# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Intercellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Phex Phosphate Regulating Neutral Endopeptidase

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Receptor, Fibroblast Growth Factor, Type 2

# keywords[]
Tumor Necrosis Factor Alpha-induced Protein 3

# keywords[]
Intracellular Signaling Peptides And Proteins

# keywords[]
Reverse Transcriptase Polymerase Chain Reaction

# keywords[]
Phex Phosphate Regulating Neutral Endopeptidase

# keywords[]
Phex Phosphate Regulating Neutral Endopeptidase

# educationAndTraining[].organization.label
Okayama University - (Okayama, Okayama, Japan)

# educationAndTraining[].organization.label
Harbin Medical University - (Harbin, Heilongjiang, China)

# educationAndTraining[].organization.label
Harbin Medical University - (Harbin, Heilongjiang, China)

# educationAndTraining[].organization.label
The University of Texas Health Science Center at Houston - (Houston, Texas, United States)

# publications[].label
The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone.

# publications[].label
[The effects of nicotine on bone calcium and phosphorus content and alkaline phosphatase activity in different part of rat].

# publications[].label
Inactivation of Fam20b in the neural crest-derived mesenchyme of mouse causes multiple craniofacial defects.

# publications[].label
Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus.

# publications[].label
Key proteolytic cleavage site and full-length form of DSPP.

# publications[].label
Expression and processing of small integrin-binding ligand N-linked glycoproteins in mouse odontoblastic cells.

# publications[].label
Dentin sialoprotein in bone and dentin sialophosphoprotein gene expressed by osteoblasts.

# publications[].label
Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage.

# publications[].label
Nuclear localization of DMP1 proteins suggests a role in intracellular signaling.

# publications[].label
Controlling the orientation of bone osteopontin via its specific binding with collagen I to modulate osteoblast adhesion.

# publications[].label
Protective roles of DMP1 in high phosphate homeostasis.

# publications[].label
Colocalization of dentin matrix protein 1 and dentin sialoprotein at late stages of rat molar development.

# publications[].label
Adhesion of MC3T3-E1 cells bound to dentin phosphoprotein specifically bound to collagen type I.

# publications[].label
Cyclosporine a inhibits apoptosis of rat gingival epithelium.

# publications[].label
Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells.

# publications[].label
Single-nucleotide polymorphisms (SNPs) of the IRF6 and TFAP2A in non-syndromic cleft lip with or without cleft palate (NSCLP) in a northern Chinese population.

# publications[].label
Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice.

# publications[].label
Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.

# publications[].label
Extracellular matrix proteins and the dynamics of dentin formation.

# publications[].label
The importance of a potential phosphorylation site in enamelin on enamel formation.

# publications[].label
Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.

# publications[].label
Loss of Fam20c causes defects in the acinar and duct structure of salivary glands in mice.

# publications[].label
An immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice.

# publications[].label
FAM20C plays a critical role in the development of mouse vertebra.

# publications[].label
An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses.

# publications[].label
Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.

# publications[].label
FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner.

# publications[].label
DMP1 processing is essential to dentin and jaw formation.

# publications[].label
Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites.

# publications[].label
Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice.

# publications[].label
A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment.

# publications[].label
Expression of FAM20C in the osteogenesis and odontogenesis of mouse.

# publications[].label
Dentin matrix protein 1 and phosphate homeostasis are critical for postnatal pulp, dentin and enamel formation.

# publications[].label
The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis.

# publications[].label
Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism.

# publications[].label
The expression of dentin sialophosphoprotein gene in bone.

# publications[].label
Transgenic expression of dentin phosphoprotein inhibits skeletal development.

# publications[].label
Distribution of SIBLING proteins in the organic and inorganic phases of rat dentin and bone.

# publications[].label
Letter to the Editor, "Osterix Regulates Tooth Root Formation in a Site-specific Manner".

# publications[].label
Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the condylar cartilage of rat mandible.

# publications[].label
Osteopontin posttranslational modifications, possibly phosphorylation, are required for in vitro bone resorption but not osteoclast adhesion.

# publications[].label
Adhesion of MC3T3-E1 cells to bone sialoprotein and bone osteopontin specifically bound to collagen I.

# publications[].label
Abrogation of epithelial BMP2 and BMP4 causes Amelogenesis Imperfecta by reducing MMP20 and KLK4 expression.

# publications[].label
Unique roles of phosphorus in endochondral bone formation and osteocyte maturation.

# publications[].label
Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis.

# publications[].label
Expression of dentin sialophosphoprotein in non-mineralized tissues.

# publications[].label
Twist1- and Twist2-haploinsufficiency results in reduced bone formation.

# publications[].label
Different forms of DMP1 play distinct roles in mineralization.

# publications[].label
Inactivation of FAM20B causes cell fate changes in annulus fibrosus of mouse intervertebral disc and disc defects via the alterations of TGF- and MAPK signaling pathways.

# publications[].label
Overexpressing the NH2-terminal fragment of dentin sialophosphoprotein (DSPP) aggravates the periodontal defects in Dspp knockout mice.

# publications[].label
The specific role of FAM20C in amelogenesis.

# publications[].label
Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice.

# publications[].label
Importance of phosphorylation for osteopontin regulation of biomineralization.

# publications[].label
Expression and distribution of SIBLING proteins in the predentin/dentin and mandible of hyp mice.

# publications[].label
Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype in Col1a1-Trps1 transgenic mice.

# publications[].label
The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment.

# publications[].label
Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects.

# publications[].label
Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues.

# publications[].label
Identification and characterization of the carboxyl-terminal region of rat dentin sialoprotein.

# publications[].label
Probing the influence of SIBLING proteins on collagen-I fibrillogenesis and denaturation.

# publications[].label
Loss of dentin sialophosphoprotein leads to periodontal diseases in mice.

# publications[].label
CRISPLD2 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate in a northern Chinese population.

# publications[].label
Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.

# publications[].label
Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype.

# publications[].label
A novel role of periostin in postnatal tooth formation and mineralization.

# publications[].label
Inactivation of Fam20B in the dental epithelium of mice leads to supernumerary incisors.

# publications[].label
Essential role of osterix for tooth root but not crown dentin formation.

# publications[].label
Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice.

# publications[].label
Repair of dentin defects from DSPP knockout mice by PILP mineralization.

# publications[].label
Abrogation of Fam20c altered cell behaviors and BMP signaling of immortalized dental mesenchymal cells.

# publications[].label
An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses.

# publications[].label
Tanshinone IIA treatment alleviated the rat gingival connective tissue overgrowth induced by cyclosporine A.

# publications[].label
A comparative study of sialic acid-rich proteins in rat bone and dentin.

# publications[].label
Detection of dentin sialoprotein in rat periodontium.

# publications[].label
Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis.

# publications[].label
Differential expression and localization of dentin matrix protein 1 (DMP1) fragments in mouse submandibular glands.

# publications[].label
Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the articular cartilage of the rat femoral head.

# publications[].label
In vitro effects of dentin matrix protein-1 on hydroxyapatite formation provide insights into in vivo functions.

# publications[].label
Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis.

# publications[].label
Age effects on ectopic bone formation induced by purified bone morphogenetic protein.

# publications[].label
Identification of full-length dentin matrix protein 1 in dentin and bone.

# publications[].label
FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors.

# publications[].label
FAM20C plays an essential role in the formation of murine teeth.

# publications[].label
Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration.

# publications[].label
Accelerated enamel mineralization in Dspp mutant mice.

# publications[].label
The LPV Motif Is Essential for the Efficient Export of Secretory DMP1 From the Endoplasmic Reticulum.

# publications[].label
Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms.

# publications[].label
Inactivation of Fam20C in cells expressing type I collagen causes periodontal disease in mice.

# publications[].label
A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-kappaB activation.

# publications[].label
Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves.

# publications[].label
In Vivo Response of Osteoblast-like and Odontoblast-like Cells in Intraperitoneal Diffusion Chamber

# publications[].publisher
Society for Hard Tissue Regenerative Biology

# publications[].label
Dspp-independent Effects of Transgenic Trps1 Overexpression on Dentin Formation.

# publications[].label
Mineralization induction effects of osteopontin, bone sialoprotein, and dentin phosphoprotein on a biomimetic collagen substrate.

# publications[].label
The specific role of FAM20C in dentinogenesis.

# publications[].label
Immunohistochemical study of small integrin-binding ligand, N-linked glycoproteins in reactionary dentin of rat molars at different ages.

# publications[].label
The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis.

# publications[].label
Loss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowth.

# publications[].label
Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice.

# publications[].label
Matrix macromolecules in hard tissues control the nucleation and hierarchical assembly of hydroxyapatite.

# publications[].label
Partial Blocking of Mouse DSPP Processing by Substitution of Gly451–Asp452 Bond Suggests the Presence of Secondary Cleavage Site(s)

# publications[].label
Developmental analysis and computer modelling of bioengineered teeth.

# publications[].label
Noggin inhibition of mouse dentinogenesis.

# publications[].label
Mineral Metabolism and its Impact on Craniofacial Bones and Teeth

# publications[].label
Expression of Small Integrin-Binding LIgand N-linked Glycoproteins (SIBLINGs) in the reparative dentin of rat molars.

# publications[].label
Spatially and temporally controlled biomineralization is facilitated by interaction between self-assembled dentin matrix protein 1 and calcium phosphate nuclei in solution.

# publications[].label
Dentin sialoprotein isoforms: detection and characterization of a high molecular weight dentin sialoprotein.

# publications[].label
MC3T3-E1 cell adhesion to hydroxyapatite with adsorbed bone sialoprotein, bone osteopontin, and bovine serum albumin.

# publications[].label
Transgenic expression of dentin phosphoprotein (DPP) partially rescued the dentin defects of DSPP-null mice.

# publications[].label
Glycosaminoglycan chain of dentin sialoprotein proteoglycan.

# publications[].label
DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.

# publications[].label
An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage.

# publications[].label
Dentin extracellular matrix (ECM) proteins: comparison to bone ECM and contribution to dynamics of dentinogenesis.

# publications[].label
Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation.

# publications[].label
Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis.

# publications[].label
Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis.

# publications[].label
Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis.

# publications[].label
Studies of the DMP1 57-kDa functional domain both in vivo and in vitro.

# publications[].label
Deficiency of the DSPP-cleaving enzymes meprin  and meprin  does not result in dentin malformation in mice.

# researcherOn[].label
Dentin Sialophosphoprotein (DSPP) and Unfolded Protein Response (UPR) in Dentinogensis Imperfecta (DGI) and Odontoblast Function

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# researcherOn[].label
Functions of Family with Sequence Similarity 20 - Member C (FAM20C) and Member A (FAM20A) in Amelogenesis and Dentinogenesis

# researcherOn[].awardedBy.label
National Institute of Dental and Craniofacial Research - (Bethesda, Maryland, United States)

# researcherOn[].label
The Roles of Fam20c (dmp4) In Odontogenesis and Osteogenesis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# researcherOn[].label
Studies of the Roles of DMP1 and DSPP In Osteogenesis and Dentinogenesis

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# researcherOn[].label
Tooth Root Formation: An Emerging Signaling Pathway

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].awardedBy.preferredLabel
DHHS-NIH-National Institute of Dental and Craniofacial Research

# streetAddress
Texas A&M University College of Dentistry; Biomedical Sciences; 3302 Gaston Avenue

# etdChairOf[].label
Jani, Priyam Himanshu (2016-12). Biological Functions of Dentin Sialophsphoprotein in Mineralized Tissues. Doctoral Dissertation.