# positions[].organizations[].parent[].label
College of Veterinary Medicine and Biomedical Sciences

# overview
Our laboratory conducts translational research with an ultimate goal to discover new anti-parasitic therapeutics by targeting metabolic enzymes and other molecules critical or essential to the parasite infection, survival and development, such as those involved in the lipid and energy metabolisms and interacting with host cells in Cryptosporidium and other protozoan parasites. Other research areas include functional genomics and molecular evolution of apicomplexan parasites, and parasitic diseases important to the conservation of wild animals.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Atp Binding Cassette Transporter, Subfamily B, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Atp Binding Cassette Transporter, Subfamily B, Member 1

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
T-cell Immunomodulatory Protein (tip) Homolog

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Type A Asparagine Synthase (asns-a Or Asna)

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Zhejiang University - (Hangzhou, Zhejiang, China)

# educationAndTraining[].organization.label
University of Georgia - (Athens, Georgia, United States)

# educationAndTraining[].organization.label
Zhejiang University - (Hangzhou, Zhejiang, China)

# educationAndTraining[].organization.label
Wadsworth Center - (Albany, New York, United States)

# publications[].label
Cryptosporidium parvum appears to lack a plastid genome.

# publications[].label
What is the phylogenetic position of Cryptosporidium?

# publications[].label
Complete genome sequence of the apicomplexan, Cryptosporidium parvum.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Prevalence of intestinal parasites in companion dogs with diarrhea in Beijing, China, and genetic characteristics of Giardia and Cryptosporidium species

# publications[].label
Implication of Potential Differential Roles of the Two Phosphoglucomutase Isoforms in the Protozoan Parasite Cryptosporidium parvum.

# publications[].label
Distribution of lethal giant larvae (Lgl) protein in the tegument and negative impact of siRNA-based gene silencing on worm surface structure and egg hatching in Schistosoma japonicum.

# publications[].label
Inhibition of the Cryptosporidium parvum S-adenosylhomocysteine hydrolase with purine nucleoside analogues

# publications[].label
Functional characterizations of malonyl-CoA:acyl carrier protein transacylase (MCAT) in Eimeria tenella.

# publications[].label
Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP).

# publications[].label
Streptococcus troglodytidis sp. nov., isolated from a foot abscess of a chimpanzee (Pan troglodytes).

# publications[].label
Characterisation of a novel transporter from Cryptosporidium parvum.

# publications[].label
Characterization in vitro and in vivo of resistance to ionophores in a strain of Eimeria tenella.

# publications[].label
Characterization of a heavy metal ATPase from the apicomplexan Cryptosporidium parvum.

# publications[].label
Unlocking the mystery of the feeder organelle and versatile energy metabolism in Cryptosporidium parvum.

# publications[].label
Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin.

# publications[].label
Molecular cloning and differential expression in tissues of a tyrosinase gene in the Pacific oyster Crassostrea gigas

# publications[].label
Establishment of a continuous in vitro culture of Babesia duncani in human erythrocytes reveals unusually high tolerance to recommended therapies.

# publications[].label
On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify the effect on the parasite target.

# publications[].label
The apicomplexan Cryptosporidium parvum possesses a single mitochondrial-type ferredoxin and ferredoxin:NADP+ reductase system.

# publications[].label
Functional characterization of the acyl-[acyl carrier protein] ligase in the Cryptosporidium parvum giant polyketide synthase.

# publications[].label
Silk Fibroin Scaffolds Facilitating the Repair of Rat Abdominal Wall Defect

# publications[].label
Quantitative RT-PCR assay for high-throughput screening (HTS) of drugs against the growth of Cryptosporidium parvum in vitro.

# publications[].label
A Vavraia-like microsporidium as the cause of deadly infection in threatened and endangered Eurycea salamanders in the United States.

# publications[].label
An apicomplexan ankyrin-repeat histone deacetylase with relatives in photosynthetic eukaryotes.

# publications[].label
Phylogenetic analyses of Texas isolates indicate an evolving subtype of the clade B feline immunodeficiency viruses.

# publications[].label
Pyruvate : NADP+ oxidoreductase from the mitochondrion of Euglena gracilis and from the apicomplexan Cryptosporidium parvum: a biochemical relic linking pyruvate metabolism in mitochondriate and amitochondriate protists.

# publications[].label
Cryptosporidium parvum Elongation Factor 1 Participates in the Formation of Base Structure at the Infection Site During Invasion.

# publications[].label
Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein.

# publications[].label
The beta tubulin gene of Eimeria tenella.

# publications[].label
Minimizing DNA recombination during long RT-PCR.

# publications[].label
Evolution of Cryptosporidium parvum lactate dehydrogenase from malate dehydrogenase by a very recent event of gene duplication.

# publications[].label
Seroprevalence of five parasitic pathogens in pregnant women in ten Caribbean countries.

# publications[].label
Host cells with transient overexpression of MDR1 as a novel in vitro model for evaluating on-target effect for activity against the epicellular Cryptosporidium parasite.

# publications[].label
Involvement of host cell integrin 2 in Cryptosporidium parvum infection.

# publications[].label
Cryptosporidium Lactate Dehydrogenase Is Associated with the Parasitophorous Vacuole Membrane and Is a Potential Target for Developing Therapeutics.

# publications[].label
New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide.

# publications[].label
Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A synthetases.

# publications[].label
Cryptosporidium parvum: functional complementation of a parasite transcriptional coactivator CpMBF1 in yeast.

# publications[].label
Two distinct oxysterol binding protein-related proteins in the parasitic protist Cryptosporidium parvum (Apicomplexa).

# publications[].label
Cysteine-independent catalase-like activity of vertebrate peroxiredoxin 1 (Prx1).

# publications[].label
The Existing Drug Vorinostat as a New Lead Against Cryptosporidiosis by Targeting the Parasite Histone Deacetylases.

# publications[].label
Cryptosporidium parvum possesses a short-type replication protein A large subunit that differs from its host.

# publications[].label
Requirement of microtubules for secretion of a micronemal protein CpTSP4 in the invasive stage of the apicomplexan Cryptosporidium parvum.

# publications[].label
Divergent polyamine metabolism in the Apicomplexa.

# publications[].label
Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S)-DHPA, against the growth of Cryptosporidium parvum in vitro.

# publications[].label
Discovery of ebselen as an inhibitor of Cryptosporidium parvum glucose-6-phosphate isomerase (CpGPI) by high-throughput screening of existing drugs.

# publications[].label
What is your diagnosis? Corneal scrape from a dog.

# publications[].label
Targeting translation initiation yields fast-killing therapeutics against the zoonotic parasite Cryptosporidium parvum.

# publications[].label
Expansion of Opportunistic Enteric Fungal Pathogens and Occurrence of Gut Inflammation in Human Liver Echinococcosis.

# publications[].label
A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium.

# publications[].label
A Single-Pass Type I Membrane Protein from the Apicomplexan Parasite Cryptosporidium parvum with Nanomolar Binding Affinity to Host Cell Surface.

# publications[].label
Peroxiredoxin 1 (Prx1) is a dual-function enzyme by possessing Cys-independent catalase-like activity.

# publications[].label
A unique hexokinase in Cryptosporidium parvum, an apicomplexan pathogen lacking the Krebs cycle and oxidative phosphorylation.

# publications[].label
Apicoplast genome of the coccidian Eimeria tenella.

# publications[].label
Establishment of a Transient and Stable Transfection System for Babesia duncani Using a Homologous Recombination Strategy.

# publications[].label
Differential expression and interaction of transcription co-activator MBF1 with TATA-binding protein (TBP) in the apicomplexan Cryptosporidium parvum.

# publications[].label
Characterization of Host Cell Mutants Significantly Resistant to Cryptosporidium parvum Infection.

# publications[].label
Type A asparagine synthetase in the zoonotic Cryptosporidium parvum (CpAsnA): Biochemical features and potential as a novel therapeutic target.

# publications[].label
Molecular and Biochemical Characterization of a Type II Thioesterase From the Zoonotic Protozoan Parasite Cryptosporidium parvum.

# publications[].label
The protozoan parasite Cryptosporidium parvum possesses two functionally and evolutionarily divergent replication protein A large subunits.

# publications[].label
Expression and functional characterization of a giant Type I fatty acid synthase (CpFAS1) gene from Cryptosporidium parvum

# publications[].label
Monophyletic relationship between severe acute respiratory syndrome coronavirus and group 2 coronaviruses.

# publications[].label
Molecular cloning, phylogenetic analysis and three-dimensional modeling of Cu,Zn superoxide dismutase (CnSOD1) from three varieties of Cryptococcus neoformans.

# publications[].label
Molecular analysis of a P-type ATPase from Cryptosporidium parvum.

# publications[].label
Peptides associated with monensin resistance in sporozoites of Eimeria tenella (Coccidia).

# publications[].label
A new eimeriid (Apicomplexa) species from endangered Attwater's prairie chickens (Tympanuchus cupido attwateri) in Texas.

# publications[].label
Molecular and biochemical characterization of Eimeria tenella hexokinase.

# publications[].label
Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa).

# publications[].label
Pathogenicity and virulence of Cryptosporidium.

# publications[].label
The mucin-like, secretory type-I transmembrane glycoprotein GP900 in the apicomplexan Cryptosporidium parvum is cleaved in the secretory pathway and likely plays a lubrication role.

# publications[].label
Advances in research of fish immune-relevant genes: a comparative overview of innate and adaptive immunity in teleosts.

# publications[].label
A genome-sequence survey for Ascogregarina taiwanensis supports evolutionary affiliation but metabolic diversity between a Gregarine and Cryptosporidium.

# publications[].label
The Action of the Hexokinase Inhibitor 2-deoxy-d-glucose on Cryptosporidium parvum and the Discovery of Activities against the Parasite Hexokinase from Marketed Drugs.

# publications[].label
An improved histone deacetylase (HDAC) assay and its application for high-throughput screening of inhibitors against Cryptosporidium parvum enzymes

# publications[].label
Energy Metabolism and Carbon Flow in Cryptosporidium parvum

# publications[].label
Annotated draft genome sequences of three species of Cryptosporidium: Cryptosporidium meleagridis isolate UKMEL1, C. baileyi isolate TAMU-09Q1 and C. hominis isolates TU502_2012 and UKH1.

# publications[].label
Amplification of ionophore resistance in a field strain of Eimeria tenella by treating free sporozoites with monensin in vitro.

# publications[].label
Viral Diversity and Ecological Impact of DNA Viruses in Dominant Tick Species in China.

# publications[].label
Molecular analysis of a Type I fatty acid synthase in Cryptosporidium parvum.

# publications[].label
Erratum: Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host.

# publications[].label
Interpretable machine learning framework reveals microbiome features of oral disease.

# publications[].label
Molecular Epidemiology of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi in Guizhou Angus Calves: Dominance of Angus Cattle-Adapted Genotypes and Zoonotic Potential of E. bieneusi.

# publications[].label
Discovery of Novel Anti-cryptosporidial Activities From Natural Products by in vitro High-Throughput Phenotypic Screening.

# publications[].label
Plant-type trehalose synthetic pathway in cryptosporidium and some other apicomplexans.

# publications[].label
The genome of the thin-necked bladder worm Taenia hydatigena reveals evolutionary strategies for helminth survival.

# publications[].label
Comparative genomics reveals adaptive evolution of Asian tapeworm in switching to a new intermediate host.

# publications[].label
Transcriptome analysis in chicken cecal epithelia upon infection by Eimeria tenella in vivo.

# publications[].label
Differential Gene Expression and Protein Localization of Cryptosporidium parvum Fatty Acyl-CoA Synthetase Isoforms.

# publications[].label
Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src.

# publications[].label
Functional characterization of replication protein A2 (RPA2) from Cryptosporidium parvum.

# publications[].label
Intron-containing beta-tubulin transcripts in Cryptosporidium parvum cultured in vitro.

# publications[].label
CONFOCAL LASER-SCANNING MICROSCOPY OF BETA-TUBULIN AND ALPHA-ACTININ IN ASEXUAL STAGES OF EIMERIA-TENELLA (APICOMPLEXA, EIMERIIDAE) IN CELL-CULTURE

# publications[].label
Cysteine-independent Catalase-like Activity of Vertebrate Peroxiredoxin 1 (Prx1).

# publications[].label
Reconstitution of a bacterial/plant polyamine biosynthesis pathway in Saccharomyces cerevisiae.

# publications[].label
Polyamine biosynthesis in Cryptosporidium parvum and its implications for chemotherapy.

# publications[].label
An old drug as a promising new cure for the hard-to-treat echinococcosis.

# publications[].label
Variant proteins associated with ionophore resistance in sporozoites of Eimeria tenella (Coccidia).

# publications[].label
Crystallization of three key glycolytic enzymes of the opportunistic pathogen Cryptosporidium parvum.

# publications[].label
Discovery of New Microneme Proteins in Cryptosporidium parvum and Implication of the Roles of a Rhomboid Membrane Protein (CpROM1) in Host-Parasite Interaction.

# publications[].label
A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions.

# publications[].label
Apical organelle discharge by Cryptosporidium parvum is temperature-, cytoskeleton- and intracellular calcium-dependent and required for host cell invasion

# publications[].label
Functional characterization of a fatty acyl-CoA-binding protein (ACBP) from the apicomplexan Cryptosporidium parvum.

# publications[].label
Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense.

# publications[].label
Immunocompetent rabbits infected with Cryptosporidium cuniculus as an animal model for anti-cryptosporidial drug testing.

# publications[].label
Presence and removal of a contaminating NADH oxidation activity in recombinant maltose-binding protein fusion proteins expressed in Escherichia coli.

# publications[].label
Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion.

# publications[].label
Heterogeneous expression and functional analysis of two distinct replication protein A large subunits from Cryptosporidium parvum.

# publications[].label
Current progress in the fatty acid metabolism in Cryptosporidium parvum.

# publications[].label
Gene discovery, evolutionary affinity and molecular detection of Oxyspirura petrowi, an eye worm parasite of game birds.

# publications[].label
18S/28S rDNA metabarcoding identifies Cryptosporidium parvum and Blastocystis ST1 as the predominant intestinal protozoa in hospital patients from Changchun, Northeast China.

# publications[].label
Computer program for calculating the melting temperature of degenerate oligonucleotides used in PCR or hybridization.

# publications[].label
Direct isolation of DNA from patient stools for polymerase chain reaction detection of Cryptosporidium parvum.

# publications[].label
Novel strategy to quantify the viability of oocysts of Cryptosporidium parvum and C. hominis, a risk factor of the waterborne protozoan pathogens of public health concern.

# publications[].label
The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development.

# publications[].label
The apicoplast biogenesis and metabolism: current progress and questions.

# publications[].label
Genomic reconstruction and features of glycosylation pathways in the apicomplexan Cryptosporidium parasites.

# publications[].label
High-Throughput Screening of Drugs Against the Growth of Cryptosporidium parvum In Vitro by qRT-PCR.

# publications[].label
Emergence of Cryptosporidium parvum IIc Subtype and Giardia duodenalis Assemblage E in AIDS Patients in Central China: Evidence for Neglected Transmission Dynamics.

# publications[].label
The reductase domain in a Type I fatty acid synthase from the apicomplexan Cryptosporidium parvum: restricted substrate preference towards very long chain fatty acyl thioesters.

# publications[].label
Differential expression of the two distinct replication protein A subunits from Cryptosporidium parvum.

# publications[].label
Multiyear Survey of Coccidia, Cryptosporidia, Microsporidia, Histomona, and Hematozoa in Wild Quail in the Rolling Plains Ecoregion of Texas and Oklahoma, USA.

# publications[].label
Unique Tubulin-Based Structures in the Zoonotic Apicomplexan Parasite Cryptosporidium parvum.

# publications[].label
Cryptosporidium parvum long-chain fatty acid elongase.

# publications[].label
SEROPREVALENCE OF FIVE PARASITIC PATHOGENS IN PREGNANT WOMEN FROM 10 CARIBBEAN COUNTRIES

# publications[].label
Transcriptome analysis reveals unique metabolic features in the Cryptosporidium parvum Oocysts associated with environmental survival and stresses.

# publications[].label
Cryptosporidium parvum: the first protist known to encode a putative polyketide synthase.

# publications[].label
Application of quantitative real-time reverse transcription-PCR in assessing drug efficacy against the intracellular pathogen Cryptosporidium parvum in vitro.

# publications[].label
Functional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum.

# publications[].label
How Much Does Roxarsone Contribute to Coccidiosis Control in Broilers when Used in Combination with Ionophores?

# publications[].label
Giardia fatty acyl-CoA synthetases as potential drug targets.

# researcherOn[].label
Discovery of inhibitors against cryptosporidial fatty acyl-CoA synthetase

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
Discovery Of Host Cell Candidate Proteins Critical To The Attachment By Cryptosporidium Sporozoites

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Allergy and Infectious Diseases

# researcherOn[].label
Bacterial-type hexokinase (HK) in the opportunistic parasite Cryptosporidium parvum

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Developing Therapeutics against Giardia and Other Anaerobic Protozoa by Targeting Parasite Fatty Acyl-CoA Synthetase (ACS)

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Evaluation of Marketed Drugs for Rapid Development As Anti- Cryptosporidial Agents

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
PCR optimization for the identification and diagnosis of microsporidia in federally listed Eurycea salamanders and voriconazole Treatment

# researcherOn[].awardedBy.label
United States Department of the Interior - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Biochemistry of Protozoan parasites in animals and humans

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Vet Med Pathobiology; 4467 TAMU

# organizations[]
College of Veterinary Medicine and Biomedical Sciences

# organizations[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US

# schools[]
College of Veterinary Medicine and Biomedical Sciences

# schools[]
"College of Veterinary Medicine and Biomedical Sciences"@en-US