# title
Amino acid nutrition and metabolism in domestic cats and dogs.

# abstract
Domestic cats and dogs are carnivores that have evolved differentially in the nutrition and metabolism of amino acids. This article highlights both proteinogenic and nonproteinogenic amino acids. Dogs inadequately synthesize citrulline (the precursor ofarginine) from glutamine, glutamate, and proline in the small intestine. Although most breeds of dogs have potential for adequately converting cysteine into taurine in the liver, a small proportion (1.3%-2.5%) of the Newfoundland dogs fed commercially available balanced diets exhibit a deficiency of taurine possibly due to gene mutations. Certain breeds of dogs (e.g., golden retrievers) are more prone to taurine deficiency possibly due to lower hepatic activities of cysteine dioxygenase and cysteine sulfinate decarboxylase. De novo synthesis of arginine and taurine is verylimited in cats. Thus, concentrations of both taurine and arginine in feline milk are the greatest among domesticmammals. Compared with dogs, cats have greater endogenous nitrogen losses and higher dietary requirements for manyamino acids (e.g.,arginine, taurine, cysteine,and tyrosine), and are less sensitive to amino acid imbalances and antagonisms. Throughout adulthood, cats and dogs may lose 34% and 21% of their lean body mass, respectively. Adequate intakes of high-quality protein (i.e., 32% and 40% animal protein in diets of aging dogs and cats, respectively; dry matter basis) are recommended to alleviate aging-associated reductions in the mass and function of skeletal muscles and bones. Pet-food grade animal-sourced foodstuffs are excellent sources of both proteinogenic amino acids and taurine for cats and dogs, and canhelp to optimize their growth, development, and health.

# publicationVenue.label
Journal of Animal Science and Biotechnology

# authors[].organizations[].label
College of Veterinary Medicine and Biomedical Sciences

# authors[].organizations[].label
College of Agriculture and Life Sciences