# preferredTitle
Senior Associate Vice President for Research

# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# positions[].label
Senior Associate Vice President for Research

# overview
Studies in the our lab are currently focused on the use of unique biomaterials for controlled release of live and subunit vaccines. Our focus is currently directed to the production of vaccines against human Brucellosisand Q fever, but will be applied to the storage and delivery of other vaccines. A study of specific immune mechanisms and potentiation through controlled releases is underway. Another focus is the study of alpha crystalline structure and function. These unique proteins protect against thermal insult and modulate folding and activity of other proteins

# hrJobTitle
Retired Interim Senior Associate Dean for Research and Professor

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
3902 Education Policy, Sociology And Philosophy

# keywords[]
Amplified Fragment Length Polymorphism Analysis

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
2.2 Factors Relating To The Physical Environment

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
Single-Strand Specific DNA And RNA Endonucleases

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# educationAndTraining[].organization.label
University of Iowa - (Iowa City, Iowa, United States)

# educationAndTraining[].organization.label
Vanderbilt University - (Nashville, Tennessee, United States)

# educationAndTraining[].organization.label
Auburn University - (Auburn, Alabama, United States)

# publications[].label
A novel 78-kDa fatty acyl-CoA synthetase (ACS1) of Babesia bovis stimulates memory CD4+ T lymphocyte responses in B. bovis-immune cattle.

# publications[].label
Controlled release vaccines and methods of treating Brucella diseases and disorders

# publications[].label
Characterization of a cDNA encoding bovine interleukin 10: kinetics of expression in bovine lymphocytes.

# publications[].label
Bovine helper T cell clones recognize five distinct epitopes on Babesia bovis merozoite antigens.

# publications[].label
Use of vitelline protein B as a microencapsulating additive

# publications[].label
Immunodominant T-cell antigens and epitopes of Babesia bovis and Babesia bigemina.

# publications[].label
Amplified fragment length polymorphism reveals specific epigenetic distinctions between Mycobacterium avium subspecies paratuberculosis isolates of various isolation types.

# publications[].label
Toll-like receptors are critical for clearance of Brucella and play different roles in development of adaptive immunity following aerosol challenge in mice.

# publications[].label
Molecular and Chemical Approaches to Brucella Vaccine Development

# publications[].label
A tractable Drosophila cell system enables rapid identification of Acinetobacter baumannii host factors

# publications[].label
Polymeric particles in vaccine delivery.

# publications[].label
Sequence homologies near the C-termini of the variable surface glycoproteins of Trypanosoma brucei

# publications[].label
Interleukin-10 is expressed by bovine type 1 helper, type 2 helper, and unrestricted parasite-specific T-cell clones and inhibits proliferation of all three subsets in an accessory-cell-dependent manner.

# publications[].label
The Brucella abortus S19 DeltavjbR live vaccine candidate is safer than S19 and confers protection against wild-type challenge in BALB/c mice when delivered in a sustained-release vehicle.

# publications[].label
IL-10 and IL-12 exert opposite immunoregulatory effects on antigen-stimulated Th cell clones and  TCR +T cells of cattle

# publications[].label
Composition and design of Fasciola hepatica eggshells.

# publications[].label
Author Correction: Protective antibody response following oral vaccination with microencapsulated Bacillus Anthracis Sterne strain 34F2 spores.

# publications[].label
Early phase morphological lesions and transcriptional responses of bovine ileum infected with Mycobacterium avium subsp. paratuberculosis.

# publications[].label
Molecular biology of trypanosome antigenic variation

# publications[].label
Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense

# publications[].label
Diameter and size distributions of Poly (lactide-co-glycolide) [PLG] based microspheres

# publications[].label
Protective antibody response following oral vaccination with microencapsulated Bacillus Anthracis Sterne strain 34F2 spores.

# publications[].label
Controlled release vaccines and methods for treating Brucella diseases and disorders

# publications[].label
Effect of mean diameter and polydispersity of PLG microspheres on drug release: experiment and theory.

# publications[].label
Hsp20, a novel alpha-crystallin, prevents Abeta fibril formation and toxicity.

# publications[].label
Induction of proliferative responses of T cells from Babesia bovis-immune cattle with a recombinant 77-kilodalton merozoite protein (Bb-1).

# publications[].label
Investigation of the mechanism of small heat shock protein beta-amyloid fibril formation and toxicity prevention

# publications[].label
Bacillus anthracis Sterne Strain 34f2 Vaccine Antibody Dose Response by Subcutaneous and Oral Administration

# publications[].label
Size discrimination in rat and mouse gastric emptying.

# publications[].label
Babesia bovis-specific CD4+ T cell clones from immune cattle express either the Th0 or Th1 profile of cytokines.

# publications[].publisher
CIRAD (Centre de Cooperation Internationale en Recherche Agronomique Pour le Developpement)

# publications[].label
Babesia bovis: Gene isolation and characterization using a mung bean nuclease-derived expression library

# publications[].label
Immunomodulation of Theiler's virus-induced demyelination [TVID] using encapsulated ovine interferon-tau [IFNT]: The novel administration of a novel type IIFN in an animal model of multiple sclerosis [MS]

# publications[].label
A Tractable Drosophila Cell System Enables Rapid Identification of Acinetobacter baumannii Host Factors.

# publications[].label
Point mutations during generation of expression-linked extra copy of trypanosome surface glycoprotein gene.

# publications[].label
Phylogenetic analysis with newly characterized Babesia bovis hsp70 and hsp90 provides strong support for paraphyly within the piroplasms.

# publications[].label
Immunogenic and invasive properties of Brucella melitensis 16M outer membrane protein vaccine candidates identified via a reverse vaccinology approach.

# publications[].label
Small heat shock proteins differentially affect Abeta aggregation and toxicity.

# publications[].label
A novel 20-kilodalton protein conserved in Babesia bovis and B. bigemina stimulates memory CD4(+) T lymphocyte responses in B. bovis-immune cattle.

# publications[].label
Comparison of the expression-linked extra copy (ELC) and basic copy (BC) genes of a trypanosome surface antigen.

# publications[].label
Use of vitelline protein B as a microencapsulating additive

# publications[].label
Babesia bovis: gene isolation and characterization using a mung bean nuclease-derived expression library.

# publications[].label
Isolation and characterization of a gene associated with a virulent strain of Babesia microti.

# publications[].label
Materials composed of the Drosophila Hox protein Ultrabithorax are biocompatible and nonimmunogenic.

# publications[].label
- Brucella induction of RIDD activity promotes intracellular parasitism by subverting BLOS1-controlled immune defense

# publications[].publisher
The American Association of Immunologists

# publications[].label
Genetic and antigenic characterization of Babesia bovis merozoite spherical body protein Bb-1.

# publications[].label
A histidine-rich protein from the vitellaria of the liver fluke Fasciola hepatica.

# publications[].label
On the diameter and size distributions of Bovine Serum Albumin (BSA)-based microspheres.

# publications[].label
Controlled release vaccines and methods for treating Brucella diseases and disorders

# publications[].label
Eggshell precursor proteins of Fasciola hepatica, I. Structure and expression of vitelline protein B.

# publications[].label
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.

# publications[].label
HSP20 inhibits amyloidogenesis and neurotoxicity

# publications[].label
Genomic polymorphisms as inherent watermarks for tracking infectious agents.

# publications[].label
Analysis of stress responsive genes induced by single-walled carbon nanotubes in BJ Foreskin cells.

# publications[].label
Identification of candidate vaccine antigens of bovine hemoparasites Theileria parva and Babesia bovis by use of helper T cell clones.

# publications[].label
Controlled release vaccines and methods of treating Brucella diseases and disorders

# publications[].label
Effects of the COVID-19 pandemic on university-based research conduct and training: Exploring university-based researchers perspectives and experiences

# publications[].label
Global Analysis of the Mycobacterium Avium Subsp. Paratuberculosis Genome and Model Systems Exploring Hostagent Interactions

# publications[].label
HSP20 inhibits amyloidogenesis and neurotoxicity

# publications[].label
Use of helper T cells to identify potential vaccine antigens of Babesia bovis.

# publications[].label
Evaluation of the safety profile of the vaccine candidate Brucella melitensis 16MvjbR strain in goats.

# publications[].label
Reduced parasitemia observed with erythrocytes containing inositol hexaphosphate.

# publications[].label
Enhanced immune response of red deer (Cervus elaphus) to live rb51 vaccine strain using composite microspheres.

# publications[].label
Molecular biology of trypanosome antigenic variation.

# publications[].label
Extended safety and efficacy studies of the attenuated Brucella vaccine candidates 16 M(Delta)vjbR and S19(Delta)vjbR in the immunocompromised IRF-1-/- mouse model.

# publications[].label
Activation of intestinal intraepithelial T lymphocytes in calves infected with Cryptosporidium parvum.

# publications[].label
Amplified fragment length polymorphism reveals genomic variability among Mycobacterium avium subsp. paratuberculosis isolates.

# publications[].label
Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappaB in human keratinocytes.

# publications[].label
Interleukin-10 downregulates proliferation and expression of interleukin-2 receptor p55 chain and interferon-gamma, but not interleukin-2 or interleukin-4, by parasite-specific helper T cell clones obtained from cattle chronically infected with Babesia bovis or Fasciola hepatica.

# publications[].label
Babesia bovis: common protein fractions recognized by oligoclonal B. bovis-specific CD4+ T cell lines from genetically diverse cattle.

# publications[].label
The candidate vaccine strain Brucella ovis abcBA is protective against Brucella melitensis infection in mice.

# publications[].label
Case Report: Paucisymptomatic College-Age Population as a Reservoir for Potentially Neutralization-Resistant Severe Acute Respiratory Syndrome Coronavirus 2 Variants.

# publications[].publisher
American Society of Tropical Medicine and Hygiene

# publications[].label
Identification of two Th1 cell epitopes on the Babesia bovis-encoded 77-kilodalton merozoite protein (Bb-1) by use of truncated recombinant fusion proteins.

# publications[].label
Eggshell precursor proteins of Fasciola hepatica, II. Microheterogeneity in vitelline protein B.

# publications[].label
Immunization with a single dose of a microencapsulated Brucella melitensis mutant enhances protection against wild-type challenge.

# publications[].label
Presclerotized eggshell protein from the liver fluke Fasciola hepatica.

# publications[].label
Oral vaccination with microencapsuled strain 19 vaccine confers enhanced protection against Brucella abortus strain 2308 challenge in red deer (Cervus elaphus elaphus).

# publications[].label
Diameter and Size Distributions of Poly (Lactide-Co-Glycolide) [PLG] Based Microspheres

# publications[].label
Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes.

# publications[].label
Investigation of drug release from biodegradable PLG microspheres: Experiment and theory

# publications[].label
Sequence and characterization of phocine interleukin 2.

# publications[].label
Interactions between fungal hyaluronic acid and host CD44 promote internalization by recruiting host autophagy proteins to forming phagosomes

# publications[].label
The Case for Live Attenuated Vaccines against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis.

# publications[].label
A unique Babesia bovis spherical body protein is conserved among geographic isolates and localizes to the infected erythrocyte membrane.

# publications[].label
Babesia bovis rhoptry-associated protein 1 is immunodominant for T helper cells of immune cattle and contains T-cell epitopes conserved among geographically distant B. bovis strains.

# publications[].label
Human DAZL binds to specific rnas coding for proteins involved in spermatogenesis.

# publications[].label
Materials composed of the Drosophila Hox protein Ultrabithorax are biocompatible and non-immunogenic

# publications[].label
Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis.

# publications[].label
About mean diameter and size distributions of poly(lactide-co-glycolide) (PLG) microspheres.

# publications[].label
Protective efficacy and safety of Brucella melitensis 16MmucR against intraperitoneal and aerosol challenge in BALB/c mice.

# publications[].label
DNA rearrangements of the variable surface antigen genes of the trypanosomes.

# publications[].label
Pathogenesis and immunobiology of brucellosis: review of Brucella-host interactions.

# publications[].label
Protective Efficacy and Safety of Brucella melitensis 16MmucR against Intraperitoneal and Aerosol Challenge in BALB/c Mice (vol 79, pg 3653, 2011)

# publications[].label
Identification of Babesia bovis merozoite antigens separated by continuous-flow electrophoresis that stimulate proliferation of helper T-cell clones derived from B. bovis-immune cattle.

# publications[].label
Characterization of the genes specifying two metacyclic variable antigen types in Trypanosoma brucei rhodesiense.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
CD4+ T-cell clones obtained from cattle chronically infected with Fasciola hepatica and specific for adult worm antigen express both unrestricted and Th2 cytokine profiles.

# publications[].label
Vaccine safety studies of Brucella abortus S19 and S19vjbR in pregnant swine.

# publications[].label
A storable encapsulated bilayer chip containing a single protein nanopore.

# publications[].label
Bovine T cell responses to recombinant thioredoxin of Fasciola hepatica.

# publications[].label
Brucellosis: the case for live, attenuated vaccines.

# publications[].label
HSP20 inhibits amyloidogenesis and neurotoxicity

# publications[].label
Activation of Host IRE1-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis.

# researcherOn[].label
Improved Live Attenuated Brucella Vaccines to Reduce Human Disease

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Collaborative Research:  Enhancing Bone Regeneration by Mimicking the Osteogenic Niche

# researcherOn[].awardedBy.label
National Science Foundation - (Arlington, Virginia, United States)

# researcherOn[].label
Advanced Methods for Mimicking the Osteogenic Niche to Heal Bone

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Arthritis and Musculoskeletal and Skin Diseases

# researcherOn[].label
Nanoparticle Adjuvants for Improved Immunity Against a Venezuelan Equine Encephalitis Virus DNA Vaccine

# researcherOn[].awardedBy.label
United States Department of Defense - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Vice Pres For Research; 1112 TAMU

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine

# inTheNews[].label
First oral anthrax vaccine for livestock, wildlife

# inTheNews[].label
Texas A&M Researchers Developing First Oral Anthrax Vaccine For Livestock, Wildlife

# etdChairOf[].label
Arenas Gamboa, Angela Maria (2007-05). Evaluation of microencapsulation as an improved vaccination strategy against brucellosis. Doctoral Dissertation.

# etdChairOf[].label
Carson, Kenneth Harris (2006-08). Study and characterization of a novel small heat shock protein from Babesia. Doctoral Dissertation.

# etdChairOf[].label
McKown, Richard Dwayne (2004-12). Localization and partial immunological characterization of Fasciola hepatica Thioredoxin. Doctoral Dissertation.

# etdChairOf[].label
Sprague, David Chase Cameron (2006-12). Structure and function of the deleted in azoospermia gene. Doctoral Dissertation.

# etdChairOf[].label
Berchane, Nader Samir (2007-12). Experimental and computational investigations of therapeutic drug release from biodegradable poly(lactide-co-glycolide) (plg) microspheres. Doctoral Dissertation.