# overview
Our group conducts research on Fe-S cluster biogenesis.

# keywords[]
Circadian Rhythm Signaling Peptides And Proteins

# keywords[]
1.1 Normal Biological Development And Functioning

# educationAndTraining[].organization.label
Southern Utah University - (Cedar City, Utah, United States)

# educationAndTraining[].organization.label
Texas A&M University - (College Station, Texas, United States)

# publications[].label
Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.

# publications[].label
Methylation of carbon monoxide dehydrogenase from Clostridium thermoaceticum and mechanism of acetyl coenzyme A synthesis

# publications[].label
Mechanism of frataxin "bypass" in human iron-sulfur cluster biosynthesis with implications for Friedreich's ataxia.

# publications[].label
Structure and Chemical Reaction Mechanism of LigU, an Enzyme That Catalyzes an Allylic Isomerization in the Bacterial Degradation of Lignin.

# publications[].label
Variable-Temperature Electrospray Ionization for Temperature-Dependent Folding/Refolding Reactions of Proteins and Ligand Binding.

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Frataxin Traps Low Abundance Quaternary Structure to Stimulate Human Fe-S Cluster Biosynthesis

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Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis.

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Structure, mechanism, and substrate profile for Sco3058: the closest bacterial homologue to human renal dipeptidase .

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Real-Time Kinetic Probes Support Monothiol Glutaredoxins As Intermediate Carriers in Fe-S Cluster Biosynthetic Pathways.

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Molecular Mechanism of ISC Iron-Sulfur Cluster Biogenesis Revealed by High-Resolution Native Mass Spectrometry.

# publications[].label
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures and modified post-translational chemistry

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Mechanism for GFP fluorophore synthesis: Electrostatic role of arginine 96 in backbone cyclization

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The rational design of green fluorescent protein metallomutants

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The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis.

# publications[].label
Elucidating the role of IscX in bacterial Fe-S cluster assembly

# publications[].label
The KaiA protein of the cyanobacterial circadian oscillator is modulated by a redox-active cofactor.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Friedreich's ataxia variants I154F and W155R diminish frataxin-based activation of the iron-sulfur cluster assembly complex.

# publications[].label
Structural evidence for an enolate intermediate in GFP fluorophore biosynthesis.

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Hydroxyl radical footprinting of the human Fe-S cluster assembly complex

# publications[].label
The Human Iron-Sulfur Assembly Complex Catalyzes the Synthesis of [2Fe-2S] Clusters on ISCU2 That Can Be Transferred to Acceptor Molecules.

# publications[].label
STABILITY OF THE NI-C STATE AND OXIDATIVE TITRATIONS OF DESULFOVIBRIO-GIGAS HYDROGENASE MONITORED BY EPR AND ELECTRONIC ABSORPTION SPECTROSCOPIES

# publications[].label
Understanding GFP chromophore biosynthesis: controlling backbone cyclization and modifying post-translational chemistry.

# publications[].label
Structural chemistry of a green fluorescent protein Zn biosensor.

# publications[].label
FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model

# publications[].label
Structure of the human Fe-S cluster assembly sub-complex: implications in Friedreich's ataxia and primary metabolism

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.

# publications[].label
Nickel superoxide dismutase structure and mechanism

# publications[].label
Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry.

# publications[].label
Mechanistic Insights into IscU Conformation Regulation for Fe-S Cluster Biogenesis Revealed by Variable Temperature Electrospray Ionization Native Ion Mobility Mass Spectrometry.

# publications[].label
Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation.

# publications[].label
Nickel superoxide dismutase structure and mechanism.

# publications[].label
Mechanism of activation of the human cysteine desulfurase complex by frataxin.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Frataxin Accelerates [2Fe-2S] Cluster Formation on the Human Fe-S Assembly Complex.

# publications[].label
Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.

# publications[].label
Human frataxin is an allosteric switch that activates the Fe-S cluster biosynthetic complex.

# publications[].label
Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents.

# publications[].label
Unraveling the structures and functions of the unusual Ni-Fe-S clusters in carbon monoxide dehydrogenase

# publications[].label
Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis.

# publications[].label
Structure-function analysis of Friedreich's ataxia mutants reveals determinants of frataxin binding and activation of the Fe-S assembly complex.

# publications[].label
Fluorescent probes for tracking the transfer of iron-sulfur cluster and other metal cofactors in biosynthetic reaction pathways.

# publications[].label
Structural insights into protein-metal ion partnerships.

# publications[].label
Structure of human Fe-S assembly sub-complex

# publications[].publisher
International Union of Crystallography (IUCr)

# publications[].label
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures.

# publications[].publisher
Proceedings of the National Academy of Sciences

# researcherOn[].label
Macromolecular juggling for a prokaryotic Fe-S assembly system

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
Structure And Mechanism Of The Human Fe-S Cluster Assembly Complex

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of General Medical Science

# researcherOn[].label
Structure and Mechanism of the Human FE-S Cluster Assembly Complex

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M University; Chemistry Department; 3255 TAMU

# etdChairOf[].label
Choi, Hyeran (2016-07). Investigating the Enzymology of Fe-S Cluster Assembly in the Bacterial ISC System. Master's Thesis.

# etdChairOf[].label
Rabb, Jennifer (2012-07). Frataxin (FXN) Based Regulation of the Iron-Sulfur Cluster Assembly Complex. Doctoral Dissertation.

# etdChairOf[].label
Patra, Shachin (2018-06). Mechanistic Analysis of the Role of Frataxin in Bacterial and Eukaryotic Fe-S Cluster Biosynthetic Pathways. Doctoral Dissertation.

# etdChairOf[].label
Martin Jr., Darrell Wayne (2016-08). A Class of Its Own: Function-Discovery of HydY, A Novel Class of [FeFe]-Hydrogenases. Doctoral Dissertation.

# etdChairOf[].label
Patra, Shachin (2018-08). Mechanistic Analysis of the Role of Frataxin in Bacterial and Eukaryotic Fe-S Cluster Biosynthetic Pathways. Doctoral Dissertation.

# etdChairOf[].label
Tsai, Chi-Lin (2012-07). Structural and Functional Studies on Human Mitochondrial Iron-Sulfur Cluster Biosynthesis. Doctoral Dissertation.

# etdChairOf[].label
Levy, Michaella J (2014-06). Protein-Protein Interactions of the Human Iron Sulfur Cluster Biosynthesis Complex. Doctoral Dissertation.

# etdChairOf[].label
Das, Deepika (2018-05). Mechanistic Analysis of Cluster Transfer to Apo-acceptors in ISC Pathway. Doctoral Dissertation.

# etdChairOf[].label
Vranish, James Nicholas (2015-04). Development of Fluorescent Reporters for Monitoring Fe-S Cluster Transfer Reactions and Discerning the Role of Glutaredoxin Proteins in Fe-S Cluster Assembly. Doctoral Dissertation.

# etdChairOf[].label
Fox, Nicholas G (2014-06). A Biophysical Approach to Investigate the Human Fe-S Cluster Assembly Pathway. Doctoral Dissertation.

# etdChairOf[].label
Thorstad, Melissa (2013-05). Functional Characterization and Surface Mapping of Frataxin (FXN) Interactions with the Fe-S Cluster Assembly Complex. Master's Thesis.