# positions[].organizations[].parent[].label
College of Agriculture and Life Sciences

# overview
Dr. Walzem's core research focus within the laboratory is directed towards understanding how the structure of triglyceride-rich lipoproteins influences their ability to carry out specific nutrient delivery tasks. Her studies include identification of mechanisms and regulatory processes that control the assembly of trigylceride-rich lipoproteins in issues, structural studies of lipoproteins themselves and physiological studies to determine substrate properties and metabolic fates of different types of lipoproteins. Diet can significantly alter lipoprotein physiology through multiple mechanisms, and studies of diet effects provides a significant sub-theme to the research program. A variety of species are used to address specific questions, however, avian and human lipoprotein metabolism as it relates to egg production and atherogenesis, respectively, are emphasized.

# keywords[]
Atp Binding Cassette Transporter, Subfamily G, Member 1

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Sterol Regulatory Element Binding Protein 1

# keywords[]
Clinical Trials And Supportive Activities

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
6 Evaluation Of Treatments And Therapeutic Interventions

# publications[].label
The HDL-C Response to Acute Exercise Depends on Dietary Monounsaturated Fatty-Acid Ratio

# publications[].label
Feed restriction ameliorates metabolic dysregulation and improves reproductive performance of meat-type country chickens.

# publications[].label
Thiamin absorption is not compromised in folate-deficient rats.

# publications[].label
Enzymatic O-methylation of flavanols changes lag time, propagation rate, and total oxidation during in vitro model triacylglycerol-rich lipoprotein oxidation.

# publications[].label
Symposium: Assembly and physiology of apolipoprotein B-containing lipoproteins: Not just for heart disease anymore! Introduction

# publications[].label
Effects of dairy ingredients on cytokine responses to LPS challenge in mice (822.5)

# publications[].label
Reduced carbohydrate and increased protein and fat during weight loss improve the atherogenic lipid profile in type 2 diabetes

# publications[].label
(+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine.

# publications[].label
Polylysine enhances cationic liposome-mediated transfection of the hepatoblastoma cell line Hep G2.

# publications[].label
Dietary fat and cholesterol change laying hen VLDLy diameter distributions

# publications[].label
Liraglutide in combination with metformin may improve the atherogenic lipid profile and decrease C-reactive protein level in statin treated obese patients with coronary artery disease and newly diagnosed type 2 diabetes: A randomized trial.

# publications[].label
Fitm2 is required for ER homeostasis and normal function of murine liver

# publications[].label
Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase.

# publications[].label
Degree of Dietary Refinement Alters Apparent Gut Permeability

# publications[].label
Unique phospholipid metabolism in mouse heart in response to dietary docosahexaenoic or alpha-linolenic acids.

# publications[].label
Altered lipoprotein profiles in cats with hepatic lipidosis.

# publications[].label
Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Effects of 1year of exercise training versus combined exercise training and weight loss on body composition, low-grade inflammation and lipids in overweight patients with coronary artery disease: a randomized trial.

# publications[].label
Dexamethasone enhancement of gene expression after direct hepatic DNA injection.

# publications[].label
Ground Beef High in Total Fat and Saturated Fatty Acids Decreases X Receptor Signaling Targets in Peripheral Blood Mononuclear Cells of Men and Women.

# publications[].label
Fitm2 is required for ER homeostasis and normal function ofmurine liver.

# publications[].label
Preserving fresh fruit quality by low-dose electron beam processing for vending distribution channels

# publications[].label
Plasma lipoprotein changes in hens (Gallus domesticus) during an induced molt.

# publications[].label
Dietary dairy proteins improve lipoprotein profiles in C57/Bl6 mice

# publications[].label
Storage conditions affect observed size distributions of very low density lipoproteins (VLDL).

# publications[].label
Consuming High-Fat and Low-Fat Ground Beef Depresses High-Density and Low-Density Lipoprotein Cholesterol Concentrations, and Reduces Small, Dense Low-Density Lipoprotein Particle Abundance.

# publications[].label
Separation of Lipoproteins for Quantitative Analysis of 14C-Labeled Lipid-Soluble Compounds by Accelerator Mass Spectrometry.

# publications[].label
Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium.

# publications[].label
A one-year intervention combining weight loss and exercise increases the proportion of lipoprotein constituted by HDL and HDL particle size

# publications[].label
P1503A one-year intervention combining weight loss and exercise increases the proportion of lipoprotein constituted by HDL and HDL particle size

# publications[].label
Palmitic acid in chicken granulosa cell death-lipotoxic mechanisms mediate reproductive inefficacy of broiler breeder hens.

# publications[].label
Validation of a modified PCR-based method for identifying mutant restricted ovulator chickens: substantiation of genotypic classification by phenotypic traits.

# publications[].label
Wine phenolics and targets of chronic disease

# publications[].label
25-Hydroxycholecalciferol Improves Cardiac Metabolic Adaption, Mitochondrial Biogenetics, and Redox Status to Ameliorate Pathological Remodeling and Functional Failure in Obese Chickens.

# publications[].label
Lipid matrix effects on alpha- and gamma-tocopherol distribution in hamster plasma

# publications[].label
High-oleic ground beef, exercise, and risk factors for cardiovascular disease in postmenopausal women

# publications[].label
Dietary supplementation of 25-hydroxycholecalciferol improves livability in broiler breeder hens.

# publications[].label
Ground beef consumption and MUFA:SAT alters HDL oxylipin profile in healthy men

# publications[].label
Overfeeding increases very low density lipoprotein diameter and causes the appearance of a unique lipoprotein particle in association with failed yolk deposition.

# publications[].label
Folate status of rats fed casein-gelatin vs amino acid diets

# publications[].label
Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.

# publications[].label
Gene expression following direct injection of DNA into liver.

# publications[].label
Effect of dietary omega-3 fatty acids on red blood cell lipid composition and plasma metabolites in the cockatiel, Nymphicus hollandicus.

# publications[].label
Estrogen induction of VLDLy assembly in egg-laying hens.

# publications[].label
Antioxidant activity of citrus limonoids, flavonoids, and coumarins.

# publications[].label
Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
Lipoproteins and the laying hen: Form follows function

# publications[].label
Decreased apolipoprotein E and VLDL receptors cause lipidemia in nephrotic syndrome

# publications[].label
OXIDATIVE SUSCEPTIBILITY OF LIPOPROTEINS INCREASE WITH INTRAVASCULAR AGE

# publications[].label
Intracellular lipid dysregulation interferes with leukocyte function in the ovaries of meat-type hens under unrestricted feed intake.

# publications[].label
THIAMIN ABSORPTION IN FOLATE-DEFICIENT RATS

# publications[].label
Reduced insulin sensitivity limits reductions in small dense LDL due to lean beef consumption (821.14)

# publications[].label
Health Benefits of Phytochemicals for Older Adults

# publications[].label
Characterization of very-low density lipoprotein particle diameter dynamics in relation to egg production in a passerine bird.

# publications[].label
Cell model for production of flavonoid metabolites.

# publications[].label
Identification of important regressor groups, subgroups and individuals via regularization methods: application to gut microbiome data.

# publications[].label
Effects of orchidectomy and hormone replacement on rat hepatic hexose monophosphate pathway enzymes

# publications[].label
Dietary supplementation of 25-hydroxycholecalciferol improves cardiac function and livability in broiler breeder hens-amelioration of blood pressure and vascular remodeling.

# publications[].label
Lipid metabolism in human pancreatic islets of Langerhans

# publications[].label
Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.

# publications[].label
Older plasma lipoproteins are more susceptible to oxidation: a linking mechanism for the lipid and oxidation theories of atherosclerotic cardiovascular disease.

# publications[].publisher
Proceedings of the National Academy of Sciences

# publications[].label
Changes in broiler breeder (BB) egg production following release from feed restriction vary with changes in plasma VLDL diameter

# publications[].label
Dairy Milk Components Differentially Affect Gastrointestinal Health Markers in C57Bl/6 Mice

# publications[].label
Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesteryl ester-selective uptake.

# publications[].label
High-carbohydrate diets affect the size and composition of plasma lipoproteins in hamsters (Mesocricetus auratus).

# publications[].label
Estrogen effects on triglyceride metabolism in analbuminemic rats.

# publications[].label
Characterization of very-low density lipoprotein particle size in egg-laying birds.

# publications[].label
Folate deficiency in rats fed amino acid diets.

# publications[].label
Consumption of High-Oleic Acid Ground Beef Increases HDL-Cholesterol Concentration but Both High- and Low-Oleic Acid Ground Beef Decrease HDL Particle Diameter in Normocholesterolemic Men

# publications[].label
WEIGHT LOSS IS SUPERIOR TO EXERCISE IN IMPROVING THE ATHEROGENIC LIPID PROFILE IN AN OVERWEIGHT, SEDENTARY POPULATION WITH CORONARY ARTERY DISEASE: THE RANDOMIZED CUT-IT TRIAL

# publications[].label
Differential allocation of lipid resources during avian egg production

# publications[].label
38-LB: Reduced Carbohydrate and Increased Protein and Fat during Weight Loss Improve the Atherogenic Lipid Profile in Type 2 Diabetes

# publications[].label
Phenamil, an amiloride derivative, restricts long bone growth and alters keeled-sternum bone architecture in growing chickens.

# publications[].label
Overfeeding-induced ovarian dysfunction in broiler breeder hens is associated with lipotoxicity.

# publications[].label
Estrogen induction of VLDLy assembly in egg-laying hens

# publications[].label
Novel lipoprotein density profiling in healthy dogs of various breeds, healthy Miniature Schnauzers, and Miniature Schnauzers with hyperlipidemia.

# publications[].label
ANALYTICAL ASSESSMENT OF SERUM LIPOPROTEIN PROFILES IN HEALTHY DOGS AND DOGS WITH EXOCRINE PANCREATIC INSUFFICIENCY

# publications[].label
A novel NanoBiT-based assay monitors the interaction between lipoprotein lipase and GPIHBP1 in real time.

# publications[].label
Effect of ground beef fatty acid composition on atherosclerotic cardiovascular disease risk factors in healthy men

# publications[].label
Avian fatty liver hemorrhagic syndrome: a comparative review.

# publications[].label
Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice.

# publications[].label
Chronic disease: long-term outcomes of metabolic dysfunction

# publications[].label
Unique responses of pancreatic phospholipid metabolism of broiler hens in response to increased plasma glucose and lipid concentrations

# publications[].label
Baseline Insulin Resistance Is a Determinant of the Small, Dense Low-Density Lipoprotein Response to Diets Differing in Saturated Fat, Protein, and Carbohydrate Contents.

# publications[].label
Effect of dietary fats and barley fiber on total cholesterol and lipoprotein cholesterol distribution in plasma of hamsters

# publications[].label
Plasma yolk precursor dynamics during egg production by female greater scaup (Aythya marila): Characterization and indices of reproductive state.

# publications[].label
Calcium effects on bodyweight appear to be mediated in part by changes in gut microflora and altered by dietary matrix

# publications[].label
Catechin is present as metabolites in human plasma after consumption of red wine.

# publications[].label
BROILER-BREEDER HEN PLASMA-LIPOPROTEIN SIZE DISTRIBUTIONS ARE AFFECTED BY FEED RESTRICTION AND EGG-PRODUCTION

# publications[].label
Nonalcoholic Components of Wine and Atherosclerotic Cardiovascular Disease

# publications[].label
Purine synthesis and reutilization in folate-deficient rat hepatocytes.

# publications[].label
Liraglutide and metformin may rock and roll the most atherogenic LDL fraction in patients with diabetes and ischaemic heart disease on stable statin therapy: a randomised trial

# publications[].label
Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
14. Modulation of lipids, lipoproteins, and other biomarkers with egg consumption and exercise

# publications[].label
DETERMINATION OF BLOOD TRANSKETOLASE - AN IMPROVED PROCEDURE WITH OPTIMIZED CONDITIONS

# publications[].label
Obesity-induced dysfunctions in female reproduction: lessons from birds and mammals.

# publications[].label
APPLIED RESEARCH NOTE: Optimized Corticosterone Extraction Following Feather Dissolution by Keratinase

# publications[].label
Effects of dietary fat restriction on particle size of plasma lipoproteins in postmenopausal women.

# publications[].label
Amiloride Derivative Phenamil Restricts Long Bone Growth in Broilers in Conjunction with Zinc Accumulation

# publications[].label
Producing high-oleic acid beef and the impact of ground beef consumption on risk factors for cardiovascular disease: A review

# publications[].label
Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice.

# publications[].label
Effects of F-strain Mycoplasma gallisepticum inoculation on serum very low density lipoprotein diameter and fractionation of cholesterol among lipoproteins in commercial egg-laying hens.

# publications[].label
Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
ASSOCIATION OF SPECIFIC SUBPOPULATIONS OF VERY-LOW-DENSITY LIPOPROTEIN WITH EGG-PRODUCTION IN TURKEY BREEDER HENS

# publications[].label
17-estradiol reduces tumor necrosis factor--mediated LDL accumulation in the artery wall

# publications[].label
A polyphenol rich sumac sorghum cereal alters lipoprotein subfractions resulting in a more cardioprotective lipoprotein profile

# publications[].label
Obesity-associated cardiac pathogenesis in broiler breeder hens: Pathological adaption of cardiac hypertrophy.

# publications[].label
Structured variable selection with q-values.

# publications[].label
Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol.

# publications[].label
EXPRESSION OF FOLIC-ACID DEFICIENCY IN RATS FED AMINO-ACID DIETS LOW IN VITAMIN-K

# publications[].label
Evaluation of density gradient ultracentrifugation serum lipoprotein profiles in healthy dogs and dogs with exocrine pancreatic insufficiency.

# publications[].label
What comes first, the zebra finch or the egg: temperature-dependent reproductive, physiological and behavioural plasticity in egg-laying zebra finches.

# publications[].label
Serum triglyceride and cholesterol concentrations and lipoprotein profiles in dogs with naturally occurring pancreatitis and healthy control dogs.

# publications[].label
80. An agricultural perspective of what does a healthy diet mean

# publications[].label
Societal aspects in the dietary management of childhood hyperlipidemia.

# publications[].label
ABSORPTION AND EXCRETION OF THIAMIN IN FOLATE DEFICIENT RATS

# publications[].label
Temperature-dependent reproductive and behavioral plasticity in breeding birds.

# publications[].label
Relationship between growth and selected liver enzyme activities of individual rainbow trout.

# publications[].label
AtheroReversa mice: Switching off hypercholesterolemia without hypolipidemic drugs or changing the diet

# publications[].label
Differential Modulation of 25-hydroxycholecalciferol on Innate Immunity of Broiler Breeder Hens.

# publications[].label
Whey components: millennia of evolution create functionalities for mammalian nutrition: what we know and what we may be overlooking.

# publications[].label
Supplemental 25-hydroxycholecalciferol Alleviates Inflammation and Cardiac Fibrosis in Hens.

# publications[].label
Effect of divergent selection for total plasma phosphorus on plasma and yolk very low density lipoproteins and plasma concentrations of selected hormones in laying Japanese quail.

# publications[].label
Wine and health: state of proofs and research needs.

# publications[].label
Modulation of lipids, lipoproteins, and other biomarkers with egg consumption and exercise

# publications[].label
Functional annotation of genomic data with metabolic inference

# publications[].label
Dietary Matrix Alters Fecal Lipids and Lipoprotein Profiles in Healthy C57Bl/6 Mice

# publications[].label
Obesity-associated cardiac pathogenesis in broiler breeder hens: Development of metabolic cardiomyopathy.

# publications[].label
The cloning and characterization of a soluble epoxide hydrolase in chicken.

# publications[].label
EFFECT OF FOLIC-ACID AND THYMIDINE ON PURINE METABOLISM IN FOLATE-DEFICIENT RAT HEPATOCYTES

# publications[].label
Dietary vitamin E in an atherogenic hamster model

# publications[].label
Mobilization of ectopic yolk in Gallus gallus domesticus: a novel reverse lipid transport process.

# publications[].label
Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low-density lipoprotein-containing human apolipoprotein B100.

# publications[].label
Dietary Supplementation of 25-Hydroxycholecalciferol Improves Livability in Broiler Breeder Hens-Amelioration of Cardiac Pathogenesis and Hepatopathology.

# publications[].label
COMBINED FOLATE AND VITAMIN-A DEFICIENCIES IN RATS FED AMINO-ACID DIETS

# publications[].label
Cationic lipid enhances in vitro receptor-mediated transfection.

# publications[].label
Fatty liver hemorrhagic syndrome in hens overfed a purified diet. Selected enzyme activities and liver histology in relation to liver hemorrhage and reproductive performance.

# publications[].label
Red wine polyphenols, but not ethanol, reduce aortic lipid deposits in hyperlipidemic hamsters.

# publications[].label
Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure.

# publications[].label
Identification of candidate genes responsible for the assembly of apolipoprotein-B containing lipoproteins in an avian system using estrogen induction

# publications[].label
Novel lipoprotein density profiling in laminitic, obese, and healthy horses.

# publications[].label
Whole and Isolated Protein Fractions Differentially Affect Gastrointestinal Integrity Markers in C57Bl/6 Mice Fed Diets with a Moderate-Fat Content.

# publications[].label
Hamburger high in total, saturated and trans-fatty acids decreases HDL cholesterol and LDL particle diameter, and increases TAG, in mildly hypercholesterolaemic men.

# publications[].label
Feed intake alters immune cell functions and ovarian infiltration in broiler hens: implications for reproductive performance.

# publications[].label
Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity.

# publications[].label
Copper and zinc balance in exercising horses fed 2 forms of mineral supplements.

# publications[].label
Leukocytes are present during the clearance of yolk from the abdominal cavity of hens.

# publications[].label
Ceramide accumulation and up-regulation of proinflammatory interleukin-1 exemplify lipotoxicity to mediate declines of reproductive efficacy of broiler hens.

# publications[].label
17beta-estradiol reduces tumor necrosis factor-alpha-mediated LDL accumulation in the artery wall.

# publications[].label
Unrestricted Feed Intake Induces -Cell Death and Impairs Insulin Secretion in Broiler Breeder Hens.

# publications[].label
Ovarian expression of functional MTTP and apoB for VLDL assembly and secretion in chickens.

# publications[].label
Lipoprotein lipase reaches the capillary lumen in chickens despite an apparent absence of GPIHBP1.

# publications[].publisher
American Society for Clinical Investigation

# publications[].label
APPEARANCE OF NOVEL LIPOPROTEIN IN PLASMA OF FORCE-MOLTED SINGLE COMB WHITE LEGHORN (SCWL) HENS

# publications[].label
Folate deficiency in rats fed diets containing free amino acids or intact proteins.

# publications[].label
Effects of fasting on serum lipids and lipoprotein profiles in the egg-laying hen (Gallus domesticus).

# publications[].label
Pilot Study to Evaluate the Effect of Consumption of Whole Pecans on Endothelial Function

# publications[].label
Weight loss is superior to exercise in improving the atherogenic lipid profile in a sedentary, overweight population with stable coronary artery disease: A randomized trial.

# publications[].label
Effects of dairy ingredients on gut microbiome biogeography in mice (822.11)

# publications[].label
Copper, Zinc-Superoxide Dismutase Activity in Exercising Horses Fed Two Forms of Trace Mineral Supplements

# publications[].label
Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion.

# publications[].label
Symposium: Assembly and physiology of apolipoprotein B-containing lipoproteins: Not just for heart disease anymore! Introduction

# publications[].label
Effects of high carbohydrate diets on the physical-chemical properties of plasma lipoproteins in hamsters

# publications[].label
Functional annotation of genomic data with metabolic inference.

# publications[].label
Transfection of avian LMH-2A hepatoma cells with cationic lipids.

# publications[].label
Solubilization of acyl heterogeneous triacylglycerols in phosphatidylcholine vesicles (vol 51, pg 477, 2003)

# publications[].label
Relationships among apolipoproteinB concentration, particle diameter and arterial plaque in transgenic mice

# publications[].label
Effect of a low-fat diet on serum triglyceride and cholesterol concentrations and lipoprotein profiles in Miniature Schnauzers with hypertriglyceridemia.

# publications[].label
Absence of hyperlipidemia in LDL receptor-deficient mice having apolipoprotein B100 without the putative receptor-binding sequences.

# publications[].label
Relative VO2 max correlates with lipoprotein subfractions in response to four different exercise modalities

# publications[].label
Effect of dietary catechin and vitamin E on aortic fatty streak accumulation in hypercholesterolemic hamsters.

# publications[].label
Separation of size subclasses of laying hen very low density lipoprotein (VLDL) by FPLC.

# publications[].label
The Impact of Egg Consumption on Visual Cognitive Performance in the Nutrition, Vision, and Cognition in Health: Egg (IONHealth-Egg) Study

# publications[].label
Ground beef from corn-fed cattle provides greater health benefits than ground beef from pasture-fed cattle

# researcherOn[].label
Nutrition, Biostatistics and Bioinformatics Training Grant

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Lipoprotein Biology in Avian Health and Disease

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Probiotic modulation of appetite to improve breeder pullet welfare

# researcherOn[].awardedBy.label
United States Department of Agriculture - (Washington D.C., District of Columbia, United States)

# researcherOn[].awardedBy.preferredLabel
USDA-National Institute of Food And Agriculture

# researcherOn[].label
Advanced Technologies for the Genetic Improvement of Poultry

# researcherOn[].awardedBy.label
National Institute of Food and Agriculture - (Washington D.C., District of Columbia, United States)

# streetAddress
Texas A&M University; Poultry Science; 2472 TAMU

# organizations[]
College of Agriculture and Life Sciences

# schools[]
College of Agriculture and Life Sciences

# inTheNews[].label
De-extinction efforts are being directed at reviving lost bird species