# positions[].organizations[].parent[].label
Texas A&M University Naresh K. Vashisht College of Medicine

# overview
The primary focus of my current research is examining the effects of morphine on recovery of function after spinal cord injury. This research includes examination of the potential for addiction after SCI as well as the behavioral and molecular changes associated with administration of morphine in a rodent model of spinal cord injury.

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
5204 Cognitive And Computational Psychology

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
Direct-pathway Medium Spiny Neurons, Dmsns

# keywords[]
Habenula-projecting Globus Pallidus Neurons, Gph

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
5.9 Resources And Infrastructure (treatment Development)

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
Interleukin 1 Receptor Antagonist Protein

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
3214 Pharmacology And Pharmaceutical Sciences

# keywords[]
30 Agricultural, Veterinary And Food Sciences

# keywords[]
Drug-Related Side Effects And Adverse Reactions

# keywords[]
Physical Injury - Accidents And Adverse Effects

# keywords[]
Machine Learning And Artificial Intelligence

# keywords[]
4201 Allied Health And Rehabilitation Science

# educationAndTraining[].organization.label
University of New England - (Armidale, New South Wales, Australia)

# publications[].label
Intrathecal minocycline does not block the adverse effects of repeated, intravenous morphine administration on recovery of function after SCI.

# publications[].label
Exercise therapy and recovery after SCI: evidence that shows early intervention improves recovery of function.

# publications[].label
A rodent model of functional electrical stimulation: Evidence spinal neurons modulate adaptive capacity

# publications[].label
Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model.

# publications[].label
Assessing Depression and Cognitive Impairment Following Stroke and Neurotrauma: Behavioral Methods for Quantifying Impairment and Functional Recovery.

# publications[].label
The impact of morphine after a spinal cord injury.

# publications[].label
BLOCKING KOR ACTIVATION PREVENTS MORPHINE-INDUCED ATTENUATION OF RECOVERY FOLLOWING SCI

# publications[].label
Assessment of depression in a rodent model of spinal cord injury.

# publications[].label
Chemogenetic Attenuation of Acute Nociceptive Signaling Enhances Functional Outcomes Following Spinal Cord Injury.

# publications[].label
A moderate spinal contusion injury in rats alters bone turnover both below and above the level of injury with sex-based differences apparent in long-term recovery.

# publications[].label
Extracellular vesicles: Unlocking new therapies for spinal cord injury.

# publications[].label
Uncontrollable stimulation undermines recovery of function after spinal cord injury

# publications[].label
SCI and depression: Does inflammation commandeer the brain?

# publications[].label
Simple Reaching Is Not So Simple: Association Between Hand Use and Grip Preferences in Captive Chimpanzees.

# publications[].label
Effects of morphine after a spinal contusion injury

# publications[].label
Continuous shock has a protective effect against the spinal learning deficit induced by intermittent shock

# publications[].label
Examining the effects of pain on morphine self-administration following a spinal contusion injury

# publications[].label
Intrathecal morphine attenuates recovery of function after a spinal cord injury.

# publications[].label
Striatal -opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect.

# publications[].label
EFFECTS OF OPIOIDS ON RECOVERY AFTER SCI IRRESPECTIVE OF KOR ACTIVATION

# publications[].label
Inflammaging and Bone Loss in a Rat Model of Spinal Cord Injury.

# publications[].label
Analgesia or addiction?: implications for morphine use after spinal cord injury.

# publications[].label
Lateralized use of the mouth in production of vocalizations by marmosets.

# publications[].label
Regulatory effects of intermittent noxious stimulation on spinal cord injury-sensitive microRNAs and their presumptive targets following spinal cord contusion.

# publications[].label
An IL-1 receptor antagonist blocks a morphine-induced attenuation of locomotor recovery after spinal cord injury.

# publications[].label
Evaluation of the effects of specific opioid receptor agonists in a rodent model of spinal cord injury.

# publications[].label
MORPHINE-INDUCED CELL DEATH IN A RODENT MODEL OF SCI

# publications[].label
Uncontrollable stimulation undermines recovery after spinal cord injury.

# publications[].label
SPINALLY CONTUSED MALE AND FEMALE RATS EXHIBIT DIFFERENTIAL HIPPOCAMPAL-ASSOCIATED AFFECTIVE AND COGNITIVE OUTCOMES IN CHRONIC RECOVERY

# publications[].label
Morphine-induced changes in the function of microglia and macrophages after acute spinal cord injury.

# publications[].label
Visuospatial reaching preferences of common marmosets (Callithrix jacchus): an assessment of individual biases across a variety of tasks.

# publications[].label
Peripheral inflammation undermines the plasticity of the isolated spinal cord.

# publications[].label
Morphine-induced changes in the function of microglia and macrophages after spinal cord injury

# publications[].label
Maladaptive spinal plasticity opposes spinal learning and recovery in spinal cord injury.

# publications[].label
Variability in Open-Field Locomotor Scoring Following Force-Defined Spinal Cord Injury in Rats: Quantification and Implications.

# publications[].label
The first 24h: opioid administration in people with spinal cord injury and neurologic recovery.

# publications[].label
Spinal neurons exhibit a surprising capacity to learn and a hidden vulnerability when freed from the brain's control.

# publications[].label
Peripheral noxious stimulation reduces withdrawal threshold to mechanical stimuli after spinal cord injury: role of tumor necrosis factor alpha and apoptosis.

# publications[].label
A brief period of moderate noxious stimulation induces hemorrhage and impairs locomotor recovery after spinal cord injury.

# publications[].label
Elevated osteocyte TNF-, IL-6, and sclerostin in a rodent model of spinal cord injury correlates with altered bone turnover.

# publications[].label
Nor-Binaltorphimine Blocks the Adverse Effects of Morphine after Spinal Cord Injury.

# publications[].label
ELEVATED BASELINE LEVELS OF INTERLEUKIN-6 ARE ASSOCIATED DEPRESSION AFTER SPINAL CORD INJURY

# publications[].label
MicroRNA dysregulation following spinal cord contusion: implications for neural plasticity and repair.

# publications[].label
Maternal age, parity, and reproductive outcome in captive chimpanzees (Pan troglodytes).

# publications[].label
The behavioral deficit observed following noncontingent shock in spinalized rats is prevented by the protein synthesis inhibitor cycloheximide.

# publications[].label
Opioid administration following spinal cord injury: implications for pain and locomotor recovery.

# publications[].label
Poster 97: The First 24 Hours: The Impact of Opioids on Spinal Cord Injury Recovery

# publications[].label
Adverse Effects of Repeated, Intravenous Morphine on Recovery after Spinal Cord Injury in Young, Male Rats Are Blocked by a Kappa Opioid Receptor Antagonist.

# publications[].label
Chimpanzees (Pan troglodytes) are predominantly right-handed: replication in three populations of apes.

# publications[].label
Pain Input Impairs Recovery after Spinal Cord Injury: Treatment with Lidocaine.

# publications[].label
118. The interplay between psychological well-being, pain and inflammation in a rat model of spinal cord injury

# publications[].label
Leading-limb preferences in marmosets (Callithrix jacchus): walking, leaping and landing.

# publications[].label
Inflammation increases the development of depression behaviors in male rats after spinal cord injury.

# publications[].label
INTERACTIONS BETWEEN PHYSIOLOGICAL FUNCTION AND DEPRESSION-LIKE BEHAVIORS IN A RODENT MODEL OF SPINAL CORD INJURY

# publications[].label
BLOCKING KOR ACTIVATION PREVENTS MORPHINE-INDUCED ATTENUATION OF RECOVERY FOLLOWING SCI

# publications[].label
Impact of behavioral control on the processing of nociceptive stimulation.

# publications[].label
An animal model of functional electrical stimulation: evidence that the central nervous system modulates the consequences of training.

# publications[].label
Hand, mouth and eye preferences in the common marmoset (Callithrix jacchus).

# publications[].label
Closed-Loop Plantar Cutaneous Augmentation by Electrical Nerve Stimulation Increases Ankle Plantarflexion During Treadmill Walking.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Acute Opioid Administration Undermines Recovery after SCI: Adverse Effects Are Not Restricted to Morphine.

# publications[].label
Striatal -Opioid Receptor Activation Triggers Direct-Pathway GABAergic Plasticity to Induce Negative Affect

# publications[].label
NORBNI DOSE-DEPENDENTLY BLOCKS THE ADVERSE EFFECTS OF INTRATHECAL MORPHINE ADMINISTRATION FOLLOWING SCI

# publications[].label
A Simple Post Hoc Transformation that Improves the Metric Properties of the BBB Scale for Rats with Moderate to Severe Spinal Cord Injury

# publications[].label
Morphine self-administration following spinal cord injury.

# publications[].label
DEPRESSIVE-LIKE BEHAVIOR IN SPINALLY INJURED MALE RATS IS ASSOCIATED WITH A DECLINE IN SPATIAL LEARNING

# publications[].label
Osteopenia in a Mouse Model of Spinal Cord Injury: Effects of Age, Sex and Motor Function.

# publications[].label
Depression-like behavior is associated with deficits in cognition and hippocampal neurogenesis in a subset of spinally contused male, but not female, rats.

# publications[].label
Neurobiological Effects of Morphine after Spinal Cord Injury.

# publications[].label
Cytisine is neuroprotective in female but not male 6-hydroxydopamine lesioned parkinsonian mice and acts in combination with 17--estradiol to inhibit apoptotic endoplasmic reticulum stress in dopaminergic neurons.

# publications[].label
Instrumental learning within the spinal cord: underlying mechanisms and implications for recovery after injury.

# publications[].label
Population-Level Right Handedness for a Coordinated Bimanual Task in Chimpanzees: Replication and Extension in a Second Colony of Apes.

# publications[].label
MORPHINE UNDERMINES RECOVERY FOLLOWING SCI: OPIOID-IMMUNE INTERACTIONS

# publications[].label
Intermittent noxious stimulation following spinal cord contusion injury impairs locomotor recovery and reduces spinal brain-derived neurotrophic factor-tropomyosin-receptor kinase signaling in adult rats.

# publications[].label
Morphine increases macrophages at the lesion site following spinal cord injury: Protective effects of minocycline.

# publications[].label
Development of hand preferences in marmosets (Callithrix jacchus) and effects of aging.

# publications[].label
Monitoring recovery after injury: procedures for deriving the optimal test window.

# publications[].label
Group I metabotropic glutamate receptors control metaplasticity of spinal cord learning through a protein kinase C-dependent mechanism.

# publications[].label
Handbook of Laboratory Animal Science, Volume III

# publications[].label
The association between spinal cord trauma-sensitive miRNAs and pain sensitivity, and their regulation by morphine.

# publications[].label
Evidence of treating spasticity before it develops: a systematic review of spasticity outcomes in acute spinal cord injury interventional trials.

# publications[].label
Eye preferences in common marmosets (Callithrix jacchus): influence of age, stimulus, and hand preference.

# publications[].label
When Pain Hurts: Nociceptive Stimulation Induces a State of Maladaptive Plasticity and Impairs Recovery after Spinal Cord Injury.

# publications[].label
Loss of learning in the spinal cord: Role of glutamate systems

# publications[].label
Inter-group variation in abnormal behavior in chimpanzees (Pan troglodytes) and rhesus macaques (Macaca mulatta)

# publications[].label
MORPHINE UNDERMINES RECOVERY FOLLOWING SCI VIA A KOR-MEDIATED MECHANISM

# publications[].label
Inflammation is increased with anxiety- and depression-like signs in a rat model of spinal cord injury.

# publications[].label
The Evolution of Lateralized Motor Functions

# publications[].label
Fully Implantable Plantar Cutaneous Augmentation System for Rats Using Closed-loop Electrical Nerve Stimulation.

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Psychological stress as a modulator of functional recovery following spinal cord injury.

# publications[].label
TARGETING NORADRENERGIC SIGNALING TO MITIGATE BONE LOSS AFTER SCI

# publications[].label
Soft, stretchable conductive hydrogels for high-performance electronic implants.

# publications[].publisher
American Association for the Advancement of Science (AAAS)

# publications[].label
Edge AI-Based Closed-Loop Peripheral Nerve Stimulation System for Gait Rehabilitation after Spinal Cord Injury

# publications[].publisher
Institute of Electrical and Electronics Engineers (IEEE)

# publications[].label
Metaplasticity and behavior: how training and inflammation affect plastic potential within the spinal cord and recovery after injury.

# publications[].label
A simple post hoc transformation that improves the metric properties of the BBB scale for rats with moderate to severe spinal cord injury.

# publications[].label
Depression-like behavior corresponds with cardiac changes in a rodent model of spinal cord injury.

# researcherOn[].label
Inflamm-aging and bone loss in a rodent model of spinal cord injury

# researcherOn[].awardedBy.label
Craig H Neilsen Foundation - (Los Angeles, California, United States)

# researcherOn[].label
The Effects of Morphine on Sensory and Motor Functions After a Spinal Cord Injury

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Therapeutic Potential of Increasing Lymphangiogenesis in a Mouse Model of ALS

# researcherOn[].awardedBy.label
United States Department of Defense - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Investigating the neural mechanisms underlying SCI-driven depression and cognitive impairment: Role of BDNF

# researcherOn[].awardedBy.label
Craig H Neilsen Foundation - (Los Angeles, California, United States)

# researcherOn[].label
Derivation of the Mechanisms Mediating the Adverse Effects of Morphine in a Rodent Model of SCI: Functional Recovery and Neuron Loss

# researcherOn[].awardedBy.label
United States Department of Defense - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
Mechanisms of Opioid Resistance after Spinal Cord Injury

# researcherOn[].awardedBy.label
Craig H Neilsen Foundation - (Los Angeles, California, United States)

# researcherOn[].label
Opioid-immune interactions and their implications for long term recovery after SCI

# researcherOn[].awardedBy.label
United States Department of Defense - (Washington D.C., District of Columbia, United States)

# researcherOn[].label
How and when does peripheral input affect recovery after SCI

# researcherOn[].awardedBy.label
Craig H Neilsen Foundation - (Los Angeles, California, United States)

# researcherOn[].label
Morphine undermines recovery of function after SCI: Neurobiological mechanisms

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# researcherOn[].label
Pavlovian Conditioning of Injured Spinal Cord Systems

# researcherOn[].awardedBy.label
National Institutes of Health - (Bethesda, Maryland, United States)

# streetAddress
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS

# organizations[]
Texas A&M University Naresh K. Vashisht College of Medicine

# schools[]
Texas A&M University Naresh K. Vashisht College of Medicine