# overview
Dr. Clark's research seeks to understand how biological and environmental factors shape substance use and addiction. Specifically, the lab focuses on the role of genetics and epigenetics in the etiology of substance use and addiction and identifying (epi)genetic biomarkers. This line of research will eventually lead to the improvement of diagnosis, prognosis and treatment of substance addiction and its related health effects. We approach these research questions using a translational framework that incorporates both human and animal studies, big data, and advanced statistical modeling techniques.

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Drug-Related Side Effects And Adverse Reactions

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Diagnostic And Statistical Manual Of Mental Disorders

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Fagerström Test For Nicotine Dependence (ftnd)

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2.3 Psychological, Social And Economic Factors

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3214 Pharmacology And Pharmaceutical Sciences

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2.3 Psychological, Social And Economic Factors

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University of California, Berkeley - (Berkeley, California, United States)

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University of California Los Angeles - (Los Angeles, California, United States)

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University of California Los Angeles - (Los Angeles, California, United States)

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Genotype-based ancestral background consistently predicts efficacy and side effects across treatments in CATIE and STAR*D.

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Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse.

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DUAL METHYLATION AND HYDROXYMETHYLATION STUDY IN BLOOD AND BRAIN IDENTIFIES BAIAP2 AS A MEDIATOR OF GENE EXPRESSION ASSOCIATED WITH ALCOHOL USE DISORDER

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S.14.08 Epigenetic aging in major depressive disorder

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Predicting Tobacco Use across the First Year of College.

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A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects.

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RaMWAS: fast methylome-wide association study pipeline for enrichment platforms.

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METHYLOME-WIDE ASSOCIATION STUDY OF ANXIETY DISORDERS

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Deep Sequencing of 71 Candidate Genes to Characterize Variation Associated with Alcohol Dependence.

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Evaluation of Methyl-Binding Domain Based Enrichment Approaches Revisited.

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Large-scale neurochemical metabolomics analysis identifies multiple compounds associated with methamphetamine exposure.

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Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences.

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Longitudinal patterns of posttraumatic stress disorder symptoms among sexual assault survivors: A latent transition analysis.

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Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses.

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DNA methylation biomarkers of alcohol use disorder

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USING STRUCTURAL EQUATION MODELING (SEM) METHODS TO EXAMINE GENOME-WIDE ASSOCIATIONS WITH A LATENT NEUROTICISM FACTOR AND ITEM-SPECIFIC RESIDUALS

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Genes, environments, and developmental research: methods for a multi-site study of early substance abuse.

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Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder.

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Behavioral metabolomics analysis identifies novel neurochemical signatures in methamphetamine sensitization.

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Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.

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47 METHYLOME-WIDE ASSOCIATION STUDIES FOR MAJOR DEPRESSIVE DISORDER IN BLOOD OVERLAP WITH METHYLATION RESULTS FROM BRAIN AND LARGE-SCALE GWAS

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Understanding the Longitudinal Impact of School-Based Health Centers on Student Attendance

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Comparing factor, class, and mixture models of cannabis initiation and DSM cannabis use disorder criteria, including craving, in the Brisbane longitudinal twin study.

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Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D.

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MBD-seq as a cost-effective approach for methylome-wide association studies: demonstration in 1500 case--control samples.

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A methylation study of long-term depression risk.

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Clarifying the Genetic Influences on Nicotine Dependence and Quantity of Use in Cigarette Smokers.

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Models and Strategies for Factor Mixture Analysis: An Example Concerning the Structure Underlying Psychological Disorders.

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A multi-method investigation of the personality correlates of digital aggression

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Enrichment methods provide a feasible approach to comprehensive and adequately powered investigations of the brain methylome.

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Methylome-wide association study of anxiety disorders.

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A Whole Methylome CpG-SNP Association Study of Psychosis in Blood and Brain Tissue.

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Regime Switching Modeling of Substance Use: Time-Varying and Second-Order Markov Models and Individual Probability Plots.

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Trajectories of depressive symptoms in response to prolonged stress in medical interns.

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Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex.

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24 PREDICTING THE FUTURE DISEASE STATUS OF DEPRESSED PATIENTS FROM DNA METHYLATION PATTERNS IN BLOOD

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Patterns of Substance Use Across the First Year of College and Associated Risk Factors.

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P.4.001 Accelerated biological aging in major depressive disorder: capturing aging patterns in DNA methylation with machine learning methods

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School attendance problems and youth psychopathology: structural cross-lagged regression models in three longitudinal data sets.

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Using classification trees to identify psychotherapy patients at risk for poor treatment adherence.

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Transcriptome-wide association study for postpartum depression implicates altered B-cell activation and insulin resistance.

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Dual methylation and hydroxymethylation study of alcohol use disorder.

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Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples.

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Testing the temporal relationship between maternal and adolescent depressive and anxiety symptoms in a community sample.

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GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS.

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Associations of depression and anxiety symptoms in childhood and adolescence with epigenetic aging.

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Cell-Type Specific Methylome-Wide Association Study of Anxiety Disorders

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High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction.

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Using Patterns of Genetic Association to Elucidate Shared Genetic Etiologies Across Psychiatric Disorders.

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Neuronal-specific methylome and hydroxymethylome analysis reveal replicated and novel loci associated with alcohol use disorder.

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Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.

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Evaluating traumatic event scoring schemas for their predictive value to concurrent diagnostic profiles: Texas Childhood Trauma Research Network.

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Refinement of schizophrenia GWAS loci using methylome-wide association data.

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Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.

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Overestimation of the classification accuracy of a biomarker for assessing heavy alcohol use.

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A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens.

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Dual methylation and hydroxymethylation study of alcohol use disorder

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Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults.

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A single-nucleus transcriptomics study of alcohol use disorder in the nucleus accumbens

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F67A COMPREHENSIVE BRAIN METHYLATION AND HYDROXYMETHYLATION STUDY IN ALCOHOL DEPENDENT PATIENTS

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A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies.

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41. Telomere Length, Epigenetic Aging and Depression in the Netherlands Study of Depression and Anxiety (NESDA)

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Longitudinal genetic analysis for loneliness in Dutch twins.

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Genome-Wide Meta-Analysis of Longitudinal Alcohol Consumption Across Youth and Early Adulthood.

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Characterizing patterns of substance use in trauma exposed youth.

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Background Characteristics and Oral Proficiency Development Over Time in Lower-Division College Foreign Language Programs

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Longitudinal interactions of pain and posttraumatic stress disorder symptoms in U.S. Military service members following blast exposure.

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Correcting for cell-type effects in DNA methylation studies: reference-based method outperforms latent variable approaches in empirical studies.

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Analysis of efficacy and side effects in CATIE demonstrates drug response subgroups and potential for personalized medicine.

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Epigenetic Aging in Major Depressive Disorder.

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Sample Size Requirements for Structural Equation Models: An Evaluation of Power, Bias, and Solution Propriety.

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The Impact of Childhood Mental Health and Substance Use on Methylation Aging Into Adulthood.

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Family and social risk, and parental investments during the early childhood years as predictors of low-income children's school readiness outcomes

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The methylomic consequences of neighborhood disadvantage for youth risk-taking behaviors.

# researcherOn[].awardedBy.label
National Institute of Child Health and Human Development - (Bethesda, Maryland, United States)

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Diagnostic and prognostic methylation biomarkers for alcohol and related health risks

# researcherOn[].awardedBy.label
National Institute On Alcohol Abuse and Alcoholism - (Bethesda, Maryland, United States)