# overview
Our long-term goal is to explore and define novel genetic mechanisms that are involved in cardiovascular disease which can ultimately translate into potential strategies for its treatment. To achieve this goal, we will use a comprehensive approach including mouse genetics and molecular and cellular biology methods to explore the mechanisms involved in the regulation of cardiovascular development and disease.

# keywords[]
Calcium Release Activated Calcium Channels

# keywords[]
Vascular Endothelial Growth Factor Receptor-2

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Calcium Release-activated Calcium Channel Protein 1 (ORAI1)

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Intracellular Signaling Peptides And Proteins

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Stem Cell Research - Nonembryonic - Non-human

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1.1 Normal Biological Development And Functioning

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Intracellular Signaling Peptides And Proteins

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Intracellular Signaling Peptides And Proteins

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4903 Numerical And Computational Mathematics

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Platelet Endothelial Cell Adhesion Molecule-1

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Platelet Endothelial Cell Adhesion Molecule-1

# educationAndTraining[].organization.label
Cornell University - (Ithaca, New York, United States)

# educationAndTraining[].organization.label
Peking University - (Beijing, Beijing, China)

# educationAndTraining[].organization.label
Shanghai Jiao Tong University - (Shanghai, Shanghai, China)

# publications[].label
An Essential Role for Cdc42 in the Functioning of the Adult Mammary Gland.

# publications[].label
Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Ca2+ release-activated Ca2+ channels are responsible for histamine-induced Ca2+ entry, permeability increase, and interleukin synthesis in lymphatic endothelial cells.

# publications[].label
Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo

# publications[].label
In utero assessment of cardiovascular function in the embryonic mouse heart using high-resolution ultrasound biomicroscopy.

# publications[].label
Analysis of Lymphatic Vessel Formation by Whole-Mount Immunofluorescence Staining.

# publications[].label
BK polyomavirus from patients with tissue-derived prostate adenocarcinoma

# publications[].label
Atlastin regulates store-operated calcium entry for nerve growth factor-induced neurite outgrowth.

# publications[].label
[FAK antisense oligodeoxynucleotides inhibit vascular smooth muscle cell migration and adhesion mediated by FAK-ERK1/2 signaling pathway].

# publications[].label
Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis.

# publications[].label
Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland.

# publications[].label
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects.

# publications[].label
Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells.

# publications[].label
Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition.

# publications[].label
[Focal adhesion kinase and mitogen activated protein kinase are involved in vascular smooth muscle cells migration and proliferation stimulated by fibronectin].

# publications[].label
Krppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a.

# publications[].label
Indirect immunostaining on mouse embryonic heart for the detection of proliferated cardiomyocyte.

# publications[].label
Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia.

# publications[].label
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis.

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Cdc42 is required for lymphatic branching, maturation and valve formation during embryonic development

# publications[].label
Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.

# publications[].label
Analysis of Angiogenesis in Mouse Embryonic Dorsal Skin by Whole-Mount Fluorescent Staining.

# publications[].label
Abstract 15945: Cdc42 is Required for Lymphatic Branching, Maturation and Valve Formation During Development

# publications[].label
Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration.

# publications[].label
Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice.

# publications[].label
Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.

# publications[].label
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.

# publications[].label
Special Issue: The 1st World Congress on Global Optimization in Engineering & Science Preface

# publications[].label
Activated focal adhesion kinase involved in adhesion and migration of vascular smooth muscle cells stimulated by fibronectin.

# publications[].label
Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein.

# publications[].label
[Content and activity of the focal adhesion kinase in cultured vascular smooth muscle cells enhanced by urotensin II].

# publications[].label
Visualization of mouse embryo angiogenesis by fluorescence-based staining.

# publications[].label
Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.

# publications[].label
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice (vol 4, pg 231, 2013)

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Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy.

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Abstract 16137: Essential Role of Cdc42 in Cardiomyocyte Proliferation and Cell-cell Adhesion During Heart Development

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RNA-Sequencing and Transcriptome Analysis after Fluid Shear Stress Stimulation in Lymphatic Endothelial Cells.

# publications[].label
Cellular and Molecular Processes in Pulmonary Hypertension.

# publications[].label
Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.

# publications[].label
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Role of focal adhesion kinase phosphorylation in smooth muscle cells adhesion and migration mediated by fibronectin

# publications[].label
Involvement of pressure-related mechanism in activation of inducible nitric oxide synthase.

# publications[].label
Focal adhesion kinase: from in vitro studies to functional analyses in vivo.

# publications[].label
Spatiotemporal sequestration of miR165/166 by Arabidopsis Argonaute10 promotes shoot apical meristem maintenance.

# publications[].label
Essential role of Cdc42 in cardiomyocyte proliferation and cell-cell adhesion during heart development.

# publications[].label
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.

# publications[].label
Isolation and characterization of vascular endothelial cells from murine heart and lung.

# publications[].label
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice.

# publications[].label
Cardiovascular Development Methods and Protocols

# publications[].label
Detecting Three-Dimensional Vascular Networks in the Mouse Embryonic Hindbrain.

# publications[].label
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.

# publications[].publisher
Proceedings of the National Academy of Sciences

# editorOf[].label
Isolation of cardiac myocytes and fibroblasts from neonatal rat pups.

# researcherOn[].label
Mast cell/histamine-mediated inflammation and subsequent decrease of lymphatic amyloid beta clearance accelerate progression of Alzheimer's disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mast cell/histamine-mediated inflammation and subsequent decrease of lymphatic amyloid beta clearance accelerate progression of Alzheimer's disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mast cell/histamine-mediated inflammation and subsequent decrease of lymphatic amyloid beta clearance accelerate progression of Alzheimer's disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Role and Molecular Mechanisms of Cdc42 in Lymphatic valve formation

# researcherOn[].awardedBy.label
American Heart Association - (New York, New York, United States)

# researcherOn[].label
Cardiac Myosin Binding Protein-C in Development and Reversal of Heart Failure

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Heart, Lung, and Blood Institute

# streetAddress
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS