suicidality: Findings from TX-YDSRN.

# publications[].label
Next-generation biomarkers for alcohol consumption and alcohol use disorder diagnosis, prognosis, and treatment: Acritical review.

# publications[].label
Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D.

# publications[].label
Using classification trees to identify psychotherapy patients at risk for poor treatment adherence.

# publications[].label
EPIGENOME-WIDE ASSOCIATION STUDIES IDENTIFY NOVEL EPIGENETIC SIGNATURES OF ANXIETY

# publications[].label
Overestimation of the classification accuracy of a biomarker for assessing heavy alcohol use.

# publications[].label
Evaluation of Methyl-Binding Domain Based Enrichment Approaches Revisited.

# publications[].label
Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies.

# publications[].label
Clarifying the Genetic Influences on Nicotine Dependence and Quantity of Use in Cigarette Smokers.

# publications[].label
Large-scale neurochemical metabolomics analysis identifies multiple compounds associated with methamphetamine exposure.

# publications[].label
Family and social risk, and parental investments during the early childhood years as predictors of low-income children's school readiness outcomes

# publications[].label
Illuminating the Developmental Etiology of Youth Resilience

# publications[].label
A methylation study of long-term depression risk.

# publications[].label
A multi-method investigation of the personality correlates of digital aggression

# researcherOn[].label
Diagnostic and prognostic methylation biomarkers for alcohol and related health risks

# researcherOn[].awardedBy.label
National Institute On Alcohol Abuse and Alcoholism - (Bethesda, Maryland, United States)

# researcherOn[].label
The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.

# researcherOn[].awardedBy.label
National Institute of Child Health and Human Development - (Bethesda, Maryland, United States)

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine