# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].organizations[].label
Center for Epigenetics and Disease Prevention

# positions[].label
John S. Dunn Chair in Disease Prevention

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Rod is a University Distinguished Professor who joined Texas A&M Health as inaugural Director of the Board of Regents designated Center for Epigenetics & Disease Prevention and John S. Dunn Chair in Disease Prevention. Tenured in the Department of Translational Medical Sciences, Texas A&M University Naresh K. Vashisht College of Medicine (VCOM), with affiliate faculty roles in the Department of Nutrition and MD Anderson Cancer Center. A Fellow of the Royal Society of Biology who received Regents' Medals for Excellence in Teaching and Research, and the Rice University Institute of Biosciences & Bioengineering Medical Innovation Award. Research dovetails epigenetic and immune approaches for precision oncology and cancer prevention, including dietary and microbiome-associated metabolites that regulate the antigen presentation pathway. In vivo and cell-based assays are integrated with clinical specimens and patient-derived organoids. Supported by the NCI Division of Cancer Prevention and the John S. Dunn Foundation.

Keywords: anticancer agents, cancer prevention, dietary factors, epigenetics, immune microenvironment, microbiome metabolites, precision oncology, translational research.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Colitis Mango Mtor Pathway Pomegranate Rat

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3201 Cardiovascular Medicine And Haematology

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Aryl Hydrocarbon Receptor Nuclear Translocator

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Histone H3 Lysine 18 Acetylation (h3k18ac)

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
3102 Bioinformatics And Computational Biology

# keywords[]
Rela, V-rel Avian Reticuloendotheliosis Viral Oncogene Homolog A

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
3205 Medical Biochemistry And Metabolomics

# keywords[]
C-terminal Binding Protein (ctbp) Interacting Protein

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# educationAndTraining[].organization.label
Plymouth University - (Plymouth, Plymouth, United Kingdom)

# educationAndTraining[].organization.label
University of Surrey - (Guildford, Surrey, United Kingdom)

# educationAndTraining[].organization.label
Oregon State University - (Corvallis, Oregon, United States)

# educationAndTraining[].organization.label
University of Portsmouth - (Portsmouth, Portsmouth, United Kingdom)

# publications[].label
Nutrients, histone modifications, and chromatin remodeling in chronic inflammation

# publications[].label
STRUCTURE ACTIVITY STUDIES WITH 5-DIMETHYLAMINOPHENYLAZOINDAZOLE AND RELATED MONOAZO DYES IN THE SALMONELLA MAMMALIAN MICROSOME ASSAY

# publications[].label
Inhibition by white tea of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced colonic aberrant crypts in the F344 rat.

# publications[].label
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis.

# publications[].publisher
Korean Society for Biochemistry and Molecular Biology - BMB Reports

# publications[].label
Anticarcinogenic activity of indole-3-carbinol acid products: ultrasensitive bioassay by trout embryo microinjection.

# publications[].label
Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells.

# publications[].label
Multi-targeted prevention of cancer by sulforaphane.

# publications[].label
Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception

# publications[].label
Metabolism as a key to HDAC inhibition by dietary constituents

# publications[].label
Frontiers in polyphenols and cancer prevention

# publications[].label
Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells.

# publications[].label
ANTICARCINOGENS AND TUMOR PROMOTERS IN FOODS

# publications[].label
Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites.

# publications[].label
3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.

# publications[].label
Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer.

# publications[].label
Dietary factors and epigenetic regulation for prostate cancer prevention.

# publications[].label
Broccoli sprouts delay prostate cancer formation and decrease prostate cancer severity with a concurrent decrease in HDAC3 protein expression in TRAMP mice.

# publications[].label
Sulforaphane inhibits HDAC activity in prostate cancer cells, retards growth of PC3 xenografts, and inhibits HDAC activity in vivo

# publications[].label
Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin.

# publications[].label
Abstract 5712: Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Sulforaphane bioavailability and bioactivity in humans

# publications[].label
BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells.

# publications[].label
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon.

# publications[].label
Targeting Epigenetic 'Readers' with Natural Compounds for Cancer Interception.

# publications[].label
In vivo disposition of the natural anti-carcinogen indole-3-carbinol after po administration to rainbow trout.

# publications[].label
Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates.

# publications[].label
Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline.

# publications[].label
Erlotinib suppresses tumorigenesis in a mouse model of colitis-associated cancer.

# publications[].label
Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane.

# publications[].label
-catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo [4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol (vol 22, pg 315, 2001)

# publications[].label
Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.

# publications[].label
Dietary manipulation of histone structure and function.

# publications[].label
Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen.

# publications[].label
Introduction to Nutrition and physical activity in aging, obesity, and cancer.

# publications[].label
HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.

# publications[].label
Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin.

# publications[].label
The disposition and in vivo covalent binding to liver DNA of the monoazodyes 6-(p-dimethylaminophenylazo)benzothiazole (6BT) and 5-(p-dimethylaminophenylazo)indazole (5I) after administration to the rat.

# publications[].label
S318 Optimized Lower Dose Combinations of Sulindac Plus Erlotinib Sustained Antitumor Efficacy and Reduced Toxicity in a Preclinical Model of FAP

# publications[].label
Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals.

# publications[].label
Development of a murine colonoscopic polypectomy model(withvideos).

# publications[].label
ADAPTATION OF INVITRO AND INVIVO BINDING ASSAYS TO DISCRIMINATE BETWEEN A CARCINOGEN NON-CARCINOGEN PAIR OF MUTAGENIC MONOAZO DYES

# publications[].label
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.

# publications[].label
Regulation of hepatic cytochrome P4501A by indole-3-carbinol: transient induction with continuous feeding in rainbow trout.

# publications[].label
Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

# publications[].label
Bioavailability and metabolomic targets of sulforaphane in humans

# publications[].label
Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonic aberrant crypts in the rat.

# publications[].label
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer

# publications[].label
Alpha-keto acid metabolites of naturally occurring organoselenium compounds as inhibitors of histone deacetylase in human prostate cancer cells.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
HDAC inhibition by sulforaphane during hyperplasia, intermediate and late stages of prostate cancer.

# publications[].label
Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis.

# publications[].label
Genome-wide transcriptome analysis of the effects of sulforphane on normal and prostate cancer cells

# publications[].label
Protective properties of chlorophylls against the covalent binding of heterocyclic amines to DNA in vitro and in vivo.

# publications[].label
Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.

# publications[].label
CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.

# publications[].label
A hypermorphic epithelial -catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.

# publications[].label
Antimutagenic activity of selenium-enriched green tea towards a cooked meat mutagen.

# publications[].label
Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling.

# publications[].label
Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat.

# publications[].label
1084 - Neonatal Colonic Inflammation Aggravates Epithelial Injury Through Mir-196 When Exposed to Another Episode of Inflammation in Adult-Life

# publications[].label
Abstract 5713: Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Emerging crosstalk between long non-coding RNAs and Nrf2 signaling.

# publications[].label
Alpha-keto acid metabolites of organoselenium compounds inhibit HDAC activity

# publications[].label
Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay.

# publications[].label
Chemoprotection by sulforaphane: keep one eye beyond Keap1.

# publications[].label
Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine.

# publications[].label
Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response.

# publications[].label
Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts.

# publications[].label
Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance.

# publications[].label
THE RELATIONSHIP BETWEEN COVALENT DNA-BINDING AND REVERTANT YIELD IN THE SALMONELLA MUTAGENICITY (AMES) ASSAY - IMPLICATIONS FOR ASSAY SPECIFICITY

# publications[].label
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.

# publications[].label
Chlorophyllin chemoprevention in trout initiated by aflatoxin B(1) bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms.

# publications[].label
The epigenome as a potential mediator of cancer and disease prevention in prenatal development.

# publications[].label
Su1677 ERLOTINIB SUPPRESSES TUMORIGENESIS IN A MOUSE MODEL OF COLITIS-ASSOCIATED CANCER

# publications[].label
Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumorigenesis in the male F344 rat.

# publications[].label
Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models.

# publications[].label
Abstract 5631: Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Chlorophylls purified by a new large-scale method inhibit aflatoxin carcinogenesis in the rat

# publications[].label
MUTAGENICITY OF THE 2 CARCINOGEN NON-CARCINOGEN PAIRS BENZO[A]PYRENE, PYRENE AND 2-ACETYLAMINOFLUORENE, 4-ACETYLAMINOFLUORENE AND THEIR RESPECTIVE RAT URINE CONCENTRATES AS PART OF THE IPCS COLLABORATIVE TRIAL

# publications[].label
Effect of carcinogen dose fractionation, diet and source of F344 rat on the induction of colonic aberrant crypts by 2-amino-3-methylimidazo[4,5-f]quinoline.

# publications[].label
Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout.

# publications[].label
Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations.

# publications[].label
A role for low-abundance miRNAs in colon cancer: the miR-206/Krppel-like factor 4 (KLF4) axis.

# publications[].label
Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.

# publications[].label
Histone Acyl Code in Precision Oncology: Mechanistic Insights from Dietary and Metabolic Factors

# publications[].label
Cancer-protective effects and bioavailability of flavonoids.

# publications[].label
MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.

# publications[].label
Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin.

# publications[].label
Gender differences in DNA damage produced during an ultramarathon run as measured by the comet assay

# publications[].label
Front cover: A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphanetreated colon cancer cells

# publications[].label
Combined in vivo DNA binding and tumor dose-response studies to investigate the molecular dosimetry concept.

# publications[].label
Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms.

# publications[].label
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Antimutagenic activity of spearmint (Mentha spicata L.)

# publications[].label
Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter.

# publications[].label
Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.

# publications[].label
Post-initiation chlorophyllin exposure does not modulate aflatoxin-induced foci in the liver and colon of rats.

# publications[].label
CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis.

# publications[].label
Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling

# publications[].label
An Evidence-based Approach to Phytochemicals and Other Dietary Factors

# publications[].label
A comparison of whole wheat, refined wheat and wheat bran as inhibitors of heterocyclic amines in the Salmonella mutagenicity assay and in the rat colonic aberrant crypt focus assay.

# publications[].label
Measuring Histone Deacetylase Inhibition in the Brain.

# publications[].label
Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention.

# publications[].label
Erratum: Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f] quinoline (Carcinogenesis (2001) vol. 22 (309-314))

# publications[].label
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.

# publications[].label
NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

# publications[].label
Metabolism and cancer: old and new players.

# publications[].label
Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout.

# publications[].label
P4758Experimental colitis impedes cardiac function through epigenetic mechanisms

# publications[].label
Dietary polyphenols as BRD7 and 9 inhibitors for cancer interception.

# publications[].label
Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development.

# publications[].label
Mechanisms of indole-3-carbinol (I3C) anticarcinogenesis: inhibition of aflatoxin B1-DNA adduction and mutagenesis by I3C acid condensation products.

# publications[].label
Deficiencies in the covalent binding index (CBI) for expressing in vivo binding to DNA with respect to predicting chemical carcinogenicity. A proposal for a target-organ binding index.

# publications[].label
Formation of Aflatoxin-Dna Adducts in Trout and Their use Ps Molecular Dosimeters for Tumor Prediction

# publications[].label
Erratum: -Catenin mutation in rat colon tumors initiated by 1,2-dimenthylhydrazine and 2-amino-3-methylimidazo [4,5-f]quinoline, and the effect of post-initiation treatment with chlorophylin and indole-3-carbinol (Carcinogenesis (2001) vol. 22 (315-320))

# publications[].label
Cellular effects of tea antioxidants in vitro and in mouse models of colorectal cancer

# publications[].label
Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts.

# publications[].label
Interactions between white tea and sulindac in the prevention of intestinal cancer

# publications[].label
Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate.

# publications[].label
Time to discontinue antigenotoxicity studies of dietary fiber?

# publications[].label
Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.

# publications[].label
Suppression of Met activation in human colon cancer cells treated with (-)-epigallocatechin-3-gallate: minor role of hydrogen peroxide.

# publications[].label
SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.

# publications[].label
Antimutagenic potency of chlorophyllin in the Salmonella assay and its correlation with binding constants of mutagen-inhibitor complexes.

# publications[].label
Weak ligands as HDAC inhibitors: useful for chemoprevention?

# publications[].label
Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure.

# publications[].label
Prevention by tolfenamic acid and characterization of the molecular targets in Pirc and FAP colorectal adenomas

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Tumor dose-response studies with aflatoxin B1 and the ambivalent modulator indole-3-carbinol: inhibitory versus promotional potency.

# publications[].label
Suppression of intestinal tumorigenesis by activator protein 2

# publications[].label
Targeting the Epigenome with Dietary Agents

# publications[].label
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl- imidazo.

# publications[].label
Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract.

# publications[].label
Analysis of genome-wide DNA methylation in CCRF-CEM cells confirms hypermethylation at reported epigenetic markers of T-cell lymphoblastic leukemia and identifies novel therapeutic targets with reduced methylation upon treatment with dietary indoles

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet.

# publications[].label
Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam.

# publications[].label
Colonic cell proliferation, apoptosis and aberrant crypt foci development in rats given 2-amino-3-methylimidaz.

# publications[].label
Heterogeneous reactions of particulate matter-bound PAHs and NPAHs with NO3/N2O5, OH radicals, and O3 under simulated long-range atmospheric transport conditions: reactivity and mutagenicity.

# publications[].label
Dietary soy and tea mitigate chronic inflammation and prostate cancer via NFB pathway in the Noble rat model.

# publications[].label
Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat.

# publications[].label
Post-initiation effects of chlorophyllin and indole-3-carbinol in rats given 1,2-dimethylhydrazine or 2-amino-3-methyl-imidazo[4,5-f]quinoline (vol 22, pg 309, 2001)

# publications[].label
Novel nitro-PAH formation from heterogeneous reactions of PAHs with NO2, NO3/N2O5, and OH radicals: prediction, laboratory studies, and mutagenicity.

# publications[].label
Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout.

# publications[].label
Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells.

# publications[].label
Abstract 2106: Combined deacetylase and bromodomain inhibition downregulates ERCC2 and suppresses growth of metastatic colon cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Chemopreventive properties of chlorophyllin: inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay.

# publications[].label
The use of in vivo-like concentrations of chemicals for validation of in vitro short-term genotoxicity assays--an in vivo equivalent dose concept.

# publications[].label
Reshaping the Gut Microbiome in An Apc-Mutant Genetic Background: Mechanistic Insights From Integrated Multi-Omics

# publications[].label
THE SYNTHESIS OF [H-3] INDOLE-3-CARBINOL, A NATURAL ANTI-CARCINOGEN FROM CRUCIFEROUS VEGETABLES

# publications[].label
The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells.

# publications[].label
Dietary histone deacetylase inhibitors: from cells to mice to man.

# publications[].label
Sulforaphane alters the expression of long intragenic noncoding RNAs that are dysregulated in prostate cancer cells (644.10)

# publications[].label
Development of Primary Colon and Duodenal Tumor Cultures from the Apc-mutant Pirc Rat for Screening Preventive Agents

# publications[].label
The role of microRNA in nutritional control.

# publications[].label
Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention.

# publications[].label
Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice.

# publications[].label
Frontiers in polyphenols and cancer prevention.

# publications[].label
Epigenetic regulation of major histocompatibility complexes in gastrointestinal malignancies and the potential for clinical interception.

# publications[].label
Cancer chemoprevention by a combination of white tea plus sulindac in a mouse model expressing an oncogenic form of -catenin.

# publications[].label
HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells.

# publications[].label
Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial.

# publications[].label
Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.

# publications[].label
Mechanisms of anti-carcinogenesis by indole-3-carbinol. Studies of enzyme induction, electrophile-scavenging, and inhibition of aflatoxin B1 activation.

# publications[].label
Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP).

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 5074: Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Increased susceptibility of adult rats to azoxymethane-induced aberrant crypt foci.

# publications[].label
beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol.

# publications[].label
Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.

# publications[].label
Abstract B33: Regulation and function of Nrf2-associated long noncoding RNA

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.

# publications[].label
Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline: effect of tea concentration and brew time on electrophile scavenging.

# publications[].label
Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics.

# publications[].label
Endothelins and their receptors in cancer: identification of therapeutic targets.

# publications[].label
Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.

# publications[].label
LIMITATIONS OF INVITRO ASSAYS FOR DISTINGUISHING BETWEEN A CARCINOGEN NON-CARCINOGEN PAIR OF MONOAZO DYES

# publications[].label
HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.

# publications[].label
Nutritional regulation of epigenetic changes.

# publications[].label
ON THE LACK OF SPECIFICITY OF THE SALMONELLA MUTAGENICITY ASSAY

# publications[].label
Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies.

# publications[].label
Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7.

# publications[].label
Inhibition of apoptosis in colon tumors induced in the rat by 2-amino-3-methylimidazo[4,5-f]quinoline.

# publications[].label
1333Epigenetic targeting of PRC2 complexes upregulates MHC-associated pathways and increases immunogenicity in neoplastic and preneoplastic colon tumor cells

# publications[].label
Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells

# publications[].label
Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) to rat liver DNA.

# publications[].label
Mutagenicity to Salmonella of four derivatives of the azo mutagen 5I: some implications for structure--activity databases and the evaluation of combinations of mutagens.

# publications[].label
Plasma Metabolomic Profiles in Healthy Adults following Consumption of Broccoli Sprouts

# publications[].label
Cancer Chemopreventive Mechanisms of Tea Against Heterocyclic Amine Mutagens from Cooked Meat

# publications[].label
Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1.

# publications[].label
Inhibition of DNA adduct formation of 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine (PhIP) by dietary indole-3-carbinol (I3C) in the mammary gland, colon, and liver of the female F-344 rat.

# publications[].label
Cellular effects of tea antioxidants in vitro and in mouse models of colon cancer

# publications[].label
Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone.

# publications[].label
Natural chlorophyll inhibits dibenzo[a,l]pyrene-induced liver and stomach carcinogenesis in rainbow trout

# publications[].label
Use of fish and fish transgenics in laboratory and field genotoxicology studies - Preface

# publications[].label
Optimizing erlotinib plus sulindac dosing regimens in a preclinical model of FAP

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells.

# publications[].label
Activator protein-2 functions as a master regulator of multiple transcription factors in the mouse liver.

# publications[].label
AZ of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer

# publications[].label
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation.

# publications[].label
Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.

# publications[].label
Ischemia-reperfusion injury in the lung: quantitation using electron microscopy.

# publications[].label
Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.

# publications[].label
Translational Advances in Cancer Prevention Agent Development (TACPAD) Virtual Workshop on Immunomodulatory Agents: Report.

# publications[].label
Experimental colitis impedes cardiac function through epigenetic mechanisms

# publications[].label
Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells.

# publications[].label
Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion.

# publications[].label
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines.

# publications[].label
Abstract CN12-02: Dietary HDAC inhibitors: Prevention or therapy?

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables?

# publications[].label
Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.

# publications[].label
Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.

# publications[].label
H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria.

# publications[].label
Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.

# publications[].label
LEVELS OF METABOLIC COMPLEXITY IN ASSAYS EMPLOYING THE INVIVO EQUIVALENT DOSE (IVED) CONCEPT - REPLY

# publications[].label
Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study.

# publications[].label
The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells.

# publications[].label
Optimized Lower Dose Combinations of Sulindac Plus Erlotinib Sustained Antitumor Efficacy and Reduced Toxicity in a Preclinical Model of FAP

# publications[].label
Differential effects of sulforaphane and related isothiocyanates on HDAC turnover and the DNA damage response in colon cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Novel polypectomy system in a preclinical model of colon cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals.

# publications[].label
PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.

# publications[].label
Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis.

# publications[].label
Dietary manipulation of histone structure and function.

# publications[].label
DNA-binding studies with 6BT and 5I: implications for DNA-binding/carcinogenicity and DNA-binding/mutagenicity correlations.

# publications[].label
The "Sufficiency Principle" from the perspective of cancer prevention.

# publications[].label
Memories of a friend and colleague - Takashi Sugimura.

# publications[].label
Sulindac plus phospholipid is effective for polyp reduction and safer than sulindac alone

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Cancer chemopreventive mechanisms of tea against heterocyclic amine mutagens from cooked meat.

# publications[].label
Tumor-suppressing effects of antioxidants from tea.

# publications[].label
NEONATAL COLONIC INFLAMMATION AGGRAVATES EPITHELIAL INJURY THROUGH MIR-196 WHEN EXPOSED TO ANOTHER EPISODE OF INFLAMMATION IN ADULT-LIFE

# publications[].label
Sulforaphane influences histone methylation in advanced prostate cancer cells (1045.15)

# publications[].label
Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens.

# publications[].label
Xenobiotic metabolism relevance to cancer.

# publications[].label
Immunomodulatory activity of sulindac plus erlotinib for colon cancer prevention in familial adenomatous polyposis

# publications[].label
Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells.

# publications[].label
The dietary phytochemical chlorophyllin alters e-cadherin and -catenin expression in human colon cancer cells

# publications[].id
 Production, proof of structure, properties.

# publications[].label
Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention.

# publications[].label
Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds.

# publications[].label
Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.

# publications[].label
Dietary manipulation of histone structure and function.

# publications[].label
EFFECT OF DIETARY INDOLE-3-CARBINOL (I3C), B-NAPHTHOFLAVONE (BNF), AND AROCLOR-1254 (PCB) ON DIETHYLNITROSAMINE (DEN) AND AFLATOXIN-B1 (AFB1) CARCINOGENESIS IN TROUT

# publications[].label
Abstract 5276: Immunomodulatory activity of intermittent low-dose erlotinib plus sulindac: Implications for hereditary and sporadic colorectal cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Preparation, Characterization and Electron Paramagnetic Resonance (EPR) Spectroscopic Studies of OXANOH

# publications[].label
Promotion of aflatoxin B1 carcinogenesis by the natural tumor modulator indole-3-carbinol: influence of dose, duration, and intermittent exposure on indole-3-carbinol promotional potency.

# publications[].label
Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo.

# publications[].label
High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

# publications[].label
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?

# publications[].label
Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.

# publications[].label
Abstract 5815: Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
The disposition and metabolism of 2-amino-3-methylimidazo-[4,5-f]quinoline in the F344 rat at high versus low doses of indole-3-carbinol.

# publications[].label
Metabolomics of Acute vs. Chronic Spinach Intake in an Apc-Mutant Genetic Background: Linoleate and Butanoate Metabolites Targeting HDAC Activity and IFN- Signaling.

# publications[].label
An RNA-seq approach to identify mechanisms by which the phytochemical sulforaphane acts to prevent prostate cancer

# publications[].label
Alternative splicing of BAZ1A in colorectal cancer disrupts the DNA damage response and increases chemosensitization.

# publications[].label
Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure.

# publications[].label
Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis.

# publications[].label
Endurance exercise results in DNA damage as detected by the comet assay.

# publications[].label
Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS.

# publications[].label
A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.

# publications[].label
Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.

# publications[].label
Modulation of Wnt signaling by white tea plus celecoxib.

# publications[].label
CONCOMITANT INVIVO DNA-BINDING TUMOR DOSE-RESPONSE STUDIES WITH AFLATOXIN-B1 AND THE NATURAL INHIBITOR INDOLE-3-CARBINOL

# publications[].label
Chemoprevention of Prostate Cancer with Cruciferous Vegetables: Role of Epigenetics

# publications[].label
Amelioration of ischemia-reperfusion injury in an isolated rabbit lung model using OXANOH.

# publications[].label
Chlorophyllin-enhanced excretion of urinary and fecal mutagens in rats given 2-amino-3-methylimidazo[4,5-f]quinoline.

# publications[].label
Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake.

# publications[].label
A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.

# publications[].label
Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors.

# publications[].label
Capsaicin represses transcriptional activity of -catenin in human colorectal cancer cells.

# publications[].label
Mechanisms of chlorophyllin anticarcinogenesis against aflatoxin B1: complex formation with the carcinogen.

# publications[].label
Optimization of dosing regimens of sulindac in combination with erlotinib for small intestine and colorectal cancer prevention

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Abstract 5632: Combinatorial epigenetic targeting of PRC2 complexes upregulates MHC antigen presentation components in melanoma and gastrointestinal cancer cells

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Antitumor efficacy of intermittent low-dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche.

# publications[].label
Combined deacetylase and bromodomain inhibition downregulates ERCC2 and suppresses growth of metastatic colon cancer cells.

# publications[].label
Combined Radiolabelling Distribution and Covalent DNA-Binding Studies to Discriminate Between a Carcinogen/Noncarcinogen Pair of Monoazo Dyes Related to the Hepatocarcinogen Butter Yellow (DAB)

# publications[].label
Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1.

# publications[].label
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.

# publications[].label
Early detection and prevention of colorectal cancer (review).

# publications[].label
Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting.

# publications[].label
Bioavailability and metabolomic targets of sulforaphane in humans (1036.2)

# publications[].label
L-theanine: From tea leaf to trending supplement - does the science match the hype for brain health and relaxation?

# publications[].label
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status.

# publications[].label
Carcinogenicity, metabolism and Ki-ras proto-oncogene activation by 7,12-dimethylbenz[a]anthracene in rainbow trout embryos.

# publications[].label
MATRIX METALLOPROTEINASE 7 CONTRIBUTES TO INTESTINAL BARRIER DYSFUNCTION BY SUPPRESSING TIGHT JUNCTION PROTEINS

# publications[].label
Alternative splicing of the chromatin modifier gene BAZ1A in colorectal cancer.

# publications[].label
Ultraviolet radiation-induced non-melanoma skin cancer in the Crl:SKH1:hr-BR hairless mouse: augmentation of tumor multiplicity by chlorophyllin and protection by indole-3-carbinol.

# publications[].label
Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac.

# publications[].label
Cancer interception by interceptor molecules: mechanistic, preclinical and human translational studies with chlorophylls.

# publications[].label
Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse.

# publications[].label
Measuring antigenotoxic effects using the ames test and comet assay

# publications[].label
Chemopreventative phytochemical 3,3-diindolylmethane inhibits histone deacetylases in prostate cancer cells

# publications[].label
Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: dose-response and time-course studies in the liver and colon.

# publications[].label
Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.

# publications[].label
Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.

# publications[].label
Metabolism as a key to histone deacetylase inhibition.

# publications[].label
Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling.

# publications[].label
991  Matrix Metalloproteinase 7 Contributes to Intestinal Barrier Dysfunction by Suppressing Tight Junction Proteins

# publications[].label
Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat.

# publications[].label
The importance of using pure chemicals in (anti) mutagenicity studies: chlorophyllin as a case in point.

# publications[].label
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun.

# publications[].label
Abstract A013: Metabolomics of acute vs. chronic spinach intake in an Apc-mutant genetic background: linoleate and butanoate metabolites targeting HDAC activity and IFN- signaling

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
An epigenetic perspective on pharmacologic ascorbate in colon cancer

# publications[].label
Abstract B84: NADPH oxidase 1 (NOX1) and related NOX isoforms as key mediators of NFB signaling in colon cancer

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Dietary agents as histone deacetylase inhibitors.

# publications[].label
Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma.

# publications[].label
Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254.

# publications[].label
Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs.

# publications[].label
Inside front cover: Comparison of antiinflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis

# publications[].label
(-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells.

# publications[].label
COMPARISON OF THE ACTIVATION OF A CARCINOGEN NON-CARCINOGEN PAIR OF MONOAZO DYES USING INVITRO AND INVIVO GENOTOXICITY ASSAYS - THE USE OF AN INVIVO EQUIVALENT DOSE CONCEPT

# publications[].label
IMPLICATIONS FOR STRUCTURE ACTIVITY DATABASES AND THE EVALUATION OF COMBINATIONS OF MUTAGENS IN THE SALMONELLA ASSAY, AS ILLUSTRATED BY STUDIES WITH THE MUTAGENIC NON-CARCINOGEN 5I

# publications[].label
Metabolomics in an Apc-mutant genetic background: Mechanistic insights from acute vs. chronic spinach intake

# publications[].label
A miRNA signature linked to human environmental risk defined from carcinogen-induced and genetically-driven colon carcinogenesis models

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Dietary polyphenols as epigenetic 'reader' inhibitors

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane.

# publications[].label
Concentration and photochemistry of PAHs, NPAHs, and OPAHs and toxicity of PM2.5 during the Beijing Olympic Games.

# publications[].label
p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance.

# publications[].label
Inhibitory activity of green and black tea in a free radical-generating system using 2-amino-3-methylimidazo[4,5-f]quinoline as substrate.

# publications[].label
Tumor Dose-Response Studies with Aflatoxin B1 and the Ambivalent Modulator Indole-3-Carbinol: Inhibitory Versus Promotional Potency

# publications[].label
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

# publications[].publisher
American Association for Cancer Research (AACR)

# publications[].label
Combined radiolabelling distribution and covalent DNA-binding studies to discriminate between a carcinogen/noncarcinogen pair of monoazo dyes related to the hepatocarcinogen butter yellow (DAB).

# publications[].label
Abstract 2614: CCAR2 acetylation establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition

# publications[].publisher
American Association for Cancer Research (AACR)

# researcherOn[].label
Comparative Mechanisms of Cancer Chemoprevention

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Immunoepigenetic Targeting of MHC Regulators in FAP

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Low-dose Erlotinib and Mesalamine for Prevention of Colitis-Associated Colorectal Cancer

# researcherOn[].awardedBy.label
National Cancer Institute - (Rockville, Maryland, United States)

# researcherOn[].label
CCAR2 as a Target for Prevention of Colorectal Cancer

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
PREVENT Cancer Preclinical Drug Development Program: Preclinical Efficacy and Intermediate Endpoint Biomarkers (Dashwood, Roderick)

# researcherOn[].awardedBy.label
National Cancer Institute - (Rockville, Maryland, United States)

# streetAddress
Director, Center for Epigenetics & Disease Prevention, Texas A&M Health; Naresh K. Vashisht College of Medicine; 1201 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# organizations[]
Center for Epigenetics and Disease Prevention

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
Texas A&M Advances Global Disease Prevention with Launch of Field-to-Clinic Initiative

# inTheNews[].label
Scientists Develop Highly Effective Detection Strategy For Childhood Brain Tumors

# inTheNews[].label
Colorectal cancer and COVID-19: Inhibitors to combat both

# inTheNews[].label
Research explains why you should eat your broccoli

# inTheNews[].label
A&M researchers link eating spinach to reducing colon cancer risk

# inTheNews[].label
Highly effective tumor detection strategy for common childhood brain tumors

# inTheNews[].label
Texas A&M Health Faculty Rank Among Top 2 Percent Of Scholars Worldwide

# inTheNews[].label
An Early Target for Acetylation in Colon Cancer Cells Treated with Sulforaphane

# inTheNews[].label
Eating Spinach Could Protect Against Colon Cancer

# inTheNews[].label
Director of New Center Looks for Foods That Protect Health

# inTheNews[].label
Center for Epigenetics and Disease Prevention receives Texas A&M Board of Regents stamp of approval

# inTheNews[].label
Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma

# inTheNews[].label
Targeting ACE2-BRD4 in Cancer and COVID-19

# inTheNews[].label
You are what you eat? Food fights disease

# inTheNews[].label
Two Texas A&M Health faculty named Distinguished Professors

# inTheNews[].label
Eight Faculty Earn Texas A&M’s Highest Honor

# inTheNews[].label
Texas A&M Health Awarded $3 Million From National Cancer Institute

# inTheNews[].label
Research explains why you should eat your broccoli

# inTheNews[].label
Q&A: Cutting-edge research explores how diet causes and prevents cancer

# etdChairOf[].label
Johnson, Gavin S. (2019-05). Expanding Epigenetic Mechanisms of Sulforaphane in Colorectal Cancer: Pseudogenes and Protein Acetylation. Doctoral Dissertation.

# etdChairOf[].label
Perkins, Ashley Lyn (2015-08). Examining the Roles of Beta-Catenin and HDAC6 in Primary Cilia Signaling in ccRCC and CRC. Master's Thesis.

# etdChairOf[].label
Chen, Ying-Shiuan (2019-05). Molecular Profiling of Prevention Strategies Using Rodent Models of Colorectal Cancer. Doctoral Dissertation.

# etdChairOf[].label
Mohan, Nivedhitha (2024-05). The BAZ Family of Chromatin Remodelers in Colorectal Cancer: Insights into Oncogenesis, Alternative Splicing and Chemosensitization. Doctoral Dissertation.

# etdChairOf[].label
Yin, Yue (2021-08). Comprehensive Data Analysis Toolkit Development for a Low Input Bisulfite Sequencing. Doctoral Dissertation.