# positions[].label
John S. Dunn Chair in Disease Prevention

# positions[].organizations[].label
Center for Epigenetics and Disease Prevention

# overview
Research integrates multiomic, genetic, epigenetic and immune approaches for precision oncology. Epigenetic readers, writers and erasers that reversibly regulate immune players in the antigen presentation pathway are of current mechanistic interest. Molecular and cell-based assays are combined with preclinical models coupled to polypectomy. Clinical specimens and organoids from patients undergoing colectomy provide for human translation. Supported by the NCI, NINDS/NIA, and the John S. Dunn Foundation.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Colitis Mango Mtor Pathway Pomegranate Rat

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
C-terminal Binding Protein (ctbp) Interacting Protein

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Rela, V-rel Avian Reticuloendotheliosis Viral Oncogene Homolog A

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
Histone H3 Lysine 18 Acetylation (h3k18ac)

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
3 Prevention Of Disease And Conditions, And Promotion Of Well-being

# keywords[]
5 Development Of Treatments And Therapeutic Interventions

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
Oregon State University - (Corvallis, Oregon, United States)

# educationAndTraining[].organization.label
Plymouth University - (Plymouth, Plymouth, United Kingdom)

# educationAndTraining[].organization.label
University of Portsmouth - (Portsmouth, Portsmouth, United Kingdom)

# educationAndTraining[].organization.label
University of Surrey - (Guildford, Surrey, United Kingdom)

# publications[].label
Dietary factors and epigenetic regulation for prostate cancer prevention.

# publications[].label
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter.

# publications[].label
Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer.

# publications[].label
Anticarcinogenic activity of indole-3-carbinol acid products: ultrasensitive bioassay by trout embryo microinjection.

# publications[].label
Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide.

# publications[].label
Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion.

# publications[].label
SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.

# publications[].label
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.

# publications[].label
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.

# publications[].label
Targeting Epigenetic 'Readers' with Natural Compounds for Cancer Interception.

# publications[].label
A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay.

# publications[].label
Experimental colitis impedes cardiac function through epigenetic mechanisms

# publications[].label
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines

# publications[].label
Front cover: A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphanetreated colon cancer cells

# publications[].label
Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites.

# publications[].label
Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells.

# publications[].label
Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial.

# publications[].label
Tumor Dose-Response Studies with Aflatoxin B1 and the Ambivalent Modulator Indole-3-Carbinol: Inhibitory Versus Promotional Potency

# publications[].label
Cancer-protective effects and bioavailability of flavonoids.

# publications[].label
Abstract 1: Sulindac plus phospholipid is effective for polyp reduction and safer than sulindac alone

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.

# publications[].label
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.

# publications[].label
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen.

# publications[].label
Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Introduction to Nutrition and physical activity in aging, obesity, and cancer.

# publications[].label
Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254.

# publications[].label
991  Matrix Metalloproteinase 7 Contributes to Intestinal Barrier Dysfunction by Suppressing Tight Junction Proteins

# publications[].label
The "Sufficiency Principle" from the perspective of cancer prevention.

# publications[].label
Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis

# publications[].label
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention.

# publications[].label
Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.

# publications[].label
Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.

# publications[].label
Inhibition by white tea of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat.

# publications[].label
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations.

# publications[].label
Abstract 5632: Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals.

# publications[].label
Nutritional regulation of epigenetic changes.

# publications[].label
Abstract 5713: Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Ischemia-reperfusion injury in the lung: quantitation using electron microscopy.

# publications[].label
Modulation of Wnt signaling by white tea plus celecoxib.

# publications[].label
Combined Radiolabelling Distribution and Covalent DNA-Binding Studies to Discriminate Between a Carcinogen/Noncarcinogen Pair of Monoazo Dyes Related to the Hepatocarcinogen Butter Yellow (DAB)

# publications[].label
Weak ligands as HDAC inhibitors: useful for chemoprevention?

# publications[].label
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.

# publications[].label
Abstract CN12-02: Dietary HDAC inhibitors: Prevention or therapy?

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Inhibitory activity of green and black tea in a free radical-generating system using 2-amino-3-methylimidazo[4,5-f]quinoline as substrate.

# publications[].label
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin.

# publications[].label
AZ of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer

# publications[].label
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon.

# publications[].label
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs.

# publications[].label
Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games.

# publications[].label
Mutagenicity to Salmonella of four derivatives of the azo mutagen 5I: some implications for structure--activity databases and the evaluation of combinations of mutagens.

# publications[].label
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.

# publications[].label
Heterogeneous reactions of particulate matter-bound PAHs and NPAHs with NO3/N2O5, OH radicals, and O3 under simulated long-range atmospheric transport conditions: reactivity and mutagenicity.

# publications[].label
Time to discontinue antigenotoxicity studies of dietary fiber?

# publications[].label
Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells.

# publications[].label
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate.

# publications[].label
Regulation of hepatic cytochrome P4501A by indole-3-carbinol: transient induction with continuous feeding in rainbow trout.

# publications[].label
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine.

# publications[].label
A hypermorphic epithelial -catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.

# publications[].label
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.

# publications[].label
MUTAGENICITY OF THE 2 CARCINOGEN NON-CARCINOGEN PAIRS BENZO[A]PYRENE, PYRENE AND 2-ACETYLAMINOFLUORENE, 4-ACETYLAMINOFLUORENE AND THEIR RESPECTIVE RAT URINE CONCENTRATES AS PART OF THE IPCS COLLABORATIVE TRIAL

# publications[].label
THE RELATIONSHIP BETWEEN COVALENT DNA-BINDING AND REVERTANT YIELD IN THE SALMONELLA MUTAGENICITY (AMES) ASSAY - IMPLICATIONS FOR ASSAY SPECIFICITY

# publications[].label
Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation.

# publications[].label
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.

# publications[].label
Memories of a friend and colleague - Takashi Sugimura.

# publications[].label
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout.

# publications[].label
EFFECT OF DIETARY INDOLE-3-CARBINOL (I3C), B-NAPHTHOFLAVONE (BNF), AND AROCLOR-1254 (PCB) ON DIETHYLNITROSAMINE (DEN) AND AFLATOXIN-B1 (AFB1) CARCINOGENESIS IN TROUT

# publications[].label
Genome-wide transcriptome analysis of the effects of sulforphane on normal and prostate cancer cells

# publications[].label
Optimized Lower Dose Combinations of Sulindac Plus Erlotinib Sustained Antitumor Efficacy and Reduced Toxicity in a Preclinical Model of FAP

# publications[].label
Analysis of genome-wide DNA methylation in CCRF-CEM cells confirms hypermethylation at reported epigenetic markers of T-cell lymphoblastic leukemia and identifies novel therapeutic targets with reduced methylation upon treatment with dietary indoles

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

# publications[].label
Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.

# publications[].label
LIMITATIONS OF INVITRO ASSAYS FOR DISTINGUISHING BETWEEN A CARCINOGEN NON-CARCINOGEN PAIR OF MONOAZO DYES

# publications[].label
Protective properties of chlorophylls against the covalent binding of heterocyclic amines to DNA in vitro and in vivo.

# publications[].label
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Cellular effects of tea antioxidants in vitro and in mouse models of colon cancer

# publications[].label
-catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo [4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol (vol 22, pg 315, 2001)

# publications[].label
Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics.

# publications[].label
The dietary phytochemical chlorophyllin alters e-cadherin and -catenin expression in human colon cancer cells

# publications[].label
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?

# publications[].label
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

# publications[].label
Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7.

# publications[].label
The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol.

# publications[].label
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.

# publications[].label
Antimutagenic activity of selenium-enriched green tea towards a cooked meat mutagen.

# publications[].label
Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.

# publications[].label
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.

# publications[].label
Preparation, Characterization and Electron Paramagnetic Resonance (EPR) Spectroscopic Studies of OXANOH

# publications[].label
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.

# publications[].label
Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1.

# publications[].label
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.

# publications[].label
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

# publications[].label
Abstract 5631: Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.

# publications[].label
Erratum: -Catenin mutation in rat colon tumors initiated by 1,2-dimenthylhydrazine and 2-amino-3-methylimidazo [4,5-f]quinoline, and the effect of post-initiation treatment with chlorophylin and indole-3-carbinol (Carcinogenesis (2001) vol. 22 (315-320))

# publications[].label
Carcinogenicity, metabolism and Ki-ras proto-oncogene activation by 7,12-dimethylbenz[a]anthracene in rainbow trout embryos.

# publications[].label
Abstract 5815: Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Metabolism as a key to histone deacetylase inhibition.

# publications[].label
A role for low-abundance miRNAs in colon cancer: the miR-206/Krppel-like factor 4 (KLF4) axis.

# publications[].id
 Production, proof of structure, properties.

# publications[].label
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.

# publications[].label
Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency.

# publications[].label
Abstract B33: Regulation and function of Nrf2-associated long noncoding RNA

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Translational Advances in Cancer Prevention Agent Development (TACPAD) Virtual Workshop on Immunomodulatory Agents: Report.

# publications[].label
Chemoprotection by sulforaphane: keep one eye beyond Keap1.

# publications[].label
Increased susceptibility of adult rats to azoxymethane-induced aberrant crypt foci.

# publications[].label
Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors.

# publications[].label
Differential effects of sulforaphane and related isothiocyanates on HDAC turnover and the DNA damage response in colon cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes.

# publications[].label
Tumor-suppressing effects of antioxidants from tea.

# publications[].label
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells.

# publications[].label
Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics

# publications[].label
Frontiers in polyphenols and cancer prevention.

# publications[].label
Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception.

# publications[].label
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.

# publications[].label
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.

# publications[].label
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.

# publications[].label
Dietary manipulation of histone structure and function.

# publications[].label
Metabolomics of Acute vs. Chronic Spinach Intake in an Apc-Mutant Genetic Background: Linoleate and Butanoate Metabolites Targeting HDAC Activity and IFN- Signaling.

# publications[].label
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

# publications[].label
Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout.

# publications[].label
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance.

# publications[].label
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract.

# publications[].label
THE SYNTHESIS OF [H-3] INDOLE-3-CARBINOL, A NATURAL ANTI-CARCINOGEN FROM CRUCIFEROUS VEGETABLES

# publications[].label
In vivo disposition of the natural anti-carcinogen indole-3-carbinol after po administration to rainbow trout.

# publications[].label
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane.

# publications[].label
Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting.

# publications[].label
Metabolism as a key to HDAC inhibition by dietary constituents

# publications[].label
Antimutagenic activity of spearmint (Mentha spicata L.)

# publications[].label
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.

# publications[].label
Sulforaphane alters the expression of long intragenic noncoding RNAs that are dysregulated in prostate cancer cells (644.10)

# publications[].label
Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake

# publications[].label
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.

# publications[].label
LEVELS OF METABOLIC COMPLEXITY IN ASSAYS EMPLOYING THE INVIVO EQUIVALENT DOSE (IVED) CONCEPT - REPLY

# publications[].label
Early detection and prevention of colorectal cancer (review).

# publications[].label
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer

# publications[].label
Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA.

# publications[].label
Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens.

# publications[].label
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.

# publications[].label
The importance of using pure chemicals in (anti) mutagenicity studies: chlorophyllin as a case in point.

# publications[].label
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay.

# publications[].label
Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen.

# publications[].label
1084 - Neonatal Colonic Inflammation Aggravates Epithelial Injury Through Mir-196 When Exposed to Another Episode of Inflammation in Adult-Life

# publications[].label
An epigenetic perspective on pharmacologic ascorbate in colon cancer

# publications[].label
Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.

# publications[].label
Dietary polyphenols as epigenetic 'reader' inhibitors

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Capsaicin represses transcriptional activity of -catenin in human colorectal cancer cells.

# publications[].label
Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP).

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
DNA-binding studies with 6BT and 5I: implications for DNA-binding/carcinogenicity and DNA-binding/mutagenicity correlations.

# publications[].label
Effect of carcinogen dose fractionation, diet and source of F344 rat on the induction of colonic aberrant crypts by 2-amino-3-methylimidazo[4,5-f]quinoline.

# publications[].label
ADAPTATION OF INVITRO AND INVIVO BINDING ASSAYS TO DISCRIMINATE BETWEEN A CARCINOGEN NON-CARCINOGEN PAIR OF MUTAGENIC MONOAZO DYES

# publications[].label
S318 Optimized Lower Dose Combinations of Sulindac Plus Erlotinib Sustained Antitumor Efficacy and Reduced Toxicity in a Preclinical Model of FAP

# publications[].label
HDAC inhibition by sulforaphane during hyperplasia, intermediate and late stages of prostate cancer.

# publications[].label
Abstract B84: NADPH oxidase 1 (NOX1) and related NOX isoforms as key mediators of NFB signaling in colon cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.

# publications[].label
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.

# publications[].label
Combined in vivo DNA binding and tumor dose-response studies to investigate the molecular dosimetry concept.

# publications[].label
Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells.

# publications[].label
Emerging crosstalk between long non-coding RNAs and Nrf2 signaling.

# publications[].label
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals.

# publications[].label
ON THE LACK OF SPECIFICITY OF THE SALMONELLA MUTAGENICITY ASSAY

# publications[].label
Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone.

# publications[].label
Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1.

# publications[].label
Inhibition of DNA adduct formation of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) by dietary indole-3-carbinol (I3C) in the mammary gland, colon, and liver of the female F-344 rat.

# publications[].label
Dietary manipulation of histone structure and function.

# publications[].label
Inside front cover: Comparison of antiinflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis

# publications[].label
Mechanisms of indole-3-carbinol (I3C) anticarcinogenesis: inhibition of aflatoxin B1-DNA adduction and mutagenesis by I3C acid condensation products.

# publications[].label
The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells.

# publications[].label
Abstract A013: Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f]quinoline (vol 22, pg 309, 2001)

# publications[].label
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis.

# publications[].label
Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma.

# publications[].label
Measuring antigenotoxic effects using the ames test and comet assay

# publications[].label
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.

# publications[].label
Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure.

# publications[].label
Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls.

# publications[].label
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells.

# publications[].label
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.

# publications[].label
Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?

# publications[].label
Alpha-keto acid metabolites of organoselenium compounds inhibit HDAC activity

# publications[].label
Multi-targeted prevention of cancer by sulforaphane.

# publications[].label
Sulforaphane inhibits HDAC activity in prostate cancer cells, retards growth of PC3 xenografts, and inhibits HDAC activity in vivo

# publications[].label
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon.

# publications[].label
Metabolism and cancer: old and new players.

# publications[].label
Chemopreventative phytochemical 3,3-diindolylmethane inhibits histone deacetylases in prostate cancer cells

# publications[].label
Bioavailability and metabolomic targets of sulforaphane in humans (1036.2)

# publications[].label
Combined radiolabelling distribution and covalent DNA-binding studies to discriminate between a carcinogen/noncarcinogen pair of monoazo dyes related to the hepatocarcinogen butter yellow (DAB).

# publications[].label
Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake.

# publications[].label
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.

# publications[].label
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.

# publications[].label
Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS.

# publications[].label
Frontiers in polyphenols and cancer prevention

# publications[].label
Measuring Histone Deacetylase Inhibition in the Brain.

# publications[].label
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

# publications[].label
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.

# publications[].label
Targeting the Epigenome with Dietary Agents

# publications[].label
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat.

# publications[].label
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.

# publications[].label
(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells.

# publications[].label
Development of a murine colonoscopic polypectomy model(withvideos).

# publications[].label
An RNA-seq approach to identify mechanisms by which the phytochemical sulforaphane acts to prevent prostate cancer

# publications[].label
Broccoli sprouts delay prostate cancer formation and decrease prostate cancer severity with a concurrent decrease in HDAC3 protein expression in TRAMP mice.

# publications[].label
Novel nitro-PAH formation from heterogeneous reactions of PAHs with NO2, NO3/N2O5, and OH radicals: prediction, laboratory studies, and mutagenicity.

# publications[].label
Cancer chemoprevention by a combination of white tea plus sulindac in a mouse model expressing an oncogenic form of -catenin.

# publications[].label
Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.

# publications[].label
Su1677 ERLOTINIB SUPPRESSES TUMORIGENESIS IN A MOUSE MODEL OF COLITIS-ASSOCIATED CANCER

# publications[].label
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.

# publications[].label
Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts.

# publications[].label
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.

# publications[].label
Novel polypectomy system in a preclinical model of colon cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 2106: Combined deacetylase and bromodomain inhibition downregulates ERCC2 and suppresses growth of metastatic colon cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout.

# publications[].label
Combined deacetylase and bromodomain inhibition downregulates ERCC2 and suppresses growth of metastatic colon cancer cells.

# publications[].label
Use of fish and fish transgenics in laboratory and field genotoxicology studies - Preface

# publications[].label
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.

# publications[].label
Dietary agents as histone deacetylase inhibitors.

# publications[].label
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis.

# publications[].publisher
Korean Society for Biochemistry and Molecular Biology - BMB Reports

# publications[].label
Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response.

# publications[].label
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.

# publications[].label
Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception

# publications[].label
Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay.

# publications[].label
Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat.

# publications[].label
Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonic aberrant crypts in the rat.

# publications[].label
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse.

# publications[].label
CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Cancer Chemopreventive Mechanisms of Tea Against Heterocyclic Amine Mutagens from Cooked Meat

# publications[].label
Endothelins and their receptors in cancer: identification of therapeutic targets.

# publications[].label
Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms.

# publications[].label
Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis.

# publications[].label
Reshaping the Gut Microbiome in An Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics

# publications[].label
Endurance exercise results in DNA damage as detected by the comet assay.

# publications[].label
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling.

# publications[].label
Sulforaphane influences histone methylation in advanced prostate cancer cells (1045.15)

# publications[].label
Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure.

# publications[].label
The epigenome as a potential mediator of cancer and disease prevention in prenatal development.

# publications[].label
Sulforaphane bioavailability and bioactivity in humans

# publications[].label
Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling.

# publications[].label
Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention.

# publications[].label
Abstract 4428: A miRNA signature linked to human environmental risk defined from carcinogen-induced and genetically-driven colon carcinogenesis models

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling

# publications[].label
Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis.

# publications[].label
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer.

# publications[].label
Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin.

# publications[].label
STRUCTURE ACTIVITY STUDIES WITH 5-DIMETHYLAMINOPHENYLAZOINDAZOLE AND RELATED MONOAZO DYES IN THE SALMONELLA MAMMALIAN MICROSOME ASSAY

# publications[].label
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.

# publications[].label
IMPLICATIONS FOR STRUCTURE ACTIVITY DATABASES AND THE EVALUATION OF COMBINATIONS OF MUTAGENS IN THE SALMONELLA ASSAY, AS ILLUSTRATED BY STUDIES WITH THE MUTAGENIC NON-CARCINOGEN 5I

# publications[].label
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.

# publications[].label
The role of microRNA in nutritional control.

# publications[].label
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidaz.

# publications[].label
Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline.

# publications[].label
Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat.

# publications[].label
Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells.

# publications[].label
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis.

# publications[].label
Prevention by tolfenamic acid and characterization of the molecular targets in Pirc and FAP colorectal adenomas

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Activator protein-2 functions as a master regulator of multiple transcription factors in the mouse liver.

# publications[].label
Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.

# publications[].publisher
The American Association of Immunologists

# publications[].label
The use of in vivo-like concentrations of chemicals for validation of in vitro short-term genotoxicity assays--an in vivo equivalent dose concept.

# publications[].label
Dietary histone deacetylase inhibitors: from cells to mice to man.

# publications[].label
Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo.

# publications[].label
Abstract 2614: CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models.

# publications[].label
Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumorigenesis in the male F344 rat.

# publications[].label
CONCOMITANT INVIVO DNA-BINDING TUMOR DOSE-RESPONSE STUDIES WITH AFLATOXIN-B1 AND THE NATURAL INHIBITOR INDOLE-3-CARBINOL

# publications[].label
BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells.

# publications[].label
Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin.

# publications[].label
Erratum: Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f] quinoline (Carcinogenesis (2001) vol. 22 (309-314))

# publications[].label
Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development.

# publications[].label
Cellular effects of tea antioxidants in vitro and in mouse models of colorectal cancer

# publications[].label
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.

# publications[].label
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.

# publications[].label
Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.

# publications[].label
Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline: effect of tea concentration and brew time on electrophile scavenging.

# publications[].label
Tumor dose-response studies with aflatoxin B1 and the ambivalent modulator indole-3-carbinol: inhibitory versus promotional potency.

# publications[].label
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac.

# publications[].label
Chlorophyllin-enhanced excretion of urinary and fecal mutagens in rats given 2-amino-3-methylimidazo[4,5-f]quinoline.

# publications[].label
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts.

# publications[].label
Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFB pathway in the Noble rat model.

# publications[].label
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention.

# publications[].label
The disposition and in vivo covalent binding to liver DNA of the monoazodyes 6-(p-dimethylaminophenylazo)benzothiazole (6BT) and 5-(p-dimethylaminophenylazo)indazole (5I) after administration to the rat.

# publications[].label
Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam.

# publications[].label
ANTICARCINOGENS AND TUMOR PROMOTERS IN FOODS

# publications[].label
Abstract 5712: Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Deficiencies in the covalent binding index (CBI) for expressing in vivo binding to DNA with respect to predicting chemical carcinogenicity. A proposal for a target-organ binding index.

# publications[].label
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.

# publications[].label
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice.

# publications[].label
H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria.

# publications[].label
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms.

# publications[].label
Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH.

# publications[].label
COMPARISON OF THE ACTIVATION OF A CARCINOGEN NON-CARCINOGEN PAIR OF MONOAZO DYES USING INVITRO AND INVIVO GENOTOXICITY ASSAYS - THE USE OF AN INVIVO EQUIVALENT DOSE CONCEPT

# publications[].label
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.

# publications[].label
Xenobiotic metabolism relevance to cancer.

# publications[].label
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation.

# publications[].label
The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells.

# publications[].label
Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells

# researcherOn[].label
CCAR2 as a Target for Prevention of Colorectal Cancer

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
PREVENT Cancer Preclinical Drug Development Program: Preclinical Efficacy and Intermediate Endpoint Biomarkers

# researcherOn[].awardedBy.label
National Cancer Institute - (Rockville, Maryland, United States)

# researcherOn[].label
Comparative Mechanisms of Cancer Chemoprevention

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Immunoepigenetic Targeting of MHC Regulators in FAP

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health and College of Medicine; Center for Epigenetics & Disease Prevention; 1201 TAMUS

# organizations[]
Center for Epigenetics and Disease Prevention

# inTheNews[].label
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma

# inTheNews[].label
Targeting ACE2-BRD4 in Cancer and COVID-19

# inTheNews[].label
Research explains why you should eat your broccoli

# inTheNews[].label
Director of New Center Looks for Foods That Protect Health

# inTheNews[].label
An Early Target for Acetylation in Colon Cancer Cells Treated with Sulforaphane

# inTheNews[].label
Scientists Develop Highly Effective Detection Strategy For Childhood Brain Tumors

# inTheNews[].label
Colorectal cancer and COVID-19: Inhibitors to combat both

# inTheNews[].label
Texas A&M Health Awarded $3 Million From National Cancer Institute

# inTheNews[].label
Two Texas A&M Health faculty named Distinguished Professors

# inTheNews[].label
Center for Epigenetics and Disease Prevention receives Texas A&M Board of Regents stamp of approval

# inTheNews[].label
Texas A&M Advances Global Disease Prevention with Launch of Field-to-Clinic Initiative

# inTheNews[].label
You are what you eat? Food fights disease

# inTheNews[].label
Eight Faculty Earn Texas A&M’s Highest Honor

# inTheNews[].label
Q&A: Cutting-edge research explores how diet causes and prevents cancer

# inTheNews[].label
Highly effective tumor detection strategy for common childhood brain tumors

# inTheNews[].label
Research explains why you should eat your broccoli

# inTheNews[].label
A&M researchers link eating spinach to reducing colon cancer risk

# inTheNews[].label
Texas A&M Health Faculty Rank Among Top 2 Percent Of Scholars Worldwide

# inTheNews[].label
Eating Spinach Could Protect Against Colon Cancer

# etdChairOf[].label
Perkins, Ashley Lyn (2015-08). Examining the Roles of Beta-Catenin and HDAC6 in Primary Cilia Signaling in ccRCC and CRC. Master's Thesis.

# etdChairOf[].label
Yin, Yue (2021-07). Comprehensive Data Analysis Toolkit Development for a Low Input Bisulfite Sequencing. Doctoral Dissertation.

# etdChairOf[].label
Johnson, Gavin S. (2019-04). Expanding Epigenetic Mechanisms of Sulforaphane in Colorectal Cancer: Pseudogenes and Protein Acetylation. Doctoral Dissertation.

# etdChairOf[].label
Chen, Ying-Shiuan (2019-02). Molecular Profiling of Prevention Strategies Using Rodent Models of Colorectal Cancer. Doctoral Dissertation.

# websites[].label
Center for Epigenetics & Disease Prevention