# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
Our long term research goals are to identify the cellular and molecular mechanisms responsible for age-related changes in cellular function that contribute to detrimental aging, and to develop targeted therapies to reverse age-related deficits.  We utilize electrophyiological, optogenetic and calcium imaging  techniques in animal models of aging and disease. Our research has focused on the basic idea that compensatory changes occur in in brain function during aging and identification of this brain activity will provide an important first step in identifying potential targets for future drug therapies.

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

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3214 Pharmacology And Pharmaceutical Sciences

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Reverse Transcriptase Polymerase Chain Reaction

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1.1 Normal Biological Development And Functioning

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Reverse Transcriptase Polymerase Chain Reaction

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Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
1.1 Normal Biological Development And Functioning

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
University of London - (London, United Kingdom)

# educationAndTraining[].organization.label
The University of Texas Medical Branch at Galveston - (Galveston, Texas, United States)

# educationAndTraining[].organization.label
Lamar University - (Beaumont, Texas, United States)

# educationAndTraining[].organization.label
Baylor College of Medicine - (Houston, Texas, United States)

# educationAndTraining[].organization.label
Lamar University - (Beaumont, Texas, United States)

# publications[].label
Altered calcium homeostasis in cerebellar Purkinje cells of leaner mutant mice.

# publications[].label
Enhanced calcium buffering in F344 rat cholinergic basal forebrain neurons is associated with age-related cognitive impairment.

# publications[].label
Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neurons.

# publications[].label
Current hypotheses for the slow inhibitory postsynaptic potential in sympathetic ganglia.

# publications[].label
Modification of ion channels and calcium homeostasis of basal forebrain neurons during aging.

# publications[].label
Deficits across multiple cognitive domains in a subset of aged Fischer 344 rats.

# publications[].label
Neonatal nicotine exposure increases excitatory synaptic transmission and attenuates nicotine-stimulated GABA release in the adult rat hippocampus.

# publications[].label
P3169: OPTOGENETIC QUANTAL ANALYSIS OF BASAL FOREBRAIN SYNAPTIC TRANSMISSION WITH PHARMACOLOGICAL TESTING OF SYNAPTIC ACTIVITY WITH GLUTAMATE AND CALCIUM MODULATORS

# publications[].label
Phenytoin reduces excitatory synaptic transmission and post-tetanic potentiation in the in vitro hippocampus.

# publications[].label
Differential expression of T-type calcium channels in P/Q-type calcium channel mutant mice with ataxia and absence epilepsy.

# publications[].label
Age-related alterations in caffeine-sensitive calcium stores and mitochondrial buffering in rat basal forebrain.

# publications[].label
Instrumentation for preparing brain slices used in electrophysiological recordings

# publications[].label
Amitriptyline Decreases GABAergic Transmission in Basal Forebrain Neurons Using an Optogenetic Model of Aging.

# publications[].label
Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome.

# publications[].label
The protective effect of phentolamine against cardiac arrhythmias in the rat.

# publications[].label
Ovarian cycle-related effects of neurosteroids on GABA-A receptor-mediated phasic and tonic currents in the hippocampus

# publications[].label
Effects of acute and chronic ethanol treatment on pre- and postsynaptic responses to baclofen in rat hippocampus.

# publications[].label
Whole-cell and single-channel analysis of P-type calcium currents in cerebellar Purkinje cells of leaner mutant mice.

# publications[].label
Persistent slow inward calcium current in voltage-clamped hippocampal neurones of the guinea-pig.

# publications[].label
Sodium valproate decreases synaptic potentiation and epileptiform activity in hippocampus.

# publications[].label
Membrane properties of cell types within guinea pig basal forebrain nuclei in vitro.

# publications[].label
An intracellular investigation of cat vesical pelvic ganglia.

# publications[].label
Enhancement of GABA-activated membrane currents in aged Fischer 344 rat basal forebrain neurons.

# publications[].label
Loss of N-cadherin and alpha-catenin in the proximal tubules of aging male Fischer 344 rats.

# publications[].label
Membrane currents in hippocampal neurons.

# publications[].label
Chronic neonatal nicotine increases anxiety but does not impair cognition in adult rats.

# publications[].label
Ethanol inhibition of reduced frequency-dependent rundown of calcium currents in acutely dissociated MS/nDB neurons from chronic in vivo lead-exposed adult rats.

# publications[].label
[P1127]: TARGETING PREDEMENTIA SYNAPTIC MECHANISMS DURING AGING AND COGNITIVE IMPAIRMENT

# publications[].label
Cholinergic transmission in cat parasympathetic ganglia.

# publications[].label
Electrophysiology of AChE-positive neurons in basal forebrain slices.

# publications[].label
Maturation and Pharmacological Properties of Postsynaptic GABAA Receptors

# publications[].label
Muscarinic inhibition of glutamatergic transmissions onto rat magnocellular basal forebrain neurons in a thin-slice preparation.

# publications[].label
Pharmacological characterization of ionotropic excitatory amino acid receptors in young and aged rat basal forebrain.

# publications[].label
Muscarinic agonists block a late-afterhyperpolarization in medial septum/diagonal band neurons in vitro.

# publications[].label
Mitochondria buffer non-toxic calcium loads and release calcium through the mitochondrial permeability transition pore and sodium/calcium exchanger in rat basal forebrain neurons.

# publications[].label
Characterization of age-related changes in synaptic transmission onto F344 rat basal forebrain cholinergic neurons using a reduced synaptic preparation.

# publications[].label
Voltage-clamp analysis of synaptic inhibition during long-term potentiation in hippocampus.

# publications[].label
Voltage-clamp analysis of posttetanic potentiation of the mossy fiber to CA3 synapse in hippocampus.

# publications[].label
Circadian regulation and function of voltage-dependent calcium channels in the suprachiasmatic nucleus.

# publications[].label
Calcium buffering systems and calcium signaling in aged rat basal forebrain neurons.

# publications[].label
Some ionic mechanisms of slow peptidergic neuronal excitation

# publications[].label
Electrophysiologic characteristics of basal forebrain neurons in vitro.

# publications[].label
Action of norepinephrine on neuronal activity recorded from cat parasympathetic ganglia

# publications[].label
Chronic neonatal nicotine exposure increases excitation in the young adult rat hippocampus in a sex-dependent manner.

# publications[].label
Sucrose-gap recordings of nerve-evoked potentials in mammalian parasympathetic ganglia.

# publications[].label
Interaction of ethanol and allosteric modulators with GABAA-activated currents in adult medial septum/diagonal band neurons.

# publications[].label
MAMMALIAN PARASYMPATHETIC GANGLIA FIRE SPONTANEOUS ACTION POTENTIALS AND TRANSMIT SLOW SYNAPTIC POTENTIALS

# publications[].label
Aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues

# publications[].label
Comparison of contractile responses of the guinea pig ileum longitudinal muscle to ethanol and GABAA agonists.

# publications[].label
Late-Onset, Short-Term Intermittent Fasting Reverses Age-Related Changes in Calcium Buffering and Inhibitory Synaptic Transmission in Mouse Basal Forebrain Neurons.

# publications[].label
Quest for ion channel modulation by free radicals during brain aging.

# publications[].label
ENHANCEMENT OF GABA-ACTIVATED MEMBRANE CURRENTS IN AGED FISCHER-344 RAT BASAL FOREBRAIN NEURONS

# publications[].label
Erratum: Enhancement of GABA-activated membrane currents in aged Fischer 344 rat basal forebrain neurons (Journal of Neuroscience (March 1995) (2407- 2416))

# publications[].label
Increased calcium buffering in basal forebrain neurons during aging.

# publications[].label
Homeostatic compensation maintains Ca2+ signaling functions in Purkinje neurons in the leaner mutant mouse.

# publications[].label
High-voltage-activated calcium currents in basal forebrain neurons during aging.

# publications[].label
Acute tolerance to ethanol inhibition of NMDA-mediated EPSPs in the CA1 region of the rat hippocampus.

# publications[].label
Long-lasting distortion of GABA signaling in MS/DB neurons after binge-like ethanol exposure during initial synaptogenesis.

# publications[].label
Low voltage-activated calcium and fast tetrodotoxin-resistant sodium currents define subtypes of cholinergic and noncholinergic neurons in rat basal forebrain.

# publications[].label
Low-voltage activated calcium currents increase in basal forebrain neurons from aged rats.

# publications[].label
Spatial reference and working memory across the lifespan of male Fischer 344 rats.

# publications[].label
Single-cell RT-PCR detects shifts in mRNA expression profiles of basal forebrain neurons during aging.

# publications[].label
Effects of chronic lead treatment on some cardiovascular responses to norepinephrine in the rat.

# publications[].label
Whole-cell and single-channel calcium currents in guinea pig basal forebrain neurons.

# publications[].label
Molecules and Membrane Activity: Single-Cell RT-PCR and Patch-Clamp Recording from Central Neurons

# publications[].label
Calcium-activated outward current in voltage-clamped hippocampal neurones of the guinea-pig.

# publications[].label
Acute ethanol dependence or long-term ethanol treatment and abstinence do not reduce hippocampal responses to carbachol.

# publications[].label
Ultrastructural analysis of the cellular distribution of mitochondria in cholinergic basal forebrain neurons during aging in the mouse

# publications[].label
Comparison of 4-aminopyridine and tetrahydroaminoacridine on basal forebrain neurons.

# publications[].label
Substance P-mediated membrane currents in voltage-clamped guinea pig inferior mesenteric ganglion cells.

# publications[].label
Calcium channel types mediating synaptic transmission during aging.

# publications[].label
Possible endogenous catecholamine modulation of the slow inhibitory postsynaptic potential (S-IPSP) in parasympathetic ganglia

# publications[].label
Age-related decline in cholinergic synaptic transmission in hippocampus.

# publications[].label
Functional compensation by other voltage-gated Ca2+ channels in mouse basal forebrain neurons with Ca(V)2.1 mutations.

# researcherOn[].label
Estrogens, Ovarian Aging and Calcium Channel Modulation

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mast cell/histamine-mediated inflammation and subsequent decrease of lymphatic amyloid beta clearance accelerate progression of Alzheimer's disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Optogenetic Approaches to Study Complex Neuronal Circuits During Cognitive Aging

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mast cell/histamine-mediated inflammation and subsequent decrease of lymphatic amyloid beta clearance accelerate progression of Alzheimer's disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Mast cell/histamine-mediated inflammation and subsequent decrease of lymphatic amyloid beta clearance accelerate progression of Alzheimer's disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
The Interaction of Varenicline, Ethanol, and CNS Development

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute on Alcohol Abuse and Alcoholism (NIAAA)

# researcherOn[].label
Epigenetics of the Aging Astrocyte: Implications for Stroke

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine